A study of 1244 patients found a 72% higher risk of heart failure in those receiving androgen deprivation therapy compared to non-users. The researchers recommend counseling patients on modifiable heart failure risk factors and providing cardiovascular examinations.
A novel antidepressant, vortioxetine, has been shown to improve subjective sleep quality and daytime sleepiness in patients with major depressive disorder. The treatment's multimodal effect on serotonin transport and reuptake may have important clinical implications for addressing sleep problems in depression.
University of Toledo scientists discover that increasing body's supply of beta hydroxybutyrate can regulate high blood pressure without exercise or sodium reduction. The study used lab rats and found significant decrease in blood pressure through kidney repair.
A review of bivalent HPV vaccine data found no new or unexpected safety concerns. The majority of adverse event reports were classified as non-serious and mild.
A new study analyzed data from two UK and US centers to find that patients with advanced lung cancer often receive multiple medications that may not be beneficial. On average, these patients were prescribed 1.9-2.6 preventative medications at admission and discharge. The authors suggest developing an intervention to reduce inappropriat...
Researchers found that bee venom and melittin suppress inflammation in atopic dermatitis by regulating T helper cell differentiation. The study suggests bee venom may be an effective treatment for eczema, potentially alleviating inflammatory skin diseases.
A review suggests that cannabidiol, a compound in cannabis, may have modest efficacy in treating severe epilepsy, particularly in children. However, more rigorous clinical trials are necessary to fully understand its potential and minimize side effects.
A new drug-delivery technology called RBC-hitchhiking has been found to dramatically increase the concentration of drugs in specific organs, potentially decreasing side effects and improving efficacy. The technology uses red blood cells to transport nano-scale drug carriers, achieving a 40-fold increase in drug uptake in the lungs.
A review of cannabinoids suggests they can stop cancer cells from dividing and invading normal tissue. Cannabinoids may also enhance the immune response against tumor growth and spread, providing potential new treatment options for cancer patients.
A recent meta-analysis compared the efficacy and safety of antihypertensive drugs during pregnancy. Labetalol, hydralazine, and nifedipine were found to have similar efficacy with negligible differences in their safety profile.
A new study found that doctors' predictions of medication-related harm (MRH) in older adults are not reliable. Despite clinical experience and confidence influencing accuracy, predictions were no more accurate than chance. New approaches to identify high-risk individuals are needed to mitigate serious consequences.
Allowing pharmacists to write prescriptions is associated with increased access to healthcare services, improved patient outcomes, and enhanced utilisation of their skills. Pharmacists' diagnosis skills were a primary concern among organisational issues.
Researchers discovered that Kapβ2, a nuclear localization signal, plays a crucial role in transporting the FUS protein into the nucleus. The study found that when this system fails, FUS proteins aggregate and form toxic droplets, contributing to neurodegenerative diseases like familial ALS.
A physiologically based pharmacokinetic model suggests BUP exposure decreases during pregnancy, requiring dose increases to maintain efficacy. After delivery, a reduction in buprenorphine dose is necessary.
A new journal series published in the British Journal of Clinical Pharmacology aims to provide insights into European medication-related guidelines. The series, developed in collaboration with the EMA, offers annotated versions of relevant guidelines and regulatory documents, facilitating discussion among professionals and patients. Ex...
A study of 1280 older adults found that medication-related harm was common, affecting 1 in 3 patients post-hospital discharge, with 50% preventable. The cost to the NHS was estimated at £396 million, largely due to hospital readmissions.
Researchers found that mutations create a hole in the voltage sensor of muscle cells, allowing sodium ions to leak and trigger muscle weakness. A new class of compounds may block this pore and prevent or treat hypokalemic periodic paralysis.
A study found that over 4 in 5 patients received potentially inappropriate prescriptions, with multiple medications increasing the risk of hospital readmissions and death. The use of STOPP and START criteria identified PIMs and PPOs, highlighting a significant concern for older adults' medication safety.
A recent study published in British Journal of Clinical Pharmacology found that large variability in urine concentrations makes it impossible to determine an administered dose from a single untimed urine sample. This highlights the need to reconsider the use of urine tests for detecting salbutamol doping, as many violations will go unn...
A study by researchers at the University of Copenhagen has confirmed a connection between the circadian rhythm and aggression in Alzheimer's patients. The team identified a circuit linking the brain's circadian clock to an aggression centre, suggesting a potential target for pharmacological intervention. This discovery may lead to new ...
Researchers at Thomas Jefferson University successfully killed tumors and prevented metastatic growth in mouse models of colorectal cancer using CAR-T cell therapy, targeting the GUCY2C antigen. The therapy achieved high survival rates without side effects, paving the way for potential human clinical trials.
