A new database, scCASdb, has been developed to standardize single-cell chromatin accessibility sequencing (scCAS) datasets in the h5ad format. This enables diverse single-cell analyses that were previously hindered by the lack of comprehensive collections.
The study reveals that orphan non-coding RNAs (oncRNAs) exist across all major cancer types and can be used as digital molecular barcodes to capture cancer cell identity. The research also identifies oncRNAs that drive cancer progression, with some showing promise as biomarkers for monitoring patients.
A second major neuroscience research project will explore the physiological and psychological impact of shared reading groups and book clubs. The study aims to build a clearer evidence base for how collective experiences shape connection and belonging.
Researchers observed episodic memory in rats, suggesting they can model complex cognitive processes. The study shows rats can recall memories with accuracy and context, even after a long delay, implying evolutionarily ancient forms of memory.
A new study evaluates the accuracy of ten satellite-based and reanalysis precipitation datasets using in-situ rain gauge measurements across Czechia from 2001 to 2021. The GSMaP dataset showed superior performance for rainy days, while ERA5-Land overestimated annual precipitation by 15–35%.
Researchers review low-power memristors for energy-efficient and fast neuromorphic computing. Memristors enable in-memory computing, artificial synapses, and neurons, reducing power consumption. Innovative designs and materials are discussed to overcome challenges.
The Emergency Medical Procedures 3D Dataset (EMP3D) captures intricate movements with unprecedented precision, enabling transformative applications in healthcare AI and robotics. EMP3D offers high-precision reconstruction, AI-ready infrastructure, and open access to accelerate innovation.
This study identifies shared genetic variants linking schizophrenia with left- vs right-hemisphere white-matter tracts, revealing hemispheric asymmetry. Hemispheric specificity was observed in the left posterior thalamic radiation and tapetum, with higher proportions of shared loci.
Researchers developed a nanodelivery system that synergizes ferroptosis and STING activation to treat metastatic bladder cancer. The system showed robust tumor control and improved survival rates, with enhanced immune response and reduced metastasis.
A new study reveals that positively charged ions accumulate in one phase, reducing electrostatic repulsion and allowing negatively charged biomolecules to localize within droplets. This mechanism explains the preferential partitioning of molecules in liquid–liquid phase separation.
The expert consensus provides a structured framework for assessing large language models (LLMs) before deployment in clinical workflows. The framework includes retrospective evaluation, six key capability domains, and essential safeguards for patient data protection and bias mitigation.
Researchers developed bioengineered lymphatic tissue (CeLyT) that restored functional lymph nodes in mice with secondary lymphedema. CeLyTs improved lymphedema symptoms by restoring lymphatic flow, filtration capacity, and immune cell populations.
Insilico Medicine has received investigational new drug (IND) clearance from the US FDA for ISM8969, an orally available NLRP3 inhibitor targeting inflammation and neurodegenerative disorders. The Phase I clinical trial plans to evaluate the safety, tolerability, and pharmacokinetics of ISM8969 in healthy volunteers.
Researchers have found a nonlinear dose-response relationship between exercise and hepatic steatosis, indicating that a combination of aerobic and resistance exercises can produce clinically meaningful improvements. The study suggests that exercising above 130 MET-min/week can lead to significant reductions in hepatic steatosis.
Research reveals significant shifts in tree diversity among tropical forests driven by global change, with some areas experiencing declines in species richness while others gain species.
A study finds that nearly half of newborns with severe spina bifida experience breathing problems during sleep, which can be detected through comprehensive sleep studies. Early treatment may significantly improve cognitive development in these high-risk infants.
Researchers studied diet changes among three whale species, fin, humpback, and minke whales, over 28 years. The study found that whales are adapting their feeding habits in response to limited resource availability and increased competition.
A new study suggests that the Moon's surface record sets a hard limit on the possibility of late meteorite delivery being the dominant source of Earth's oceans. The researchers analyzed oxygen isotopes in lunar regolith samples, finding that even generous assumptions about impactor flux would only supply a small fraction of Earth's water.
Research led by University of Miami researchers shows that effective fisheries management can coexist with predator recovery, contradicting previous assumptions. The study found that fishing effort, not predator recovery, drives fishery yields in the North Sea.
Platelet-derived PITTs (Platelet-derived Integrin- and Tetraspanin-rich Tethers) are released from platelets during severe pathological conditions, driving damaging inflammatory processes. Blocking αIIbβ3 with monoclonal antibodies reduces PITT formation and tissue damage in disease models.
