Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
People with heart failure who can travel outside their home without assistance are less likely to be hospitalized or die within a year. Life-space mobility, a measure of how far patients move in their communities, is a reliable marker of risk for adverse outcomes in chronic diseases.
A new study by Korea University researchers reveals that switching to besifovir may improve patient kidney and bone health for long-term hepatitis B treatment. The study showed that patients who switched to besifovir had higher estimated glomerular filtration rate indicating improved kidney function and higher hip and spine bone densit...
A study found that US avoidable mortality has increased across all states, while neighboring high-income countries have seen improvements in health outcomes. This unexpected trend raises questions about the efficiency of US healthcare spending.
Two Indian hospitals, Apollo Hospital in Hyderabad and Aster Hospital in Calicut, have been certified as Comprehensive Stroke Centers by the American Heart Association. These centers meet rigorous standards for stroke care, including advanced imaging and treatment capabilities. This certification is part of the Association's efforts to...
Researchers at Institute for Systems Biology (ISB) have discovered a non-genetic adaptation mechanism that allows melanoma cells to evade BRAF inhibitors within hours. By blocking this early response with a combination therapy approach, the study aims to improve treatment outcomes and prolong the effectiveness of existing treatments.
Patients from American Indian and Black communities are less likely to have elevated CA-125 levels at diagnosis, suggesting current thresholds may miss diverse patients. Inclusive diagnostic guidelines are needed to address disparities in ovarian cancer diagnosis and treatment.
Researchers at WVU have discovered a way to fine-tune zinc activity to improve messaging in the brain, with potential applications for treating conditions such as autism, schizophrenia and Alzheimer's disease. The study identified new compounds that can selectively change synaptic connections by modulating zinc levels.
CHEST MedCast offers over 400 videos and podcasts with personalized content recommendations, available on-demand and at any time from any device. The platform features an algorithm-based recommendation engine and up to 100 available CME credits/MOC points.
A new study has developed CoLDiT, a conditional latent diffusion model capable of generating high-resolution breast ultrasound images. The model achieved comparable performance to real images in BI-RADS classification and realism evaluation, while safeguarding patient privacy through nearest neighbor analysis.
The Bronchiectasis and NTM Care Center Network facilitates access to specialized care and support for hundreds of thousands of people with bronchiectasis and NTM lung disease. The network aims to improve quality of life and advance a cure for these conditions.
Researchers have discovered how cholesterol crystals form in human bodies, shedding light on heart disease and gallstones. The team identified a special solvent that mimics the body's natural environment, allowing them to watch how cholesterol crystals grow in real time.
Researchers used a rat model to explore electroacupuncture's effectiveness in reducing neuropathic pain, promoting urinary function and decreasing neuroinflammation. The study suggests electroacupuncture as a promising treatment strategy for bladder pain syndrome.
A systematic review and meta-analysis found that approximately 40% of adults with chronic pain experience clinically significant depression and anxiety. Women, younger people, and those with nociplastic pain are most vulnerable to these conditions.
Researchers used AI to analyze 126 individuals with generalized anxiety disorder (GAD) and identified key variables predicting recovery and nonrecovery. Higher education level, older age, and positive affect were most important for recovery, while depressed affect and medical visits proved most important for nonrecovery.
The study found that combining coronary calcium score with a primary prevention strategy in intermediate-risk patients with a family history of coronary artery disease reduces atherogenic lipids and slows plaque progression compared to usual care. This data supports the use of CAC scores to assist intensive preventive strategies.
A new study found that sports gambling frequency is associated with the trajectory of alcohol-related problems over time. Screening and treatment interventions are recommended for this high-risk group to prevent further problems.
A POSTECH research team developed a photoacoustic computed tomography (PACT) system that non-invasively monitors cerebrovascular changes in small animals with early stages of an ischemic stroke. The technology also measures oxygen saturation in blood vessels, allowing precise tracking of vascular recovery after stroke.
Children who frequently miss school due to abdominal complaints are more likely to have gut-brain axis disorders like IBS, which can be missed by medical tests. The study found that frequent absences were nearly five times more likely to be caused by functional GI disorders than specific illnesses.
A recent study from the University of Gothenburg found that dental implants continue to function well after nearly forty years. The implants, developed by Professor Per-Ingvar Brånemark, have been shown to remain stable and integrate with bone over an extended period.
A report by the University of Auckland highlights that six out of ten people globally lack safe medical oxygen access, resulting in hundreds of thousands of preventable deaths. The lack of access is particularly severe in low and middle-income countries, with five billion people affected.
The collaboration aims to close gaps in early recognition and management of IPF by equipping healthcare providers, public health professionals, and patients with necessary resources. The organizations will employ designated activities to build a knowledge base, develop survey tools, and create educational and awareness assets.
Low-dose microplastic exposure leads to abnormal reproduction in females, characterized by oocyte meiotic maturation defect and H4K16 hyperacetylation. HDAC3 insufficiency is proposed as a key mechanism underlying this toxicity.
In a new study published in The Lancet, researchers found that one in eight patients in African hospitals are critically ill, with one in five dying within a week. Basic but crucial health interventions can significantly reduce mortality and are inexpensive enough to be provided in general wards.
Research from UVA Health and the Flo app finds that many women experience perimenopause symptoms as early as their 30s, including anxiety, depression, and physical problems. The study sheds light on the often-ignored transition period leading to menopause and aims to improve care and support for women approaching this stage.
The American College of Chest Physicians (CHEST) has developed an educational program and formal certification exam for nurse practitioners and physician assistants/associates in critical care. The program validates clinical expertise and demonstrates professional acumen, aiming to improve patient care.
