A novel method testing directly from urine can tell doctors which antibiotic will work in an average of 5.85 hours, reducing the risk of resistance developing and potentially lethal sepsis. The test agrees with reference methods in 96.95% of cases for seven first-line antibiotics.
Dr. Renuka Jain has been appointed as the new chair of the American College of Cardiology Board of Governors, a role that will empower governors and strengthen Chapter foundations. Her priorities include setting up governors for success, strengthening advocacy at state and national levels, and creating leadership pipelines.
Research suggests that cost of living and male job dissatisfaction played a major role in Europe's populist surge. Financial insecurity emerged as the strongest predictor of an anti-elite outlook, increasing the chances of voting populist by 17-20 percentage points.
A new study finds that air pollution alerts issued in China's cities significantly reduce PM2.5 levels and prevent nearly 54,000 premature deaths over a five-year period. The alerts trigger short-term actions to limit pollution, resulting in a 30-40% reduction in acute mortality risk due to PM2.5.
Researchers found that adults with type 2 diabetes who switched from dulaglutide to tirzepatide reported improved emotional responses and a greater quality of life. The study suggests that tirzepatide may offer broader benefits beyond glucose control, improving patients' physical and emotional well-being.
The event provided free blood pressure, glucose, and cholesterol screenings, as well as colorectal cancer risk assessments with take-home test kits. Families also participated in interactive health education activities and received CPR education.
Researchers have identified protein BCL-2 as a critical mechanism driving persistent pulmonary fibrosis, and a potential therapeutic target to reverse the disease. Blocking BCL-2 with targeted therapy promotes lung repair and reduces scarring in preclinical models.
A study published in PNAS found that the brain's social perception is more inclusive when a shared national identity is made salient. The research suggests that this neural flexibility can help bridge divisions and foster harmonious intergroup relations. By emphasizing common identities and shared goals, social cohesion can be improved.
A global research team has identified fluvoxamine as a medication that significantly improves fatigue and quality of life among adults with long COVID. The study found consistent and meaningful benefits from the widely available antidepressant.
Developed by WashU Medicine researchers, the immunotherapy targets specific blood cancers called T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma. Early-phase clinical studies have demonstrated manageable side effects and early success in treating these aggressive blood cancers.
A recent study published in Gait & Posture found that analyzing a person's walk and getting up from a chair can identify elevated depression and anxiety symptoms. The researchers used machine-learning models trained on data from participants' movements combined with information about their mental state, achieving high accuracy rates.
Researchers are analyzing real-world patient data to study the safety and effectiveness of GLP-1 drugs in preventing Alzheimer's. The study aims to determine if these widely available diabetes medications can delay or prevent the onset of Alzheimer's, a complex public health crisis that affects millions worldwide.
A University of Kansas scholar argues that history standards are prone to politicization, which can lead to a lack of understanding of historical events and people. In contrast, states like Kansas and Maine's 'minimalism' approach focuses on high-level concepts and guiding principles rather than specific content recommendations.
A new tool called GraFT enables precise analysis and reconstruction of actin filamentous structures in plant cells. The tool helps understand the dynamics and spatial arrangement of filaments, crucial for cell shaping, stability, and movement.
A study found that olezarsen significantly lowered triglycerides in patients with hypertriglyceridemia, but did not alter non-calcified coronary plaque volume at one year. Researchers suggested that a more substantial impact on both triglycerides and apolipoprotein B may be needed to observe measurable effects on plaque volumes.
Rock art discovered in northwest Arnhem Land reveals up to 14 new images of the Tasmanian tiger, challenging the theory that it became extinct around 3,000 years ago. The artwork, created using red ochre and white pipe clay, provides rare insight into the cultural importance of thylacines in everyday life.
Researchers discovered that even tiny amounts of PFDA cause visible facial changes and increase risk by 10% at low exposure levels. PFDA blocks key enzyme CYP26A1, disrupting retinoic acid metabolism and leading to abnormal facial development.
Early and continuous acoramidis treatment resulted in sustained incremental reductions in all-cause mortality, cardiovascular-related mortality, and first cardiovascular hospitalization. The findings support the importance of early and continuous long-term treatment with acoramidis in transthyretin amyloid cardiomyopathy.
A Mayo Clinic study found that AI-derived heart fat measurement can predict cardiovascular events more accurately when combined with traditional risk assessment approaches. The measurement significantly improved long-term risk prediction, especially among patients at low-risk categories.
A new study reveals that improving surrounding landscape quality can increase bird species survival in forest remnants, with modest increases in nearby tree cover substantially boosting numbers. This contradicts traditional views on habitat fragmentation and highlights the importance of a more hospitable matrix for conservation.
