psiTPTE22-HERV is a methylation-silenced tumor suppressor that restrains gastric cancer growth and metastasis. Its inhibition of PI3K/AKT/mTOR/EIF4E signaling pathway establishes its potential as a prognostic biomarker and therapeutic target.
Researchers found that tensile force activates glycolysis in PDL fibroblasts, driving histone H3 lysine 18 lactylation and CXCL1 secretion, which enhances mitochondrial oxidative phosphorylation and promotes pro-resolving M2 macrophage polarization. This metabolic-epigenetic link supports a pro-resolving immune niche for bone deposition.
A Fudan University-led team introduces interventional embedding entropy (IEE), a new framework that measures causal strength directly from recorded time series, without any knowledge of the system's dynamical equations or performing a single experiment. IEE successfully identifies causal relationships in complex systems, including neur...
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a complex, systemic syndrome with widespread pain, sensory hypersensitivity, and metabolic and autoimmune diseases. A new framework proposes precision diagnosis and treatment through a four-step, subtype-guided approach, aiming to restore axis homeostasis.
This study demonstrates that interleukin-33 alleviates the immunosuppressive tumor microenvironment in hepatocellular carcinoma, activating the STING/IRF axis and increasing functional CD8⁺ T cells. Combining IL-33 with anti-PD-L1 therapy synergistically reduces tumor burden and boosts anti-tumor immunity in vivo.
Researchers found that pegylated interferon-α therapy significantly increases hepatitis B surface antigen clearance in different chronic hepatitis B infection groups, including nucleos(t)ide analogs-experienced patients and children. The therapy achieves high clearance rates in these groups, particularly in those with high baseline lev...
A cross-sectional study of 1,917 older adults found a positive association between dietary lecithin intake and cognitive function, with higher intake reducing the risk of mild cognitive impairment. The study also revealed that educational level may serve as a key moderator in this relationship.
A decade of climate reporting scores from 8,959 firms reveals that gains among consistently disclosed companies improve more than the overall average, despite a widening reporting population. Detailed analysis of CDP scores finds that sustained reporting, governance, and data systems contribute to improved disclosures.
The aorta is not a biologically uniform structure, with different regions influenced by immune cells that contribute to development, maintenance, and disease. Myeloid immune cells vary across regions, with some supporting repair and others contributing to inflammation and tissue remodeling.
Causal machine learning and reinforcement learning can bridge the gap between predictive models and personalized therapy in critical care. Causal ML estimates individualized treatment effects, while RL generates adaptive treatment policies over time. Future directions include reliable treatment effect estimates, conservative Q-learning...
Researchers used machine learning-assisted live-cell imaging to investigate the impact of transcription on chromatin motion in living human cells. The study found that transcription by RNA polymerases I and II shapes the physical behavior of different chromatin classes, with varying effects on euchromatin and heterochromatin.
Researchers have discovered a link between CDK1 protein activity and breast cancer response to CDK4/6 inhibitors. Higher CDK1 activity is associated with more aggressive cancer and poorer outcomes. The study suggests that tracking CDK1 activity could help doctors identify patients most likely to benefit from targeted therapy.
A new study suggests that East Antarctic ice sheet may be more resilient to extreme long-term warming due to increased snowfall and cloud cover. This effect partially offsets ice loss even under high carbon dioxide concentrations, leading to a different overall response compared to West Antarctic Ice Sheet.
A study from the University of Vaasa examines the management of artificial intelligence across national borders, highlighting the importance of corporate leadership accountability. The research provides practical guidelines for executives to safeguard AI users and achieve collective societal well-being.
Engineers at the University of Pennsylvania have developed a chip that generates entangled photons and transfers a skyrmion's pattern to a quantum state shared by two photons, demonstrating a potentially powerful new approach to making quantum networks more resilient. The researchers found that the skyrmion's topological property remai...
Insilico Medicine will deliver keynote speeches on competitive landscape and AI commoditization at the China Healthcare Summit. The company showcases its robust pipeline momentum and platform translational capability at the 9th China International Import Expo (CIIE).
A new integrated CO2 capture and oxidative dehydrogenation process enhances ethylene production and CO2 utilization. The process combines CO2 adsorption and catalytic conversion within a single reactor, achieving high CO2 capture capacity and ethylene yield.
Researchers found that hyperactive YAP and TAZ proteins increase PD-L2 expression, making cancer cells more recognizable to the immune system while also helping them evade immune attack. This combination may improve outcomes for patients treated with immune checkpoint inhibitors.
A new thesis from Uppsala University finds that pupils at for-profit independent schools have, on average, higher grades than would statistically be expected given their backgrounds. This suggests that grading is more generous in independent schools, giving pupils from high-income households a greater advantage in the competition for p...
