A survey of over 400 young doctors found that one in five experience burnout, bullying, and poor work-life balance. Women's experiences are particularly worse than men's, with a higher likelihood of feeling unappreciated and frustrated.
Researchers at Utah State University have developed a genetic tool that makes it easier to identify bacteria responsible for releasing toxic forms of arsenic in groundwater. The new primer allows for more accurate detection of arsenate-reducing microorganisms, which can help reduce the prevalence of arsenic contamination worldwide.
A recent study published in Applied and Environmental Microbiology reveals that lecithin synergistically increases the antimicrobial properties of eugenol, a natural essential oil. This finding has significant implications for food preservation and suggests potential biomedical applications.
Researchers studied the impact of antibiotic treatment on gut microbes and metabolites in mice, finding significant changes in bacterial populations and metabolic output. The study highlights the importance of considering both microbiota composition and metabolome in understanding human health.
Researchers have discovered a novel combination therapy that successfully treats infections caused by a pernicious form of antibiotic resistance. The treatment regimen, which includes ceftazidime/avibactam and aztreonam, overcomes the resistance caused by metallo-ß-lactamases, a growing global public health problem.
Researchers discovered that yeast breaks down amino acids to create a pool of nitrogen for use in protein synthesis, contrary to conventional wisdom. This finding could lead to better control of fermentation and improved wine quality.
Researchers at UM SOM and SOD published 22 articles on infectious agents, vaccines, and immune system activation. Studies focused on Ebola, Clostridium difficile, biofilms, and other topics, advancing knowledge in infection and immunity research.
A new marine bacterium, Fuerstia marisgermanicae, has been named in honour of UQ microbiologist Emeritus Professor John Fuerst. The discovery reflects the global scientific community's high regard for Professor Fuerst's contributions to planctomycete research.
A new TB vaccine using biobeads to present antigens from the tuberculosis bacterium has shown promising results in mice. The vaccine is designed to induce cell-mediated immune responses and could potentially provide protective immunity against TB.
Researchers found that Legionella pneumophila grows well in warm tap water installations with ample dissolved organic matter, supporting biofilm formation. The study suggests that microgram-per-liter concentrations of biodegradable compounds can induce bacterial growth on surfaces, promoting proliferation of the bacteria.
A new battery-powered detection system can identify 16 virulent pathogens with high sensitivity and provides positive identification from as few as 10 DNA sequences. The device is designed for use in remote locations where laboratory resources are lacking, addressing the lack of timely diagnosis and effective treatment.
New research reveals the mechanism by which probiotic Lactobacillus paracasei DG promotes health. The probiotic releases a novel polysaccharide that stimulates the immune system to release anti-inflammatory chemicals.
A new study by the University of Leicester reveals that small amounts of damage to salad leaves in bagged salads encourage the presence of Salmonella enterica. Juices released from damaged leaves also boost the pathogen's ability to attach to the salad's plastic container, doubling its motility and allowing it to multiply rapidly.
George Washington University researchers received a $2.2 million grant from the National Cancer Institute to investigate the role of human endogenous retroviruses (HERVs) in cancer development. They plan to use a novel computational pathway program, Telescope, to pinpoint HERV expression in various cancers.
Researchers found pesticide exposure associated with decreased bacterial diversity and specific taxon reductions in farmworkers' oral microbiomes. Azinphos-methyl detection correlated with lower Streptococcus and Halomonas populations.
Research reveals that isolates of Helicobacter pullorum from Indian poultry markets are resistant to multiple classes of antibiotics, posing a potential public health risk. The study suggests that the bacterium could be transmitted from poultry to humans, highlighting the need for increased awareness and regulation.
Researchers at the University of Tennessee have identified 32 bacterial genes and 38 mouse genes that may help reduce malaria severity. This discovery could lead to more effective treatments, as it provides a limited number of genes to work with.
The LudusScope, a 3D printed smartphone microscope, enables kids to play games and make serious observations with miniature light-seeking microbes called Euglena. The device allows students to build their own instrument and collect data on Euglena behavior, swimming speed, and natural biological variability.
Researchers found that Klebsiella pneumoniae siderophores play a crucial role in facilitating invasive infection by triggering inflammation and activating HIF-1 alpha, allowing bacteria to spread from the lungs to the spleen. The study suggests that therapies targeting siderophore production could provide a two-pronged attack against K...
A team of Chinese researchers characterized the 'mobile resistome,' a network of easily transferred antibiotic resistance genes between bacteria, including humans and animals. The study found that these genes are shared among multiple human pathogens and can be disabling for six major classes of antibiotics.
