Researchers have discovered a new technique that can prevent biofilms on catheters and medical implants by coating them with tissue plasminogen activator. This method has the potential to reduce hospital-acquired infections and save thousands of lives annually.
A new phage treatment has shown strong anti-microbial activity against Cronobacter sakazakii, a bacterium that can kill up to 40% of infected infants. The treatment, CR5, killed the bacteria quickly and effectively, without producing toxins or virulence factors.
Researchers found exotic ticks carrying disease-causing bacteria on thousands of migratory birds arriving in the US each spring. The estimated 19 million exotic ticks introduced annually pose a potential threat to the ecosystem and human health.
A review article in Trends in Microbiology reveals that microbial invasions follow a general ecological pattern, with invasion phases including introduction, establishment, spread, and impact. The study found that species diversity is the best defense against invading microbes.
Researchers have created new crosses among relevant yeasts to open up new horizons of taste in lager beers. Genetic studies showed a lack of genetic diversity among lager yeasts, resulting from only two parent yeast species.
A study published in mBio found that children with cerebral malaria have an accumulation of white blood cells and platelets in the brain, which is more severe in HIV-positive children. This discovery may lead to better treatment algorithms for CM.
People fed β-glucan-enriched pasta for two months showed increased populations of beneficial Lactobacilli and reduced LDL cholesterol. The study also found an increase in certain short-chain fatty acids with anti-inflammatory activity.
A study by American Society for Microbiology found that decontamination protocols effectively eliminated methicillin-resistant Staphylococcus aureus (MRSA) and antibiotic-resistant Enterobacteriaceae bacteria from a pig farm. The protocol involved high-pressure cleaning, disinfection, and treatment with complex solutions.
Canadians with nonspecific symptoms like joint pain and fatigue may receive false-positive results from commercial US laboratories, as many use unproven testing methods. Tests at the National Microbiology Laboratory of Canada using CDC guidelines are more accurate.
Research found that oysters serve as a major reservoir for noroviruses, with over 80% of human norovirus genotypes detected in oyster samples. This highlights the importance of surveillance and safe handling of oysters to prevent transmission.
A team of scientists has identified a novel tungsten-containing enzyme in the bacterium Caldicellulosiruptor bescii, which shows potential for converting plant biomass into useful chemicals and fuels. The discovery could lead to more efficient production of commercial renewable fuels and reduce greenhouse emissions.
Researchers discovered that Listeria monocytogenes can grow on refrigerated smoked salmon by utilizing different metabolic pathways than those used in laboratory media. This finding could lead to the development of inhibitors to control pathogen growth on foods and improve risk assessments.
A Johns Hopkins researcher reveals that raising awareness of gender disparities can boost the number of female speakers at scientific meetings. By involving women in conference planning, he reports a significant increase in female representation from 27% to nearly 50%. This approach has been successfully implemented at the American Soc...
A team of scientists has identified potential probiotics for frogs to combat the devastating chytrid fungus. The researchers found dominant bacterial species that may provide disease resistance and antifungal properties to their host. This discovery holds promise for protecting vulnerable amphibian populations worldwide.
A recent study published in Applied and Environmental Microbiology suggests that dairy products can boost the effectiveness of probiotics. The researchers found that mice fed milk with the probiotic Lactobacillus casei BL23 had reduced symptoms compared to those without the probiotic.
A team of Belgian researchers has discovered a yeast species that significantly improves chocolate fermentation, resulting in better and more consistent chocolate. The new method allows for the creation of specialty chocolates with unique flavors.
Clostridium difficile, the most common cause of hospital-acquired diarrhea, tightly controls its intracellular iron levels to avoid DNA damage. The pathogen has multiple systems for importing ferrous iron compounds, which are more critical in anaerobic conditions.
A Temple-led research team has discovered that bacterial biofilms found in the gut can provoke the onset of systemic lupus erythematosus (SLE) in lupus-prone mice. The researchers found that curli amyloid and DNA complexes in biofilms lead to inflammation, self-attacking antibodies, and autoimmune disease symptoms.
Research shows that Wolbachia-infected male fruit flies fight less aggressively than their uninfected peers. The infected flies took three times longer to initiate fights and started fewer battles, but their bouts lasted as long as those of uninfected counterparts.
Researchers found that hantaviruses are highly dependent on cholesterol in cell membranes to gain access into cells. Disrupting the S1P pathway reduced their ability to infect cells, suggesting potential therapeutic targets. However, further studies are needed to fully understand the viruses' dependence on cholesterol.
