Researchers at Fred Hutchinson Cancer Center have successfully transplanted gene-modified blood stem cells into brain cancer patients to protect their bone marrow against chemotherapy's toxic effects. The study showed that two patients survived longer than predicted, with one remaining alive for over three years.
Researchers from the University of Pennsylvania report that genetically modified T cells remain healthy up to 11 years after initial therapy in a decade-long study of HIV patients. The approach provides a framework for gene therapy as a powerful weapon in treating HIV, cancer, and other diseases.
A new bioluminescent real-time reporter (BART) technique combined with loop-mediated isothermal amplification (LAMP) detects genetically modified crops at 0.1% GM contamination levels, surpassing EU limits. This approach simplifies DNA extraction and detection, providing a field-ready solution for monitoring GMOs.
Researchers at Moffitt Cancer Center are developing 'designer lymph nodes' that use gene-modified cells to produce a pre-planned immunologic response for cancer patients. These innovative nodes aim to rebuild and augment the immune system, overcoming dysfunction caused by tumors or treatments.
A new report from the University of Michigan reveals that GenX adults prepare an average of 10 meals a week and eat out or buy fast food three times a week. Men are surprisingly involved in cooking and grocery shopping, with men cooking an average of 8 meals per week. The study also highlights the importance of families gathering toget...
Researchers have devised a new method for producing genetically modified animals using haploid embryonic stem cells, which may enable genetic modification of animals that can't be modified by today's means. The technique could also potentially be used in assisted human reproduction for those affected by genetic disease.
Researchers at Ludwig-Maximilians-Universität München have developed a genetically modified strain of pigs whose beta-cells can restore glucose homeostasis and inhibit human-anti-pig immune reaction. This breakthrough could potentially treat type 1 diabetes, overcoming the major barrier of immune rejection.
Researchers found genetically modified Bt corn has lower colonization of arbuscular mycorrhizal fungal roots compared to non-Bt corn, but no impact on root biomass or shoot growth. This study contributes to understanding the effects of GM crops on non-target soil organisms and highlights the need for further research.
Researchers have made a breakthrough in treating autoimmune diabetes using genetically modified gut bacteria, increasing the frequency of cured mice compared to traditional methods. The new approach has no adverse side effects and allows the immune system to function normally.
Researchers have developed a modified protein, SuperFAK, that reduces cell damage after heart attacks by 50 percent without causing inflammation. The study suggests this protein may protect the heart during chemotherapy or following a heart attack.
Researchers have discovered a modified bone drug that can effectively kill the malaria parasite in infected mice, working at very low concentrations with no toxicity observed. The new compound, BPH-703, targets a key enzyme essential for the parasite's survival and immune evasion.
Researchers discovered that reduced expression of OGFr accelerates tumorigenesis in human ovarian cancer. The OGF-OGFr axis plays a fundamental role in regulating cell proliferation.
Scientists emphasize the importance of evidence-based policies and challenge 'policy-biased evidence' to ensure impartial decision-making. They also urge the scientific community to think globally and act with greater public engagement to guard against science misuse in policy-making.
Increased use of glyphosate-type herbicides has led to a dramatic increase in genetically-resistant weeds, according to Penn State researchers. Integrated weed management programs, including planting cover crops and using mechanical control methods, can lower herbicide use by up to 94% while maintaining profit margins.
A new study by the University of Leicester found that combining anti-obesity drugs with a modified lifestyle is effective in reducing weight and body mass index. Lifestyle advice alone was also shown to lead to weight loss at 6 and 12 months, highlighting the importance of balanced diet and exercise for weight management.
A study by Max Planck scientists found that available scientific information on genetically modified insect releases is highly restricted. They call for clear and accurate descriptions to be widely circulated before releases, particularly if mosquito species are involved.
A new collection of articles in PLOS Neglected Tropical Diseases examines the use of genetically modified (GM) insects for controlling infectious diseases. The articles discuss technological advances, regulatory frameworks, and societal dialogue necessary for widespread application.
A Georgetown University Medical Center professor applauds the decision to temporarily halt research on H5N1, emphasizing the importance of clear explanations and risk minimization. The moratorium will allow institutions to assess dual-use research oversight and ensure public health benefits outweigh potential harm.
Two Georgetown University professors argue that a fair, transparent process is preferable to governmental constraints on scientific information. They recommend strengthening precautions around high-risk research and suggest a balanced approach between scientific freedom and national security.
The JIPM authors refute Greenpeace's claim that genetically modified corn caused the western bean cutworm to spread. Instead, they cite various ecological and agronomic factors, such as conservation tillage, reduced insecticide use, and climate change, which may have contributed to the WBC's range expansion.