Researchers found that mixed bacterial-fungal biofilms in chronic wounds are associated with poor outcomes and longer healing times. The study identifies the most abundant fungi species, including Cladosporium herbarum and Candida albicans, which can hinder healing.
Research on smokeless tobacco products has identified several bacteria species associated with opportunistic infections, such as Bacillus licheniformis and Bacillus pumilus. These bacteria can produce toxins that cause illness in large quantities and may also contribute to the formation of carcinogenic compounds.
The study found a small number of species associated with periodontitis, but not gingivitis, including Prevotella, Treponema, and Selemonas. This research may lead to an inexpensive and rapid point-of-care test based on distinguishing the two conditions' microbiomes.
Researchers have developed a new model to study the phenomenon of secondary bacterial pneumonia caused by S. aureus and influenza A virus. The model, which simulates the natural pathogenesis of infection, reveals that viral infection induces bacteria to disseminate to the lungs.
Researchers isolated MCR-1 gene from a diabetic patient's foot infection in Brazil, marking the first detection of the gene in humans. The discovery highlights the potential for antibiotic resistance to spread within countries.
Drs. Henry Boom and Moses Joloba at Case Western Reserve University and Makerere University, respectively, have received a $1.5 million five-year grant to strengthen Ugandan biomedical research capacity. The program aims to provide PhD-level training in microbiology and immunology to talented young Ugandan scientists.
A study published in the Journal of Bacteriology found that two genes, ArsS and ArsR, play a crucial role in regulating biofilm formation in H. pylori. The researchers created strains with mutations in these genes and observed that they formed thicker and more rapid biofilms.
A new variant of the emerging antibiotic resistance mechanism mcr-1 has been discovered on a multidrug-resistant strain of Klebsiella pneumoniae, which was isolated from a child hospitalized with leukemia. The newly identified gene, mcr-1.2, confers resistance to colistin, a last-resort antibiotic.
A clinical isolate of bacterial pathogen carrying the colistin resistance gene mcr-1 has been detected in humans in the US, sparking concerns about antibiotic resistance. The isolate was found to be susceptible to several commonly used antimicrobial agents, but its plasmid-mediated nature is still unknown.
Research suggests that beneficial bacteria like Lactobacillus and Streptococcus may protect women from breast cancer by inducing anticarcinogenic properties. Probiotics could be a potential tool to boost these beneficial bacteria, potentially lowering the risk of breast cancer.
The SpecID system combines detection and identification into a single step, offering faster answers and streamlined workflow for clinical microbiology laboratories. The $2.8M award supports the development of quality and manufacturing systems required for regulatory clearance, bridging the gap between manufacture and clinical trials.
A new study finds that probiotic bacteria can reduce cadmium absorption in the intestines of mice by mitigating oxidative stress. The research provides evidence that probiotics can inhibit the toxic effects of cadmium on the gut barrier, potentially offering a solution to heavy metal contamination in public health.
Researchers found that low temperatures trigger genes involved in biofilm formation, toxin production, and cold adaptation in Vibrio cholerae. Expression of virulence factors is reduced at low temperatures, suggesting a link to environmental lifecycle.
Researchers have developed a method to identify HPV infections using self-collected vaginal swabs, which provides accurate results similar to clinician-collected cervical specimens. This technology enables same-day screening and treatment, critical for preventing premature deaths from HPV-associated cancers in low-income countries.
A team of Danish investigators manipulated the metabolic properties of yogurt-producing bacteria to create a sweeter, less-sweetened yogurt. They achieved this by modifying the bacteria to consume galactose instead of glucose, resulting in a product with reduced lactose and increased natural sweetness.
A study found that cities have distinct microbial communities, with offices in the same city showing minimal variation. Human skin was a significant source of microbes in office environments, accounting for 25-30% of the microbiome.
A team of researchers has identified the compound in mothers' milk that supplies nourishment to infants' gut microbiota. This compound can be obtained from cow's milk and may be used as a prebiotic for infants, potentially improving their formula.
Professor Joseph M. Suflita, a leading researcher at the University of Oklahoma, has been awarded the 2016 DuPont Industrial Biosciences Award for his distinguished achievements in applied and environmental microbiology. His work focuses on bioremediation and the role of anaerobic microorganisms in contaminant degradation.
A 2010 outbreak in Maryland was caused by Vibrio parahaemolyticus, a strain sourced from raw oysters from Asian restaurants. Whole genome sequencing helped identify the pathogen's origin and introduced techniques for future outbreaks.
