A recent study published in Endocrinology Today holds promise for cancer patients undergoing chemotherapy to protect their fertility and defense systems. Researchers found that the potent humanin analogue (HNG) protected male germ cells and white blood cells, reducing infertility and infection susceptibility.
A randomized trial found that metformin did not improve glycemic control after 6 months, despite reducing weight gain and insulin doses. The study included 140 adolescents with type 1 diabetes, aged 12-19 years, and was conducted at 26 pediatric endocrinology clinics.
The global diet is getting sweeter, particularly when it comes to beverages, with many packaged foods containing caloric sweeteners. The World Health Organization promotes initiatives to reduce intake, but policies face challenges such as a lack of consensus on low-calorie sweetener substitutes.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that Viagra improves insulin sensitivity in individuals with prediabetes. The medication also reduces a biological marker that signals heightened risk of kidney and heart disease.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism has found that weekday sleep changes may raise the risk of developing metabolic problems such as diabetes and heart disease. Researchers discovered a link between social jetlag, which refers to the mismatch between an individual's biological...
Australian researchers have defined key characteristics of metabolically healthy obesity, shedding light on the paradox. They found that obese individuals sensitive to insulin in muscle or liver are metabolically healthier, with lower blood pressure and less deep abdominal fat. This discovery provides significant insight into human ins...
Researchers find that using kisspeptin instead of hCG during IVF treatment safely matures eggs and reduces the risk of ovarian hyper-stimulation syndrome (OHSS), even in high-risk patients. The average live birth rate was 45% across all doses, rising to 62% for women given the best performing dose.
A preliminary study found that soy protein and isoflavones can slow down bone loss and lower the risk of osteoporosis in early menopause. The study suggests that incorporating soy foods into a diet could be an effective option for improving bone health in women during this period.
A preliminary study suggests that taking vitamin D supplements daily can improve exercise performance by increasing cycling distance and reducing physical exertion signs. The study also found lower blood pressure and cortisol levels in participants, indicating a potential link between vitamin D and cardiovascular health.
A large meta-analysis of over 68,000 adults found that low-fat diets do not lead to greater weight loss in the long term compared to higher-fat diets. The analysis suggests that alternative diets like low-carb or Mediterranean diets may be more effective for achieving long-term weight loss.
Researchers at Oregon State University have successfully used gene therapy to aid weight loss in rats without causing significant bone loss. The study, published in the Journal of Endocrinology, found that delivering leptin directly to the brain via gene therapy reduced abdominal fat and preserved bone density.
A recent study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that mothers with gestational diabetes have slower-firing brains in their unborn children. This may be due to the mother's metabolism influencing her child's development and increasing their risk of obesity and diabetes later in life.
A new study published in Endocrinology found that prenatal exposure to fracking chemicals can lower sperm counts in male mice. The researchers tested 24 chemicals used in fracking and found that 23 of them were endocrine-disrupting chemicals, mimicking or interfering with hormones.
New research suggests that obese patients with type 2 diabetes should be prioritized for obesity surgery, as they often experience remission of diabetes and reduced healthcare costs. The study, based on the Swedish Obese Subjects (SOS) study, found that total healthcare costs were lower in surgery patients who had prediabetes or diabetes.
Researchers found a strong link between prenatal exposure to the Ukrainian Famine of 1932-33 and an increased risk of type 2 diabetes in adulthood. The study, which included over 43,000 cases of type 2 diabetes, suggests that early gestation is a critical period for the development of long-term health outcomes.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that interrupting sedentary behavior with short walking breaks can improve children's blood sugar levels. This benefit was observed even after a sugary drink was consumed, suggesting potential long-term benefits for metabolic health.
A revised Society for Endocrinology guideline offers new recommendations for assessing children with disorders of sexual development (DSD), emphasizing the need for multidisciplinary teams, psychological support, and thorough evaluation. The guideline aims to improve diagnosis and treatment outcomes for affected children.
Researchers found that retrieving eggs from smaller follicles at an earlier stage in IVF improves embryo quality and clinical pregnancy rates. Granulosa cells' reduced ability to grow and multiply in older women's ovaries was linked to increased hormone sensitivity, leading to premature luteinisation.
Modeling research suggests that universal iodine supplementation during pregnancy in mildly iodine deficient countries like the UK could save the National Health Service £200 per expectant mother, while providing monetary benefits of around £4500 per child from increased lifetime earnings.
Mayo researchers found that class II HDAC inhibitors signal through a newly discovered pathway to promote synergy with chemotherapy treatment in anaplastic thyroid cancer. The study identified vorinostat and belinostat as effective agents, which can increase activity of RhoB, a tumor suppressor and stimulate cell death.
