Articles tagged with Drug Combinations
A new study from Mayo Clinic and Baylor College of Medicine found that targeted genomic information can significantly impact drug prescribing practices. By applying drug-gene testing, clinicians can identify nearly every patient as a potential candidate for preemptive testing, particularly for drugs with unknown genetic influences.
Researchers found that sequencing drug combinations can enhance the anti-tumor immune response in liver cancer, potentially reducing toxic drug exposure. The new strategy primes the tumor with an immune checkpoint inhibitor before using a multikinase inhibitor, enhancing its effectiveness.
Researchers at UCSF develop a new cancer treatment that targets RAS-mutated tumors by exploiting their high levels of ferrous iron. The treatment, TRX-cobimetinib, is more effective and tolerable than current treatments like cobimetinib, which can cause serious side effects in normal tissues.
Researchers discovered that combining polymerase and exonuclease inhibitors reduces SARS-CoV-2 replication by 10 times more than single polymerase inhibitors. This combination approach has great potential to stop the spread of COVID-19 and other coronavirus diseases.
A new study published in JAMA Network Open finds that a combination treatment of nicotine replacement therapy and varenicline is more effective for smoking cessation in heavy drinkers, resulting in 44.3% abstinence rate. Participants also showed significant reductions in drinking rates, with 25% decrease in weekly drinking days.
Scientists at the Princess Máxima Center for Pediatric Oncology discovered a new combination treatment strategy for childhood T-cell acute lymphoblastic leukemia (T-ALL) by analyzing protein activity. The study found that blocking specific proteins, such as LCK and SRC, in combination with an overactive chain reaction of INSR/IGF-1R, k...
Researchers at IBiS have developed a new treatment that completely eliminated glioblastoma tumors in animal models, offering a new therapeutic option against this aggressive disease. The therapy combines the use of ADI-PEG20 with focal brain radiotherapy and has shown promising results without side effects.
Researchers adapted cancer models to predict effective drug combinations for treating Covid-19 at different stages of the disease. The study identified existing therapeutics that might be suitable for treating severe cases, and could help lower Covid-19 related deaths.
A national study found that states with higher labor underutilization, non-Hispanic white populations, and opioid prescriptions had higher SIM rates. States with centralized medicolegal death investigation systems detected more SIM cases due to toxicologic testing.
Researchers have identified a powerful combination of antivirals to treat COVID-19 by combining brequinar with remdesivir or molnupiravir. The combinations inhibited the SARS-CoV-2 virus in human respiratory cells and mice, suggesting increased potency compared to individual drugs.
A recent study found that drug checking programs can reach people who would not access services otherwise, reducing overdoses and increasing HIV testing. The program also improved demand for other services like treatment for opioid use disorder.
Scientists at Technical University of Munich discovered a promising combination therapy for mesenchymal PDAC subtype, showing improved T-cell infiltration and cell cycle arrest when using nintedanib with trametinib. The treatment significantly improves the response of highly aggressive mesenchymal PDAC subtypes in mice.
A retrospective analysis of 13 clinical trials found that most combination therapies involving immune checkpoint inhibitors worked due to independent drug action, rather than synergy or additivity. This discovery has implications for cancer clinical trial design and may help improve treatment outcomes.
The combination of relatlimab and nivolumab doubled progression-free survival benefit compared to nivolumab alone, with significant benefits across pre-specified subgroups. The treatment was associated with a lower risk of disease progression or death.
A randomized controlled trial involving 51 GP practices and 404 patients found a significant reduction in the number of medicines prescribed for older people with multimorbidity. The intervention group experienced over 800 medicines being stopped, with only mild adverse reactions reported.
A new study suggests that combining two drugs can reduce postoperative opioid use and side effects in adolescents with scoliosis. The combination of intrathecal morphine and oral gabapentin provides more effective pain control, resulting in fewer side effects and lower narcotic consumption.
Researchers create plan for proactively developing drug cocktails against virus families, aiming to provide effective treatments in weeks, not months. The approach prioritizes combination therapy to reduce disease spread and limit viral adaptation.
Researchers used PET scans to quantify antibiotic levels in orthopaedic implants, discovering rifampin penetration is only about 14% as much as previously believed. A higher dose of rifampin achieved higher bacterial killing and fewer antibiotic-resistant strains, suggesting a shorter treatment regimen may be effective.
New research suggests that cannabis use can lead to harmful drug-drug interactions by interfering with two families of enzymes that metabolize a wide range of drugs. This could result in unintended side effects such as toxicity or accidental overdose, particularly for older individuals using medications.
Research shows that common medicines have distinct effects on gut bacteria, with some having beneficial and others detrimental impacts. The study found associations between certain medications and changes to the gut microbiome, particularly with statins and gastric acid medication.
