Young people aged 16-25 are three times more likely to start drinking alcohol than non-alcohol alternatives, according to new research from the University of Sheffield. Despite concerns about a potential 'gateway' effect, no evidence was found that no/lows impact young people's alcohol consumption.
A research team from China has developed a material with high charge-to-spin conversion efficiency, achieving record-breaking performance in spintronic devices. The discovery utilizes nonsymmorphic symmetry to stabilize the material and enables ultra-low power magnetic switching.
A research team developed an innovative method to analyze histone modifications during cell division, revealing three distinct phosphorylation programs that follow a clear temporal sequence. The study refutes the previous assumption that removal of certain chemical groups from histones is crucial for DNA compaction.
The upper-level subtropical westerly jet over East Asia shows a weakened long-term trend under orbital forcing but strengthens under greenhouse gas forcing. This study challenges the simple assumption that warming means weakening and suggests the jet could become stronger under future global warming.
Researchers identified 16 clinical laboratory markers linked to PTSD, including cholesterol and glucose levels, liver indicators, and red and white blood cell counts. These biomarkers may reveal the physical impact of PTSD on the body, supporting timely interventions to mitigate chronic disease risk.
A research team developed an implantable sensor to monitor dynamic H₂O₂ levels in plants, enabling real-time tracking of plant stress responses. The system achieved high time resolution and maintained stable performance under various conditions.
A new study published at the Pediatric Academic Societies Meeting found that adolescents with high social media use had triple the odds of recent alcohol use compared to non-users. The study suggests that digital literacy and safe online navigation are crucial in reducing exposure to alcohol-related content.
A new research study by Australian energy companies and waste management firms has shown how organic waste can be safely turned into clean gas for homes and businesses. The team identified critical specifications for optimal biomethane quality, making it more cost-effective to produce.
New findings suggest that clopidogrel monotherapy is associated with a lower risk of net adverse clinical events compared to aspirin monotherapy, even in patients at high risk of bleeding. This benefit is more pronounced in patients with high bleeding risk and complex procedures.
A cohort study of 6,802 pregnant women found an inverse association between grip strength and the risk of hypertensive disorders of pregnancy. The study suggests that relative grip strength may be a useful tool for risk stratification of HDP.
The study found that outpatient care for youth is driving the growth, with nicotine, cannabis, and opioids being the most common substances. Despite this, alcohol-related visits have declined in all care settings over the past 16 years.
A new study found that electronic provider notifications significantly increased aortic valve replacement rates and improved survival among older patients with severe symptomatic aortic stenosis. The DETECT-AS trial showed that clinicians who received automated email alerts with abnormal heart ultrasound results detected AS were more l...
Researchers reveal how expansion of bone marrow fat promotes immunosuppressive PD-L1 signaling, leading to enhanced osteoclast activity and accelerated bone loss. Reducing bone marrow fat improves bone structure.
A cohort study found that bereavement was associated with increased cardiovascular disease risk both before and during the COVID-19 pandemic. The strongest association was observed for partner or sibling loss during the pandemic, highlighting the importance of targeted clinical monitoring and preventive care for bereaved individuals.
Researchers at Griffith University and Queensland University of Technology have developed a machine-learning model to design efficient urea catalysts using waste gases. The model accurately predicted key co-adsorption energy values, narrowing down over 1,400 candidates to promising ones.
This research explores how vibration can convey emotional qualities like reassurance and encouragement, as well as represent abstract experiences through touch. The findings highlight the potential of vibration as an alternative to sound-based navigation for blind and low vision people.
A novel blood return system has been shown to significantly reduce blood loss during pulmonary embolism procedures, with a median reduction of 97%. The study found that the system improved procedural efficiency and maintained hemodynamic efficacy without added therapies or major complications.
Young scholars explore how to make clinical decisions from biomarkers to immunotherapy. They present innovative approaches for targeted therapy sensitivity and guidelines, shedding light on neoadjuvant care.
A new study found that infants receiving maternal RSV vaccination or Nirsevimab after birth had significantly lower RSV infection rates and fewer severe complications. The study showed a high uptake of the vaccines among pregnant patients and newborns, leading to declining rates of RSV-related illnesses.
A new study found that COVID-19 significantly worsens cardiovascular outcomes, leading to higher one-year mortality rates in patients with severe heart attacks. Patients who survived a heart attack and experienced COVID-19 had a 25% higher one-year mortality rate compared to those without COVID-19.