Researchers found that human urine's unknown factors interfere with bacterial FimH protein's ability to adhere to cells and switch off pilus production assembly. This exposes a crucial weakness in pathogen's ability to infect, making potential non-antibiotic treatments more effective
A study found that ERs misdiagnosed UTIs and STIs in women nearly half the time, resulting in unnecessary antibiotic use. The misdiagnoses were often due to similar symptoms and abnormal urinalysis results.
Researchers have identified two compounds that target the synthesis of fungal glucosylceramide, leading to highly effective antifungal activity. These new agents may pave the way for a new class of antifungals to treat serious fungal infections, which cause significant morbidity and mortality worldwide.
Researchers found that Agion silver zeolite technology significantly reduced bacterial populations on door handles, particularly gram-negative bacteria. The study suggests that the technology may be more effective than previously thought, but further research is needed to address concerns about standardization and potential side effects.
Researchers have identified Niemann-Pick C1 (NPC1) as a critical protein for the Ebola virus to infect a host, providing a new target for drug development. Blocking NPC1 could lead to effective treatments for this deadly disease.
Researchers found that nearly half of chicken meat samples contained viruses capable of transferring antibiotic resistance genes. Phages were able to transfer resistance to multiple antibiotics, including extended spectrum betalactam antibiotics.
A fecal microbiota transplant successfully cured a patient's C. difficile infection, eliminating populations of multi-drug resistant organisms from the gut and other body sites. The treatment method replenishes normal gut flora, stopping the release of antibiotic-resistant microbes and potentially saving lives.
Researchers from Penn Medicine and the Perelman School of Medicine will engineer T cells to be resistant to HIV-1 infection using a new gene therapy approach. The project aims to make more CD4 T cells resistant to the virus, re-invigorating the immune response.
A team of French clinicians diagnosed a patient with rabies after an unusual clinical presentation despite no obvious exposure to animal bites. The strain was identified as circulating among dogs in West Africa, highlighting the risk of healthcare personnel via bodily fluids.
Researchers have genetically modified Salmonella to kill cancer cells and shrink tumors, offering a potential new therapy. The modified bacteria can target and destroy cancer cells while remaining safe for patients.
A study found that some dogs can mount an immune response to human norovirus, suggesting they may be infected. However, the risk of canine infection and transmission to humans is unclear.
The article highlights the importance of antimicrobial resistance, citing its impact on human and animal health. Global collaboration and innovative approaches are necessary to tackle this complex issue.
Researchers found that camel antibodies protected uninfected mice from MERS and helped infected mice expunge the disease. The study suggests these antibodies might be therapeutic for MERS patients and protect uninfected household members and healthcare workers.
Research finds that malaria-infected cells produce specific terpenes attractive to mosquitoes, which can be detected in breath or sweat. This discovery may lead to new diagnostic tests and improve malaria control by understanding mosquito attraction.
The American Society for Microbiology has received a grant from the Bill & Melinda Gates Foundation to host joint sessions at ASM's Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in San Diego. The program aims to support developing world scientists attending ICAAC through the Gates Travel Award.
Researchers at Concordia University have grown mutant E. coli bacteria up to 3/4 millimeter long, 750 times their normal length, by blocking cell division. This breakthrough has potential applications in the nanoscale industry and may lead to a better understanding of pathogens.
Veronica Garcia, a UT graduate student, has been awarded a Robert D. Watkins Graduate Research Fellowship to study the molecular mechanisms of Alzheimer's disease and other disorders. The fellowship aims to increase diversity in microbiological sciences research.
Researchers discovered that Ebola and Marburg viruses edit their genetic material by adding extra nucleotides to their RNA. This process, known as RNA editing, was previously unknown in these viruses and could lead to a better understanding of their biology and the development of new treatments.
The NIH is conducting an early phase trial to evaluate the VSV-ZEBOV vaccine candidate, which was developed by researchers at Canada's National Microbiology Lab. The trial will enroll 39 healthy adults aged 18-65 and assess the vaccine's safety and ability to generate an immune response.
A study found that a type of gut bacteria called Clostridium ramosum promotes obesity in mice, particularly when fed a high-fat diet. The bacteria appears to improve nutrient uptake, leading to increased energy conversion and weight gain.
Research published in Applied and Environmental Microbiology found that polyester clothes smell worse than cotton after exercise due to bacteria growth. Bacteria like micrococci thrive on polyester surfaces, breaking down sweat and hormones into odor-causing molecules.
