The CCE-DART project aims to develop interconnected tools to reduce the complexity of investigator-initiated trials, incorporating cutting-edge digital technologies. It will harmonize molecular multi-tier profiling platforms to precisely match patients to novel anti-cancer medicines based on genetic tumor specificities.
A new study found that global clinical trials enrolled less than half the proportion of Black patients as U.S. trials, highlighting a trend that may exacerbate racial disparities in cancer research and care. The study suggests that globalization of cancer clinical trials may be a key driver of these disparities.
A study found that less than one-third of COVID-19 clinical trials are led by women, a disparity compared to non-COVID-19 trials. The research suggests that gender biases and imbalances may expose systemic inequalities in women's access to research activities and funding.
A Vanderbilt University Medical Center survey identified strong collaborative relationships as a key factor in retaining clinical research coordinators. The study also found that compensation, career growth opportunities, and collegial relationships through hands-on involvement in clinical trials were significant predictors of retention.
A research team at Toyohashi University of Technology has developed a lightweight, compact, Bluetooth-low-energy-based wireless neuronal recording system for use in mice. The system weighs less than 3.9g and offers high signal quality, good versatility, and low cost compared to wired recording.
A new study developed a transparent and reproducible machine learning tool, TL-Lite, to facilitate analysis of health information. The tool can be used in clinical forecasting, predicting trends and outcomes in individual patients, and is particularly useful for organizing clinical data into meaningful visualizations.
Scientists at the University of Würzburg have successfully applied optogenetic methods in tobacco plants, enabling non-invasive manipulation of intact plants or selected cells by light. This breakthrough allows researchers to study molecular mechanisms of plant growth processes in detail.
Researchers at St. Jude Children's Research Hospital published a clinical trial report providing molecular profiling insights into pediatric medulloblastoma. The study confirmed the need for integrated molecular assessment of these tumors, highlighting differences in prognosis based on molecular groups.
Researchers at the National Eye Institute discovered a brain region, superior temporal sulcus (fSTS), crucial for processing and making decisions about visual information. This finding could provide clues to treating visual conditions from stroke.
New study assesses association between clinical and financial integration, finding that financial integration has few positive effects on patient outcomes. Clinical integration, however, is associated with greater use of quality-focused care delivery processes and less spending.
The National Institute of Allergy and Infectious Diseases has established four HIV clinical trials networks to advance research on prevention, vaccines, therapeutics, and maternal/adolescent/pediatric treatments. The networks aim to increase efficiency and effectiveness in NIH's HIV clinical trial operations.
The UC San Diego-led Collaborative Clinical Trials Unit (CTU) will investigate therapeutic strategies for a cure and functional cure of HIV. The CTU will also evaluate viral persistence and latent reservoirs, as well as new antiretroviral drugs and treatments for co-infections.
Researchers found previously unknown changes in brain networks after polio and neurological diseases like MND/ALS, suggesting abnormal communication between muscles and brain. The study increases understanding of brain plasticity and its implications for rehabilitation and new biomarker development.
A recent survey by the American Cancer Society found that nearly 1 in 5 cancer patients are less likely to enroll in clinical trials during the pandemic. The top reason cited is fear of COVID-19 exposure. This could lead to reduced enrollment in trials already struggling to find patients.
Dr. Anne B. Newman will receive the American Heart Association's 2020 Clinical Research Prize for her work on aging and cardiovascular disease. She is being recognized for her extensive research career, including long-term cohort studies and clinical trials on aging and physical functioning.
A new brain imaging technology, BrainPhys, has been developed to support optimal neuronal function and viability in live imaging experiments. This breakthrough could lead to better personalised medicine for brain disorders such as Parkinson's, brain cancer, and childhood dementia.
Research identifies commonalities in COVID-19 patients' brain activity, highlighting potential long-term effects on older males. Abnormal EEG readings suggest permanent brain damage, prompting the need for comprehensive care including brain imaging.
Scientists identified changes in the brain that drive alcohol abuse among people with PTSD, highlighting sex-specific differences that could lead to targeted treatments. Researchers found that males and females exhibit different symptoms and brain features of PTSD and alcohol use disorder.
Researchers have identified STAT3 as an important factor in emotional reactivity, establishing a link between the immune system, serotonergic transmission, and affective disorders. STAT3 deficiency reduces emotional reactivity in mice, suggesting its role as a molecular mediator in regulating emotional behavior.
Scientists have discovered that spinal modules in macaques can independently control forelimb force direction and magnitude, offering new insights into movement disorders and potential recovery methods. This finding, known as the 'spinal motor module hypothesis,' has significant implications for robotics and clinical medicine.