Researchers develop CAR T cells designed to target both cancer cells and supportive cells in the tumor microenvironment, bearing the surface protein uPAR. The new approach shows significant power to fight cancer with limited impact on other healthy tissues and cells.
Researchers at Osaka Metropolitan University identified the tegmentum region as the area where light signals from the eyes and pineal organ are integrated. This integration enables fish to swim up or down based on differences in light wavelength, aiding survival decisions.
Researchers at NIST have developed a new way to package photonic integrated circuits, allowing them to operate in extreme environments. The HCB technique creates an inorganic bond between the optical fiber and the photonic chip, enabling precise alignment and efficient light coupling.
A study found that elevation of artemin could serve as a disease marker and potential therapeutic target for osteoarthritis in cats. The researchers confirmed that TRP channels commonly associated with osteoarthritis pain were expressed and functional in healthy cat DRG neurons, and increased artemin blood concentrations were correlate...
A new study found that over 40% of children who experienced peer victimization showed clinically significant trauma symptoms. Researchers tracked 250 students' experiences with peer victimization and found that trauma-related symptoms persisted for more than six months.
Researchers developed a perovskite-type ceramic catalyst that maximizes ethanol-to-hydrogen conversion through exsolution of nickel nanoparticles. The study demonstrated the importance of calcination temperature in controlling catalyst performance.
A new study found that modern genetic testing can identify clinically significant genetic explanations for schizophrenia in about 6% of patients, or roughly 1 in 16 individuals. Early age of onset and co-occurring neurodevelopmental disorders are associated with a higher likelihood of finding a genetic explanation.
A large-scale computational study found that point-of-origin effects significantly influence protein diversification, with relatively small divergence seen from ancestral proteins. The research reinforces existing theories on initial protein formation and highlights the limitations of modern AI protein design methods.
A new AI-based system analyzing blood vessels at the back of the eye has been shown to identify people at risk of heart problems with strong correlation. The system, called CLAiR, received Breakthrough Device designation and demonstrates promise as a noninvasive screening method.
Researchers at UMass Amherst have made a breakthrough in shrinking the size of quantum computers by integrating laser systems onto photonic chips. This technology has the potential to enable large-scale quantum computing and make optical clocks portable, with applications in fields such as deep space navigation and GPS.
A recent study found that discontinuing beta-blockers in stable, low-risk patients who have had a heart attack is non-inferior to continuing them. The results suggest that lifelong beta-blockers may be unnecessary for some patients. Discontinuation was associated with similar outcomes and quality of life compared to continued therapy.
Researchers have developed copper-loaded starch nanoparticles that can be broken down by specific bacteria to release antibacterial copper molecules. These nanoparticles were effective against Staphylococcus aureus and Bacillus subtilis, with improved targeting capabilities compared to previous studies.
A team of researchers has created a 3D model of pediatric brain tumors using biopsy-derived organoids, allowing for more accurate testing of new drugs. The model, which accurately reproduces the human environment, preserves the molecular characteristics of the original tumor and maintains cellular heterogeneity.
Researchers have developed a highly sensitive electronic 'skin' using tiny devices that can measure force applied over an area. This technology has the potential to improve prosthetic limbs and robotic manipulation, allowing robots to accurately track hand movements and grasp delicate objects.
Researchers found a 38% higher risk of diabetes in adults with HIV who switched from protease inhibitors to integrase inhibitors. The study suggests that medication changes may have adverse metabolic impacts, warranting close monitoring, regardless of weight gain.
Two studies suggest that loneliness is not just a lack of connection, but how people experience those connections, with increased risk of disease and death associated with feelings of lonelier-than-objective isolation. Daily life perceptions of social threat also contribute to self-reinforcing sequences of emotional states, behaviors, ...
A study reveals dermcidin, a human body natural molecule, exhibits antiviral activity against the influenza virus. Higher baseline levels of dermcidin in individuals who don't develop flu-like symptoms may be associated with lower susceptibility to infection.
Researchers found that the ICM's mathematical predictions are due to a flaw in standardization and lack of evidence supporting inhibitory growth processes. The model was applied to non-sequential traits, contradicting its sequence-based development claim.
Researchers at University of Michigan Engineering and Michigan Medicine used protein nanoparticles to genetically modify several types of human cells, including liver cancer and immune cells. The goal is to develop a safer method for delivering gene therapies without using modified viruses.
Frangopol and his team develop a framework to optimize seismic retrofit strategies for deteriorating bridge columns, balancing risk and cost. The approach integrates time-dependent risk assessment, economic evaluation, and real options analysis to identify optimal intervention timing under uncertainty.
