The new model simplifies trial openings and streamlines patient enrollment, enabling rapid expansion across multiple locations. City of Hope operates a single centralized hub with diverse research locations, reducing patient enrollment times and increasing access to leading-edge treatment options.
The $3.5 million gift will enable the center to triple its patient capacity and expand into a new, 16,000-square-foot space, centralizing care for clinical trial patients. This expansion will bring potentially life-extending treatments to more patients than ever.
A new AI-based model identifies four central state dimensions that better capture the progression of MS, including physical disability and brain damage. The findings could fundamentally change diagnosis and treatment for MS patients.
Researchers have deciphered the fly brain's process of filtering out visual information during sleep, creating a 'window' that allows strong stimuli to wake them up. This study may hold parallels for human brain function and could reveal a universal principle of sleep.
The International Progressive MS Alliance has launched the MS Clinical and Imaging Data Resource (CIDR), providing access to anonymized data from thousands of people with MS who participated in clinical trials. The resource aims to accelerate research on progressive MS by enabling investigators to conduct more informed studies and spee...
Researchers found measurable changes in brain signals responsible for motor control and movement after 12 dynamic cycling sessions. The study suggests long-term exercise programs could have wider restorative effects on the brain signals of Parkinson's Disease patients.
Researchers will evaluate technology as a clinical tool for personalized cancer therapy, with potential to test various treatments on patient biopsies. The collaboration aims to obtain CAP/CLIA certification and conduct clinical studies to validate the utility of organoid-based assays.
The Damon Runyon Cancer Research Foundation has awarded $4.2 million to five new Clinical Investigators conducting patient-oriented cancer research. The awards will support the development of new treatments for cancer patients, with a focus on enhancing efficacy and safety.
A new study highlights major hurdles for multinational clinical trials in Europe, including differences in timelines and processing times between countries. Researchers found that the UK made significant gains in efficiency during the pandemic, while non-UK countries lagged behind.
The American Thoracic Society has launched an initiative to provide paid time-off for employees participating in clinical trials. This effort aims to reduce barriers to participation, particularly among underserved communities, and promote diversity in medical research.
The Association for Molecular Pathology publishes guidelines for detecting homologous recombination deficiency (HRD) in cancer. The report includes recommendations for clinical laboratories, addressing technical aspects of genomic instability and HRD analysis.
Researchers from the Mount Sinai Health System are presenting new studies on the impact of sleep on neurodegenerative diseases like Alzheimer's. The studies explore the relationship between obstructive sleep apnea and Alzheimer's pathogenesis, as well as the effects of sleep disruption on spatial learning and neuroinflammation.
The Cuyahoga County Healthcare Sector Partnership is launching an initiative to train more nurse educators, aiming to address the national nursing educator shortage in Northeast Ohio. The program will recruit and train clinical faculty to support increased enrollment in nursing programs and reduce student waitlists.
A research team from the Medical University of Vienna has identified a molecular mechanism that may play a role in the development of seizures. They found that paroxysmal depolarisation shifts (PDS) can lead to altered energy metabolism in neurons, paving the way for seizure-like electrical discharges.
The annual Alzheimer's disease drug development pipeline report, led by Dr. Jeffrey Cummings, highlights an increase in active clinical trials and promising drugs, offering reason for optimism. The report assesses 138 drugs currently being studied and notes the growing importance of biomarkers in clinical trials.
FAIR Health's shared decision-making tools support clinical point-of-care decisions with older patients and their caregivers, aligning with the 4Ms framework of age-friendly care. Key takeaways from a Learning Exchange session highlight the flexibility and value of these tools in diverse care settings.
Researchers have discovered that blow flies can detect forces with high sensitivity, not only magnitude but also rate of change, which is crucial for balance and locomotion. The study's findings have promising implications for the design of next-generation walking robots.
Researchers found that insulin signaling changes affect both Alzheimer's disease and epilepsy in animal tests. This discovery confirms clinical evidence of increased risk of Alzheimer's in people with epilepsy and highlights the need for a broader therapeutic approach to address the complex nature of Alzheimer's disease.
Terrence Sejnowski has been elected to the Royal Society and the American Philosophical Society, a testament to his groundbreaking contributions to computational neuroscience. His pioneering work includes inventing the Boltzmann machine and NETtalk program, which revolutionized artificial neural networks and speech recognition.
Researchers found that astrocytes transmit signals, revealing new ways the brain processes information. The study provides direct evidence for the real-time action of astrocytes in live brains of fruit flies, suggesting their role in mediating neurophysiology and behavior.