Researchers engineered Anopheles mosquitoes to produce higher levels of Rel2, an immune system protein that attacks malaria parasites. The study suggests that this approach could lead to the development of malaria-resistant mosquito populations.
Salmonella forms two genetically identical types, each with an advantage in infection and evasion. The bacteria's ability to produce flagellin triggers a self-destructive response in immune cells, but restricting production helps it colonize hosts.
A team of scientists created a genetically modified zebrafish model that can visualize early events in human atherosclerosis. The model, which is efficient and cost-effective, allows researchers to test the potential effectiveness of new antioxidant and dietary therapies.
Researchers at Max Planck Institute found that certain mutations can be maintained in populations if they have a heterozygote disadvantage, reducing their spread. This could help achieve safer release of genetically modified animals, such as mosquitoes resistant to malaria.
A team of researchers at the University of Western Ontario has demonstrated that eliminating a specific neurotransmitter in the striatum may improve brain function in Parkinson's disease. By using genetically-modified mice and high-level behavior and imaging techniques, the researchers found that neurons responsible for this neurotrans...
Researchers discovered that eliminating acetylcholine secretion boosted dopamine actions, potentially improving motor symptoms in Parkinson's disease. The study used genetically modified mice to investigate the role of neurotransmitters in the striatum, a region affected by the disease.
Researchers have made significant progress in xenotransplantation using genetically modified pigs, showing promising results in pig islet and neuronal cell transplants. Clinical trials are underway or planned for these techniques, which could expand to include other organs such as the liver and heart.
Scientists have developed two new Bt toxins, Cry1AbMod and Cry1AcMod, to overcome resistance in pest insects. These novel toxins are effective against five resistant species, including the diamondback moth and European corn borer.
Researchers have discovered genetically engineered canola populations growing outside of established cultivation regions along roadsides across North Dakota. These 'escaped' plants accounted for 45% of total roadside plants sampled and persisted from year to year, raising questions about oversight and monitoring protocols.
Research from the University of Edinburgh and Warwick University finds that powerful lobby groups in Europe are threatening public acceptance of genetically modified (GM) food. This has resulted in greater restriction of plant biotechnology research and development, hindering efforts to address global hunger and climate change.
SuviCa Inc. has partnered with the University of Colorado at Boulder to develop and commercialize a drug screening technology that identifies novel therapies for cancer treatments. The patented tool uses genetically modified Drosophila fruit flies to screen compounds effective against various types of cancer.
New research modifies soybean seed to increase phosphorus content, improving animal nutrition and reducing feed costs. The study suggests that low phytate soybean seeds may cause low vigor seedlings, which can be easily addressed through seed treatments.
Researchers developed a genetically modified Mycobacterium smegmatis vaccine that induces strong immune response in mice, protecting them from TB infection. The vaccine effectively lowers TB bacteria levels by 1,000 times compared to the current BCG vaccine.
The researchers are using genetically modified plants to encapsulate a tolerance-inducing protein within plant cells to prevent fatal allergic reactions in patients with hemophilia A and B. The new funding will help propel the research to determine if the technique can work in other models and potentially to clinical trials.
Researchers discovered the expression of cancer-killer SAC-GFP activity in bone marrow cells after transplantation, suggesting successful transfer and colonization of anti-cancer tissue. The study shows promise for treating primary and metastatic tumors with genetically modified stem cells that secrete potent Par-4/SAC killer proteins.
A new Rutgers study found that applying caffeine directly to the skin may help prevent damaging UV light from causing skin cancer. The study, which involved genetically modifying mice with diminished ATR enzyme, showed that the modified mice developed fewer tumors and had reduced risk of invasive tumors compared to unmodified mice.
A new study develops and tests genetically engineered spider silk for safe and efficient gene delivery, offering a promising alternative to viral vectors. The material successfully attaches to diseased cells and injects DNA without harming mice in lab studies.
Researchers at the University of Pennsylvania have successfully treated advanced chronic lymphocytic leukemia (CLL) patients with genetically engineered 'serial killer' T cells. The treatment involves removing and reprogramming patient cells to target specific proteins, resulting in sustained remissions and reduced side effects.
Purdue University scientist William Muir argues that genetically engineered salmon, AquAdvantage (AA), poses little real risk to the environment or human health. Once assessed and deemed safe, AA salmon should be allowed for production and sale in the US to increase food supplies for a growing world population.
Researchers have discovered modified rhodium that changes color in response to different gases, including nitrogen, oxygen, and carbon monoxide. This finding could lead to the development of more sensitive air quality sensors.