UT Southwestern Medical Center's COVID-19 adjustments streamlined clinical trials, allowing for remote consents and telehealth visits. A survey of UTSW clinical research professionals found positive experiences with these changes, with over 90% supporting continued use after the pandemic ends.
A new investigation by Science reveals that the FDA's enforcement of clinical trial regulations is often light-handed, slow-moving, and secretive. The agency rarely levels sanctions or disqualifies scientists from clinical research, and cases are frequently resolved based on unverified claims.
The National Institutes of Health has awarded grants to support researchers' efforts in using tiny, bioengineered models of human tissues and organ systems to study diseases and test drugs. The goal is to develop ways to predict which patients are most likely to benefit from an investigational therapy prior to initiating clinical trials.
A study presented at ESMO 2020 found significant variations in access to cancer medicines and clinical trials across European countries. Western European nations tend to have more clinical trials, while Eastern and Central European countries face barriers due to limited infrastructure and resources.
Research from the University of Kent found that TRESK plays a crucial role in regulating the brain's central circadian clock. Lowering TRESK levels disrupted the biological rhythm, causing the clock to lose its day-night association.
Researchers at George Mason University are developing a senior-year capstone course and summer clinical immersion program to integrate nursing and health informatics students into Bioengineering Design teams. The program aims to apply the new curriculum in real-world clinical contexts, addressing newly identified clinical needs.
Researchers investigated the impact of sleep deprivation on glymphatic system function, which regulates waste removal in the brain. The study found that astrocytes play a crucial role in regulating this process, and disruptions to circadian rhythms can lead to neurological disorders such as Alzheimer's disease.
A team of researchers at Children's Hospital of Philadelphia used new computational methods to link characteristic presentations of childhood epilepsies with specific genetic variants. They analyzed clinical information and large-scale genomic data, finding associations between 11 genetic causes and specific symptoms.
Researchers identified a link between female authors and increased enrollment of women in heart failure clinical trials. The study, published in Circulation: Heart Failure, found that clinical trials with female first or senior authors had a higher proportion of enrolled female participants.
The National Institutes of Health has established a new clinical trials network to enroll thousands of volunteers in large-scale clinical trials testing various COVID-19 vaccines and monoclonal antibodies. The COVPN will leverage existing infrastructure and engage communities to secure participants for late-stage clinical trials.
Researchers found that HIV-positive adults' brains process speech cues differently, with disrupted responses even when hearing tests are normal. This non-invasive test holds promise for understanding brain dysfunction in HIV and other disorders.
A CHOP study demonstrates that remote continuous EEG monitoring can detect seizures in at-risk neonates, impacting clinical care and guiding treatment decisions. The study showed that seizures occurred in about one-quarter of the records, with CEEG impacting outcomes in three-quarters of cases.
A new investigator-initiated clinical trial in metastatic breast cancer is underway at HUS Comprehensive Cancer Center, testing a combination treatment regimen that targets the MYC oncoprotein. The study aims to find the right dosage for further studies and biomarkers to guide patient selection with improved precision.
Researchers developed a novel clinical decision support system to predict individual trauma patient outcome based on historical data and real-world evidence. The system uses an evidential reasoning rule to process clinical signs and symptoms, identifying patients at risk of adverse events such as ICU admission or in-hospital death.
The Association for Molecular Pathology (AMP) has released consensus recommendations to aid in the design, validation and interpretation of clinical genotyping tests for predicting warfarin response. The guidelines define a minimum set of pharmacogenetic alleles for inclusion in clinical warfarin sensitivity genotyping tests.
The Altman Clinical and Translational Research Institute at UC San Diego has received a five-year, $54.7 million Clinical and Translational Science Award from the National Institutes of Health. This grant will refine fundamental work and provide new resources to launch a wave of discovery and transformation.
The Wits Journal of Clinical Medicine published the first clinical data on COVID-19 in South Africa, covering various aspects of the pandemic. The special issue includes articles on diagnosis, ethics, social dimensions, and herd immunity as a strategy for fighting COVID-19.
A study found that age-related hearing loss damages the brain's hippocampus, a key memory organ. The findings suggest that progressive hearing impairment impairs memory formation by altering neurotransmitter receptors.
Novotech Research reveals that the top 10 biotech sites in Australia are open for clinical trial activity. The country's favorable environment is supporting clinical research during the global COVID-19 crisis, with many sites modifying their practices to ensure continuity of operations.