Researchers at Terasaki Institute are developing 3D-bioprinted retinal grafts using Filamented Light technology to treat age-related macular degeneration and retinitis pigmentosa. The grant will support the development and preclinical validation of this innovative retinal graft platform.
A new Mn-doped NiSe2 catalyst exhibits enhanced UOR activity and stable electrochemical performance. Mn enables reversible phase cycling, regenerating functional catalytic sites and preventing over-oxidation, leading to improved hydrogen production and efficiency in urea electrolysis.
A metal-free electro-driven strategy has been proposed to synthesize structurally diverse tetrahydrofuran derivatives under mild conditions, opening a new avenue for green synthesis. The method features a broad substrate scope and good functional group tolerance, and has been successfully scaled up to the gram scale.
A study by Dr. Lena Glaser found that taking cold showers reduces CO2 emissions by 15 kilograms per person and saves money on energy consumption. Participants also reported feeling more awake, refreshed, and motivated to stick with the habit.
Researchers developed a high-speed microscopy technique that captures images at 19.2 images per second, enabling the creation of 3D
Crowding in model protein-rich droplets increases enzymatic activity, while enzyme activity can make molecules in the droplet more mobile. This unexpected finding challenges traditional views of enzyme behavior in crowded environments.
Fox Chase Cancer Center researchers have identified a potential new target for pancreatic cancer by blocking a protein called ANO6. ANO6 helps pancreatic cancer cells obtain nutrients from surrounding cells while suppressing the immune system's ability to fight tumors.
Researchers at Chonnam National University have developed a new electrolyte for sodium metal batteries that addresses safety and stability issues. The new electrolyte, known as PDES, combines efficient Na ion transport with improved safety and leakage resistance, making it a promising candidate for practical sodium-metal batteries.
Researchers create more sensitive gas sensors using a 10-millisecond light pulse to improve room-temperature detection of nitrogen dioxide. The flash thermal synthesis method helps to preserve the material's surface and incorporate catalyst atoms, resulting in a 23.6-fold stronger response to NO₂.
Researchers found vegans had lower gut bacterial diversity compared to omnivores, despite consuming more plant-based foods and fiber. However, vegans with higher protein intake had comparable biodiversity levels to omnivores, suggesting protein may be an overlooked factor for a diverse gut microbiome among vegans.
A systematic review of five studies found no statistically significant improvements in cognitive function among women taking testosterone during menopause. The authors suggest further research is needed to guide treatment decisions and support women in making informed choices about their care.
Researchers discovered a potential mechanism to enhance magnetic compass responses in cryptochrome, a blue-light-sensitive protein. The study found that structural rearrangements and chirality-induced spin selectivity can influence electron-spin polarization and improve directional dependence of downstream chemical reactions.
A new study mapped human urogenital development, revealing how neighboring organs coordinate their development through cellular communication and molecular signaling. The study identified 33 cell types and found coordinated steroidogenic programs across the adrenal gland and gonad, linking their functions to sex differentiation.
A recent study suggests that as little as 7-8% hydrogen is required to ignite ammonia in engines, enabling the production of zero-carbon fuels for marine propulsion. This innovation has the potential to significantly reduce emissions in the shipping industry, which accounts for 11-12% of global transport emissions.
Researchers found albumin boosts inflammatory response in vaginal yeast infections, triggering a cycle of inflammation that fuels the infection. The protein shields the fungus from immune cells, allowing it to survive and thrive.
Astronomers have found a giant molecular jet emanating from a compact object in a binary star system, suggesting a microquasar is powering the system's gamma-ray emission. The discovery strengthens support for a quasar-like mechanism, with a high-energy jet driving the interaction with surrounding gas.
Researchers have released CHN10-CUG, a high-resolution road dataset covering ten Chinese cities with annotations. The benchmark reproduces general and road-specific models, testing cross-region transfer and long-term mapping. Road-specific models generally outperform generic ones, with graph methods better preserving connectivity.
Researchers at Hefei Institutes of Physical Science developed a new theoretical framework to understand tungsten transport in tokamak plasmas. They found that lower-Z impurities alter tungsten transport, particularly when the poloidal asymmetry of these impurities becomes dominant, leading to deviations in transport estimates.
A study found that docosahexaenoic acid (DHA) selectively inhibits certain oral bacteria, increasing the abundance of Neisseria and Porphyromonas, while decreasing Prevotella and F. nucleatum. DHA's effects are species- and strain-dependent, suggesting a potential role in oral microbiome regulation.
A recent paper employs machine learning algorithms to predict manufacturing deviations in direct laser writing, enabling pre-correction of designs prior to printing. This approach reduces time and resources required, with neural networks trained on 2.5D structures and promising results of up to 90% deviation reduction.
