Articles tagged with Cell Transplantation
Researchers transplanted human stem cell-grown pituitary tissue into a monkey with a removed pituitary gland, restoring cortisol production and improving lifespan. The study demonstrates the potential for lab-grown human pituitary cells to survive and function after transplantation into a primate.
Dr. Mina Sedrak has received a $3.6 million NIH grant to develop strategies for improving physical recovery and reducing frailty in older adults after hematopoietic cell transplantation. The grant will support a multisite randomized clinical trial testing the effectiveness of combining exercise with a senolytic therapy in improving phy...
A new study suggests that younger, less genetically matched donors can produce encouraging outcomes for blood cancer patients. Researchers found that carefully selected mismatched donors can produce favorable outcomes, potentially widening access to a potentially lifesaving transplant.
Researchers at Penn State have developed genetic 'switches' that can program 3D-printed bone tissue to grow blood vessels, enabling the regeneration of bone tissue in severe trauma or infections. The technique uses microRNA molecules to push cells down a differentiation pathway optimized for either tissue growth or vascularization.
The DKMS John Hansen Research Grant supports innovative cell therapy approaches and transplant immunology. The grant enables young researchers to build a network and advance lifesaving therapies for blood cancer.
Scientists create a biomimetic zona pellucida coating called BZP to mimic the natural barrier on egg cells, protecting donor islets from the immune system and reducing blood sugar levels in diabetic mice for 100 days. This approach could lead to a promising commercial cell therapy platform for treating various diseases.
A study analyzing outcomes from 795 patients with severe aplastic anemia found that donor age significantly impacted long-term survival and graft success. Younger donors experienced consistently better outcomes, while older donors were associated with worse results.
Researchers developed an AI-based tool called BIOPREVENT to identify patients at higher risk for chronic GVHD and dying from transplant-related causes. The tool combines immune biomarkers, clinical data, and machine learning to create a personalized risk estimate over time.
Researchers developed bioengineered lymphatic tissue (CeLyT) that restored functional lymph nodes in mice with secondary lymphedema. CeLyTs improved lymphedema symptoms by restoring lymphatic flow, filtration capacity, and immune cell populations.
Researchers at Sanford Burnham Prebys found that transplanted stem cells develop neurons with unique codes to navigate and form connections in the brain. These codes guide the growth of axons and explain why most neurons of a particular subtype send axons to specific brain regions.
Researchers at the Medical University of South Carolina are developing a new therapy for Type 1 diabetes that combines stem cell biology, immunology, and transplantation science. The goal is to restore beta cell function and insulin production in people with T1D without using immunosuppressive drugs.
Researchers have found that patients with blood cancers can safely receive stem cell transplants from mismatched, unrelated donors using a protective regimen. The study's findings could make transplants accessible to nearly all patients with blood cancers, regardless of ancestry.
A recent study found that young donors (18-35 years old) with minor HLA differences can provide better survival rates and outcomes compared to older sibling donors. Additionally, gender and CMV status also play a role in donor selection.
The ASAP study found that transplantation as soon as possible does not provide a survival advantage over remission induction, but reduces hospital stays and chemotherapy exposure. Age and AML genetics are the most important risk factors influencing survival.
Stem cell transplantation has been shown to reverse stroke damage in mice by regenerating neurons and restoring motor functions. The treatment also improved blood-brain barrier integrity, reduced inflammation, and promoted new blood vessel formation.
The DKMS John Hansen Research Grant is supporting innovative research projects in blood cancer therapy, aiming to improve treatment outcomes. The grant, worth almost €1 million, will support young scientists with a focus on transplant immunology and novel diagnostic and therapeutic strategies.
A new treatment approach using cyclophosphamide has been found to prevent most graft-versus-host disease in mismatched transplants. The study shows that 80% of patients are alive after a year, similar to outcomes seen in fully matched transplants.
A new treatment method using microglia replacement has shown promising results in halting the progression of genetic neurological disease ALSP in both mice and human individuals. The treatment, developed at Fudan University, successfully replaced mutated microglia with healthy ones, improving neurological function and extending life ex...
Scientists at the University of Birmingham have developed a method to coat Hepatic Progenitor Cells (HPCs) with natural sugars, making them stickier and increasing their ability to repair liver tissues. The coating does not harm the cells or stop them from working properly.
A new study reveals persistent inequalities in children's access to life-saving kidney transplants across the UK. Early disparities in ethnicity, socioeconomic status, and gender persist even after being placed on the waitlist.
A team of international scientists successfully 3D printed functional human islets using a novel bioink, paving the way for more effective and less invasive treatment options. The bioprinted constructs maintained their structure without clumping or breaking down and showed promising results in laboratory tests.
