The Linda and Mike Mussallem Foundation has donated to USC's Keck School of Medicine to enhance clinical trials for individuals with Down syndrome at risk for Alzheimer's. This will increase domestic and international sites, accelerating the development of treatments specifically for this population.
Researchers developed an AB-TENG with a transistor-inspired architecture to transform physical limitations into functional advantages, advancing skin-electricity-enhanced thin-film TENGs. This breakthrough design establishes a new paradigm for next-generation self-sustaining HMI and IoT devices.
A 50-year study in Kerala, India found that expanding tree plantations can result in zero net carbon gains underground. The research highlights the importance of considering the type of plantation and historical soil profile when designing climate mitigation strategies.
Researchers discover that adding micro- and nano-scale bone char triggers a biological revival in arsenic-contaminated rice paddies, increasing urease and catalase activity and organic carbon levels. The biochar fundamentally alters soil microbiome behavior, reinforcing natural detoxification capacity by shifting microbial gene abundance.
A new study reveals that microplastics and hydrochar can mobilize trapped phosphorus in rice paddies, triggering distinct microbial strategies. Hydrochar increased available phosphorus by 21.1%, while microplastics pushed it up by 14.2%.
A collaborative research team has developed a gas-induced structure evolution strategy to create a 'self-transforming' catalyst that selectively converts CO2 into carbon monoxide. The catalyst achieves a targeted shift in product selectivity, increasing the CO/CH4 ratio and enhancing CO selectivity.
A Cochrane review found that chlorhexidine application to umbilical cord stumps likely reduces infections by 29% and may lower mortality rates, particularly in LMICs. Umbilical cord care is crucial for preventing infection and promoting healthy healing.
A research team has revealed quantum interference between direct and indirect reaction pathways in the photodissociation of partially deuterated water, demonstrating that interference can occur even within a single reaction path. This finding suggests a new route to control nonadiabatic dynamics in chemical reactions.
The companies are leveraging generative AI to develop innovative candidates for challenging neurological diseases, aiming to provide a broader range of therapeutic options. Insilico's Pharma.AI platform and Tenacia's expertise will continue to generate innovative solutions with strong translational potential.
Scientists have developed a novel catalyst that enables efficient conversion of CO2 into formate, which is widely used across industries. The catalyst, comprising Co atoms confined within the MoS2 lattice, shows superior catalytic activity and selectivity compared to traditional materials.
A team of archaeologists used uranium–thorium dating to establish precise construction timelines for houses built out of coral in French Polynesia. The findings reveal previously hidden patterns of architectural development and cultural life in Pacific societies, challenging earlier theories about coral reuse.
Researchers combine biochar with naturally occurring minerals to create more durable and effective materials for improving soil fertility, capturing contaminants, and delivering nutrients. Engineered composites show promising potential for agricultural and pollution control applications.
Researchers developed a system combining biochar with arbuscular mycorrhizal fungi to target specific pollutants in red mud. The results showed that each fungal species played a distinct role in detoxifying arsenic and lead, as well as improving soil health.
A landmark study found that food fortification prevents approximately 7 billion nutrient gaps annually at a cost of just 18 cents per person. However, the study identified three priority actions to dramatically expand food fortification programs, including improving compliance and expanding coverage in high-need regions.
Researchers at Rice University have developed a synthetic origin of replication for plasmids, allowing for precise control over copy numbers and eliminating incompatibility issues. This innovation enables scientists to modify plasmids instead of workarounds, simplifying experimental workflows and expanding possibilities.
Historian Dr Michael Edwards reveals that Samuel Pepys curated his correspondence to hide his connections to slavery and slave trading. In a surprising twist, Pepys rejected an offer of an enslaved boy as a bribe, demonstrating his sensitivity over the issue.
The BrainHealth Network connects researchers across the country to understand brain health improvement through advanced MRI imaging and data analysis. The network leverages a comprehensive multimodal brain imaging dataset, including a longitudinal study of 100,000 healthy participants over 10 years.
A research team successfully developed an electrochemically mediated dearomatization saturation strategy for pyridine, resulting in efficient multifunctional modification of the molecule. The strategy achieves chemo, regio, and stereoselective transformation of pyridine into complex piperidine skeletons.
A study of over 25,300 participants found that consuming a high amount of dietary salt (4,200mg/day) increases the risk of new-onset heart failure by 15%. Reducing sodium intake could lead to a significant reduction in heart failure cases and deaths.
Researchers create a new way to generate optical frequency combs at the chip scale, utilizing robust light pulses called topological solitons. This advance promises to make frequency combs more practical and easier to use outside the laboratory.
