Mayo Clinic researchers have identified a previously hidden step in the immune system's preparation to fight cancer, suggesting that the thymus plays a crucial role in training T cells before they enter circulation. This discovery could lead to more effective and longer-lasting cancer immunotherapies.
Researchers developed a new methodology to identify biomarkers for male infertility, enabling comprehensive analysis of lipids and metabolites. They found 955 potential metabolites and 473 lipids that could be present in sperm.
Researchers at Linköping University found that old oak trees and semi-natural grasslands are crucial habitats for many species. The study identified thresholds for habitat size needed to support species survival, providing conservationists with concrete data to prioritize cost-effective interventions.
A study found that supplementing with HMB before surgery improves liver regeneration in animals by preserving energy function and improving the quality of recovery. The supplementation was shown to have a beneficial effect on mitochondrial function and metabolic performance, even after it was discontinued.
A recent study published in JAMA Otolaryngology–Head & Neck Surgery reveals a higher incidence of smell and taste disturbances among GLP-1 RA users. The findings underscore the importance of regular monitoring and awareness to mitigate these adverse effects.
Researchers developed a compact, cost-effective diagnostic platform combining lensfree holography and deep learning for automated HER2 scoring. The system reached 84.9% accuracy for four-level HER2 classification and 94.8% accuracy for binary scoring, effectively lowering diagnostic risks.
JMIR Publications invites submissions on the 2026 Ebola disease public health emergency of international concern, focusing on response strategies, risk communication, and surveillance. The World Health Organization has declared a public health emergency due to population mobility and ongoing uncertainty in the Democratic Republic of th...
A recent review highlights the pivotal role of lactate and lactylation in PDAC progression, including their function as alternative metabolic fuel, signaling molecule, and epigenetic regulator. Therapeutic strategies targeting lactate metabolism offer promise, but clinical translation faces significant hurdles.
Researchers found that bariatric surgery can lead to a significantly higher risk of developing alcohol problems. The altered anatomy affects how the body processes and absorbs alcohol, leading to faster intoxication and prolonged recovery times.
Researchers discover a novel mechanism where PVT1 and EIF4A1 drive gastric cancer metastasis through the Notch-1 signaling pathway, resulting in increased tumour cell migration, invasion, and proliferation. Elevated STC1 levels confirm its role as a key downstream effector of this axis.
Researchers at Hiroshima University report a remarkable decline in chronic HBV and HCV cases, from 3.0-3.07 million to 1.1-1.4 million between 2000 and 2020. Projections suggest the number of HBV infections will drop to around 200,000 cases by 2050, while HCV is estimated to decline to fewer than 20,000 cases.
The 2026 Warren Alpert Foundation Prize was awarded to five scientists who developed curative genetic therapies for two major blood disorders. These treatments, CASGEVY and LYFGENIA, have been approved by the FDA for use in the US and have shown significant advancements in the field of gene therapy.
Research finds that millennials' fear of growing up decreases as they age, while younger generations report higher maturity fears. The study, published by the American Psychological Association, suggests that broader societal factors such as economic uncertainty and social pressures shape how young people view adulthood.
Scientists have discovered a way to track whales using fiber-optic cables by detecting low-frequency pressure waves generated by their movement. This method allows researchers to identify whale tracks even when the animals are not vocalizing, expanding their capabilities for remote sensing applications.
A WSU study explores the environmental cost of influencer PR gifts, finding that only 1% of comments mention packaging sustainability. The research suggests influencers can promote eco-friendly behaviors by discussing sustainable practices in their unboxing videos.
A recent study evaluated the safety and effectiveness of the J-Valve Transfemoral System in treating symptomatic severe aortic regurgitation. The study showed sustained valve performance, meaningful symptom improvement, and evidence of reverse left ventricular remodeling at one year.
Researchers have uncovered a potential strategy to eliminate cancer cells that survive KRAS inhibition, preventing relapse. By targeting the metabolic pathways that support the survival of drug-tolerant persister cells, treatment regimens could be designed to shrink tumors and prevent cancer recurrence.
A study found that discussing from a third-person perspective in virtual environments improves consensus agreement, accuracy in understanding others' opinions, and reduces intragroup conflict. However, it also decreases emotional connection among participants.
A pilot study found that an examiner-worn, neck-mounted camera can supplement the observation and review of clinical skills during OSCE assessments. The results showed moderate to strong agreement between live and video-based assessments, with the wearable camera enabling more observations to be evaluated than the fixed camera.
Researchers identify OsFeSOD3 gene that supports chloroplast health while enhancing plant survival under drought conditions. This discovery could help overcome crop yield limitations and improve climate-resilient crops.