A recent study published in The Lancet Diabetes and Endocrinology found that treating obese pregnant women with the diabetes drug metformin does not reduce their babies' birth weights. Despite this, the treatment did help lower blood sugar levels in mothers-to-be and markers linked to pre-eclampsia and premature births.
Researchers found that teenagers and young adults with congenital adrenal hyperplasia have significantly more abdominal fat tissue, which increases their risk for harmful conditions such as cardiovascular disease. The study suggests a need for targeted prevention and therapeutics to avoid these adverse effects.
A collaborative meta-analysis found that creatinine-based eGFR and albuminuria improve cardiovascular prediction, particularly for mortality and heart failure. The assessment of albumin-to-creatinine ratio (ACR) outperformed traditional risk factors, suggesting its potential broad implications for cardiovascular risk classification.
CHOP's Dr. Michael Levine has received the Master of the American College of Endocrinology (MACE) Award for his distinguished career in pediatric endocrinology and diabetes research. He is a world authority on the genetics of parathyroid disease and has published over 250 manuscripts, chapters, and reviews.
A study published in the Journal of Clinical Endocrinology & Metabolism found that an enzyme called 11β-HSD1 is increased in muscles of older women, leading to reduced grip strength and insulin resistance. The researchers believe inhibiting this enzyme could hold the key to preventing or reversing muscle wasting associated with aging.
The Lancet Diabetes & Endocrinology publishes a series on depression and diabetes, revealing a bi-directional association between the two conditions. The studies also suggest that depression-distress mediates the association between depression and glycaemic control.
A study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that people with osteoporosis are at a 1.76-fold higher risk of developing sudden sensorineural hearing loss. Researchers analyzed medical records of over 10,600 individuals with osteoporosis and found that they were more likely to be diag...
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that consuming sugar-sweetened beverages can suppress cortisol and stress responses in the brain. This may contribute to habit-forming sugar overconsumption during times of psychological or emotional stress.
Research published in The Lancet Diabetes & Endocrinology suggests that being underweight in middle age is associated with a higher risk of developing dementia. In contrast, obese middle-aged individuals are nearly 30% less likely to develop dementia than those of a healthy weight, contradicting previous research findings.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that pesticide exposure contributes to heightened cardiovascular disease risk and inflammation in premenopausal women. The research suggests that endocrine-disrupting chemicals like DDT can aggravate complications of obesity, including...
A new risk score called Globorisk predicts 10-year heart disease and stroke risk for individuals aged 40+, using data from eight cohort studies with over 50,000 participants. The score can be updated to fit local conditions and risk factor levels in different countries.
Researchers from The Children's Hospital of Philadelphia found that infant BMI-childhood obesity relationship is strong in African-American children. A better understanding of infancy growth patterns can lead to more effective early efforts at obesity prevention.
A BBC News team received the Endocrine Society's Award for Excellence in Science and Medical Journalism for their coverage of hormonal fluctuations at different times of day. The winning package, 'The Day of the Body Clock,' included TV, radio, and online coverage from May 13, 2014.
A comprehensive review of hormone therapy in transgender adults has found no significant increase in cancer risk despite previous concerns. The study, published in the Journal of Clinical and Translational Endocrinology, provides reassurance for individuals requiring hormone treatments, reducing anxiety and increasing access to care.
A leading group of obesity experts argues that obesity is a chronic disease with biological causes that cannot be cured by diet and exercise. Many people with obesity struggle to lose weight and regain it, as their bodies have adapted to conserve energy during times of food scarcity.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that low childhood vitamin D levels are associated with increased carotid intima-media thickness and subclinical atherosclerosis in adulthood. The study, which analyzed 2,148 subjects from the Cardiovascular Risk in Young Finns Study, ...
A large meta-analysis involving over 200,000 people with type 1 diabetes found that women face a 40% increased excess risk of death from all causes and have more than twice the risk of dying from heart disease compared to men. Women with type 1 diabetes also face a greater excess risk of strokes and kidney disease.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that women diagnosed with polycystic ovary syndrome (PCOS) are twice as likely to be hospitalized for reasons unrelated to reproductive health or injury. The study, which examined health records of over 2,500 women with PCOS, also foun...
Researchers successfully mutated the thyroid hormone receptor in tadpoles, disrupting hind limb development and providing insight into the importance of hormones in early development. The study also has potential applications in understanding human developmental disorders such as cretinism.
The Endocrine Society has selected 14 accomplished endocrinologists as winners of the organization's prestigious Laureate Awards. The award recipients include renowned researchers and clinicians recognized for their groundbreaking contributions to the field of endocrinology.
