The study reveals that the glucocorticoid receptor (GR) can directly bind to DNA at NF-kappaB sites, one at a time, turning down inflammation genes. This finding could lead to reinterpretation of previous studies and potential development of targeted drugs.
A study found that postnatal Zika virus infection in rhesus macaque infants resulted in persistent brain structure and function abnormalities, as well as behavioral and emotional changes. The researchers recommend long-term clinical monitoring for affected infants.
Researchers report successful cataract surgeries in 34 Ebola survivors, improving visual acuities from Hand Motions to 20/30 levels. The study provides evidence for safe elective eye surgery in Ebola survivors at risk of uveitis and vision impairment.
A team of scientists has established a pig model of Huntington's disease using genetic engineering technology, offering a practical way to test treatments. The pig model closely matches human symptoms and provides advantages over existing mouse models in terms of size and delivery of treatments.
A dietary supplement commonly used to strengthen joints can also speed the growth of a type of melanoma, according to preclinical research. Chondroitin sulfate boosts growth in melanoma cells carrying the V600E mutation, but not other types, and may pose risks for people with elevated melanoma risk.
Researchers at Emory University uncover the role of hemimethylation in looping DNA and its impact on gene expression. They found that hemimethlyation is deliberately maintained and passed down through cell generations.
Researchers developed AI software to predict glioma patient survival by analyzing tissue biopsies, outperforming human pathologists' predictions. The approach combines deep-learning and conventional methods to provide more accurate and consistent information for doctors.
Researchers at Emory University have discovered heteroresistance to colistin in already carbapenem-resistant Klebsiella pneumoniae, making it harder to monitor and treat. The findings pose a significant threat to public health, highlighting the need for novel diagnostics to rapidly detect colistin resistance.
Researchers exposed rhesus macaques to sevoflurane three times during infancy and found increased behaviors such as self-touching and self-grooming at one and two years of age. These subtle changes persist even after the animals are no longer under stress, suggesting a long-term impact on anxiety levels.
Researchers found that high glucose levels are associated with a higher risk of heart attack and kidney dysfunction in people with prediabetes. The study suggests that identifying and treating this group can lead to significant reductions in cardio-metabolic risks.
Biomedical engineers developed a miniaturized system mimicking blood vessel injury, allowing for the study of bleeding and clotting. The device replicates all aspects of blood vessel injury, including clot formation and repair, and responds to drugs and other alterations.
A new study found that individuals who think further into the future tend to avoid risks, but this is not related to investment behavior. Instead, those with longer future-sightedness are more likely to choose waiting for future rewards.
A study of US insurance claims found that children whose families visited a doctor in the previous year were less likely to experience complications from appendicitis. The research suggests that establishing a relationship with a primary care doctor can lead to prompt emergency care and lower complication rates.
Emory immunologist Max Cooper and Dr. Jacques Miller are recognized for deciphering the two types of lymphocyte lineages involved in adaptive immunity, laying the groundwork for understanding nearly all fields touched by immunology. Their discoveries have fueled advancements in anti-cancer drugs and treatments for autoimmune diseases.
Researchers at Emory University have successfully tested a tactic for controlling dyskinesias in Parkinson's disease by reducing striatal projection neuron hyperactivity with NMDA receptor antagonists. The study aims to develop new treatment options with improved effectiveness for people with Parkinson's disease.
A cellular traffic jam affects neurons in most ALS forms, with TDP-43 causing transport defects and disrupting protein import. A drug, KPT-335, may compensate for these disruptions, showing promise for treatment.
A new study published in PeerJ found that individuals with trypophobia exhibit a physiological response more associated with disgust than fear. The researchers used eye-tracking technology to measure pupil size and found that images of clusters of holes elicited greater constriction of the pupils, a response linked to feelings of disgust.
A team of scientists led by Guido Silvestri at the Yerkes National Primate Research Center has sequenced the sooty mangabey genome, revealing clues that may help people infected with HIV. The study found two key differences in proteins of the immune system that may contribute to the mangabeys' resistance to AIDS.
Researchers have measured and mapped the key molecular forces on platelets that trigger blood clotting. The findings suggest that platelets care about the direction of forces applied to them, requiring a lateral force signal to prevent unnecessary clotting.
Researchers found that direct electrical stimulation of the human amygdala can enhance next-day recognition of images, with a significant boost in memory performance. The study used low-level current and showed an improvement in memory recall for patients with epilepsy and average memory performance.
Researchers found that memory T cells retain an 'epigenetic signature' from their effector state, allowing them to rapidly respond to future threats. This breakthrough has significant implications for vaccine development and could aid efforts to eliminate HIV from the body.
A new analysis published in Perspectives on Psychological Science concludes that the Goldwater Rule is not well-supported scientifically and is outdated. Examining someone directly may not be necessary if other valid sources of information are compiled, such as interviews with family members or extensive public records.
Researchers found that fasudil, a drug that inhibits Rho kinase, promotes goal-directed behavior in mice by pruning dendritic spines, a process involved in learning new behaviors. The treatment showed promise in reducing cocaine self-administration and could be an effective adjunct to cognitive behavioral therapy for treating drug abuse.
Chemists at Emory University have developed a new catalyst that selectively activates a carbon-hydrogen bond without using a directing group. The breakthrough holds promise for the pharmaceutical industry and could lead to new classes of drugs.
A leaf-eating beetle has evolved a symbiotic relationship with bacteria that allows it to break down pectin, a plant cell wall component. The bacterium, which has a tiny genome, has the power to degrade pectin, enabling the beetle's digestive system to access nutrients.