A new machine learning framework for satellite-based CO2 retrievals provides highly accurate concentration estimates while quantifying uncertainty, outperforming traditional physics-based methods in speed and accuracy.
A new study using satellite data confirms that California's shift to electric vehicles is making measurable differences in air quality and public health. For every 200 ZEVs added, nitrogen dioxide levels dropped 1.1%.
Physicists report the first experimental observation of quantum state transfer enabled by hidden symmetries in a network of laser-written optical waveguides. This discovery dramatically expands the design space for quantum circuits, opening the gates towards new classes of networks for secure quantum communication and cryptography.
A new study develops a video-based method to measure cardiopulmonary coupling, synchronizing heartbeat and breathing variations without contact. This approach produces consistent results with traditional devices, offering a promising solution for long-term monitoring and comfort.
A research team at Kumamoto University has developed a breakthrough drug-delivery platform using a small-intestine-permeable cyclic peptide, enabling efficient oral delivery of insulin. This approach achieves a pharmacological bioavailability of approximately 33–41% relative to subcutaneous injection.
Researchers have developed a GNSS-only method that consistently outperforms existing methods in dense urban areas, enabling safer and more reliable autonomous navigation. The approach uses a probabilistic framework to estimate position without relying on carrier-phase integer ambiguity resolution.
Citizen science is essential for improving how restoration success is evaluated and managed over time. By integrating public observations into formal monitoring systems, restored wetlands can be better understood and maintained.
A statistically significant spike in shark bites occurs every October in Hawaiian waters, primarily driven by tiger sharks. The research found a strong link between the October spike and the tiger shark's reproductive cycle, specifically parturition, which occurs during September-October.
The new platform, led by PPPL, aims to speed up simulations needed to advance fusion energy research. STELLAR-AI will integrate CPUs, GPUs, and QPUs to tackle the challenges of private fusion companies, enabling faster design and optimization of stellarator devices.
Researchers develop a novel DNA origami-based method to synthesize stable, monolithic amorphous silver nanostructures. The technique introduces geometric frustration that suppresses crystallization in metallic silver, resulting in high-stability and disordered atomic arrangements.
Researchers used molecular dynamics simulations to study how organic molecules move with supercritical water inside carbon nanotubes. Aromatic compounds significantly slowed down their own motion and surrounding water, while alkanes moved relatively freely. Temperature played a key role in overcoming transport limitations.
A recently identified tree species in Australia, Rhodamnia zombi, is facing extinction due to myrtle rust, a fungal disease that attacks and kills its young shoots. Researchers are working on finding clean cuttings and propagating them to grow resistant seedlings, which may hold the key to resurrecting the 'zombie' tree.
Researchers found that biochar produced at high temperatures can effectively immobilize cadmium in soil, while low-temperature biochar may increase metal uptake by crops. The study highlights the importance of considering biochar production temperature and microbial interactions for effective heavy metal remediation.
Researchers created a new frequency-aware approach to crafting adversarial images that better match human visual perception. The method, called Input-Frequency Adaptive Adversarial Perturbation (IFAP), significantly outperformed existing techniques in structural and textural similarity.
A comprehensive review of 233 studies identifies the connection between workplace conditions and loneliness, highlighting the importance of job quality, stress management, and social support. Chronic loneliness harms emotional and cognitive well-being, while interventions such as mindfulness and volunteering can provide relief.
A new study published in The Lancet Obstetrics, Gynaecology, & Women's Health found that postmenopausal women receiving hormone therapy lost 35% more weight while taking tirzepatide, a GLP-1-based obesity medication. This research could help develop personalized strategies for managing cardiometabolic risk in postmenopausal women.
A study found that brief exposure to benzo[a]pyrene disrupted normal development and skeletal health in fish, with effects persisting across multiple generations. The researchers identified specific metabolic signatures that could serve as early warning indicators of long-term toxicity.
A research team at UNH uses unmanned aerial vehicles (UAVs) to monitor corn fields, providing insights into crop yields and disease risks. The study demonstrates the ability of UAV imagery to differentiate between corn varieties with high accuracy.
Researchers found that using words with clear opposites can shape people's sense of certainty when evaluating messages. This means that certain wording types can make messages less effective among skeptics, while boosting confidence among believers.
Researchers identified genes controlling cell wall changes in ripening pistachio hulls, which can lead to cracks and tears. The study also found that the physics of forces and humidity influence degradation, with applications for other non-berry fruit crops.