A new study published in the Journal of Clinical Endocrinology & Metabolism found that urban stressors contribute to a rising rate of diabetes in developing nations. High cortisol levels were found to be a key factor, with urban residents having significantly higher levels than rural counterparts.
A study published in The Lancet Diabetes & Endocrinology found that obesity is associated with a dramatic increase in risk of developing type 2 diabetes and cardiovascular disease. As a result, adults who are overweight or obese may lose up to 19 years of healthy life, while those who are very obese may lose up to 8 years.
A new study published in The Lancet Diabetes and Endocrinology found that obesity can decrease life expectancy by up to 8 years. Researchers used data from the National Health and Nutrition Examination Survey to develop a model estimating annual risk of diabetes and cardiovascular disease in adults with different body weights.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism suggests that testosterone has a limited impact on menopausal women's interest in sex and sexual function. Psychosocial factors such as emotional well-being and intimate relationships are found to be stronger contributors to sexual health.
A new study published in The Lancet Diabetes & Endocrinology found that bariatric surgery can reduce the risk of developing type 2 diabetes by around 80% in obese people compared to standard care. This significant reduction was observed even after controlling for other important factors such as smoking and high blood pressure.
A genetic analysis of childhood obesity found a strong link between genetic susceptibility and body size, shedding light on the causes of this complex condition. The study identified specific genetic markers associated with increased risk of obesity in children, highlighting the importance of early intervention.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that diabetic men with low testosterone levels are more likely to develop severe atherosclerotic plaques and other cardiovascular markers. The research suggests a strong association between low testosterone concentration and the severi...
A new study published in The Lancet Diabetes & Endocrinology found that gradual weight loss is not more effective than rapid weight loss for achieving long-term weight control. In the trial, participants who lost weight quickly were more likely to achieve target weight loss and had lower drop-out rates.
A study published in the Journal of Clinical Endocrinology & Metabolism found that mutations in the ARMC5 gene promote the growth of benign tumors in the adrenal glands and meninges. This discovery provides new insights into the causes of Cushing's syndrome, a disease characterized by elevated cortisol levels.
A new study published in Endocrinology found that testosterone treatment increased the incidence of prostate carcinomas in rats. The research suggests that testosterone alone is a weak carcinogen in male rats and creates a hospitable environment for tumors to develop when combined with cancer-causing chemicals.
A recent study from Tel Aviv University suggests that prenatal exposure to viruses may cause type 1 diabetes and other autoimmune diseases in children. The researchers found a link between winter epidemics and increased levels of damaging antibodies in cord blood, indicating autoimmune damage to islet cells during gestation.
A large genetic study has found no evidence of a causal link between vitamin D levels and the development of type 2 diabetes. The study, conducted by scientists at the University of Cambridge, examined the genes that control blood levels of vitamin D and found no association with the risk of developing type 2 diabetes.
BioMed Central partners with the University of Michigan to launch an open-access journal focused on clinical research surrounding diabetes and endocrine diseases. The new journal aims to promote better care for patients by sharing new knowledge, both research and clinical, on various aspects of endocrine disorders.
A systematic review and meta-analysis found that people working more than 55 hours a week, especially those in low socioeconomic status jobs, have a 30% greater risk of developing type 2 diabetes. The study suggests that work factors affecting health behaviors and stress may need to be addressed for prevention.
A collaborative registry and community support approach could improve diabetes care in China, where 12% of adults have diabetes and half are at risk of prediabetes. The disease is linked to cardiovascular disease, chronic kidney disease, and cancer unless effective national intervention prevents it.
Researchers found that statin use decreased the risk of diabetic neuropathy, retinopathy, and gangrene in individuals with diabetes. However, statin use did not affect the risk of kidney disease.
A new series published in The Lancet Diabetes & Endocrinology finds that the growing global diabetes epidemic is hampering progress in controlling and eliminating tuberculosis. With over 1 million cases annually, diabetes-associated TB cases are expected to offset the present downward trend in global TB cases by 8% or more by 2035.
A major study estimates that nearly half of the US adult population will develop type 2 diabetes by age 20, with Hispanic men and non-Hispanic black women facing the highest risk. The study found a significant increase in lifetime risk of diabetes over 26 years, driven by rising rates and longer life expectancy.
A study published in the Journal of Clinical Endocrinology & Metabolism found that women with high levels of perchlorate during pregnancy may have children with below-average IQs. Perchlorate, a common chemical contaminant, can affect thyroid function and lead to hypothyroidism, which is associated with cognitive impairment.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that individuals with schizophrenia have lower levels of vitamin D than healthy people. People with vitamin D deficiency are 2.16 times more likely to have schizophrenia, highlighting a potential connection between vitamin D and psychi...