A pilot study of 100 exclusively breastfeeding women found that maternal dairy intake is associated with decreased concentrations of numerous human milk lipids. The study suggests a link between healthy dairy intake and lower levels of specific milk lipid species, which may have implications for infant health.
New research suggests exposure to fathers' depression in pre-adolescence is associated with poor educational outcomes among males, but not females. Early identification and family-centered support can help promote school success and long-term well-being for affected sons.
Researchers found that obakulactone reduced joint swelling, restored cartilage structure, and improved immune organ function in RA rats. It also suppressed proinflammatory cytokines and shifted macrophage polarization to anti-inflammatory M2.
Researchers developed Plan & Protect, a technology-guided safety planning program for rural youth with suicidality seeking care in emergency departments. The program aims to enhance accessibility and usability of safety planning in resource-limited settings, supporting more effective crisis care for adolescents in rural communities.
Researchers developed a next-generation phototherapeutic agent, NDI-COE, which induces pyroptotic cell death in hypoxic tumor tissues. The agent's superior photochemical mechanism involves strong binding to water molecules and efficient electron transfer to oxygen.
A new study calls for tripling energy efficiency, electrification and action against extreme energy consumption by 2035. This would accelerate the spread of efficient technologies and generate revenue to expand energy access and support low-carbon investment.
A new study examined geographic patterns in autism diagnosis by primary care providers among Medicaid-enrolled children in 29 states, finding significant variation between regions. The study found that 29% of children were diagnosed with ASD by a primary care provider, with rates varying from 20.0% in the Midwest to 36.4% in the West.
Researchers at Goethe University Frankfurt are exploring modern quantum materials, which exhibit fascinating phenomena in response to external stimuli. Olena Fedchenko investigates electronic structure and properties of these materials using various photon sources.
The study found that low influenza vaccination rates among children are associated with increased healthcare visits, hospitalizations, and ICU admissions. Achieving a 70% immunization rate could prevent up to 2.2 million outpatient visits and 123 pediatric deaths during high-incidence flu seasons.
The MitraClip procedure has been shown to be safe and effective for patients with mitral annular calcification, improving symptoms and quality of life. Despite higher mortality rates, patients with MAC experienced significant reductions in mitral regurgitation and improvements in quality of life, indicating a promising treatment option.
A study uncovers the connection mechanism between ketone bodies and the mTORC1 pathway, identifying RagC as a key player. The findings suggest RagC-K349bhb as a potential therapeutic target for BHB-based CRC treatment strategies.
The INSEAD for Impact programme is a three-day immersive executive forum that helps leaders translate emerging trends into practical strategies and prioritized actions. The programme aims to move beyond analysis to execution, supporting leaders in understanding forces reshaping business and building personal and organizational resilience.
The study provides atomic-level templates of GHRHR's active and inactive states, enabling the design of highly selective agonists and potent antagonists. This breakthrough transforms our understanding of GPCR signaling from static snapshots to a dynamic framework for drug development.
Researchers have produced complete genome sequences for six peanut varieties, identifying two candidate genes linked to oil content and seed size. These findings provide a comprehensive blueprint for future peanut breeding and improvement strategies.
Researchers found that elevated Lipoprotein(a) levels are associated with a higher risk of major adverse cardiovascular events, including stroke and death. Patients with high Lp(a) levels should work closely with their healthcare provider to aggressively lower LDL cholesterol and manage other cardiovascular risk factors.
The study found that out-of-state Chicago Abortion Fund callers traveled more than 3 times the distance to Illinois after Dobbs compared to before. These callers were also more likely to have private or no insurance, be from rural areas, and receive hospital-based care during their pregnancy.
A new study reveals that over 75% of older adults have used complementary health approaches, including mindfulness, yoga, tai chi, acupuncture, and more. The study highlights the need for healthcare providers to discuss the risks and benefits of these therapies with their patients.
The CARPOOL study demonstrates radial-to-peripheral access achieves comparable procedural success rates to traditional common femoral artery access for lower extremity peripheral artery disease revascularization. However, the R2P group had higher major adverse limb events at six months due to target vessel revascularization.
A new study found that influenza D viruses can vigorously replicate in human cells and lung tissue samples, suggesting a strong potential to spill over to humans. Researchers also detected antibodies against Influenza D in people who work with cattle, but no active human infection has been discovered to date.
AI models can analyze complex data to predict disease progression and identify early signs of kidney damage. This allows for earlier detection and better treatment planning, making a significant impact on patient outcomes.