Researchers identified karyoptosis as a key link between toxic protein accumulation and neuron death in neurodegenerative diseases like Alzheimer's and frontotemporal dementia. The study found that targeting proteins acting as 'switches' in this pathway may slow or prevent cell death by karyoptosis.
Research from the University of Michigan shows that switching to fuel cells or batteries can reduce lifetime greenhouse gas emissions by up to 90% compared to diesel-powered vehicles. The study found that hydrogen fuel cells and battery electric powertrains offered the largest emissions reductions.
Researchers reveal a previously unrecognized form of actin self-organization that may help explain how cells spontaneously generate shape and movement. Live-cell imaging and computational modeling show that these self-propelled treadmilling actin filaments (SpTAs) drive cellular protrusions through a process powered by treadmilling.
New therapies using regulatory T cells, known as Tregs, could target diseases with inflammation, such as cancer and autoimmune conditions. Early evaluations show good tolerance and safety profiles, but precision is key to tailoring treatments for specific patients.
Elsevier's ClinicalKey Student now incorporates StudyFinder AI, providing students with access to trusted, evidence-based content and eliminating risks associated with generic AI tools. This enhancement aims to support medical students in making clinical decisions by leveraging verified sources from Elsevier textbooks and NICE guidelines.
A new study has found that changes in a senior dog's gait can be an early warning sign of dementia. The research tracked the stride length of 88 geriatric dogs over time, revealing a significant decrease in front leg stride length with worsening cognitive decline. This change was found to be more pronounced than age-related decline alone.
Researchers discovered biomarkers indicating overactivity and dysfunction in the immune system, which can lead to chronic critical illness. Identifying these markers could allow doctors to intervene earlier, leading to shorter ICU stays and improved patient outcomes.
Researchers developed a simple oxide system with intrinsic self-recoverable mechanoluminescence without external energy input. The material exhibits strong near-infrared emission under mechanical stimulation, featuring reversible ionization and recapture process enabling consistent emission over thousands of loading cycles.
Researchers develop a new strategy to control electronic and magnetic properties of oxide thin films through nanoparticle exsolution, resulting in giant insulator-to-metal transition and room-temperature superparamagnetism
A new electrochemical system converts biomass-derived compounds into valuable chemicals while reducing energy consumption, producing essential products such as glutaric acid and ammonia. The nickel-vanadium layered double hydroxide catalyst accelerates both chemical reactions efficiently.
Researchers developed a novel single-active-region mid-infrared QCL architecture that achieves broad spectral coverage and high gain uniformity. The diagonal multi-state-to-continuum active region design enables strong coupling between upper lasing levels, substantially broadening the gain bandwidth of the active region.
Researchers propose that natural hallucinogens evolved to serve ecological functions such as defense, communication, and stress response. By modulating serotonin signaling pathways, these compounds can influence behavior in other species.
Researchers at Tohoku University have created a clearer map for searching for hydrogen storage materials, identifying key physical factors that control their performance. The study suggests adjusting geometry and lattice flexibility to raise capacity while tuning stiffness to keep equilibrium pressure near everyday conditions.
The ECMWF's global forecasting system now incorporates new cloud radar data from the ESA-JAXA EarthCARE space mission, enhancing weather forecasting accuracy. This move is expected to improve predictions for extreme weather events like typhoons and heavy rainfall.
A recent study in Japan found that direct survey questions can make negative attitudes toward the mass media appear stronger than they actually are. The study compared direct questioning with indirect questioning using a list experiment and found a significant gap of 15.4 percentage points in agreement rates.
A POSTECH research team has created an automated, modular system for assembling reconstituted cell-free systems, significantly reducing costs by 95% and preparation time to 2 days. This innovation enables the customization of individual components, paving the way for improved biologically engineered high-value therapeutics.
Researchers found that rice stink bugs acquire beneficial symbiotic bacteria from soil and that high soil pH suppresses acquisition. The study reveals that mildly acidic soils facilitate the establishment of symbiosis, providing a potential tool for environmentally sustainable pest control strategies.
Researchers have developed a polymer membrane that separates crude oil at room temperature, significantly reducing the need for energy-intensive heating in conventional refining. The membrane uses self-assembled separation channels smaller than 2 nanometers to selectively separate lighter fractions from heavier components.
A study published in Frontiers in Cellular and Infection Microbiology found that healthy infant gut microbiomes are linked to reduced risk of malaria. Babies with beneficial microbes like Bifidobacterium were less likely to develop the disease. However, further research is needed to confirm this association.
Devadas pioneered the field of hardware security, making foundational contributions to Trusted Execution Environments (TEEs), Physical Unclonable Functions (PUFs), and Side Channel Resistant Processors. His innovations have shaped both academia and industry, safeguarding data in a digital world.