A recent study published in the New England Journal of Medicine found that clot removal up to 24 hours after stroke can significantly reduce disability for properly selected patients. Almost half of those who underwent thrombectomy showed considerable improvement in activities of daily living.
Scientists have identified a new group of cells responsible for keeping humans awake. The supramammillary nucleus is part of the caudal hypothalamus and plays a crucial role in maintaining wakefulness. When activated, it promotes prolonged wakefulness during normal sleep periods.
A new study by Emory University researchers found that mandatory state policies are associated with the largest reductions in power plant emissions. The analysis shows that policies with mandatory compliance resulted in an average of 2.6 million metric tons of CO2 emissions per year reduction.
Researchers at Emory University found that a system of lifeless particles can change between crystalline and fluid states, mimicking collective behavior seen in living systems. This phenomenon occurs when the environment remains stable, suggesting that complex properties can emerge from simple systems.
Geneticists at Emory University School of Medicine have discovered a mysterious DNA modification in animals, specifically adenine methylation, which increases four-fold under conditions of stress in the brain. This epigenetic modification may play a role in neuropsychiatric disorders.
Scientists at Emory University School of Medicine have developed a method for generating endothelial cells from human induced pluripotent stem cells, which can survive for over 10 months when surrounded by a supportive gel. This breakthrough could lead to new treatments for peripheral artery disease.
Researchers identify regulatory T cells containing replication-competent virus in lymph nodes and gut, providing a strong rationale for targeting CTLA4. The discovery could help design immunotherapies to purge the viral reservoir and induce a stronger antiviral immune response.
Researchers discovered that LSD1 removal in adult mice induces changes in gene activity similar to Alzheimer's disease. LSD1 protein is also perturbed in human brain samples with Alzheimer's and FTD, suggesting it as a central player in these neurodegenerative diseases.
Elliptic curves are mathematically doughnut-shaped objects with specific configurations of rational points that determine their properties. Mathematicians have found a new form of moonshine that reveals deep information about these curves, including infinitely many and their general behavior.
Researchers discovered that alpha-synuclein, a protein involved in Parkinson's disease, blocks signals from the important brain growth factor BDNF. This 'tug of war' between alpha-synuclein and BDNF affects brain cells' survival and explains why dopamine-producing neurons are more vulnerable to degeneration.
Researchers found that fire ant venom compounds can reduce skin thickening and inflammation in a mouse model of psoriasis. The solenopsin analogs, similar to ceramides, can restore the skin's barrier function and decrease immune cell infiltration.
A new study in the American Economic Review found that viewers who stumble upon Fox News first while channel surfing are more likely to vote for a Republican presidential candidate. The study used voter records and survey data to compare individuals from different cable news channel positions, finding a significant association between ...
Scientists recommend reducing disease impacts on honeybees by limiting colony mixing and supporting natural bee behaviors. This approach could help reduce parasite transmission and promote disease resistance among the bees.
Research finds that indoles produced by intestinal bacteria enhance mobility, resistance to stress, and reproductive span in worms, flies, and mice. Indoles may help maintain the intestinal barrier and limit systemic inflammatory effects, suggesting a potential therapeutic avenue for improving healthspan.
Researchers detect granulins inside cells for the first time, suggesting a potential FTD treatment strategy by targeting lysosomal function. The discovery may have therapeutic potential for Alzheimer's disease and Parkinson's disease as well.
Researchers identify FMR1 and ZC3H14 as friend genes, regulating messenger RNA in neurons, affecting learning and memory. Mutant flies and mice display impaired working memory and altered brain development.
Researchers found that genetics play a significant role in shaping infants' social behavior, including how they look at and respond to facial expressions. The study also showed that this behavior is disrupted in children with autism, providing a new link between genetic causes and behavioral presentation.
Researchers found that the AEP enzyme trims alpha-synuclein into toxic pieces, similar to its effect on tau in Alzheimer's disease. This discovery offers a potential drug target for Parkinson's disease.
A phase I clinical trial found that influenza vaccination using microneedle patches was as effective as traditional shots, generating robust immunity against influenza. The patches were well-tolerated, with no adverse events reported, and participants preferred them over traditional vaccination methods.
Researchers have built simple machines out of DNA consisting of arrays whose units switch reversibly between two different shapes. The arrays' properties shed light on how to build structures with more complex, dynamic behaviors. By harnessing these DNA mini-machines, scientists may be able to create nanotech sensors and amplifiers.
Researchers have identified a new brain mechanism that contributes to learning an association between an auditory warning and a fearful event. Changes in lattice-like structures in the brain known as perineuronal nets are necessary to capture and consolidate the fear association, which can aid research into combating PTSD.
Field experiments show that removing a dominant pollinator species alters foraging patterns among remaining pollinators, leading to changes in plant visitation and reduced biodiversity. This study highlights the importance of considering ecological cascades in predicting the impact of pollinator extinctions on ecosystems.
A new study found that children with feeding disorders who received behavioral intervention and D-cycloserine experienced more rapid treatment gains, with a 76 percent improvement in feeding after five days of treatment. The results also suggest that the brain changes account for the drug's ability to result in behavioral changes.
A recent study by Emory University highlights the importance of insecticide-resistance monitoring in controlling the spread of Zika and other mosquito-borne diseases. The research found that applying insecticides like deltamethrin in areas with high resistance can be ineffective, emphasizing the need for targeted control measures.
Scientists used CRISPR/Cas9 gene editing to reverse Huntington's disease pathology and motor symptoms in a mouse model. The treatment delivered enzymes to brain cells, reducing toxic protein aggregates and improving motor abilities.