Researchers at the University of Michigan have developed a new compound that could offer pain-relieving properties without the risk of addiction. The compound interacts with two types of opioid receptors, one responsible for pain relief and another that can reduce addiction liability.
Researchers used adipose-derived mesenchymal stem cells to treat spinal cord injuries in rats, resulting in improved motor function and reduced damage. The study's findings suggest a promising therapeutic approach for repairing nervous tissue after injury.
A new study of nearly 1,500 newborns found significant variations in drug prescriptions between neonatal intensive care units (NICUs) in The Netherlands. Cardiovascular and nervous system drugs were often prescribed off-label, with varying degrees of appropriateness.
PDE5 inhibitors have been approved to treat lower urinary tract symptoms and pulmonary arterial hypertension, with potential benefits in diabetes and cancer treatment due to their blood vessel dilation effects
A recent study found that celecoxib, an NSAID, had better gastrointestinal safety than ibuprofen or naproxen when co-prescribed with esomeprazole. The medication was associated with infrequent gastrointestinal side effects in arthritis patients, making it a safer option for those taking these medications.
The British Journal of Pharmacology has published updated guidance for authors on designing experiments, analyzing data, and presenting results. The editorials aim to improve reproducibility and transparency in preclinical research by providing approaches to data presentation and checklists for immunoblotting and immunohistochemistry.
Research by Dr Elena K Schneider investigates the pharmacology of cystic fibrosis medications, specifically cytochrome P450 3A4 induction. The study finds that lumacaftor induces cytochrome CYP3A4 activity more than ivacaftor, potentially reducing plasma concentrations and affecting treatment efficacy.
A non-invasive adhesive patch has been created to measure glucose levels through the skin without a finger-prick blood test. The patch can accurately track glucose levels across several hours and does not require calibration with a blood sample.
A recent review and analysis of published studies found no consistent association between NSAIDs or acetaminophen use and exacerbation of Crohn's disease. However, a low-bias study showed a link between NSAID use and worsening of Crohn's disease symptoms.
Scientists at NIDA uncovered evidence of a more complex role for GPCRs, suggesting a conceptual advance in biochemistry and pharmacology. The discovery reveals that GPCRs form part of pre-coupled macromolecular complexes that act as computing devices to gather and process information.
Scientists at Michigan State University have discovered a promising new drug that targets the c-Myc gene, which is linked to obesity and various cancers. The drug, I-BET-762, delays the development of existing cancers by inhibiting critical proteins involved in cancer cell growth.
A study of 3024 women found that serotonin reuptake inhibitors in late pregnancy were not linked to low milk supply, but those with underlying psychiatric illnesses were at greatest risk. The findings highlight the importance of providing mental health support during breastfeeding.
A recent study published in British Journal of Clinical Pharmacology found a significant link between nonsteroidal anti-inflammatory drugs (NSAIDs) and an increased risk of atrial fibrillation. The research highlights the importance of closely monitoring NSAID use for heart health, particularly among high-risk individuals.
A recent study published in Alimentary Pharmacology & Therapeutics found that long-term proton pump inhibitor (PPI) use does not increase the risk of hip fractures among people with Alzheimer's disease. The study followed a cohort of over 4,800 participants and analyzed their medication use.
A study published in the British Journal of Clinical Pharmacology suggests that methylphenidate, an ADHD medication, may be subject to misuse and/or abuse. The study found inconsistent patterns of use among adult users, particularly those aged 25-49 years.
A new analysis found a link between weight loss surgery and an increased risk of inflammatory bowel disease (IBD), with patients having a nearly 2-times higher likelihood of developing IBD. The mechanism behind this association is unclear, but alterations in gut microbes and vitamin D/bile salt deficiencies may play a role.
A study investigated tau phosphorylation-related targets for Alzheimer's disease treatment, focusing on four kinases and one phosphatase. The model suggests the role of each enzyme in AD pathogenesis and identifies potential targets for therapy. This work builds upon InSysBio's quantitative systems pharmacology (QSP) modeling approach.
Researchers found that only 15% of patients with rheumatoid arthritis could use a HandiHaler inhaler correctly, while 94% of healthy controls could. The study highlights the importance of ensuring patients can properly use their prescribed inhalers to manage their respiratory disease.
A recent study published in Pharmacology Research & Perspectives reveals racial disparities in Hepatitis C cure rates among patients receiving optimal therapies. The findings show lower cure rates for African American individuals compared to White individuals, highlighting the need for further exploration of underlying causes.
