Problem-solving therapy led to short-term changes in the amygdala, a key region for emotion regulation, in individuals with comorbid depression and obesity. The study suggests that neural target changes at two months predicted improved behavioral outcomes after 12 months.
Researchers at University of Illinois Chicago found a potential direct connection between neurodegenerative diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), glaucoma, and herpesvirus. The study suggests OPTN protein restricts HSV-1 virus spread in cells.
Researchers develop a novel method to convert nitrate in wastewater into ammonia with nearly 100% efficiency and zero greenhouse gas emissions. The system utilizes cobalt catalysts and solar power to achieve unprecedented solar-to-fuel efficiency, outperforming existing technologies.
Researchers will track oral health behaviors and caries risk in low-income urban young children over five years, collecting data on caregiver-reported habits, dental plaque scores, and social risk factors. The study aims to understand the impact of community-level factors on individual behaviors.
A new health program aims to improve pregnancy outcomes for Black patients by combining four evidence-based strategies, including racially concordant care providers and coordinated care. The five-year study will enroll 432 women and compare their experiences with usual maternity care versus a new model.
Researchers at University of Illinois Chicago outline strategies to enhance healthcare access for sex workers, including holistic wellness exercises and destigmatizing healthcare practices. The study emphasizes the importance of provider training and responsiveness to patient needs.
Researchers at UIC have received a $725,000 grant to develop an AI system that can help protect US Navy divers from waterborne bacteria, parasites, and other harmful pathogens. The system aims to provide real-time information on water conditions, allowing divers to make informed decisions about their mission.
Researchers at UIC are developing a potential COVID-19 treatment using VT-109, which has shown promise in animal models by restoring lung function and reducing inflammation. The new funding will be used to conduct pre-clinical studies to determine efficacy, toxicity, and dosages before human trials.
Studies investigate how ideological differences impact attitudes towards diverse community features and what 'diversity' means to conservatives and liberals. Researchers find that demographics, viewpoints, and consumer features are perceived as relevant aspects of diversity.
A new machine learning algorithm, BITFAM, helps identify transcription factor activity in individual cells, providing insights into gene regulation. This system can aid researchers in understanding biological functions and developing new treatments for diseases.
Researchers at UIC are expanding testing for vulnerable communities, performing genomic sequencing on samples to identify emerging SARS-CoV-2 strains. This helps gather info on variant dynamics and human immune responses, aiding public health surveillance.
Researchers at the University of Illinois Chicago have developed a graphene-based sensor that can detect SARS-CoV-2 virus in laboratory experiments. The sensor uses atomic-level vibrations to identify COVID-positive samples, with results evident in under five minutes.
Researchers at UIC's Center for Alcohol Research in Epigenetics have discovered a key regulator of gene expression and anhedonia during alcohol withdrawal. Blocking STAT3 activity alleviates withdrawal-induced depression in rats, and similar results are seen in human postmortem hippocampus samples of individuals with alcohol use disorder.
Researchers found that a mother's birth weight and litter size were associated with early neonatal death, but not adult maternal characteristics. The study suggests that current approaches to understanding perinatal mortality are incomplete and highlight the need for further research on structural and intergenerational factors.
Researchers at the University of Illinois Chicago have developed a microgel coating that can optimize cell-based therapy for pulmonary fibrosis. The coating boosts the therapeutic potential of donor cells by degrading scar tissue and promoting healthy lung tissue regeneration.
Researchers at UIC have developed a novel continuous-flow microfluidic device that enables parallel-connected micromixers to screen polymorphs, morphology, and growth rates of L-histidine in eight different conditions. The device significantly reduces screening time by about 80% compared to conventional methods.
New research identifies persistent Gαs associated signaling changes in lipid rafts following drug withdrawal as the cause of antidepressant withdrawal syndrome. This finding has significant implications for developing personalized treatment for depression.
Researchers developed an AI system to guide oncologists in treating head and neck cancer patients, considering treatment efficacy and potential future decisions. The system analyzes real patient data to provide personalized recommendations and maximize survival outcomes while minimizing chemotherapy and radiation side effects.
The University of Illinois Chicago is leading a multi-center collaborative to improve community vaccinations, testing, and engagement in clinical research. The Chicagoland COVID Collaborative aims to bolster COVID-19 vaccine confidence and access among Black and Latino communities.
A new study by UIC researchers shows that antibiotics designed for bacteria can also inhibit protein synthesis in human cells, potentially treating diseases like cancer and neurodegenerative disorders. The team engineered yeast ribosomes to be more bacterial-like, allowing them to respond to macrolide antibiotics.
A survey conducted by Elizabeth Papautsky at the start of the COVID-19 outbreak found that 48% of respondents experienced delayed health care, with the top reasons being fear of infection and discouragement from healthcare providers.
Researchers found that areas with low environmental quality had stronger associations with late-stage prostate cancer diagnoses, particularly in Black men. The study suggests that addressing environmental factors such as land, water, and sociodemographic variables could improve treatment outcomes.
According to a new study, hospitals participating in the 340B Drug Pricing Program provide more medication access services than comparably sized non-340B hospitals. The study found that 340B hospitals offered an average of 6.2 services, including prior authorization assistance and free or discounted outpatient medications.
A new genetic mutation found in African Americans significantly increases risk of atrial fibrillation and heart failure, prompting researchers to recommend genetic testing for this population. The study also identifies a potential link between a newly discovered gene and early-onset AFib.
Researchers found that decreased neuronal complexity may be a feature of chronic migraine and propose restoring this complexity as a treatment. HDAC6 inhibition restored cytoskeletal flexibility and relieved migraine-associated pain.