Researchers developed a robotic system inspired by social insects to optimize mining operations. The honeybee-inspired approach outperformed others in tests, reducing travel distance by up to 80% and completing ore delivery tasks 60% faster.
Researchers at Rice University and Baylor College of Medicine have discovered that bilingual brains preserve a shared overall geometric organization despite tuning themselves differently for each language. This 'shared semantic geometry' allows individuals to effortlessly translate thoughts between languages without confusion.
Researchers have discovered two rare 'super-puff' planets with densities lower than candy floss, orbiting an F7-type dwarf star. The study provides a unique laboratory for understanding how these planets form and evolve, offering insights into their extremely low densities.
A study by geoscientists at the University of Sydney reveals why some ancient continental edges became fertile sites for major mineral deposits, while others did not. The research developed a dynamic model of the Earth going back 1.8 billion years to identify how mineralised ores formed in specific places.
Researchers led by Dr. Nima Nassiri have successfully transplanted a human bladder for the first time, with patient Oscar Larrainzar thriving a year after the operation. The breakthrough procedure has paved the way for a new field of surgery and offers hope to patients with end-stage bladder disease.
Combined hepatocellular-cholangiocarcinoma is a rare and aggressive form of primary liver cancer that poses significant diagnostic and therapeutic challenges. The absence of standardized treatment guidelines limits effective management, emphasizing the need for thorough pathological evaluation and multidisciplinary management.
Rates of new obesity cases rose by 4% between 2019 and 2025, with the largest increases seen among young adults. The study also found significant disparities in obesity rates across sociodemographic groups and geographical regions, highlighting the need for deep-seated change to address the underlying factors driving obesity.
A new UK study has found that plant-based alternatives contain twice as many additives as animal products, with a total of 199 versus 100. The study analyzed 71 like-for-like pairs of products from a UK supermarket range and found that plant-based products contained more ingredients and E-numbers.
A new oral drug AC01 has been shown to improve heart function and be well-tolerated in patients with chronic heart failure. The study found no serious side effects and suggested potential clinical benefits, warranting further investigation.
A new study found that Australia's Social Media Minimum Age Act has little effect on reducing teen social media use, with many under 16s using platforms despite age restrictions. The study also showed that many teens are actively circumventing age verification checks.
A UChicago research team developed a nanoplasmonic 'leaf' that harvests light energy to stimulate nerves and pace heartbeats in an animal model. The material was shown to have high performance levels and could potentially be used for new forms of therapy and human-computer interfaces.
The FDA approved palbociclib in combination with trastuzumab and endocrine therapy for patients with hormone receptor-positive, human epidermal growth factor receptor 2-positive advanced breast cancer. The PATINA trial demonstrated a significant prolongation of progression-free survival by over 15 months, providing new hope for individ...
A new genome and multiomics study has uncovered a coordinated molecular framework underlying the plant's organ-specific metabolic specialization. Flavonoids are mainly enriched in aerial tissues, while triterpenoids preferentially accumulate in roots.
The Palace Project has partnered with NYU and Columbia University to offer seamless access to thousands of Taylor & Francis eBooks through a mobile reading application. This partnership enables university libraries to provide secure and streamlined connection to a vast range of resources on-demand.
Scientists at MIT developed a theoretical model that predicts the severity of most mass extinctions based on the mismatch between environmental change and biological adaptation rates. The study successfully predicted the fraction of life that went extinct in Earth's history, suggesting that life has evolved to adapt at a similar scale ...
Mary Beth Farrell has been honored with the 2026 SNMMI-TS Lifetime Achievement Award for her decades-long dedication to elevating the nuclear medicine profession. Her leadership in accreditation, research, and education has shaped national standards and driven quality improvement initiatives that continue to impact patient care.
A new review found that the conditions which help women General Practitioners (GPs) build long and rewarding careers are being routinely undermined. Women GPs value spending longer with patients and find this meaningful work, but their extra time is often not recognised or rewarded, leading to burnout.
MIT researchers developed a framework that allows users to apply constraints to algorithmically generated structures, making them more buildable. The approach has the potential to reduce carbon emissions in construction by up to 90% by designing structures with multiple materials and taking into account materials' properties.
Cancer cells develop multiple resistance mechanisms to antibody-drug conjugates, including antigen downregulation and mutation, internalization deficits, and payload efflux. Researchers propose innovative strategies, such as bispecific ADCs, dual-payload designs, and combination regimens, to overcome these defenses.
MSU scientists have discovered a protein called TPPP3 that helps ovarian cancer cells withstand chemotherapy. Removing this protein restores the drug's effectiveness, suggesting a new approach to overcoming resistance. This breakthrough has implications for improving existing treatments and may lead to new therapeutic strategies.