Researchers found that individuals with a smaller hippocampus are more vulnerable to stress and pain, leading to increased risk of chronic pain. Stress management techniques, such as relaxation and meditation, may help alleviate symptoms and prevent chronicity.
A large study found that two-thirds of eligible patients experience significant and lasting benefits from deep brain stimulation (DBS) for neuropathic pain. Benefits vary by cause, with improved outcomes seen in patients with amputation and stroke. Continued improvement is observed with longer follow-up.
A study reveals racial differences in chronic pain management, with black patients experiencing less frequent pain level documentation and more urine drug tests. This may impact the effectiveness of pain management for black patients who overcome barriers to opioid prescriptions.
A new study from Kaiser Permanente found that men on long-acting opioids are 5 times more likely to have low testosterone levels than those on short-acting opioids. The study compared 81 men with chronic pain and found that long-acting opioids significantly increased the risk of low testosterone.
A new poll from the University of Michigan found that only 35% of parents are very concerned about misuse of narcotic pain medicines by children and teens. Despite rising rates of abuse and overdoses, most parents do not support policies to discourage misuse or return unused medications.
A research team from Université Laval has discovered a molecular pathway by which morphine can increase pain, leading to potential new strategies to improve treatment of post-operative and chronic pain. The researchers identified specialized cells called microglia as the culprit behind morphine-induced pain hypersensitivity.
Researchers at Rush University Medical Center identified a chemokine known as monocyte chemoattractant protein-1 (MCP)-1 and its receptor, chemokine receptor 2 (CCR2), as central to the development of osteoarthritis pain. This finding could lead to new treatments for this debilitating condition.
Researchers used brain imaging technique to examine patterns of brain connectivity in adults with chronic back pain and without. They found specific brain regions became less connected, predicting worsening chronic pain, suggesting potential biomarker for chronic pain perception.
A brain imaging study found that THC, the psychoactive ingredient in cannabis, reduces the emotional reaction to pain but does not reduce the intensity of pain. The study suggests that individual responses to cannabis-based pain relief may vary greatly.
A recent study published in PLOS Genetics found a specific set of genes interacting to regulate pain sensitivity in humans. The research used exome sequencing to analyze DNA samples from individuals with varying levels of pain sensitivity, revealing distinct patterns of genetic variants in each group.
Researchers discovered rare genetic variants in genes related to blood pressure regulation also influence sensitivity to pain. The study suggests existing blood pressure treatments could be used to control chronic pain, offering a new approach to pain relief.
Researchers have developed a computer algorithm that accurately predicts lower back pain in patients 76% of the time using brain scans. The study suggests structural changes in gray matter are associated with chronic lower back pain and may reflect pathology within the brain.
Patients with severe back pain who quit smoking reported less pain than those who continued to smoke, according to a recent study. The study found that quitting smoking led to significant improvements in pain levels and disability indexes for nonsmokers.
A cross-sectional study of over 5,370 adolescents found a significant association between parental chronic pain and chronic pain in offspring. The study suggests that family pain models and shared environmental factors play an important role in the origin of chronic pain.
Researchers discovered a specific mutation in the sodium channel Nav1.7 that predicts which chronic pain patients will respond to carbamazepine treatment. The study offers hope for more systematic and effective treatment of chronic pain, potentially benefiting millions of Americans suffering from the condition.
Obese children with lower extremity pain have worse physical function and poorer psychological health compared to their obese peers without pain. Physical fitness levels also show a decline in those reporting lower extremity pain, suggesting potential impact on exercise regimes.
Researchers at Mount Sinai identified reliable predictors of pain in inpatients, enabling interdisciplinary teams to develop targeted intervention plans. These plans resulted in decreased pain levels and increased patient satisfaction across various departments, with reported pain levels decreasing by 3.6% per quarter.
A study found that women with breast cancer are at risk of severe pain after surgery, especially those with chronic pain or low psychological state. The research suggests using factors like pre-operative pain and psychology as indicators for extra pain relief support.
A University of Michigan Health System study found that women with vulvodynia are at a higher risk for other chronic pain conditions. The study showed that millions of women suffer from unexplained vulvar pain that can severely impact daily life.
Chronic pain patients with depression are more likely to misuse opioids, and primary care physicians should take a leading role in setting opioid prescribing standards. Safer alternatives like physical therapy and cognitive behavioral therapy can be effective treatments for chronic pain.