A Taiwanese database study of 55,629 patients with hypertension found no significant difference in cardiovascular risk between cyclooxygenase-2 enzyme selective NSAIDs and nonselective NSAIDs. Most commonly used NSAIDs have similar cardiovascular safety profiles under low-to-moderate daily doses and short-term treatment periods.
Two novel ocular hypotensive agents, netarsudil and latanoprostene bunod, have been approved for use in humans, reducing intraocular pressure with lasting results. These breakthrough drugs also show promise for treating dry eye disease and delivering ophthalmic drugs via microneedles.
A recent study analyzing pediatric drug dosage guidelines found inconsistencies in recommended doses, with varying results from allometric scaling and prior patterns of use. The analysis suggests a need for more precise treatment approaches to address the complexities of pediatric dosing.
A new study suggests that a re-evaluation of fosfomycin's dosing regimen may be effective in treating systemic multi-drug-resistant bacterial infections. Researchers found that a higher dosage schedule is required to combat these infections, offering a potential alternative to developing new antibiotics.
A study published in British Journal of Clinical Pharmacology analyzed herbal product interactions with prescription medications. The analysis revealed significant adverse drug reactions, particularly among patients taking warfarin and statins for cardiovascular complications.
A recent study found that none of the 89 approved pediatric drug products include dosing information for obese kids. Obesity affects how the body takes up medicine, where it retains it and how quickly it is excreted. More efforts are needed to provide safe dosing guidelines for children with obesity.
A recent review of US Food and Drug Administration registration data reveals that the proportion of women participating in clinical trials gradually increases from phase 1 to phase 2/3 trials. The analysis of 38 drugs with over 185,000 trial participants shows no systemic significant under-representation of women.
Research suggests that melatonin treatments can improve sleep quality, physical health, and mental well-being in older adults. Melatonin deficiency is associated with decreased circadian system robustness and increased risks of age-related diseases.
A research team led by Tanya Prozorov has demonstrated the first high-resolution mapping of magnetic fields in bacterial cells and magnetic nano-objects in liquid. This capability has vast potential for scientific breakthroughs in physics, nanotechnology, biofuels conversion, biomedical engineering, catalysis, batteries, and pharmacology.
A study published in British Journal of Clinical Pharmacology found that pregnant women with pre-gestational diabetes who take metformin are at a higher risk for major birth defects and pregnancy loss compared to the general population. The increased risk is not due to metformin, but rather the underlying diabetes.
New research reveals exercise during nicotine exposure decreases withdrawal symptoms by activating α7 nicotinic acetylcholine receptors in the brain. This protective effect may aid smoking cessation by reducing withdrawal severity and promoting recovery.
The efficacy of many FDA-approved cancer drug combinations is not due to synergistic interactions between drugs, but rather to a form of bet hedging. Genetic variations in cancer lead to differences in drug response, making combination therapy more effective by boosting the likelihood that a patient will benefit from at least one drug.
Researchers at Saint Louis University report promising results slowing DMD progression using SR8278, a nuclear receptor regulator drug that increases lean mass and muscle function while decreasing fibrosis and protein degradation.
A new study examines how opioids affect proteins in the brain beyond opioid receptors, revealing potential analgesic and toxic effects. The researchers found that certain synthetic opioids inhibit serotonin transporters, which may contribute to their pain-relieving properties but also increase the risk of serotonin syndrome.
A new study found that an infliximab biosimilar is safe and effective for treating inflammatory bowel disease, with comparable drug levels to the original medication. However, a high rate of discontinuation was observed due to subjective disease worsening or elective withdrawal after switching to the biosimilar.
Researchers found that omega-3 polyunsaturated fats in fish oil push stem cells towards forming bone cells, rather than fat cells. This fundamental research may provide insight into the connections between dietary fats and various clinical outcomes.
A new study published in the British Journal of Clinical Pharmacology demonstrates pain relief in humans using a Trk inhibitor. The study involved 20 participants and compared the inhibitor with pregabalin, ibuprofen, and placebo.
A recent study of publicly available regulatory documents found that biosimilars have a comparable safety profile to their originators. The analysis identified only minor differences in safety concerns for most substances, with the exception of infliximab, where more issues were reported.
Researchers investigated the effects of synthetic cannabinoid JWH-018, finding initial impairments in neurocognitive function and subjective feelings of high. The results suggest that common use scenarios may not be fully represented by the low drug concentrations used in the trial.
A new review article examines the effectiveness of lipid-based products, including liposome lid sprays and emulsion eye drops, in treating dry eye disease. The studies found that these products provide immediate relief of symptoms and improve the structure and stability of the tear film lipid layer.