The University of Texas at Arlington offers pre-health students valuable hands-on experience through an innovative collaboration. Students in SCIE 4304 participate in immersive clinical simulation lab at the UTA Smart Hospital, developing rudimentary clinical skills and overcoming imposter syndrome.
Researchers analyzed trends in efficacy endpoints for glioblastoma phase II clinical trials, finding a shift towards using time-to-event measures like progression-free survival (PFS) and overall survival (OS). This trend reflects the complexity of GBM treatment evaluation and may indicate evolving clinical trial design.
The University of Rhode Island will host the international XV Progress in Motor Control Conference from June 30 to July 2, featuring over 30 invited speakers from around the world. The conference will focus on theoretical advances in motor control, motor learning and neural plasticity, motor disorders and rehabilitation.
A team of researchers from Bonn and Tübingen investigated the brain's ability to retain a sequence of events in memory using implanted electrodes. They found that the traditional theory was contradicted by their data, but an alternative mechanism emerged through AI simulations.
The collaboration aims to enhance clinical trial efficiency, reducing data entry time by up to 37 seconds per CRF. This enables researchers to focus more on patient care, improving the overall experience.
Researchers found that cannabidiol stimulates the biomineralization of teeth even under inflammatory conditions, promoting tissue repair. The substance also inhibited the synthesis of inflammatory mediators in macrophages, suggesting an anti-inflammatory effect.
The American College of Cardiology has issued a new clinical policy providing streamlined processes for the evaluation and management of cardiogenic shock. The guidelines emphasize early recognition, comprehensive assessment, and effective medical management to preserve organ performance and reduce mortality rates.
Mayo Clinic researchers have developed a new way to more precisely detect and monitor brain cell activity during deep brain stimulation, a common treatment for movement disorders. The study uses custom algorithms to record broadband signals associated with hand movement in patients undergoing awake DBS surgery.
A new study found that Black Americans are more willing to participate in medical studies led by Black doctors and researchers. Diversifying clinical trial leadership could improve enrollment of underrepresented groups and ensure the benefits and risks of treatments are understood across populations.
A recent study found that the NIH provides critical funding for pediatric clinical trials in diseases not prioritized by industry. Pediatric research in asthma and lung diseases has been chronically under-funded, highlighting the need for increased funding.
Male fruit flies use high-frequency wing flicks to jam rival songs, while also performing courtship behaviors to win over females. The study reveals that mating decisions in flies are influenced by interactions between males, challenging previous assumptions about female preference.
The Cardiovascular Research Foundation will host THT 2025, showcasing late-breaking clinical science presentations on transcatheter approaches to managing a wide spectrum of heart failure patients. Four dedicated sessions feature exclusive first-release data from pivotal studies and dynamic discussions on controversies in clinical trials.
A set of international acupuncture guidelines has been published for treating non-specific low back pain, providing seven recommendations for clinical questions. The guidelines aim to improve the efficacy and safety of acupuncture and moxibustion therapy for NSLBP, with a focus on patient-centered care.
The Lancet Commission on Clinical Obesity proposes a new model for diagnosing clinical obesity based on objective measures of illness at the individual level. The proposal aims to settle the ongoing dispute around the idea of obesity as a disease, providing a medically coherent framework for diagnosis.
The project aims to improve the design of clinical trials for neurological conditions like stroke, Parkinson's disease, and vascular cognitive impairment and dementia. Community partners will facilitate academic and community partnerships for clinical trial development.
Lewis S. Nelson, M.D., takes helm as dean of FAU's Schmidt College of Medicine, spearheading innovative medical education programs and research initiatives. With over 30 years of leadership experience, Nelson aims to foster innovation, research, and clinical excellence at the college.
Researchers at Vanderbilt University have successfully completed a phase I clinical trial of VU319, a drug that increases the efficacy of acetylcholine at the M1 receptor, showing promise as an Alzheimer's treatment. The trial demonstrated no side effects and target engagement at the highest dose tested.
The Keck School of Medicine of USC has joined the Ryght Research Network to leverage AI tools and optimize cancer clinical trials. The collaboration aims to offer more clinical trials to patients, build new AI tools, and speed up the development of medical treatments.
The study found that slow electrical waves during deep sleep strengthen synaptic connections and make the neocortex more receptive to information. This enhances memory formation by creating a state of elevated readiness in the cortex.
A new study reveals that concussions impact aperiodic brain activity in high school football players, leading to slowed cognitive function and worse post-concussion symptoms. The research highlights the importance of protective measures in contact sports and may lead to new treatments for concussion recovery.
