Researchers identified six distinct subtypes of triple-negative breast cancer, each responding differently to chemotherapies. The study provides molecular targets for drug discovery and development efforts, offering hope for personalized therapy.
Research published in BioMed Central's Breast Cancer Research journal found that two-thirds of women with breast cancer died from other causes, with cardiovascular disease being the leading cause of death. Women over 50 with co-existing health conditions were most likely to die from non-cancer related causes.
A study found that gamma imaging outperformed ultrasound in detecting breast cancer, especially in women with dense breast tissue. Gamma imaging provided 100% sensitivity and 82% specificity, leading to a better prognosis for breast cancer patients.
Women with obesity before and after diagnosis have a higher risk of dying from breast cancer. Obesity is strongly linked to death due to breast cancer, particularly in estrogen receptor-positive cases.
Researchers identified a key role for hedgehog in breast cancer cellular cross-talk, finding that silencing the molecule slows tumour growth and spread. The discovery applies to all breast cancers, particularly basal breast cancer, which has no current targeted therapy.
A recent study published in Breast Cancer Research found that coffee consumption is associated with a lower incidence of ER-negative breast cancer. The research, which adjusted for other lifestyle factors, suggests that moderate coffee consumption may offer protective effects against this type of breast cancer.
A recent study published by the American Association for Cancer Research found that consuming soy food did not increase the risk of cancer recurrence or death among breast cancer survivors. In fact, women who consumed more soy isoflavones had a reduced risk of mortality and cancer recurrence compared to those with lower intake levels.
Breast cancer survivors who experience extreme weight gain have an increased risk of death and cancer recurrence. Moderate weight gain did not affect breast cancer outcomes, according to a study presented at the AACR 102nd Annual Meeting.
Researchers have developed a method to assess breast cancer risk using epithelial cells found in breast milk. The study showed that average RASSF1 methylation levels were higher in biopsied breasts compared to non-biopsied breasts, suggesting a potential correlation between epigenetic signals and breast cancer risk.
In developing countries, breast cancer mortality rates are high due to inadequate diagnosis, treatment, and awareness. The Lancet Oncology review highlights the need for resource-appropriate solutions to improve outcomes.
The Breast Health Global Initiative has published a landmark publication offering diverse but not insurmountable barriers to breast cancer screening and treatment in developing nations. Key findings include the need for public awareness, pathology services, and supportive care services to improve breast health care programs.
Carey Anders will receive a $181,000 grant to test the effectiveness of PARP-inhibitors and nanoparticle agents in treating triple-negative breast cancer brain metastases. The research aims to improve survival rates for women with this aggressive form of breast cancer.
Women with DCIS who develop invasive breast cancer in the same breast have higher mortality rates, study finds. Radiation treatment after lumpectomy reduces risk of ipsilateral invasive breast cancer, while treatment with tamoxifen also offers protection.
A novel clinical trial is exploring a new method to potentially prevent recurrence of early stage, aggressive breast cancer. The study is recruiting patients with HER-2 neu+ breast cancer and aims to identify high-risk patients who may benefit from an additional cancer-targeting drug.
Breast cancer is a significant global health issue, with most deaths occurring in low- and middle-income countries. A Personal View published in The Lancet Oncology suggests that population-based mammography screening is not practical or cost-effective in these countries.
A study by Amanda Phipps at Fred Hutchinson Cancer Center found that full-term pregnancies increase the risk of triple-negative breast cancer, while never giving birth lowers it. Conversely, childless women face a higher risk of estrogen-receptor-positive breast cancer.
Women with a history of breast cancer have double the cancer rates as those without, according to a comprehensive study. Annual mammography screening detects second breast cancers early, but may not be as effective in detecting invasive breast cancer.
Researchers at UT MD Anderson Cancer Center discovered that overproduction of the EZH2 protein promotes growth of breast cancer stem cells. The team also identified two drugs that block the molecular events leading to breast tumor-initiating cell formation, which drives cancer progression.
Researchers found that oestrogen can reduce the proportion of breast cancer stem cells, explaining a better prognosis for tumours expressing the oestrogen receptor. This study presents new insights into oestrogen's effect on cancer stem cells and opens doors to developing tools for preventing breast cancer.
A new study reveals that BRCA1 mutations regulate cell fate in breast tissue, leading to the formation of aggressive basal-like tumors. Cells with mutant BRCA1 exhibit elevated Slug levels and remain immature, stalled in a premature state of development.
