Articles tagged with Small Samples
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
This cohort study found a high risk of developing functional somatic disorder (FSD) in individuals with a history of sexual assault. The pooled analysis underscores the biopsychosocial consequences of sexual assault and highlights the importance of further research and targeted interventions to address this critical issue.
A new study provides a method to estimate sample size required for microbiome studies based on effect sizes and analysis methods. For strong associations, around 500 participants were needed to achieve 80% statistical power, while weaker associations may require thousands of samples.
A recent study found that people with plaque in their neck arteries have higher amounts of tiny plastic particles compared to those with healthy arteries. The concentration of these plastics was significantly higher in individuals who had experienced a stroke, mini-stroke, or temporary vision loss due to clogged blood vessels.
A study published in the Journal of Medical Entomology found a gene mutation in bed bugs that may contribute to their resistance to insecticides. The researchers, led by Warren Booth, discovered the mutation in 134 unique populations of bed bugs collected from North America between 2008-22.
In extremely thin films of niobium diselenide (NbSe₂), superconductivity becomes confined to the surface when thinner than six atomic layers. This discovery challenges previous theories and could have important implications for understanding superconductivity and developing advanced quantum technologies.
The OSIRIS-REx mission returned a large sample from asteroid Bennu, which Japanese collaborators detected includes all five nucleobases required for life. The analysis revealed high concentrations of ammonia and nitrogen-rich organic matter.
A team of researchers at Johns Hopkins Medicine has developed a biomarker algorithm that can detect Barrett’s esophagus and esophageal cancer using a noninvasive method. The algorithm uses methylation patterns in genes to identify biomarkers, achieving an AUC of nearly 0.97 in distinguishing healthy tissue from esophageal cancer.
Researchers have created a new circuit model that accounts for small changes to the sensor's behavior, allowing it to detect protein or DNA molecules from a sample. The device could lead to earlier diagnosis of diseases and more precise therapies tailored to each patient.
A new system can quickly identify emerging virus variants and provide information on their genetic changes, helping to understand why they spread differently in human populations. This enables the development of more effective vaccines and targeted treatments for diseases such as flu, COVID, and tuberculosis.
Researchers developed a miniaturized all-fiber photoacoustic spectrometer for intravascular gas detection, achieving detection limits of 9 ppb and response times as quick as 18 milliseconds. The system detects trace gases at the ppb level and analyzes nanoliter-sized samples with millisecond response times.
A new blood test reveals heart transplant patients at risk of rejection by analyzing DNA fragments in their blood. This non-invasive test is comparable to existing US tests and could save millions in public healthcare costs.
High-flow nasal oxygen was found to be more effective than noninvasive ventilation in preventing endotracheal intubation or death within 7 days in four of five patient groups with acute respiratory failure. However, the results were sensitive to analysis models and may require further study in specific patient populations.
A Virginia Tech researcher has received a collaborative grant to improve cancer therapies by developing 3D liver organoids and employing cutting-edge microscopy technology. The project aims to identify the most effective treatments for cancer, enabling better-targeted treatments.
A Chinese Medical Journal study reveals that patients with prostate cancer can undergo surgical removal without a pre-operative biopsy, using a combination of mpMRI and PSMA PET/CT imaging. This approach reduces costs and complications associated with traditional biopsy methods.
An international team of researchers has confirmed the location of the oldest ochre mine in the world, dating back around 48,000 years. Ochre was found to have spread from the mine to nearby areas, revealing ancient extraction and transport networks.
A groundbreaking metagenomic sequencing test has proven effective in rapidly diagnosing almost any kind of pathogen, including viruses, bacteria, fungus or parasite. The test analyzes all nucleic acids present in a sample, replacing multiple tests with a single one and speeding up diagnosis.
Three Ph.D. students and a postdoctoral researcher from Texas A&M are working on RTE projects to create new materials for future nuclear reactors. They are using the Texas A&M Accelerator Laboratory and Idaho National Laboratory to irradiate material, creating voids that can help understand swelling in nuclear reactors.
The study reveals large genomic differences between European aurochs, North Asian aurochs, and South Asian ancestor, with evidence of human intentional feeding and targeted domestication. The genome of the central European aurochs was fully decoded for the first time, providing insights into the history of wild cattle in Europe and Asia.
A study published in Biology Letters reveals that harbor seals in Alaska's Iliamna Lake are genetically isolated from other seal populations across the Pacific. The researchers found significant differences between the lake seals and marine populations, suggesting they may be a unique endemic form of harbor seal.
Researchers from Osaka Metropolitan University have developed a method to detect coronavirus spike proteins quickly and selectively using a light-induced immunoassay. The technique uses a milliwatt-level laser and can complete the entire process in under 5 minutes.