Researchers found that viewing media coverage of terrorist attacks increased pain levels and sensory component of pain in people already suffering from chronic pain. Stress and media exposure were also strongly related.
A Northwestern University study found that chronic pain develops when two brain sections communicate excessively, increasing the likelihood of chronic pain. Researchers predicted with 85% accuracy which participants would develop chronic pain based on brain scan data.
Researchers have identified a naturally occurring protein involved in generating chronic pain in rats, which could lead to new therapeutic treatments. The discovery highlights the impact of molecular signalling events on nerve transmission and offers promising avenues for pain relief.
Exercise significantly reduces neuropathic pain severity and inflammation-promoting cytokine expression in rats with sciatic nerve injury. This study provides evidence that exercise can be a helpful, non-pharmacological therapy for managing neuropathic pain.
Researchers at UCSF have successfully treated chronic neuropathic pain in mice by transplanting immature embryonic nerve cells into the spinal cord. The transplanted cells integrated into the nerve circuitry, forming synapses and signaling pathways with neighboring neurons, leading to a significant reduction in pain hypersensitivity.
Researchers have successfully transplanted embryonic cells into adult mouse spinal cords to alleviate persistent pain. The study suggests that this approach may not only treat symptoms but also correct underlying disease pathology. This new therapy offers hope for patients with neuropathic pain, a condition with limited treatment options.
A new meta-analysis of research on athletes and pain perception reveals that regular exercise can help alleviate pain. Athletes were found to have consistently higher pain tolerance than normally active adults, with endurance athletes exhibiting moderate tolerance and game sports athletes showing a higher but more varied tolerance.
Researchers have identified an unexpected source of diabetic neuropathy pain in laboratory rats with diabetes: changes in the structure of dendritic spines. This finding suggests a potential therapeutic strategy by targeting abnormal spines to alleviate pain.
A large study published in CMAJ found that back pain symptoms improve significantly in the first six weeks, but pain and disability may persist even after one year. Patients with acute low-back pain experience a 90% reduction in pain intensity at one year, while those with persistent low-back pain see only a 50% improvement.
A new drug, BL-7050, is being developed to manage resistant chronic pain caused by nerve or tissue damage. The medication targets potassium channels to prevent hyper-excitability and induce calm in neurons, offering relief to millions of sufferers.
A recent study by McGill University researchers has identified a key gene affecting chronic pain sensitivity, offering a potential new approach to individualized therapy. The findings suggest that targeting the pore-forming function of P2X7 receptors may provide relief for patients with genetically inherited low pain sensitivity.
The study found that primary care physicians need training on monitoring opioids and assessing risk factors, whereas specialists emphasize the importance of formulating treatment plans and teaching medication safety. The findings highlight the need for targeted education programs to improve public health.
A team of scientists has identified a key player in the amplification of pain signals in the spinal cord, which could lead to the development of novel treatments for chronic pain. By removing an enzyme called PKG-1 from pain-sensing nerves, researchers found that LTP was abolished and pain-related memory and behavior were also altered.
A University of Michigan Health System study found that living in a poor neighborhood worsens chronic pain for young adults. The research highlights the importance of considering structural barriers and access to resources in pain management.
Researchers developed a visual tool to help doctors assess patients' pain levels by analyzing their movement patterns, providing a more precise assessment than traditional questionnaires. The new 'barcode' tool offers a dynamic view of a patient's condition, enabling doctors to monitor progress and adapt treatment accordingly.
Recent studies have found that physical and social pain are processed in the same brain regions, with shared emotional components. This overlap is validated by research, suggesting that people who experience social rejection may be more empathetic towards those with physical pain.
Researchers at McGill University have discovered that erasing neuronal memories of pain can reduce both persistent pain and heightened sensitivity to touch. By blocking the activity of a protein kinase, they were able to reverse hypersensitivity to pain in neurons.
A new therapeutic strategy using a single injection of fibronectin has shown potential to improve patient outcomes in treating chronic neuropathic pain following spinal cord injury. This approach inhibits the development of mechanical allodynia, a common type of chronic pain experienced by spinal cord injury patients.
Men with anxiety traits experience higher post-operative pain ratings and longer hospital stays. Women report higher pain levels and are less satisfied with pain control following total knee replacement surgery.
The Gerontological Society of America has launched new resources to improve pain management services for older adults. The resources aim to provide information on how advances in pain prevention, treatment, and management can improve quality of life. GSA's publications address shortfalls in assessment and treatment for older adults wit...
