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Uncertainty about breast cancer risk and screening choices and perceived risk heighten with breast density awareness following mammography

Awareness of breast density increases perceived risk and uncertainties about screening choices in Spanish-speaking women. However, these effects are short-term and do not persist over time, suggesting that educational outreach may help clarify implications for personal risk and screening decisions.

SourceColumbia University's Mailman School of Public Health·JournalBreast Cancer Research·DateFeb 2, 2023

FDA needs to ensure that information on dense breast notifications are clear and understandable to all members of the public

The FDA's proposed breast density notifications may not be clear enough for all women, particularly those with lower literacy levels. Researchers recommend that the agency uses rigorous evaluation methods to test language and reactions, ensuring that warnings are communicated effectively.

SourceBoston University School of Medicine·JournalJAMA·TypeNews article·DateDec 12, 2022

Women with benign breast disease face higher risk of breast cancer in the long term

A large observational study found that women diagnosed with benign breast disease through screening are at a higher risk of developing breast cancer in the long term. The risk persisted for at least two decades and was found to be significantly higher among women with benign breast disease compared to those without.

SourceEuropean Organisation for Research and Treatment of Cancer·JournalInternational Journal of Environmental Research and Public Health·TypeObservational study·DateNov 17, 2022

Personalized breast cancer screening could improve cancer survival and reduce overdiagnosis

A new model predicts individual breast cancer risk based on ten known risk factors, allowing for tailored screening strategies. The study found that the risk of developing breast cancer ranges from 0.22% to 7.43%, with some factors, such as exercise, having a greater impact than previously thought.

Possible biological explanation for increased cancer risk in dense breasts

Research at Linköping University suggests that dense breasts have unique biological characteristics that promote cancer growth, leading to a fivefold increased risk. The study used MRI and microdialysis techniques to measure proteins in breast tissue, finding elevated levels of inflammatory markers and growth factors.

SourceLinköping University·JournalBritish Journal of Cancer·TypeExperimental study·DateOct 31, 2022

Study finds earlier mammograms for women with family history of breast cancer may not be needed

A new study found that women with a first-degree family relative diagnosed with breast cancer may benefit from screening 5-8 years earlier than their relative's diagnosis age. This is equivalent to the recommended age for average-risk women of 50. The study analyzed data from over 300,000 women and found that increasing the age for ini...

A next-generation liquid biopsy detects nano-sized signs of breast cancer in early-stage patients, USC researchers find.

A USC-led team has found indications for an early breast cancer detection method using high-definition liquid biopsies. The test detected multiple cancer biomarkers, including 'oncosomes,' in the blood samples of most early-stage breast cancer patients.

SourceUniversity of Southern California·Journalnpj Breast Cancer·TypeRandomized controlled/clinical trial·DateSep 28, 2022

Contrast-enhanced mammography vs. MRI: Neoadjuvant therapy response in breast cancer

A prospective study compared CEM and MRI for NAT response assessment in patients with breast cancer. CEM yielded comparable assessments of lesion size and RECIST categories as MRI, but with lower sensitivity for pathologic complete response. Delayed CEM acquisition detected residual ductal carcinoma in situ (DCIS).

SourceAmerican Roentgen Ray Society·JournalAmerican Journal of Roentgenology·TypeObservational study·DateJun 22, 2022

Accuracy of diagnostic mammograms may vary across racial and ethnic groups

A study published in Cancer Epidemiology, Biomarkers & Prevention found that diagnostic mammogram accuracy differed across racial and ethnic groups. Asian/Pacific Islander women were more likely to receive false-positive reports, while non-Hispanic Black women were more likely to receive false-negative reports.

SourceAmerican Association for Cancer Research·JournalCancer Epidemiology Biomarkers & Prevention·DateJun 17, 2022

Study finds that accurate diagnostic mammography outcomes vary by racial and ethnic groups

A multi-institutional study found that diagnostic mammography outcomes vary across racial and ethnic groups, with higher accuracy in non-Hispanic white women and lower accuracy in Hispanic women. The study suggests that imaging facility and concurrent use of breast ultrasound or MRI may contribute to some disparities.

SourceUNC Lineberger Comprehensive Cancer Center·JournalCancer Epidemiology Biomarkers & Prevention·TypeData/statistical analysis·DateJun 17, 2022

New study examining women’s breast density knowledge suggests opportunities for improvement

A new study suggests that while breast density knowledge may be increasing due to existing state laws, there is still room for improvement. The study found that most women with non-dense breasts did not correctly know their own density, and that lower education was associated with a lower chance of accurately knowing one's own density.

SourceDartmouth Health·JournalJournal of the American College of Radiology·TypeSurvey·DateApr 25, 2022

Half of all women experience false positive mammograms after 10 years of annual screening

A study published in JAMA Network Open found that half of all women will experience at least one false positive mammogram over a decade of annual breast cancer screening with 3D mammography. The risk of false positives is lower for women screened every other year, and non-dense breasts also show a lower false positive risk.