A new study from European universities has developed a method to analyze wastewater data from seven major cities, identifying thousands of disease-causing bacteria, viruses, and antimicrobial resistance. This approach can detect potential health threats simultaneously, potentially preventing epidemics from escalating into outbreaks.
Researchers at the University of Kansas are analyzing noninfectious mosquito saliva to understand how it affects the immune system and changes at a molecular level. The goal is to identify specific proteins that can serve as candidates for vaccine development.
The research aims to develop a new method for detecting foodborne viruses like norovirus and hepatitis A in time to prevent or quickly respond to an outbreak. The technology uses magnetic liquids to concentrate viruses from large food samples into smaller volumes, streamlining the detection process.
A new system developed by universities of Córdoba and Valencia can detect THC in saliva with high sensitivity and speed. This technique uses dispersive microextraction by sorption and needle-based electrospray ionization emitters for mass spectrometry, reducing the analysis process to just two steps.
A new handheld device enables rapid non-invasive detection of harmful chemicals and biological molecules using a Raman spectrometer and cellphone camera. This technology reduces analysis time from days to minutes, making it ideal for remote areas where laboratory spectrometers are impractical.
Researchers studied Chang'e-5 samples to understand how solar wind irradiation and micrometeorite impacts form metallic iron nanoparticles, revealing distinct effects on size and optical properties. The study provides insights into lunar surface color variations and remote sensing measurements.
Researchers at Cornell University have used a combination of almond analysis, pottery dating, and radiocarbon dating to determine the Kyrenia shipwreck's age. The team estimated that the ship sank between 296-271 BCE, with a strong probability it occurred between 286-272 BCE.
Researchers at the University of Delaware have developed a simplified method for preparing protein samples for proteomics analysis, enabling faster, cheaper and more efficient testing. This breakthrough could pave the way for precision medicine by helping scientists better understand protein changes in the body.
Researchers developed DiFC, a two-color diffuse flow cytometry system that detects rare cancer cells in the bloodstream without invasive methods. The technology provides insights into cancer progression and response to treatments by studying different subpopulations of cancer cells simultaneously.
A University of Houston researcher has developed a new method to detect cancer using PANORAMA imaging and fluorescent imaging, achieving a 98.7% accuracy rate. The method analyzes the number and cargo of small EVs in patients' blood samples, allowing for early detection and improved treatment efficacy.
Researchers have developed a new imaging technique that rapidly and accurately identifies cancerous tissues in breast samples. The method uses machine learning algorithms trained on hyperspectral dark-field microscopy data to pinpoint regions of invasive ductal carcinoma and invasive mucinous carcinoma.
Researchers developed a bioelectronic chip that can detect vitamins C and D in body fluids, offering a low-cost and easy-to-use solution for micronutrient monitoring. The chip is disposable, flexible, and can be adapted for wearable devices, enabling personalized diets and prevention of deficiencies.
A study found that early Mesozoic animals, including dinosaurs, grew quickly around 230 million years ago. This feature is not unique to dinosaurs but was shared by several non-dinosaur reptiles as well.
Researchers developed a custom-built, low-cost mesoscope that can adapt to different neuroimaging experiments in live mice and rats. The system offers excellent spatial and temporal resolutions, achieved through its reversible tandem lens configuration, which enables flexible experimentation.
The Perseverance rover has collected and remotely determined the original orientations of most bedrock samples to date. This breakthrough will help scientists answer key questions about Mars' past, including its magnetic field, water flow, and tectonic processes.
Researchers found six pesticides and related compounds in kale from small farms in Maryland, but levels were much lower than a concern. The study provides insight into the safety of farm-raised greens and will help identify health risks associated with other fruits and vegetables.
A new nanocomposite porous antifouling coating has been developed, enabling higher numbers of biomarker-detecting probes and up to 17-fold higher sensitivities than previous best-in-class sensors. This breakthrough broadens the diagnostic horizon for multiplexed electrochemical sensors across multiple diseases.
Researchers confirm ancient lake sediments at Jezero crater on Mars using radar imaging, revealing eons of environmental changes and potential signs of past life. The discovery supports the search for evidence of life in Perseverance rover's soil and rock samples.
Researchers at Brookhaven National Laboratory have developed a universal method for producing functional 3D metallic and semiconductor nanostructures using DNA. The new method produces robust nanostructures from multiple material classes, opening opportunities for 3D nanoscale manufacturing.
Researchers at Xi'an Jiaotong-Liverpool University have developed a sensitive and robust pH sensor that can detect pH variation in just a few microliters of samples. The new sensor uses novel materials and methods to overcome the current method's limitations, which are not sensitive enough or fragile for commercial-scale use.