A recent review highlights differences in gastric cancer immunotherapy outcomes among various populations, particularly between Asian and non-Asian patients. The study suggests that treatment responses may be influenced by factors such as tumor biology, host immunity, infection, and environmental exposures.
Researchers have developed microfluidic platforms that capture dynamic cell behavior and reveal how cancers evade immunity, how therapies succeed or fail. These systems can test cellular therapies, identify biomarkers, and support personalized cancer treatment.
A pilot study found that axillary radiotherapy may be as effective as surgery in killing cancer cells while reducing the risk of painful swelling. The trial compared radiotherapy to axillary lymph node dissection and found similar cancer outcomes, but lower rates of lymphoedema after radiotherapy.
Researchers discovered that stroke survivors with severe motor impairment show signs of brain 'youthfulness' in undamaged regions, suggesting the brain's ability to adapt and compensate. This finding provides new insights into neuroplasticity and may guide personalized rehabilitation strategies.
A 14-year field study shows that biochar can simultaneously reduce heavy metal risks in agricultural soils while enhancing carbon storage. Biochar improved soil carbon storage, reducing toxicity by up to 91 percent and increasing organic carbon content.
A global panel of experts recommends a 10-year trial with 5,000 participants at high risk of cancer due to pre-cursor conditions. The trial will evaluate the potential efficacy of GLP-1 and dual receptor agonists in preventing obesity-related cancers.
A new analysis shows elinzanetant effectively relieves moderate-to-severe vasomotor symptoms (VMS) associated with endocrine therapy, regardless of the type of hormone treatment. The drug reduces VMS frequency and severity by blocking a protein that triggers these symptoms.
Researchers found that breast cancer cells trigger the lung's natural repair system, leading to chronic inflammation and promoting tumor growth. A repurposed drug, roflumilast, may slow this process by preventing the lung environment from aiding tumor growth.
Professor Lee's doctoral thesis Empty Garden reinterprets uiwon through contemporary data and media language, exploring human sensation and existence in an AI-dominated environment. The work has been acquired by the Ashmolean Museum for its permanent collection, marking a rare distinction even within Oxford's 900-year history.
Experts warn that US policy changes pose a grave threat to global health, risking multiple international infectious disease outbreaks. The authors argue that the recent US decisions meet the criteria for a Public Health Emergency of International Concern (PHEIC) under International Health Regulations (IHRs).
Registration is now open for TCT 2026, the annual scientific symposium of CRF, taking place October 31 - November 3 in San Diego. The event will feature a dynamic program with groundbreaking research and expert-led tutorials.
New research from the Dog Aging Project reveals that dog owners experience strikingly similar emotional impacts whether their dogs died through euthanasia or unassisted death. Owners reported comparable feelings of grief, guilt, and blame regardless of the circumstances surrounding their dog's death.
A Tulane University study reveals how the brain regulates defensive behavior and fine-tunes fear responses as perceived threats diminish. Researchers identified distinct roles for neurons in the central amygdala, which help determine whether an animal responds with intense escape behavior or freezing.
A new paper by the University of Sydney reveals that corporations manufacturing and marketing health-harming products are primary vectors of non-communicable disease. The authors propose solutions such as policy safeguards, stronger research focus, and prohibition on financial ties between industry and researchers.
Researchers have discovered an RNA-guided CRISPR system that can activate genes without cutting DNA, opening up new possibilities for gene regulation and therapeutic strategies. The system uses a strand of RNA as a guide to recruit the cell's transcription machinery, allowing for precise control over gene expression.
A multi-phase clinical study will examine dosing, safety and long-term effects of rapamycin in older adults to guide future research on extending health span. Researchers aim to establish evidence-based guidance for the drug's use and move beyond speculation.
The inaugural US-based Chagas disease conference will strengthen research and patient care efforts in the US, building on recognition of the disease as a national concern. Approximately 300,000 Americans are infected with Chagas disease, and improved surveillance, testing, and research can help address severe heart complications.
A large clinical trial led by UCL researchers has shown that hormone patches are as effective as injections in controlling locally advanced prostate cancer. The patches cause fewer side effects, including hot flushes and breast tissue swelling, while improving quality of life for men with the condition.
The phase III Alliance ATOMIC trial shows that adding immunotherapy to standard chemotherapy improves clinical outcomes for patients with stage III dMMR colon cancer. The study found a 50% reduction in cancer recurrence risk and a 86.3% disease-free survival rate at three years.
Microtubules are regulators of enzymatic reactions through reshaping geometry of enzyme's substrate proteins attached to them. The discovery sheds new light on one-way chromosome attachments and quality-control system that helps prevent chromosome-segregation errors, a hallmark of many cancers.