BrainHealth Week 2026 will explore precision brain health, biosensor technology, and mental resilience, offering actionable strategies for improving daily performance and quality of life. The event brings together industry leaders, scientific community, students, and the community at large to discuss practical roadmap for longevity.
A recent study from University Hospitals Cleveland Medical Center found that diagnostic abnormalities were no more likely to occur among adults with unintentional weight loss than among comparison patients. In most cases, the weight loss was not linked to a serious underlying condition, with only a .7% overall rate of cancer.
Researchers at the University of Rochester have developed a new way to harness the properties of tungsten carbide as a catalyst for producing valuable chemicals and fuels. The method, which involves carefully manipulating tungsten carbide particles at the nanoscale level, has shown promising results in reducing costs and increasing eff...
Researchers analyzed 58 human studies to investigate the link between gut microbiome imbalances and cognitive decline. The findings suggest that individuals with mild cognitive impairment and Alzheimer's disease have distinct gut bacteria profiles compared to healthy individuals.
The University of Houston is launching an online certificate program in film and media production and leadership to prepare students for careers in the growing film industry. The program aims to strengthen workforce development and build a career-ready workforce that attracts independent filmmakers to Houston.
A recent study led by researchers at Drexel University's Autism Institute found that early intervention is key to helping most non-speaking autistic children develop spoken language. The study suggests that duration of the intervention rather than intensity may be more effective in achieving outcomes for these children.
Researchers used machine learning to evaluate 1,773 bus stops across Massachusetts, identifying 13 crash-relevant characteristics and proposing countermeasures. The study found that bus stop types in mixed-use arterial corridors and dense urban cores have the highest prevalence of crashes.
Researchers found structural and functional differences between mitral annular calcification and rheumatic mitral stenosis, which may lead to inaccurate diagnoses and treatment. The study suggests using disease-specific diagnostic criteria and management guidelines for patients with MAC-related stenosis.
The W8Buddy study, a major real-world evaluation of digitally delivered specialist weight management pathways, is recruiting 450 participants from 4 Specialist Weight Management Services across England and Wales. The study aims to assess the long-term health benefits and economic impact of digital tools for obesity care.
American Heart Association names Indiana University head coach Curt Cignetti national college football Coach of the Year, marking a dramatic turnaround in his second season. The award honors exceptional leadership and excellence, with proceeds benefiting heart health research and awareness.
A study found that witnessing terminal lucidity in children is a profoundly spiritual experience, influencing caregivers' belief systems and sparking personal growth. Caregivers reported disclosing what they witnessed to others, receiving mixed reactions from healthcare professionals and colleagues.
Research reveals that nanoplastics amplify the toxicity of tire-derived chemicals, causing severe eye malformations and impaired vision in zebrafish embryos. The study highlights a previously underappreciated risk of combined pollution, emphasizing the need for integrated approaches to environmental management.
The American College of Lifestyle Medicine (ACLM) has elected seven new members to its Board of Directors, bringing diverse expertise in clinical practice, public health, and education. The new board members will support ACLM's efforts to integrate lifestyle medicine into healthcare, furthering the field's growth and impact.
Researchers are studying microchimeric cells that can play complex roles in a person's body, including healing wounds and regulating the immune system. However, more research is needed to understand their role in health outcomes, particularly pregnancy complications and autoimmune diseases.
Researchers have resurrected ancient nitrogenases, enabling a new window into the origins of life on Earth. The study provides insights into the evolution of early life and its relevance to understanding life elsewhere in the universe.
Researchers at Tufts University used sourdough starters to test a pairwise interaction model that reliably forecasts how up to nine microbial species will interact. The study provides insights into predicting microbial coexistence, improving food safety, and informing human health.
Researchers at Rockefeller University discovered that fruit flies use a two-neuron system to calculate wind direction, leveraging double-duty signaling mechanisms. This finding redefines our understanding of how neurons compute direction and navigate their environment.
A study published in Stem Cell Reports suggests that transferring young microbiota to the intestines of older mice can speed up healing and improve the regenerative potential of intestinal stem cells. This approach may have implications for treating gut-related conditions such as inflammatory bowel disease.
A new study found that high body mass index (BMI) increases the risk of vascular-related dementia. The researchers believe treating or preventing high blood pressure may help reduce this risk. Early weight-loss interventions could potentially prevent dementia, especially vascular-related dementia.
Researchers at Mount Sinai detail how decades of cancer vaccine research have converged into more precise and effective immunotherapies. Decades-long clinical trials show personalized neoantigen vaccines are safe and capable of generating robust immune responses across various cancers.