Researchers found Mycoplasma pneumoniae infections in over half of hospitalized children with pneumonia in Beijing, predicting an ongoing epidemic. The study may help clinicians slow the spread of the disease.
A new study found that nonpathogenic viruses can be transferred during fecal transplants, but these viruses appear to be harmless to humans. The researchers analyzed fecal transplants from a single donor to three children with chronic ulcerative colitis and found mostly temperate bacteriophages were transmitted.
Research finds that botulism in waterbirds is spread by an invasive species of freshwater snail carrying Clostridium botulinum, which thrives in polluted wetlands. Global warming is expected to exacerbate outbreaks due to increased temperatures and drought.
Whole-genome sequencing reveals the emergence and spread of the virulent Salmonella strain DT104 over 40 years in 21 countries. The strain's resistance to five antibiotics and ability to infect multiple livestock species contributed to its success.
A team of Danish investigators has created a modeling system that actually mimics indoor fungal aerosols, studying the impact of residential mold on human health. The system, published in Applied and Environmental Microbiology, contains at least eleven species of fungus associated with water damage, found in both Danish and US buildings.
Scientists have isolated a new type of herpes virus from bat cells, providing insights into the biology of these viruses and their potential to transmit to humans. The discovery could aid in understanding why bats are often associated with viral infections that can be transmitted to humans.
Researchers developed a real-time system to track Ebola virus particles' interaction with human cells, revealing crucial host and viral proteins involved in fusion. The study identifies specific cellular proteins required for fusion, offering insights into designing future drugs or vaccines.
A new study reveals that the transition to family foods drives gut microbiota development in infants, rather than maternal obesity. The study found that breastfeeding duration and complementary diet composition played key roles in shaping the infant's gut microbiome.
A study published in Nature Microbiology found that Akkermansia muciniphila and other anaerobic bacteria temporarily bloom in response to injury, contributing to wound healing. The researchers suggest exploiting these microbes as treatments for inflammatory bowel disease.
A team of Dutch investigators has identified NS4B as a potential target for antiviral drug development against dengue virus. A metabolite of acetaminophen, AM404, inhibits replication of the virus. The researchers found that mutations in the viral NS4B protein render the virus insensitive to AM404.
A team of researchers has successfully inserted the gene for Bt into a harmless bacterium, which can be used to deliver the protein to people afflicted with roundworms through dairy products or probiotics. This could provide an inexpensive treatment option for millions of people worldwide infected with intestinal nematodes and roundworms.
Researchers discovered that yeasts used to ferment cocoa can modify aroma, enabling creation of unique flavors in boutique chocolates. The findings could lead to a wider range of flavors similar to wines and coffee.
A study found that coconut oil consumption reduced gastrointestinal colonization by C. albicans in mice, suggesting a potential way to prevent invasive infections. The researchers plan to launch a clinical trial testing coconut oil in hospitalized infants at high-risk for developing systemic candidiasis.
Scientists have developed a fast method to sequence irradiated anthrax spores, which can aid in tracking biocrimes. The new approach uses computer programming to reconstruct full DNA sequences from broken fragments.
Researchers have discovered a new technique that can prevent biofilms on catheters and medical implants by coating them with tissue plasminogen activator. This method has the potential to reduce hospital-acquired infections and save thousands of lives annually.
A new phage treatment has shown strong anti-microbial activity against Cronobacter sakazakii, a bacterium that can kill up to 40% of infected infants. The treatment, CR5, killed the bacteria quickly and effectively, without producing toxins or virulence factors.
Researchers found exotic ticks carrying disease-causing bacteria on thousands of migratory birds arriving in the US each spring. The estimated 19 million exotic ticks introduced annually pose a potential threat to the ecosystem and human health.
A review article in Trends in Microbiology reveals that microbial invasions follow a general ecological pattern, with invasion phases including introduction, establishment, spread, and impact. The study found that species diversity is the best defense against invading microbes.
Researchers have created new crosses among relevant yeasts to open up new horizons of taste in lager beers. Genetic studies showed a lack of genetic diversity among lager yeasts, resulting from only two parent yeast species.
A study published in mBio found that children with cerebral malaria have an accumulation of white blood cells and platelets in the brain, which is more severe in HIV-positive children. This discovery may lead to better treatment algorithms for CM.
People fed β-glucan-enriched pasta for two months showed increased populations of beneficial Lactobacilli and reduced LDL cholesterol. The study also found an increase in certain short-chain fatty acids with anti-inflammatory activity.