Bromochloropyrene, a mixed-halogen pollutant, was detected in industrial soils and sediments, showing distinct environmental and biological properties. Its stability under sunlight and biological activity were found to be different from those of brominated or chlorinated pyrene.
A research team developed a method to measure electrical transport in freestanding thin films under high pressure, finding that crystal dimensionality affects pressure response in SrIrO3. Three-dimensional films undergo a semimetal–insulator–metal transition, while two-dimensional films remain insulating.
A silica nanoparticle-based foliar fertilizer improves nutrient retention in rice leaves, retaining 71.33% of nitrogen after simulated rainfall. This study boosts rice yield by 17.5% while reducing total nitrogen input, offering insights into improving foliar fertilizer efficiency.
Researchers developed a compact sensing platform that can identify molecules from their characteristic fingerprints and quantitatively analyze multiple components in mixtures. The platform provides a promising route toward portable THz fingerprint sensing for real-world molecular analysis.
The study reveals TlGaS2 shows both in-plane and out-of-plane polarization, with a stronger response along the in-plane direction. The material's incipient ferroelectric behavior is linked to a soft phonon mode and structural phase transitions, offering new insights into its multifunctional properties.
A team of researchers and industry experts, including UBC and Unilia, are working together to develop fuel cells that can power aircraft while meeting weight and performance requirements. They aim to create a compact, high-power stack that can run at high temperatures and low humidity, addressing technical barriers to using hydrogen fu...
A new educational activity using WaterPuzzle, a 3D-printable magnetic model, helps students understand how water molecules interact. The model allows students to physically construct and investigate molecular networks, developing a deeper appreciation of molecular interactions.
A national study of nearly 1,000 elementary and middle school teachers found that prompting teachers to communicate high expectations and confidence in students' potential leads to more detailed feedback, but also surfaces small race- and gender-linked differences in feedback about students' math ability and effort.
A recent study found that about 1 in 4 patients who took lemborexant experienced frightening nights and groggy mornings, leading to high discontinuation rates. The researchers suggest that the medication's side effects, including vivid dreams and sleep paralysis, may be contributing factors.
Researchers developed a membrane technology that enables faster and more precise molecule separation, reducing energy consumption and increasing efficiency in industrial processes. The breakthrough addresses a longstanding challenge in membrane science, allowing molecules to move faster while maintaining exceptional separation precision.
The study found sustained disease control with estimated progression-free survival of 60% and overall survival of 71% at 10 years. Long-term outcomes also showed improved lung function and skin score, but highlighted the importance of careful patient selection and monitoring.
Researchers have developed a highly efficient photoelectrode that produces hydrogen using sunlight through a water-based, low-voltage process. The new technology significantly reduces the use of organic solvents and reliance on high voltages, making it a major breakthrough in eco-friendly hydrogen production.
A new study from King's College London found that the parts of fruits and vegetables most thrown away contain significantly higher levels of dietary fibre than commonly consumed parts. This discovery could address the global dietary fibre deficit and reduce food waste. By incorporating often-overlooked parts into meals, people can incr...
Nurses draw on clinical expertise, ethical judgement, and close observation to guide care during a patient's final days. The study highlights the importance of knowing a patient's cues and wishes, with decisions linked to family engagement and care needs.
Two international studies provide strongest evidence for non-invasive tests to diagnose and measure liver disease severity, targeting patients for specialist care and advancing MASH clinical trials.
A team of researchers, led by University of Florida professor Sumit Jha, has developed a system called ATLAS to detect and correct AI agents that drift from their assigned tasks. The system works inside large language models, steering them back on track without retraining or significant computing demands.
The new 'Four As' framework for AI governance aims to balance competition and innovation with safeguards against harmful capabilities. It identifies four key areas: Action, Access, Authority, and Allocation, and requires proportionate safeguards, human control, and regular reassessment.
Penn's Fast Feature Field transforms event-camera data into information that many different kinds of robots can use, improving robots' ability to recognize objects, estimate distances and perceive motion. The tool could transform robotics by allowing for the widespread use of event cameras in self-driving cars and drones.
Researchers suggest that tectonic forces on the opposite side of the Pacific Ocean may have accelerated the Gulf of California rifting, with the process being sped up by 30-80 million years. The study used computer simulations to model the impact of double subduction zones on plate interactions.
The open-source platform NetZero Brazil 2050 uses energy modeling and land-use data to guide decarbonization policies, simulating carbon-neutrality scenarios for Brazil by 2050. The tool calculates the lowest-cost decarbonization pathways in real-time, facilitating transparent and evidence-based energy transition strategies.
Researchers at the University of São Paulo found that crop diversification and cover crops can increase productivity and protect fields from extreme weather events. The study used cover crops as a biological buffer against droughts and floods, and showed yields above the state average, with greater stability from year to year.