Researchers at Flinders University have discovered a complex array of sensory nerve endings in the lower colon that can detect sensory stimuli and communicate with the spinal cord. This breakthrough could lead to new medications to treat disorders related to gut-to-brain communication.
A recent NIH study has identified a genetic mutation that improves cognitive flexibility in mice by modifying a protein regulating potassium channels. The mutation was found to enhance the ability of mice to adapt to changing situations, such as finding a relocated platform.
A new framework has been developed to share clinical data for research and AI algorithm development, prioritizing patient privacy and ethical standards. The framework supports the release of de-identified and aggregated data, with safeguards in place to protect patient identity.
Researchers developed a new method to accurately record brain activity at scale, enabling the creation of brain-computer interface systems. The technology overcomes challenges in recording brain activity across large areas and minimizes tissue damage.
Researchers at Karolinska Institutet have discovered a detailed blueprint for the development of the human cortex in the ancient lamprey brain, shifting its origin to over 500 million years ago.
Research reveals bias and stereotyping among healthcare professionals when recruiting patients for cancer clinical trials. The study highlights language barriers, misconceptions, and negative perceptions of minority participants as challenges. Experts call for culturally tailored approaches to address biases in clinical trial recruitment.
Research shows that cancer clinical trials inadequately report treatment efficacy and adverse effects specific to older adults. A new study has developed templates to address this issue, providing a framework for more accurate assessment of senior cancer patients.
Researchers used a virtual flight simulator to compare the effects of two pesticides on locusts, finding that the newer sulfoxamine pesticide does not impair motion detection ability at low dosages. The study suggests that the pesticide may be safer than current neonicotinoid options for agriculture use.
A new smart jumpsuit quantitatively assesses children's spontaneous movement, helping to detect abnormal neurological development. The device provides valuable insights into infant motility, which can be used to support everyday activities and interventions.
The Wilderness Medical Society has released new clinical practice guidelines addressing critical issues in wilderness medicine, including diabetes management and spinal cord protection. The guidelines emphasize personalized care and evidence-based approaches to prevent complications and optimize patient outcomes.
Researchers found that only 0.1% of cancer patients were enrolled in clinical trials as their first course of therapy after diagnosis. White males with private health insurance and metastatic cancers are more likely to enroll, but the low enrollment rate is still troubling due to the potential for increased life expectancy.
The consortium will conduct Phase 1-4 vaccine and treatment trials, including human challenge trials. The leadership group will prioritize candidate vaccines, diagnostics, and therapeutics to test in clinical trials.
A new study found that Huntington's disease patients are at risk of therapeutic misconception due to a lack of understanding about clinical trial risks and benefits. Investigators recommend improving patient-doctor communication to address this issue.
The Ivy Brain Tumor Center is collaborating with SonALAsense to develop and test sonodynamic therapy, a promising new treatment for recurrent glioblastoma. The Phase 0/2 clinical trial will assess the safety and efficacy of this non-invasive therapy in patients with glioblastoma.
Researchers developed SleepFit, a new app to monitor Parkinson's disease, which showed good agreement between prospectively and retrospectively collected data. The study found that patients with higher disagreement tended to have more advanced disease or worse sleep quality.
The new 2019 Clinical Performance and Quality Measures for Adults with High Blood Pressure aim to accelerate translation of scientific evidence into clinical practice. The measures evaluate patient care in accordance with the 2017 Hypertension Clinical Practice Guidelines, including timeliness, safety, effectiveness, efficiency, equity...
Researchers at UCL found that newborn baby hiccups trigger a large wave of brain signals, potentially helping babies learn how to regulate their breathing. The study used brain scans to record EEG activity in 13 newborn infants with hiccups, finding that the contractions evoked a pronounced response in the brain's cortex.
Researchers found that slow-wave sleep triggers waves of cerebrospinal fluid that flush out toxic metabolic waste products from the brain. This process supports memory processing and consolidation, and may be crucial for preventing neurodegeneration and diseases like Alzheimer's.
Researchers found atypical brain activity in people with autism when coordinating visual and motor information. This can lead to difficulties with daily activities such as handwriting or playing sports. The study aims to better understand the diverse challenges experienced by individuals with ASD.
The Georgia Cancer Center at Augusta University has received a six-year $6 million grant from the NCI to improve access to clinical trials for minority and rural populations. The grant will be used to recruit patients to conduct multi-site cancer clinical trials and care delivery studies in their communities.
A survey of European patients with lung cancer revealed that many were unaware of or had never heard of clinical trials. Despite positive experiences by over 50%, respondents identified difficulties in accessing trials, including language barriers, limited information, and disparities across Europe.