A new deblurring algorithm has been developed to improve the resolution of microscopy images without amplifying noise. This breakthrough technique, called 'deblurring by pixel reassignment,' uses local gradients to sharpen images while preserving larger structures.
Researchers used a unique X-ray technique to capture soundwaves' propagation in a diamond crystal, revealing ultrafast structural phenomena that were previously beyond scientific reach. The breakthrough enables real-time imaging of solid materials with unprecedented resolution and speed.
A significant breakthrough sheds light on Parkinson's disease mechanisms, revealing that mitochondrial DNA damage triggers the spread of debilitating symptoms. The researchers' findings offer promising potential for innovative treatments and diagnostics.
A KAUST researcher has created a highly sensitive glucose detector based on a thin-film transistor that can measure glucose levels in saliva with high accuracy. The device uses an enzyme to oxidize glucose present in the saliva, producing electrons that indicate the glucose concentration.
Researchers demonstrate the potential of optical imaging for safely measuring vocal fold elasticity and pliability. The study found good agreement between Brillouin microspectroscopy results and conventional elasticity measurements.
A large international database analysis found nearly a quarter of esophageal adenocarcinoma patients had normal endoscopies but were still diagnosed within a year. The study suggests using high-quality equipment, rigorous sampling protocols, and future research on biomarker panels to improve screening effectiveness.
EPFL researchers have created a novel biosensor, ImmunoSEIRA, to detect misfolded protein biomarkers linked to Parkinson's and Alzheimer's diseases. The sensor employs AI-powered neural networks for disease stage quantification and features gold nanorod arrays with antibodies for specific protein detection.
Researchers at Duke University have developed a new approach to building point-of-care diagnostic devices that uses gravity to transport and mix liquid droplets. The device relies on commercially available surface coatings that can tweak the wettability and slipperiness of the channels, allowing for complex fluid paths to be designed.
Researchers used proteomics and small RNA sequencing to analyze 103 human blood plasma samples, identifying 21 proteins and 315 small RNAs associated with aging. Combining protein and miRNA data improved age predictions (R2 = 0.70 ± 0.01), suggesting a broader range of age-related physiological changes.
A nationwide VR research project is working to create diverse groups of participants to reflect real-world social dynamics. The Virtual Experience Research Accelerator (VERA) aims to provide researchers with access to large, reliable, and diverse groups for various VR research projects.
A new high-speed two-photon microscope was developed with an unprecedented line scanning frequency of 400 kHz, achieving up to 10,000 frames per second. This allowed for precise observations of complex biological processes in living tissues, including calcium signal propagation and blood flow measurements.
The study revealed lower age-standardized rate of NENs incidence in China (1.14 per 100,000) compared to the USA (6.26 per 100,000). The most common sites for primary NEN tumors progressed were found to be the pancreas, stomach, lungs, and rectum.
The University of Central Florida has developed the Virtual Experience Research Accelerator (VERA), a large-scale system for extended reality human subjects research. This project aims to facilitate human subjects research and improve extended reality technologies, making them more inclusive for underrepresented groups.
Researchers have developed a novel autonomous, submersible, 3D holographic microscope and imaging system to study marine particles and plankton in their natural environment. The AUTOHOLO system achieved 90% accuracy in detecting red tide blooms at varying concentrations, enabling near real-time monitoring and tracking of bloom phases.
Scientists have detected uracil and nicotinic acid in asteroid Ryugu samples collected by the Hayabusa2 spacecraft. The discovery suggests that important building blocks for life were created in space and delivered to Earth via meteorites, supporting current theories on the source of nucleobases.
Scientists have identified two-million-year-old DNA fragments in northern Greenland's Ice Age sediment, providing insights into the past ecosystem and its potential to predict climate change. The discovery has sparked hopes that it could help academics build a picture of the DNA evolution of species still in existence today.
Researchers developed an efficient engineered pathogen capture method to quickly identify infectious microbes in tiny blood samples. This advanced technology could significantly improve clinical outcomes for children with bloodstream infections and sepsis.
Researchers discovered three essential amino acids - leucine, valine, and tryptophan - as potential metabolic biomarkers for HCC. The study used metabolomics to analyze the differences in tumor and non-tumor tissue metabolomes, revealing striking differences that could aid in diagnosis.
Researchers from the University of Ottawa found an association between marijuana smoking and chronic damage to airways, including higher rates of paraseptal emphysema and airway inflammatory changes. The study suggests that marijuana smoking may lead to additional lung damage beyond what is seen in tobacco smokers.
Researchers from the University of Kassel developed an approach to extend the limits of interferometric topography measurements for optical resolution below small structures. Microsphere assistance enables fast and label-free imaging without requiring extensive sample preparation.