A research team developed an AI framework that analyzes protein interactions to predict effective and low-toxicity cancer drug combinations. The framework, GraphSynergy, outperforms conventional models in identifying synergistic combinations.
Researchers at UConn Health have discovered that eliminating senescent cells in human fat tissue can alleviate signs of diabetes and improve insulin sensitivity. The study suggests that clearing away these dysfunctional cells could lead to game-changing new treatments for Type 2 diabetes.
Researchers are modifying an arm of a worldwide clinical trial to evaluate a combination of drugs targeting two brain proteins: amyloid and tau. The Tau NexGen Trial aims to test the effectiveness of these treatments in slowing disease progression by targeting both Alzheimer's disease pathologies.
Researchers have discovered a potential new treatment for COVID-19 by targeting the pentose phosphate pathway, which is necessary for SARS-CoV-2 replication. The study found that inhibiting this pathway with benfooxythiamine suppresses viral replication and reduces virus production.
New study reveals that blocking interleukin-23 is more effective than targeting both interleukin-23 and interleukin-12 in treating psoriasis. Interleukin-12, previously thought to contribute to the disease, actually protects against it by maintaining normal skin cell function.
A research team from the University of Zurich has identified a common genetic variant in the AQP1 gene that affects treatment efficacy and patient survival on peritoneal dialysis. Patients carrying this variant have a higher risk of death, but researchers found a way to circumvent the problem using colloid osmotic agents.
A systematic review of tobacco cessation pharmacotherapies and e-cigarettes found that combined treatments, particularly varenicline and nicotine replacement therapy (NRT), were the most effective in helping people quit smoking. E-cigarettes showed promise but require further research to establish their safety.
Researchers at NTNU have developed a promising new drug combination that effectively suppresses SARS-CoV-2 infection by targeting the TMPRSS2 factor. The combination of nafamostat and Pegasys (IFNα) shows great potential in treating COVID-19, with low doses needed for clinical advantages.
A novel combination of abiraterone acetate and prednisolone has been shown to prolong survival in patients with hormone/castration-sensitive prostate cancer. Studies PEACE-1 and STAMPEDE found that the addition of these drugs to standard therapy lengthened survival compared to standard therapy alone.
A new study from Yale University found that adding oleclumab or monalizumab to durvalumab improves progression-free survival for patients with locally advanced non-small cell lung cancer. The combination reduced the risk of disease progression or death by 56% and 35%, respectively.
Researchers found that ribociclib achieved pharmacologically-relevant concentrations in tumor tissue, while everolimus showed minimal penetration. The combination is promising for brain cancer treatment and could lead to new therapeutic drug combinations.
The study found that patients with low risk of exacerbations do not benefit from low to moderate dose inhaled corticosteroids, while high doses are associated with severe side effects. Tailoring treatment according to patient characteristics, such as age and blood cell count, can minimize over- and underuse of inhaled corticosteroids.
Scientists investigated a method to enhance immunotherapy for lung cancer and found that combining it with certain chemotherapy drugs could eliminate harmful immune cells. This approach showed promising results in preclinical studies, inducing the regression of about 70% of tumors.
Researchers have developed an immunotherapy strategy that combines three drugs to boost the immune system against tumors. The new therapy showed promising results in mice, with pancreatic tumors shrinking or disappearing completely in about half of the animals.
Researchers identified a novel drug duo that exploits a weakness in SCLC's reproduction process, increasing replication stress and damaging DNA. The berzosertib-topotecan combination helped improve symptoms in over one-third of patients in a clinical trial.
A combination of metoclopramide and diphenhydramine has been shown to reduce headache pain by more than five points in people who experienced a head trauma. However, the study's results may not be generalizable due to the participants' limited socioeconomic access.
Researchers have identified a potential revolutionary drug combination that is 'spectacularly effective' in eradicating DIPG cancer cells. The treatment, a combination of difluoromethylornithine (DFMO) and AMXT 1501, was found to be highly effective in animal studies and pre-clinical testing.
Researchers from NUS utilised a ground-breaking AI platform to derive an optimal combination of available therapies against SARS-CoV-2, resulting in a treatment that was 6.5 times more effective than remdesivir alone. The top-ranked combination included the drugs remdesivir, lopinavir, and ritonavir at specific doses.
Researchers have discovered a combination of MEK and SHP2 inhibitors effective in targeting the mechanism driving cancer growth in malignant peripheral nerve sheath tumours. The treatment has shown promise in both cell culture and mouse models, offering hope for improved treatment outcomes for patients.