Altmetric adds Clinical Guidelines as an attention source to track the impact of research in clinical practice. This enables users to see attention from Clinical Guidelines and gain insights into the practical applications and long-term impact of their research.
The NIH-developed AI algorithm, TrialGPT, can identify relevant clinical trials for eligible patients and provide a clear explanation of their eligibility. The researchers found that clinicians using TrialGPT spent 40% less time screening patients while maintaining the same level of accuracy.
A study found that smoking habits interfere with performance on cognitive tasks involving memory and attention, and impairs a person's ability to detect deception. The study revealed two clusters of participants with differing physiological responses to stress, including pupil dilation and heart rate parameters.
Kuhn's 'landscape of consciousness' explores diverse theories of consciousness, including materialism, non-reductive physicalism, and quantum theories. The taxonomy is designed to examine their impact on ultimate questions like meaning, purpose, and value.
Researchers found that fruit fly brains use modular circuits to quickly adapt to different mating signals, allowing species to develop unique courtship strategies without rewiring their brains. This discovery sheds light on the flexibility of neural circuits in the face of new sensory inputs and has implications for understanding brain...
The American Academy of Pediatrics has published its first clinical guideline for pediatricians on prescribing opioids, emphasizing the importance of safe use in treating acute pain. The guideline recommends routine prescription of naloxone alongside every opioid prescription to reverse overdoses.
A survey found that spiritual beliefs and distrust of clinical research contribute to Black patients' hesitation to enroll in cancer trials. Despite trusting their medical teams, some patients express concerns about the purpose of research and its potential impact on their health and community.
A recent study by FAU researchers reveals how the brain coordinates food intake to ensure we receive the right amount of energy. The hypothalamus, a control center in the brain, triggers behaviors like eating and satiety through a complex mechanism involving four teams of neurons that work together like relay runners.
A survey of experts revealed six key challenges to biomarkers of aging in the clinical setting, including standardization and regulatory frameworks. Recommendations have been formulated to address these issues, aiming to advance the use of these tools in optimizing healthy lifespan.
A systematic review of pharmacogenomics clinical decision support systems found that e-health tools can help integrate personalized medicine into everyday clinical practice. However, current implementation is limited, particularly in non-US healthcare systems.
A new scoping review suggests that clinical hypnosis is more effective than cognitive behavioral therapy in managing hot flashes. Clinical hypnosis interventions showed a significant reduction of over 60% in hot flash frequency and severity, while cognitive behavioral therapy had minimal impact on hot flash reduction.
A new study from Aarhus University reveals that older individuals' brains work harder to compensate for age-related changes in memory function when listening to familiar music. The study uses classical music by Johann Sebastian Bach to map brain activity and identify potential biomarkers for dementia.
Researchers will investigate the psychological influence of online communications developed with artificial intelligence, including misinformation and radicalizing messages. The team aims to develop a holistic model of multi-level belief resonance that can counter foreign influence on campaigns and radicalization.
A study by HSE University scientists found that changes in heart rate can serve as an early biomarker for anxiety and depressive disorders. The research used PPG technology to analyze heart function during cognitive tasks, revealing more pronounced changes in individuals with higher levels of anxiety or depression.
The National Institutes of Health has awarded $15.5 million to establish a national network structure to include more nursing home residents in clinical trials. The NEXT STEPs initiative aims to remove barriers to participation and increase the quality of clinical trials conducted in nursing homes.
The study reveals that light-sensitive channels can be used to target specific ion signals in plants, allowing for the comparison of different signaling pathways. This breakthrough enables researchers to investigate plant stress responses in greater detail.
The MedPearl platform improved primary care clinician productivity, decreasing time waste on administrative tasks and enhancing the quality of referrals to specialists. Clinician users reported a 72% improvement in clinical management and workups, with a high user retention rate after system-wide integration.
The Access for All in ALS Consortium has successfully enrolled its first participant, marking a significant step forward for ALS research. The consortium aims to disrupt the clinical research landscape using open science methods to advance ALS research.
A new study found that two Medicaid policies can interact to increase oncology clinical trial enrollment among Black and Hispanic patients. Medicaid expansion under the ACA alone did not improve diversity, but states with pre-existing mandates requiring coverage of clinical trial costs saw a significant increase.
The Association for Molecular Pathology has published consensus guidelines for clinical DPYD genotyping assays to improve patient care and standardize testing. The recommendations include a tiered system of variants with well-characterized effects on protein function, gene expression, and minor allele frequency.