Researchers at Osaka University identify a specific molecule, HLA-DRB1, that can be targeted by CAR-based therapy for AML. Engineered CAR T cells showed strong and specific anti-AML effects in vitro and in vivo with mice, without overt toxicity.
Researchers from Emory University are using the International Space Station to study cardiac cells and accelerate the development of cell-based regenerative therapies. The team's findings have led to multiple peer-reviewed publications and could significantly advance methods to produce cardiac cells for heart disease treatment.
Researchers have developed a way to activate adult stem cells from human bone marrow, enabling their expansion outside the body for use in bone marrow regeneration. The new method significantly improves transplant success rates for patients with genetic disorders or those who require a bone marrow transplant.
An international team of scientists has molecularly decoded blood stem cell differentiation pathways using state-of-the-art sequencing methods. They identified a crucial surface protein, PD-L2, which suppresses the immune response by preventing T cell activation and release of inflammatory substances.
A new stem cell transplant treatment has shown promising results in clearing clinical safety hurdles for the treatment of wet age-related macular degeneration. The treatment involves removing abnormal blood vessels and transplanting stem cell-derived retinal cells to replace damaged or lost retinal cells.
Researchers at Osaka Metropolitan University have successfully generated feline embryonic stem cells, a major breakthrough for veterinary regenerative medicine. The high-quality stem cells can differentiate into various cell types and be transplanted to restore internal damage.
A novel bone marrow transplant process has been shown to be safe and curative for adults with sickle cell disease, offering a viable alternative to recent gene therapy products. The treatment, which uses a 'half-matched' donor, results in high cure rates and low side effects, making it a more accessible option for patients.
Researchers developed reprogrammed vascular endothelial cells that provide strong support for islets, allowing them to survive and reverse diabetes long-term. The study showed that mice transplanted with islet cells plus R-VECs regained normal blood glucose control after 20 weeks.
Researchers will present findings on Treatment Outcomes By Duffy Genotype in Patients with Newly Diagnosed Multiple Myeloma, highlighting longer progression-free survival for those receiving Lenalidomide, Bortezomib, and Dexamethasone alone or with autologous stem cell transplantation. Another study found that immune reactions leading ...
A new case report reveals a rare and aggressive form of leukemia developing from donor cells nine years after a stem cell transplant. The disease, driven by genetic mutations in key genes, progresses despite intensive treatment and ultimately proves fatal.
A new study published in the European Respiratory Journal found that extracorporeal photopheresis significantly reduces acute rejection episodes and chronic rejection risk in lung transplant patients. The treatment involves exposure to UV light, leading to apoptosis of immune cells and minimizing side effects.
Scientists at UCSF have developed engineered T cells that act as immune referees to soothe overreacting immune responses and mope up inflammatory molecules. These cells could improve treatment for organ transplants, type 1 diabetes and other autoimmune conditions by reducing the need for harsh immunosuppressant drugs.
Researchers have successfully transplanted human stem cell-derived heart cells into monkeys with a rare heart condition, offering a potential treatment for congenital heart defects. The study demonstrated the safety and integration of these cells into the host myocardium, paving the way for future clinical applications.
Researchers at Johns Hopkins Medicine have identified a potential link between donor intestinal epithelial cells and improved outcomes for patients undergoing fecal microbiota transplants. The study found that these cells, which line the intestinal tract, may be responsible for restoring gut health in some patients.
Researchers tracked the long-term dynamics of transplanted stem cells in patients' bodies up to three decades post-transplant. They found that younger donors produce more vital stem cells, while older donors experience reduced immunity and higher relapse risk. The study provides new insights into donor selection and transplant success.
TP53 mutations are commonly associated with therapy-related AML and complex cytogenetics. Researchers found improved long-term outcomes when allo-HCT was performed during Complete Remission 1 (CR1), despite limited effective therapies for TP53-mutated AML.
Researchers have successfully transplanted human embryonic stem cell-derived retinal organoid sheets into monkeys with macular holes, resulting in graft survival and maturation of light-detecting cells. The study suggests that this method could become a practical treatment option for difficult macular hole cases.
A retrospective analysis of over 2,600 patients found that Black children were more likely to suffer severe graft-versus-host disease but overall survival rates improved across all racial groups. The study suggests that cord blood transplants are a vital lifeline for many patients and improve care for those without a matched donor.
Researchers discovered that mutations in the SYNGAP1 gene disrupt prolonged human neuron development, leading to accelerated maturation and altered cognitive function. This finding has implications for understanding and treating intellectual disabilities and autism.