A study published in Evolutionary Applications found that genetically modified Atlantic salmon can reproduce and pass their genes to the wild, posing a danger to wild populations. The research explores the potential reproductive implications of GM salmon as they are considered for commercial farming.
Researchers found that genetically identical trees grew differently in response to drought conditions depending on their nursery origin. This study reveals a form of molecular 'memory' where trees retain information about their past experiences, influencing their behavior in the environment.
A Lithuanian company developed a technique that has cleaned over 22,000 tons of soil using non-genetically-modified bacteria, transforming contaminated soil into usable land for plant growth. The natural process eliminates the need for chemicals or genetically-modified technologies.
Researchers found a group of approximately 20 cells in the brains of fruit flies that controls when and how long they sleep. This sleep state is essential for long-term memory formation, suggesting a connection between memory and sleep. The discovery opens up new possibilities for understanding sleep and its role in memory consolidation.
Researchers have successfully used gene-modified stem cells to protect bone marrow cells from chemotherapy's toxic effects in patients with brain tumors. The treatment involved infusing gene-modified blood stem cells into patients, which persisted for over a year without showing any harmful effects.
Researchers in China have developed a genetically modified form of E. coli that can extract toxic pesticides like parathion and methyl parathion from the air with high efficiency. The biofilter system has shown average removal efficiencies of up to 95.2% for parathion and 98.6% for methyl parathion.
Researchers successfully reprogrammed diseased human hepatocytes into induced pluripotent stem cells, offering a potentially unlimited source for liver disease treatment. This breakthrough could enable the generation of genetically corrected liver cells via auto-transplantation, avoiding liver transplants and immunosuppression.
Researchers are using genetically modified salmonella packaged with Interlueken 2 to create a two-prong attack on cancer. The therapy, administered orally, shows promise in controlling tumors in the gut and may offer a cheaper and less toxic alternative to chemotherapy and radiation.
Modified-release sildenafil reduced the frequency of Raynaud's phenomenon in patients with limited cutaneous systemic sclerosis by 44%, according to a recent clinical trial. The treatment was well-tolerated, with only minor or moderate side effects reported.
Researchers have engineered E. coli bacteria to produce n-butanol, a chemical that could be used as a substitute for diesel oil and gasoline. The new genetically altered E. coli produced nearly five grams of n-butanol per liter, about 10 times better than current industrial microbe systems.
A new patented therapy has been developed by WSU researcher Dr. Karli Rosner, which uses genetic constructs to target cancer cells and induce apoptosis, eliminating the need for external medications. The treatment shows promise in treating various types of cancers, including melanoma, prostate, lung, and breast cancers.
A new study by NIH-funded researchers has developed genetically modified fungi that can kill malaria-causing parasites in mosquitoes, significantly reducing parasite development. The transgenic fungi block the development of malaria parasites in mosquitoes, preventing transmission to humans.
Researchers at North Carolina State University have developed roses that incorporate a gene from celery to fight botrytis, a major post-harvest disease. The genetically modified roses aim to extend vase life and reduce shipping times, making them more viable for the cut flower industry.
A new study by Washington University in St. Louis anthropologist Glenn Stone suggests that genetically modified Bt cotton seeds may have overemphasized crop yield gains, potentially harming sustainable farm management. The research found a modest rise in crop yields despite decreased pesticide sprayings.
Scientists have genetically modified a trial crop of banana plants to survive Tropical Race Four, a fungus that has wiped out plantations in the Northern Territory. The modified plants have been inserted with a gene that starves the fungus, preventing it from attacking the plant.
Researchers have developed a new method for treating genetic diseases using modified mRNAs, which can be administered repeatedly without increasing the risk of cancer or severe immune reactions. In mouse models, this technique successfully restored lung function in mice with a congenital lung defect.
Researchers have created a method to detect protein oligomers, small toxic aggregations that can initiate amyloid fiber formation in neurodegenerative diseases. The test uses fluorescence techniques and genetically modified yeast to locate and monitor oligomer formations.
A novel form of personalized therapy using genetically engineered anti-tumor immune cells shows promising results in treating metastatic melanoma and synovial cell sarcoma. The technique, called adoptive immunotherapy, resulted in response rates of 45% and 67% in malignant melanoma and synovial cell sarcoma patients, respectively.
A study investigated the impact of disease-resistant genetically-modified (GM) wheat lines on insect food webs. The findings show that the differences between GM and non-GM wheat strains are similar to those found between different conventional wheat strains, suggesting no ecological problems with GM wheat.
Researchers have successfully developed genetically modified chickens that do not transmit avian influenza virus to other chickens, potentially stopping bird flu outbreaks within poultry flocks. This genetic modification has the potential to reduce the risk of bird flu epidemics leading to new flu virus epidemics in humans.