NRG Oncology has appointed Dr. John Nakayama as Vice Chair of the NRG Ancillary Projects Committee, Dr. Ibrahim Nassour as Vice Chair of the Surgical Oncology Committee, and Dr. Scott Okuno as Vice Chair of the Sarcoma Subcommittee. Dr. Angeles Alvarez Secord was also appointed Chair of the Investigator & Career Development Committee.
Researchers from UCSB and UMass Amherst successfully integrated stabilized laser chips with a room temperature trapped ion qubit, enabling compact and portable quantum systems. This breakthrough paves the way for applications in quantum sensing, computing, and fundamental science.
Researchers have designed a system that releases algaecide steadily over weeks or months, making it less expensive and more efficient than existing options. The buoys removed nearly all cyanobacteria without the need for frequent reapplication.
Researchers analyzed 48 isolates of P. griseola and found a potential symbiotic relationship between the fungus and endophytic bacterium Achromobacter xylosoxidans, influencing disease severity. The study sheds light on how the pathogen evolves and may point to new strategies for breeding disease-resistant crops.
Researchers have discovered how a disease-causing bacterium uses a single protein to interfere with the body's defenses in multiple ways, offering a clearer picture of how infections take hold at the cellular level. This discovery highlights the importance of targeting specific interactions between bacterial proteins and human cells in...
A study calls for increased coral assisted evolution research to help reefs cope with rapidly warming oceans. The international team identified nine research priorities, including expanding large-scale field-based research and long-term funding to understand coral biology.
The collaboration aims to improve manufacturing of silicon carbide ceramics, a strong material that can withstand high heat and radiation. Researchers will combine 3D printing and digital technologies to enhance production efficiency and reduce defects.
Researchers have developed a reconfigurable textile interface that supports flat touch, folded 3D manipulation, and shape-change commands. The 'one cloth, many states' framework reduces the need to swap props and recalibrate alignment, making it promising for constrained-space operation training and human-machine interaction scenarios.
Researchers develop ISAMFP, a computational framework that leverages natural target motion to enable super-resolution imaging of dynamic non-cooperative targets. By exploiting angular diversity and phase modulation, the method achieves high-frequency information recovery from sub-aperture intensity measurements.
Researchers have found that targeted ultrasound can aid in unlearning fear more efficiently by stimulating the amygdala, a key region in processing emotions. Participants who received ultrasound stimulation showed reduced fear responses to previously frightening stimuli.
A research team discovered that a protein complex consisting of SMG1, SMG8, and SMG9 ensures the efficient execution of nonsense-mediated mRNA decay (NMD). The study found that this complex is essential for maintaining the stability of NMD under various conditions.
A new systematic review found that screen time use among children and adolescents has dramatically risen over the past three decades, with a clear increase occurring after the onset of the COVID-19 pandemic. The review analyzed 60 peer-reviewed studies and found that older children and adolescents reported higher screen time than young...
A study published by HKUMed found that Resmetirom, a drug approved for treating metabolic dysfunction-associated fatty liver disease, demonstrates potential in preventing and suppressing liver cancer caused by fatty liver disease. The treatment also reduces liver fat, improves metabolic health, and modulates the tumour microenvironment.
Researchers at Tohoku University developed a method to transform regular surfaces into keyboards for AR/MR technology, using the blanching phenomenon to detect fingertip contact. The system requires no special sensors or devices and allows users to rest their fingers on the surface during operation, promoting comfortable interaction.
Scientists have discovered that a fast-rising strep bacterium comes in more forms than expected, with distinct variants linked to specific types of infections. The study provides critical genetic data to improve diagnosis, infection control, and future vaccine planning for this growing bacterial threat.
The new study introduces a comprehensive framework for conducting umbrella reviews in education, providing a structured and accessible guide for researchers. The study's findings highlight the potential of this method to provide high-quality evidence syntheses and strengthen educational research.
Researchers identified a bacterium strongly linked to noma, a deadly disease that affects young children in extreme poverty. Early detection through diagnostic tools could save lives and prevent severe disfigurement.
A study found that dentists have a higher prevalence of vision-related problems due to prolonged exposure to artificial lighting. Chronic dental lighting caused retinal damage, disruption of the blood-retinal barrier, and inflammation, ultimately impairing visual health.
Research in mice reveals direct gene regulation by alcohol metabolites, with varying effects on brain regions and exposure durations. Short-term exposure influences more genes and epigenetic programs compared to lengthy exposure.
Research using high-density EEG recordings found that infant brain activity changes rapidly between 3-6 months, reflecting synaptic connection growth and neural network maturation. This study provides a new method for early diagnosis of neuropsychiatric conditions.