A national multicenter study found that younger women and those with non-malignant diseases had a higher chance of successful pregnancies after allogeneic hematopoietic cell transplantation. The study analyzed data from 2,654 women who underwent transplantation between 2003 and 2018.
A study published in the Journal of Clinical Immunology found alemtuzumab to be safe and effective in treating Asian patients with inborn errors of immunity after allogeneic hematopoietic cell transplantation. The drug was shown to improve overall survival rates, with 94.7% of patients surviving post-transplantation.
A new study sheds light on fatty liver disease MASH's pathology, revealing T cell activation and growth in response to poor diet. The research holds promise for developing a biomarker test to track disease progression before it's at a late stage.
A new combined cell therapy for kidney transplants uses a combination of bone marrow cells from the donor and Treg cells from the recipient to reduce the donor-specific reaction. This approach preserves the overall diversity of the T-cell receptor repertoire, crucial for immune defence.
A new study published in PNAS reveals that cancer patients who receive hematopoietic cell transplants from donors with lower socioeconomic status experience reduced overall survival and increased transplant-related mortality. The research highlights the profound impact of social inequality on health outcomes, particularly in cancer care.
The new treatment, nonmyeloablative haploidentical bone marrow transplant (BMT) with thiotepa and posttransplant cyclophosphamide (PTCy), has shown a two-year overall survival of 94.1% in children and adults, with no difference between age groups. The therapy is proving to be well-tolerated and offers an affordable alternative to expen...
A new study reveals specialized proteins can dramatically delay ice crystal formation in extreme cold, paving the way for impossible organ transplants. Cryogenic damage compromises cellular structures, leading to irreversible damage and organ failure.
A University of Houston researcher has made a breakthrough discovery about the development of the heart in the womb, revealing that a certain gene deletion can cause a common type of heart muscle disease called left ventricular non-compaction.
Researchers developed an antioxidant gel to preserve islet function after pancreas removal, significantly improving survival and preserving normal blood sugar levels in animals. The new approach could enable patients to live pain-free without complications of diabetes.
A breakthrough discovery by Nara Institute of Science and Technology researchers identifies EPHA2 as a critical surface protein for preserving stem cell potency. This finding holds promise for safer regenerative medicine by reducing the risk of tumorigenesis, paving the way for organ repair and treatment of degenerative conditions.
Researchers have successfully grown functional human liver cells in a different species, offering a potential solution to the shortage of donor organs for liver transplants. The breakthrough uses interspecies blastocyst complementation to produce transplantable human liver cells, which can effectively mitigate chronic liver fibrosis.
Researchers found PLS occurs significantly more frequently in unequal AB0 settings, leading to haemolysis and anaemia in patients. Blood group A patients with O transplants are particularly at risk.
Researchers successfully regenerated mouse brain circuits in mice using rat stem cells, offering new opportunities for restoring lost brain function due to disease and aging. The studies found that blastocyst complementation can synchronize the development of stem cells from different species with the host's brain.
Researchers at Columbia University Irving Medical Center have created mice with hybrid brains, allowing them to use rat neurons to sense odors accurately. The study's findings suggest that adding replacement neurons isn't plug-and-play, highlighting the need to remove dysfunctional neurons for functional replacement in neurodegenerativ...
Researchers have identified a subset of T-cells that acts like stem cells and continuously generates effector T-cells that attack transplanted organs. Targeting the transcription factor IRF4 may lead to innovative therapies for patients with chronic infections, cancers, autoimmune diseases and transplanted organs.
A novel risk score predicts cardiovascular complications after bone marrow transplant with high accuracy, helping guide patient selection and post-transplant management. Patients with preexisting cardiovascular conditions are more likely to experience long-term complications.
Researchers at Johns Hopkins Medicine have reported promising results from a clinical trial testing a novel immunotherapy combination to target advanced, potentially lethal skin cancers in kidney transplant patients. Two out of six patients experienced complete tumor regression after adding a second checkpoint inhibitor to the regimen.
University of Melbourne researchers have received a $35 million grant to develop a world-first tissue engineered cornea to treat corneal blindness. The technology has the potential to provide corneal tissue to surgeons worldwide, including countries with limited eye banks.
Researchers discovered that combining fludarabine, melphalan, and low-dose total-body irradiation offers the best survival rate and lowest relapse rate in cord blood transplantation for myeloid malignancies. The study analyzed data from 1395 cases and found fewer deaths from infection with this combination.
Researchers found that ASCOT reverses some age-related protein expression changes, enriching processes related to the complement cascade and immune system in patients with poor ovarian response. In contrast, patients with premature ovarian insufficiency showed enrichment in responses to oxygen-containing compounds and growth hormones.