SourceUniversity of California - Davis Health·JournalJAMA Network Open·TypeData/statistical analysis·DateMar 25, 2022

Breast cancer overdiagnosis may not happen as frequently as previously thought

A modeling study suggests that breast cancer overdiagnosis may occur in about 15% of screen-detected cases, rather than the estimated 30%. This could spare around 25,000 women unnecessary treatment. Researchers used data from the Breast Cancer Surveillance Consortium to estimate the rate of overdiagnosis.

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeComputational simulation/modeling·DateFeb 28, 2022

Follow-up costs can add up if a free cancer screening shows a potential problem

New studies from Michigan Medicine researchers aim to remove financial barriers for patients who receive abnormal test results, enabling them to complete the diagnostic process. The findings suggest that removing cost barriers could save lives by increasing screening uptake, particularly among women and underserved populations.

SourceMichigan Medicine - University of Michigan·JournalJAMA Network Open·TypeData/statistical analysis·DateFeb 14, 2022

The first AI breast cancer sleuth that shows its work

Researchers at Duke University developed an artificial intelligence platform that analyzes potentially cancerous lesions in mammography scans. The algorithm is interpretable, showing physicians how it came to its conclusions, making it more trustworthy and useful for training students and aiding physicians in sparsely populated regions.

SourceDuke University·JournalNature Machine Intelligence·TypeExperimental study·DateJan 14, 2022

Recalled noncalcified lesions: ultrasound vs. ultrasound plus mammography

A prospective study found that ultrasound alone adequately completed the diagnostic evaluation of 71.2% of noncalcified lesions, diagnosed 92.1% of cancers, and yielded a sensitivity of 94.9%. Radiologists should consider performing ultrasound first for digital breast tomosynthesis-recalled noncalcified masses.

SourceAmerican Roentgen Ray Society·JournalAmerican Journal of Roentgenology·TypeImaging analysis·DateDec 15, 2021

Racial disparities and facility access in mammography recovery after COVID-19 closures

A study found that racial disparities in mammography screening worsened after COVID-19 closures, with non-white patients facing reduced access to facilities. Early interventions aimed at expanding access to these facilities helped to recover late recovery volumes for patients of races other than white.

SourceAmerican Roentgen Ray Society·JournalAmerican Journal of Roentgenology·TypeObservational study·DateDec 2, 2021

Diagnosing breast cancer

A new diagnostic tool for breast cancer uses a low-voltage electrical current to detect changes in lymphatic interstitial fluid, showing 70% effectiveness in predicting cancer presence. The device can be used repeatedly on women of any age, providing an additional diagnostic option for younger patients and those with dense breast tissue.

SourceUniversity of Utah·JournalIEEE Access·TypeExperimental study·DateNov 30, 2021

Model suggests extending annual mammography screening past age 75 may be cost-effective for some healthy older women

A modeling study found that annual mammography screening beyond age 75 may provide little to no benefit in terms of lives saved, while increasing costs and potential harms from overdiagnosis. Biennial screening up to age 80 is more cost-effective but yields a small number of deaths averted.

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeComputational simulation/modeling·DateNov 22, 2021

LLU study identifies uptick in mammogram cancellations from early pandemic

A Loma Linda University Health research study found that mammogram cancellations increased during the early months of the COVID-19 pandemic before decreasing to pre-pandemic levels. The study's findings could help breast cancer surgeons prepare for a potential surge of patients presenting with more advanced stages of breast cancer.

SourceLoma Linda University Adventist Health Sciences Center·JournalThe American Surgeon·TypeData/statistical analysis·DateOct 13, 2021

Association of population screening for breast cancer risk with mammography among women in medically underserved racial/ethnic minority groups

Individualized breast cancer risk estimates led to a significant increase in annual mammography rates among women at high risk. The study found that nearly all Hispanic or Black women who received personalized risk assessments used mammography more frequently, with rates rising from 37% to 51%.

SourceJAMA Network·JournalJAMA Network Open·DateSep 10, 2021

AI DBT impact on mammography post-breast therapy

A single-center retrospective study found that AI-CAD reduced recall rates and improved accuracy compared to digital mammography (DM) and DBT. The study showed lower recall rates and higher accuracy for DM with AI-CAD, indicating a practical addition to lowering false-positive findings.

SourceAmerican Roentgen Ray Society·JournalAmerican Journal of Roentgenology·TypeObservational study·DateAug 11, 2021

Screening strategy based on baseline breast density at age 40 may be effective and cost-effective for reducing breast cancer mortality

A mammography screening strategy based on a baseline breast density measure at age 40 is the most effective and cost-effective way to reduce breast cancer mortality. The study suggests that this approach can lead to a significant reduction in breast cancer mortality, but also increases the number of mammograms performed and false posit...

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·DateFeb 8, 2021

Mammogram-based breast cancer risk model could lead to better screening guidelines

A new machine learning algorithm named Mirai estimates breast cancer risk in women more accurately than current models, identifying 41.5% of patients at risk within 5 years. The model was effective across various races and ethnicities, supporting its potential to inform screening guidelines for diverse populations.

SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience Translational Medicine·DateJan 27, 2021