Research suggests that smoking before menopause may be associated with an increased risk of developing breast cancer. Women who smoked more or longer had a higher risk of breast cancer, while passive smoking was not linked to an increased risk.
A study found that preoperative Breast MRI detected occult cancer in nearly 1 in 8 patients, resulting in an added cancer yield of 12%. The use of preoperative Breast MRI is a relatively new indication for the test, with benefits seen in detecting otherwise hidden additional disease.
Researchers at Arizona State University have identified a broad panel of 28 early predictors, or biomarkers, that may aid in the early diagnosis of breast cancer. The biomarkers were specific to breast cancer patients and not found in healthy women or those with benign breast disease.
Researchers at Kimmel Cancer Center have found that breast inflammation promotes the development and progression of breast cancer. By selectively blocking inflammation in the breast, they were able to prevent tumor formation and reduce cancer stem cells.
A study found that body fat distribution is associated with an increased risk of ER-negative breast cancer. Abdominal adiposity was more strongly linked to ER-negative breast cancer than ER-positive breast cancer, suggesting sex hormone-independent pathways may be involved.
A phase II study at Georgetown University Medical Center suggests exemestane reduces mammographic breast density in high-risk postmenopausal women by 7%. The treatment is considered an intermediate marker for breast cancer and may offer a safer alternative to tamoxifen, which has rare but serious side effects.
Dr. George W. Sledge Jr is a pioneer in developing novel therapies for breast cancer. His work has improved the lives of countless cancer patients through anti-angiogenic therapy and molecular studies.
A study suggests that women with a personal history of breast cancer should consider annual MRI screening to detect cancers earlier. The research found higher cancer yields and lower false-positive rates in this group, supporting the consideration of MRI as an adjunct to mammography.
A new risk factor for developing breast cancer has been identified as a DNA methylation modification to the BRCA1 gene, which inactivates its protective function. This epimutation is present in the blood of some women with breast cancer and appears not to be inherited.
Researchers found that women treated with aromatase inhibitors experience a wide range of side effects, including hot flashes, fatigue, and breast sensitivity. The study suggests that addressing these side effects is crucial for improving treatment adherence and patient outcomes.
A study found that Mexican-American women with breast cancer experienced an earlier onset of menopause, potentially reducing their risk due to shorter estrogen exposure. Weight gain during adulthood also reduced breast cancer risk, regardless of menopausal status.
A large prospective cohort study found that smoking significantly increased the risk of breast cancer progression and overall death among multiethnic women. Current or past smokers had a 39% higher rate of dying from breast cancer.
Lasofoxifene statistically reduced the overall risk of breast cancer and ER positive invasive breast cancer in postmenopausal women with low bone density. The study found a significant reduction in coronary events, strokes, vertebral fractures, and non-vertebral fractures.
A study by the American College of Radiology found that nearly all US community facilities performing breast MRI exams meet ACRIN and EUSOBI technical requirements. The Breast Cancer Surveillance Consortium data revealed excellent adherence to equipment recommendations, with 94% of scanners using a dedicated breast coil.
Women with dense breasts and no lobular involution are at a higher risk for developing breast cancer. A study of 2666 women found that mammographic breast density and extent of lobular involution are independent risk factors for breast cancer.
A large-scale study published in BMC's Breast Cancer Research journal found no overall association between green tea intake and the risk of breast cancer. The study assessed over 54,000 Japanese women and found that drinking green tea had no protective effect against breast cancer regardless of tea type or quantity.
Regular physical activity, maintaining a healthy weight, and reducing alcohol consumption lower breast cancer risk for women with and without a family history of the disease. A study of over 85,000 postmenopausal women found that these behaviors significantly reduce breast cancer risk.
The AACR will honor two leading breast cancer researchers, Klaus Pantel and Alan Ashworth, for their groundbreaking work on detection and treatment of breast cancer. Pantel will receive the Outstanding Investigator Award for his pioneering research on minimal residual disease, while Ashworth will deliver the Distinguished Lectureship f...
Researchers found that Puerto Rican women with triple-negative breast cancer had a higher risk of death from breast cancer, even after adjusting for age and cancer stage. Women under 50 years old with regional/distant disease were also more likely to die from their breast cancer.
A study by the University of Melbourne found that close relatives of women diagnosed with breast cancer before age 35 have a higher risk of developing other cancers. These include prostate, lung, brain, and urinary tract cancers, with increased risks ranging from 2 to 8 times higher than expected.