Researchers found that the European CA-MRSA clone CC80 evolved from a sub-Saharan African methicillin-sensitive ancestor. The bacteria simultaneously acquired resistance to methicillin and fusidic acid, which is thought to be due to selective pressure in North Africa and Europe.
The San Antonio Life Sciences Institute has awarded over $750,000 in grants to researchers studying the intersection of immunity, microorganisms, and cancer. These collaborations aim to address public health issues and diseases with global impact, such as diabetes and cancer.
A recent study published in Clinical Microbiology and Infection warns of the high risk of Chikungunya virus spread in the Americas and Europe due to mosquito-borne transmission. The disease can cause severe symptoms, including fever, joint pain, and muscle aches, with no available treatment.
Researchers found 101 non-antibiotic drugs with potential to prevent growth of certain bacterial pathogens, including those causing Legionnaires' disease and brucellosis. These drugs interfere with host cell functions to stall intracellular bacterial infections.
Researchers have developed a simplified method to purify water using Moringa oleifera seed extracts, significantly reducing harmful bacteria levels. This cost-effective approach holds promise for improving access to safe drinking water in developing countries where millions die from waterborne diseases annually.
Researchers found distinct bacterial communities in healthy and incontinent women, suggesting a potential link between bacteria and female urinary health. The study identified new bacteria not detected by standard culture techniques, which may contribute to the lack of response to conventional treatments for urinary incontinence.
A study published in mBio found that fecal transplants partially restored a diverse community of healthy gut bacteria to recipients, reducing the amount of infectious Proteobacteria and increasing Firmicutes and Bacteroidetes bacteria. The transplants also improved metabolic pathways, including those involved in stress response.
Researchers found that dog-treated beaches had significantly lower E. coli counts than control beaches due to reduced gull presence. Border collies effectively excluded gulls from beaches, improving beach water quality.
Dr. Jon McCullers reviews the co-pathogenesis of influenza viruses with bacteria, highlighting complex interactions leading to severe disease and increased morbidity. He calls for large-scale studies to unlock unanswered questions about co-infections and viruses to prevent future pandemics.
A recent study published in Applied and Environmental Microbiology has identified a distinct population of microbes in the breast tissue, with Proteobacteria being the dominant phylum. The presence of beneficial bacteria like Lactobacillus and Bifidobacteria suggests a potential protective effect for both mother and child.
Researchers discovered tamoxifen, a breast cancer treatment, also kills Cryptococcus, a fungus causing deadly brain infections. The combination of tamoxifen and fluconazole was synergistic, showing improved activity against the fungus. This finding offers a new approach to treating cryptococcal meningitis.
A study led by Albert Einstein College of Medicine found that including at least one woman on the team organizing a scientific symposium increases female speaker proportion by 72%. This strategy can help women advance in their careers and reduce underrepresentation in senior academic positions.
A new study reveals that including at least one woman on a convening committee increases the proportion of female speakers by as much as 74%, while reducing the likelihood of all-male sessions. The inclusion of women on these committees promotes gender equity and could have a significant impact on career advancement for women in science.
Researchers found that probiotic Enterococcus faecium reduced pathogenic E. coli strains in piglets' intestines, promoting gut balance and reducing antibiotic use. The study suggests probiotics could substitute for antibiotics as growth promoters.
A study published in Journal of Clinical Microbiology found that over one quarter of residents in 26 nursing homes in Orange County, California carry community-associated MRSA. The strains are more easily transmitted and may cause more severe infections than traditional hospital-acquired MRSA.
Research reveals that contaminated bivalve molluscs contain toxins at higher levels than the surrounding environment, posing a risk to human health.
Two Tufts University biomedical graduate students, Seblewongel Asrat and Jennifer Nwankwo, have been awarded HHMI International Student Research Fellowships to study Legionnaires' disease and sickle cell disease. The fellowships provide $43,000 in funding for the first year, with renewal opportunities for two additional years.
Scientists have developed a palm-sized microarray platform that can grow up to 1,200 individual cultures of fungi or bacteria. This technology has the potential to accelerate drug discovery for treating various types of infections.
Drusano's work in pharmacokinetic and pharmacodynamic modeling has been instrumental in simulating and validating dosing regimens to maximize the safety and efficacy of antibiotics. He is recognized for his groundbreaking research on anti-infective pharmacology and antimicrobial resistance.