Researchers analyzed past studies on cancer-related pain reduction and found that psychosocial interventions can significantly improve cancer patients' pain severity. Skill-based interventions and educational approaches were most successful in reducing pain and its impact on daily life.
Researchers from London-area hospitals and Oxford measure brain activity in infants to assess their pain response, providing a more reliable alternative to current methods.
A systematic review of chronic pain in children and adolescents found that most types of pain are more prevalent in girls than in boys, with headache being the most common studied pain type. The prevalence rates of childhood pain have increased over the last several decades, highlighting the need for early interventions.
A recent UCSF study suggests that combining cannabinoids with opiates may lead to greater pain relief for chronic pain patients. The study found that patients who received both treatments experienced significant reductions in pain scores, with some showing a 33% decrease in morphine use.
Chronic abdominal pain has seen a significant rise in opioid prescriptions, driven by factors such as campaigns to recognize pain as the "fifth vital sign". The use of opioids for non-cancer chronic pain is supported by limited evidence and can lead to gastrointestinal symptoms and worsen abdominal pain.
A new study by the University of North Carolina Health Care found that elderly patients are less likely to receive pain medication in hospital emergency departments compared to middle-aged patients. The study suggests that physicians may be cautious about potential side effects in older adults, leading to a significant gap in pain mana...
A large-scale clinical study has provided insights into the causes of temporomandibular joint disorders, known as TMD, and identified demographic, biological, psychological, and genetic factors associated with chronic cases. The study's findings may lead to new methods of diagnosing facial pain conditions and predicting susceptibility.
Researchers identified increased sensitivity to pain stimuli, altered heart rate responses, and genetic variations in patients with chronic TMJD. The study also found that socio-economic status does not correlate with TMJD incidence, contrasting with other chronic pain conditions.
A study published in the journal Pain found that opioid-dependent patients treated with escitalopram experienced significant reductions in pain severity and interference. The findings suggest that antidepressants may be an effective alternative to non-opioid pharmacologic therapies for managing chronic pain in this population.
A new UCI study reveals that many children suffer from chronic postoperative pain, with 13% reporting lingering pain for months after surgery. The researchers emphasize the need for improved pediatric care and effective pain management strategies within 48 hours of surgery.
A study found yoga classes to be more effective in reducing symptoms and improving function for patients with chronic low back pain compared to a self-care book. Stretching exercises also showed moderate benefits in reducing back pain, suggesting that the mental component of yoga may not be the primary factor in its effectiveness.
A study published in Pain found that observers estimate lower pain intensity and are perceptually less sensitive to patients they don't like. Researchers used video fragments of patients experiencing shoulder pain and asked participants to rate pain severity and likability.
A European Survey of Oncology Nurse Breakthrough Cancer Pain Practices revealed an enormous opportunity to improve pain outcomes through education, with most nurses reporting inadequate training and confusion over medication options. The survey calls for nurse-specific guidelines and training to address the gap in management.
Patients with acute low back pain who were advised to stay active despite the pain fared better in recovery and mental health compared to those told to adjust their activity in line with their pain. This study found that staying active can help patients recover more quickly and manage depression.
A new study found that neuroticism is linked to increased brain activity during pain anticipation in individuals with irritable bowel syndrome (IBS). This heightened emotional response may exacerbate chronic pain conditions. Physicians should consider a patient's mental state when determining treatment regimens.
A new study from the University of Michigan found that over 25% of women in the metro Detroit area have experienced ongoing vulvar pain, while only 2% sought treatment. The study sheds light on the demographics and characteristics of vulvodynia, a condition causing unexplained pain at the vagina's opening.
Researchers have developed a diagnostic tool that uses brain activity patterns to give an objective physiologic assessment of pain, accurately predicting thermal pain in healthy subjects 81% of the time. The study aims to improve detection and treatment of chronic pain.
Scientists at University of Cambridge identify gene HCN2 as key regulator of chronic pain. The discovery opens up possibility of developing new, targeted pain medications.
A Cochrane Review analyzed 35 Cochrane Reviews of randomized trials to evaluate the effectiveness of 46 different drug/dose combinations against acute pain. The review found that no single drug provides high levels of pain relief for all patients, but some options have a solid evidence base
Researchers used a new imaging technique to study brain activity in patients with chronic low back pain, finding increased activity in specific brain regions during worsening pain episodes. The study provides insights into the basic physiology of pain processing and may lead to tailored therapies.