A new study published in the Journal of Sexual Medicine found that 70% of women are facing sexual function problems approximately two years post-diagnosis. The study suggests that specific treatments for breast cancer, such as aromatase inhibitors, can exacerbate menopausal symptoms leading to sexual problems.
A study found that breast cancer survivors with functional limitations affecting motion, strength, and dexterity are at risk of dying from other causes, but not breast cancer recurrence. The study highlights the importance of addressing physical limitations in cancer survivorship plans.
A new study has found that alcohol consumption after a breast cancer diagnosis may increase the risk of cancer recurrence. The study followed 1,897 women with early-stage breast cancer and found that those who consumed 3 to 4 drinks per week had a higher risk of breast cancer recurrence and death compared to non-drinkers.
Women with secondary breast cancer face inadequate support due to lack of knowledge, experience and staff numbers among healthcare professionals. Better training, resources, and services are needed to address this complex condition.
Prophylactic mastectomy and salpingo-oophorectomy significantly reduce breast and ovarian cancer risks in women with BRCA1/2 mutations. The study found that risk-reducing mastectomy decreased breast cancer risk, while salpingo-oophorectomy lowered ovarian cancer risk.
Walter and Eliza Hall Institute researcher Dr Marie-Liesse Asselin-Labat is unraveling the mysteries of breast stem cells, their development, and influence by oestrogen and steroids. Her groundbreaking studies aim to uncover how breast cancer progresses and why it sometimes returns.
A study published in The Journal of the National Cancer Institute found that alcohol consumption is more strongly related to the risk of lobular carcinoma than ductal carcinoma, and more strongly related to hormone-receptor-positive breast cancer than hormone-receptor-negative breast cancer.
Researchers found that human breast cancer cells overexpress the alpha 9 subunit of the nAchR, promoting tumor growth. Reducing α9-nAchRs inhibited tumor growth in laboratory experiments.
A new study found that smoking increases breast abscess risk by 6 times, while nipple piercing is also a risk factor. Smoking also leads to higher recurrence rates, with 40-50% of cases recurring.
A study led by researchers at the University of Louisville found that individuals with a male first-degree relative with breast cancer perceive themselves as being at higher risk than those with a female relative. However, many lack awareness and discussion about genetic testing.
A study published in JAMA found that a genetic risk score is strongly associated with an increased risk of breast cancer and can predict the type of disease. The researchers identified specific genes that have different effects on different subtypes of breast cancer.
Researchers found that African women are more likely to develop triple-negative breast cancer, a condition characterized by the absence of estrogen and progesterone receptors. The study suggests that African ancestry may be associated with a higher risk of hereditary predisposition for breast cancer related to BRCA1 gene mutations.
A three-year clinical study will examine the relationship between physical function decline and age-related disparities in breast cancer treatment. The study aims to develop a well-validated instrument for measuring functional decline among senior adults with cancer, ultimately improving breast cancer outcomes for older women.
Researchers found that women who used more air fresheners and products for mold and mildew control had a higher incidence of breast cancer. The study suggests that cleaning products may contribute to breast cancer risk, highlighting the need for further investigation into this potential link.
Two new studies have tested three different methods for accurately measuring breast density. A third technique called dual-energy mammography showed promise in measuring breast density. The researchers hope to use this method to improve the accuracy of breast cancer risk assessments.
Researchers have successfully induced epigenetic reprogramming in human and mouse breast cancer cells, making them more susceptible to tamoxifen treatment. This targeted epigenetic therapy has shown promising results in reversing the growth and invasive properties of triple-negative breast cancer cells.
A four-year clinical trial will investigate the effects of weight loss and increased physical activity on quality of life and co-existing medical conditions in overweight breast cancer survivors. The study aims to reduce breast cancer recurrence risk and improve psychosocial problems.
The TARGIT-A trial found that targeted intraoperative radiotherapy (TARGIT) is non-inferior to whole breast external beam radiotherapy in reducing local recurrences. Patients who underwent TARGIT had similar recurrence rates to those receiving conventional radiotherapy, with lower rates of radiotherapy toxicity.
A nationwide study confirms the benefit of estrogen-lowering drugs before surgery for breast cancer patients. The treatment increased the likelihood that women could undergo breast-conservation surgery instead of mastectomy. After 16-week aromatase inhibitor therapy, 82% of women had successful breast-conservation surgery.
Researchers found that minor adjustments to estrogen receptor alpha and p53 genes can lead to precancerous changes in breast tissue. Testing healthy women for these gene variations may help predict future breast cancer risk.