Scientists have developed a technique that quickly identifies optimal synergistic combinations of anticancer drugs, reducing tumour growth by 80% and outperforming chemotherapy. The technology, called TGMO, achieves results in under two weeks, paving the way for personalized, effective, and safe cancer treatment.
A joint study by University of Cologne researchers predicts the outcomes of combining certain antibiotics using mathematical models. The scientists found that interactions between antibiotics are often caused by bottlenecks in the translation cycle, allowing them to predict the effects of antibiotic combinations without trial and error.
Biomedical engineers at Duke University created a combination molecule featuring GLP-1 and FGF21 that controls blood sugar levels and promotes weight loss in mice for up to a week after a single injection. The slow-release ELP linker ensures stable drug release over time.
A study by Radboud University Medical Center found that a single pill of dolutegravir per day is equally effective as a combination therapy in children, reducing dosage complexity and increasing treatment accessibility. This simplified dosing regimen has been integrated into World Health Organization guidelines and FDA approval.
A NUS-led team has developed an artificial intelligence platform called IDentif.AI to rapidly identify optimal drug combination therapies for infectious diseases. The platform uses machine learning to examine billions of possible combinations and doses, resulting in unprecedented speed and accuracy in discovering new treatments.
Researchers at Duke-NUS Medical School in Singapore have identified a common therapeutic vulnerability for a genetically diverse and deadly form of leukemia. The study reveals that the polycomb repressive complex plays a critical role in driving progression to blast crisis, a nearly always fatal stage of the disease.
The Akay Lab has developed a new microfluidic brain cancer chip that can simultaneously administer multiple drugs and assess their response to glioblastoma cells. The device enables fast drug combination testing in as little as two weeks, potentially improving patient survival rates.
New study reveals antibiotic tolerance promotes the evolution of antimicrobial resistance even under combination drug treatments. The results suggest that designing antibiotic treatments must consider drug tolerance to prevent the emergence of resistance.
A new treatment option for Ewing sarcoma is proposed by combining chemotherapy drug imatinib with diabetes medication metformin, according to Houston Methodist researchers. The combination has shown potential in treating the aggressive tumor in clinical trials.
A University of Michigan AI solution, INDIGO, can predict how current drugs can be combined to create more effective tuberculosis treatments. The tool identified several strong combinations, including those with antipsychotics and antimalarials.
Researchers identified a panobinostat-marizomib combination that effectively kills childhood brain cancer cells and counters genetic mutations. The study uncovered a previously unrecognized vulnerability in cancer cells, which may lead to new strategies against the disease.
A phase-3 trial shows that combining rituximab with ibrutinib keeps patients disease-free for nearly three years and improves overall survival rates. The new treatment is more effective and better tolerated than traditional chemotherapy, revolutionizing the standard of care for chronic lymphocytic leukemia.
Boston University researchers suggest making buprenorphine available behind the counter with age and quantity limitations to increase access for treating opioid use disorder. This could lead to reduced health costs, lower drug-related crime, and more lives saved.
Researchers at Beth Israel Deaconess Medical Center have identified novel combinations of antifungal and antibacterial drugs that demonstrate activity against multidrug resistant Candida auris. The study used a modified inkjet printer to test multiple combinations, finding three effective treatments in under two hours.
Researchers at UNIGE have created a 3D cell co-culture platform to test personalized cancer treatments, demonstrating that low-dose combinations of drugs are more effective than high-dose monotherapies. The platform opens the door to rapid and cost-effective treatment options for various types of tumors.
Researchers at UCLA have found a way to significantly reduce the duration of tuberculosis treatment using artificial intelligence and data analysis. The new approach identifies synergistic drug combinations that work together to cure TB more quickly and effectively.
A new study by researchers at the University of Illinois found that combining two cancer drugs, selinexor and 4-OHT, may prevent endocrine resistance in breast tumors. The treatment protocol was more effective than either drug alone in reducing tumor cells' viability.
A new UK-based study reveals that alcohol, cannabis, MDMA, and cocaine are the most commonly combined with sex. The research found that people of all genders and sexual orientations engage in substance-linked sex, but gay and bisexual men are more likely to do so.
A new study published in Sleep found a 250% increase in Americans taking opioids with benzodiazepines or Z-drugs between 1999 and 2014. This alarming trend is associated with increased risks of serious adverse outcomes, including breathing problems and death.
Scientists have found a drug combination that can halt the progression of fibrosis, a condition responsible for almost half of all deaths. The study, published in European Urology, tested a combination of phosphodiesterase type 5 inhibitors and selective oestrogen receptor modulators on cells and animals.
The Quadratic Phenotypic Optimization Platform (QPOP) uses AI to analyze small datasets and design optimal drug combinations based on real experimental data. This approach can optimize and personalize combination therapy for individual patients with complex diseases, such as multiple myeloma.