A study by University of Illinois Chicago pediatric dentist Dr. Flavia Lamberghini tested asymptomatic pediatric dental patients and found a 2.3% SARS-CoV-2 positivity rate. The study suggests that PCR testing for COVID-19 in asymptomatic patients adds value to screening questionnaires.
Tumor gene profiling decreases patient acceptance of active surveillance among men with clinically similar prostate cancers and low health literacy, a new study found. The study suggests that education on prostate cancer treatment options is needed for this population.
A study by University of Illinois Chicago researchers found strong associations between doctors' financial conflicts of interest and the party that hired them when classifying X-rays. The findings suggest a systemic problem with bias among doctors who review chest X-ray images for coal miner's black lung claims.
Researchers found that certain genes in inflammatory cells called glial cells increased their activity and grew longer appendages after death. This discovery challenges current understanding of post-mortem gene expression and cell activity, which may impact research on disorders like autism, schizophrenia, and Alzheimer's disease.
Researchers at UIC have found that HPSE drives antiviral immunity, proliferative signals and cell death, with potential applications in treating dysregulation of the protein in various diseases. This discovery has broad implications for diseases such as cancer, atherosclerosis and autoimmune disorders.
A study by the University of Illinois Chicago reveals that employee engagement and performance are highest when employees are mentally prepared to return to work and their managers prioritize health and safety. Managers must set a good example, communicate effectively, and enforce safety protocols to promote workplace well-being.
Researchers at the University of Illinois Chicago have developed new 4D hydrogels that can change shape in response to external trigger signals. These materials may help create tissues with more realistic architecture by simulating forces that drive movement during development, leading to improved tissue engineering outcomes.
Researchers identified three patient segments based on blood lymphocyte counts and PET/CT scan findings, indicating varying levels of disease activity. The discovery could help guide treatment and understand the underlying mechanisms associated with sarcoidosis.
Researchers developed novel hydrogel-based 4D materials that can change shape in response to physiological stimuli, supporting high cell densities and mimicking natural tissue development. These materials have potential for bioengineering blood vessels, organs, and studying biological processes involved in early development.
A new protocol aims to identify and measure suicidal ideation in research studies, ensuring participant safety. The protocol uses the Columbia-Suicide Severity Rating Scale to score risk levels, triggering interventions such as stopping data collection or contacting mental health resources.
Researchers have discovered a new gene-editing technique that allows for the programming of sequential cuts in genes, enabling researchers to better investigate time-sensitive processes like cancer development. The discovery was made by UIC's Bradley Merrill and colleagues using special molecules called 'proGuides',
University of Illinois Chicago faculty members advocate for research ethics reforms to engage Black populations in COVID-19 and BLM-related studies. The authors recommend understanding ongoing trauma, acknowledging historical context, and ensuring diverse research teams to foster trust.
Researchers have discovered a way to convert methane in natural gas into liquid methanol at room temperature using a catalyst material and electricity. This process reduces the need for high heat and pressure, making it a more efficient and affordable method for producing methanol.
Researchers at UIC aim to develop an antibody-based eye drop to treat dry eye and ocular surface disease caused by inflammatory and immune system disorders. The new treatment, which uses pooled human immune globulins, is expected to be particularly helpful for patients with immune-related dry eyes.
A study of 850,000 Danish pregnancies found that nitrate in maternal drinking water was associated with lower birth weights and smaller body lengths, highlighting a critical data gap in current water standards for nitrate.
Researchers at the University of Illinois Chicago have discovered a second site on the filovirus glycoprotein that small drug molecules can bind to prevent infection. This finding holds promise for developing effective treatments for Ebola and Marburg viruses, which cause hemorrhagic fever with mortality rates ranging from 25% to 90%.
Researchers develop peptide-based 'booster' inhibitors that use generic hepatitis B antibodies to neutralize SARS-CoV-2 viruses. This approach offers a rapid response time and could provide guidance for preparing generic therapeutics against emerging pathogens.
A recent study published in JAMA Oncology found significant racial disparities in breast cancer prognosis testing among Black women, who have higher recurrence and mortality rates than non-Hispanic white women. The study suggests that genomic tumor tests may require re-calibration to reflect racial differences.
Researchers have successfully treated two patients with beta thalassemia and sickle cell disease using CRISPR-Cas9 gene editing, a promising treatment for these severe red blood congenital diseases. The new approach uses the patient's own cells and eliminates the risk of rejection or graft-versus-host disease.
A new study reveals that a single water molecule is essential for the binding of macrolide antibiotics to bacterial ribosomes, explaining why resistant bacteria are immune to these drugs. This discovery offers a promising lead in developing new antibiotics that do not require this water molecule for binding.
Scientists have created highly detailed 3D models of chromosomes for individual cells using a computational technique that uncovers spatial relationships between genes. These models provide valuable insights into how genes work together to drive biological processes, such as development and cell differentiation.
Researchers at the University of Illinois Chicago developed a new catalyst made from 10 elements that can lower methane combustion temperatures by half. This could lead to a significant reduction in harmful greenhouse gases produced by burning natural gas in households, power turbines, and cars.
Researchers define surgical smoke as a hazardous vapor composed of aerosolized chemicals, with potential to obscure vision, cause respiratory issues, and even contain viruses. Laws mandating its evacuation from operating rooms are recommended to reduce health impacts.
A study published in JAMA Network Open found that sweetened beverage sales rebounded quickly after the Cook County tax was repealed. Despite a significant decrease in consumption during the tax's four-month period, sales returned to pre-tax levels, suggesting that price point alone drove down demand.
A study published in Science Translational Medicine shows that MEK inhibitors can stimulate PAX6 expression in the eye of mice with aniridia, partially normalizing their eye development. Researchers also found that topical administration of the drug enhanced PAX6 and cleared corneas, allowing mice to see better.