Researchers at Worcester Polytechnic Institute developed a palm-sized aerial robot that uses ultrasound sensors and AI to navigate through fog, smoke, and other difficult conditions. The drone achieved a success rate of 72% to 100% in navigating challenging courses during 180 tests.
A meta-analysis published in Neurology found no link between hormonal contraception and an increased risk of idiopathic intracranial hypertension. The study included over 5,000 participants and covered various types of birth control methods.
The study reveals that ZFTA-RELA exploits open regions of the genome to trap immature brain cells in developmental limbo. This finding may lead to novel therapeutic strategies to test, such as forcing cells past immature developmental states.
Fusarium head blight (FHB) is a destructive wheat disease that can reduce yields and contaminate grain with toxins. New research in Plant Disease identified several emerging fungal pathogens, including a previously undescribed species, responsible for the severe outbreak in Ethiopia.
Researchers at Rice University have developed a new method to recover nearly all critical minerals from spent lithium-ion batteries, including metals like lithium and graphite. The process uses microwave-induced plasma treatment with room-temperature solvents, resulting in high recovery rates and minimal environmental impact.
Researchers from SDSU discovered surprising similarities among ancient writing systems from Africa and the Caucasus region. The study suggests the Armenian alphabet may be more closely related to the ancient Ethiopic writing system than previously thought, revealing possible cultural contact and influence between regions.
The Global Initiative on the Taking of Migratory Species (GTI) aims to tackle the root causes of illegal and unsustainable taking, safeguarding wildlife and livelihoods. The initiative focuses on improving data, strengthening laws, engaging communities, and raising awareness.
Researchers are using preclinical mouse models and patient studies to identify cellular and circuit-level mechanisms driving mood-state transitions. The goal is to develop new treatments by rescuing dysfunctional brain circuits in depression.
A team of paleontologists has uncovered fossilized remains of giant tortoises, armadillos, and other Ice Age animals in a Central Texas water cave. The discovery, published in Quaternary Research, provides new insights into the region's past environment and animal community.
Two studies led by Boston University School of Public Health researchers found that people living in redlined neighborhoods were less likely to conceive than those in favorable areas. The findings suggest that historical practices like redlining continue to influence reproductive health disparities in present-day communities of color.
Restored oyster reefs in the US Atlantic coast remove more nitrogen from the water than previously estimated. Additionally, their restoration provides greater economic value for coastal communities, supporting sustainable marine ecosystems.
Analysis of 40,516 students across 75 master's and 78 doctoral programs reveals grade inflation in both fields, stronger in master's programs, and influenced by the Covid-19 pandemic. The study's findings have implications for employment, admissions, and merit-based funding decisions.
Researchers explore pragmatic pharmacist-led deprescribing interventions, including ALIGN, to improve medication management in older adults with cognitive impairment. Validation of hospitalization, death, and hospice care data from skilled nursing facility EHRs and Medicare claims shows promise for improved care coordination.
Douglas P. Kiel, a senior scientist at the Hinda and Arthur Marcus Institute for Aging Research, has been elected to membership in the Association of American Physicians due to his significant contributions to advancing medical knowledge and improving health through scientific research and academic leadership. His research focuses on o...
A study of over 14 million cardiovascular deaths found that colder temperatures are responsible for significantly more heart-related deaths than milder months. The optimal temperature for heart health is 74°F, with temperatures under this point accounting for approximately 40,000 deaths each year.
A new book by Swansea University researchers argues that attention impairments, rather than memory dysfunction, are a key aspect of dementia. The authors suggest that recognizing these changes could lead to earlier identification, improved diagnosis, and better care for those affected.
Palliative care aims to alleviate suffering early on, manage symptoms, and support patients throughout a long course of illness. An international review calls for its integration into cardiovascular medicine to prioritize quality of life over survival.
A recent study found that prescriptions for direct-acting antivirals (DAAs) for hepatitis C increased rapidly after their introduction but declined sharply over time. As a result, many curable patients remain untreated, with treatment levels below national elimination targets.
A new approach allows oral delivery of drugs previously requiring injection by piggybacking on natural fat absorption pathways. The medication, GlyphAllo, bypasses the liver's security checkpoint and is absorbed through the gut's lymphatic system, allowing it to enter the bloodstream directly.
Researchers from Heidelberg University and international partners have optimized their ECHo experiments to determine the neutrino mass. They achieved a lower upper limit on the neutrino mass scale than previous similar experiments, paving the way for future large-scale investigations.