A novel study in Biological Diversity reveals the integrated physiological and symbiotic adaptation mechanism underlying P. purpuratum's ex situ conservation. The research demonstrates that ex situ conservation elevates seed-set rates but incurs trade-offs in photosynthetic capacity and oxidative stress.
This eight-year analysis showed that tenofovir alafenamide (TAF) maintained viral suppression, normalized alanine aminotransferase levels, and improved renal and bone safety in patients with CHB. The study's findings support the use of TAF as the preferred long-term treatment option for this population.
The new SCORE2-LAC model aims to improve cardiovascular risk prediction in Latin America and the Caribbean. The model applies region-specific data from 32 countries, incorporating 2.6 million individuals, and will be validated using an additional 37 million people from Brazil.
Researchers have developed SmartDJ, an AI-powered editor that allows users to reshape audio experiences with simple words. The system uses language models and diffusion models to interpret high-level requests and generate edited outputs.
Researchers at Tokyo University of Science demonstrated a method for manipulating metallic chiral nanoparticles using circularly polarized light. By confining light to an evanescent field near the surface of ultra-thin optical fibers, they selectively transported left- and right-handed particles based on their chirality.
A study on elite male football players found that athletes of Black ethnicity, particularly those from West and Central African regions, exhibited more pronounced repolarisation abnormalities and structural remodelling. The findings suggest that treating athletes of Black ethnicity as a single group may oversimplify clinically meaningf...
A study published at ESC Preventive Cardiology 2026 found that climate change is driving extreme weather events, leading to increases in major cardiovascular events. Heatwaves had an immediate impact, while coldwaves produced a delayed and more sustained effect. Air pollution further amplified the effects of extreme temperatures.
A new study reveals that conspicuous markings, including 'eyespots', evolve under specific ecological conditions. Smaller skates and rays, lacking strong physical defences, are more likely to develop bold spots or eyespots in well-lit, shallow waters.
Monash University researchers have made a breakthrough in using phage therapy to treat life-threatening infectious diseases. The treatment involves injecting viruses called bacteriophages to kill bacterial infections that have not responded to other treatments.
Researchers have discovered a new vulnerability in senescent cells, which can be targeted to kill them and treat cancers. The approach could complement existing treatments, leading to improved outcomes for patients.
A new study improves gene editing efficiency by identifying key genes in human cells that drive particle assembly. By disabling a single gene, researchers boosted production of potent delivery vehicles. The discovery has broad implications for the widespread application of gene editing technologies.
Researchers mapped epigenome changes in cells that regulate blood sugar levels, finding patterns differ between people with and without type 2 diabetes. Epigenetic alterations impact insulin-producing beta cells, leading to impaired energy production and reduced insulin release.
A new study warns that by 2085, 36% of animal habitats on land may experience multiple extreme events like heatwaves, fires, or floods. However, rapidly cutting emissions to net zero could limit the areas affected to just 9%.
Researchers found that building everyday behavioral skills in early childhood can shield young brains from the detrimental effects of prenatal stress. Children with stronger adaptive skills showed comparable brain activation patterns to their unexposed peers, suggesting these skills may protect brain function.
A recent study has found a significant link between ambient air pollution and an increased burden of respiratory infections in the first year of life. The Immune Development in Early Life (IDEaL) Rome Cohort study suggests that exposure to urban pollutants during infancy may fundamentally shape immune resilience, leading to a higher ri...
A new CHOP study investigates the relationship between parenting and gaming disorder in young children with ADHD, finding that negative parenting behaviors are associated with an increased risk of problematic gaming. The study also highlights the importance of parental involvement in gaming and household limits on gaming consoles.
A new study examined measles vaccination coverage in a primary care network following a large post-elimination outbreak. The findings show that MMR coverage remained below herd immunity levels, highlighting the fragility of measles elimination.
Partial heart transplantation replaces only defective valves and related structures, eliminating need for repeat replacements. This procedure can provide thousands of additional valve transplants annually, benefiting young patients worldwide.
A new study found that US children experience higher all-cause mortality than peers in other high-income nations, with a gap of over 800,000 excess child deaths between 1975 and 2023. The mortality disadvantage is now concentrated among older adolescents, particularly males.
A recent study found that states with stricter firearm laws had significantly lower rates of youth-perpetrated firearm homicides, with a 66% lower rate compared to those in weaker law states. The study also highlighted the importance of understanding how firearm laws shape youth-perpetrated homicides in prevention efforts.