A cohort study found that patients with obesity undergoing joint replacement who experienced significant weight loss after initiating anti-obesity medications had a lower risk of 5-year and 10-year revision. This suggests that safe and sustainable weight loss may improve implant survivorship in obese patients.
The University of Texas at Arlington is joining forces with the Texas A&M Engineering Experiment Station to operate a new biomanufacturing center. This partnership will expand UTA's capabilities and provide access to financial support and industry partners, enabling researchers to develop and commercialize production of new bioprod...
A study published in the Journal of Neurosurgery found that surgery can alleviate psychiatric distress and improve cognitive function in patients with Chiari Malformation type 1. Nearly 90% of patients showed improvements in cognitive function or psychiatric symptoms, with many reporting a significant reduction in brain fog.
A study published in JAMA Ophthalmology found a modest increase in the risk of nonarteritic anterior ischemic optic neuropathy among individuals with type 2 diabetes associated with semaglutide use. The findings suggest that further investigation is needed into the clinical implications of this association.
Only about 1 in 5 older Americans have undergone cognitive screening in the past year, highlighting a persistent barrier to diagnosis and treatment. Researchers emphasize the importance of early conversations about cognitive health to prevent progression and improve outcomes.
The article reviews additive manufacturing technology for biomedical metals, enabling customized implants with precise internal structures. It highlights the integration of AI and 4D printing, addressing challenges in production costs, regulatory compliance, and post-processing.
New UCLA-led research finds that Paxlovid does not significantly reduce COVID-19 hospitalization and mortality among vaccinated older adults. The study suggests that Paxlovid's potential effect on COVID-19 hospitalization in vaccinated older adults is four times weaker than originally reported.
A new mobile health app-based intervention, BEST-U, is expanding to train non-mental health professionals in delivering the treatment. The 11-week program has shown 'most participants were fully recovered from their eating disorder' at the University of Kansas.
A representative study of adults experiencing homelessness in California found a high proportion of current drug use and unmet need for treatment. Improving access to treatment tailored to their needs could improve outcomes.
A new device has been designed to effectively treat cerebral venous sinus thrombosis (CVST) by navigating complex venous anatomy and removing large thrombi. The device features controllable axial and longitudinal maneuverability, improving clinical outcomes for patients with CVST.
Researchers from University of Leicester identified genetic variants linked to successful smoking cessation using varenicline. The study sheds light on the biological processes involved in responding to the drug.
Hunter Medical Research Institute has formed a memorandum of understanding with Novartis (Aust & NZ) to explore future research projects focused on improving cardiovascular health. The partnership aims to accelerate innovation and enhance patient care through collaborative research initiatives.
A new global guideline has been published to manage fungal infections caused by Candida, affecting millions worldwide annually. The guideline establishes standards for prevention, diagnosis, and innovative treatment approaches.
A study reveals disparities in telehealth services for substance use disorder treatment, with Medicare-enrolled individuals more likely to use telehealth. The finding highlights equity concerns for Medicaid populations and suggests a potential benefit for rural individuals.
A cohort study found ADHD symptoms among US youths increased risk of nicotine and tobacco use. Early ADHD diagnosis and effective treatment may help alleviate symptoms and reduce the risk of nicotine and tobacco use.
Sodium-glucose cotransporter-2 inhibitors and GLP-1RAs show reduced risk of moderate/severe COPD exacerbations compared to dipeptidyl peptidase 4 inhibitors. This finding may inform glucose-lowering medication prescribing for patients with type 2 diabetes and active COPD.
The study found a notable drop in common ophthalmic procedures following the COVID-19 pandemic, especially laser peripheral iridotomy, which declined significantly in the hardest hit areas of the Northeast. Eye drug injections showed minimal changes during this time.
Researchers at Arizona State University propose a unifying explanation for Alzheimer’s disease, focusing on the role of chronic stress granules in disrupting gene activity. The condition causes massive changes in gene expression, affecting every known neuropathology and clinical manifestation.
A new drug-free intervention targets the root cause of progressive loss of neural function in SMA by gradually reawakening functionally silent motor neurons. Early results show improved leg muscle strength and walking in adults with SMA, regardless of symptom severity.
Researchers found that a person's lack of recognition is the biggest barrier to effective treatment, while patients who contact healthcare often do not receive it. The study highlights gaps in service needs and outcomes for nine common disorders, identifying areas for targeted investments.
A study by Texas A&M University found that most people in the US are not in favor of detaining sick undocumented immigrants who reach interior border checkpoints. However, they do support detention after medical treatment is complete. The survey also found broad public support for expanding existing policies to allow undocumented indiv...
A systematic review and network meta-analysis of 601 trials revealed that SGLT2 inhibitors were more cardioprotective in older adults, while GLP-1 receptor agonists offered greater benefits to younger patients. These findings suggest personalized treatment approaches for type 2 diabetes based on age and sex.
A cohort study reveals a robust association between headache diagnoses and suicidal behavior, highlighting the importance of behavioral health evaluation and treatment for these patients. The findings suggest that patients with headache diagnoses should be screened for suicidal ideation and provided with appropriate support.
The American College of Physicians recommends preventing episodic migraines with monotherapy, including beta-adrenergic blockers and antiseizure medications. However, a comparative effectiveness systematic review found no significant differences in clinical net benefit among treatments.
A cohort study found that patients without type 2 diabetes had higher discontinuation rates and lower reinitiation rates of GLP-1 receptor agonist therapy. Inequities in access and adherence to effective treatments exacerbate disparities in obesity.
The study found a significant decrease in antidepressant use during pregnancy without an accompanying increase in psychotherapy. This suggests that pregnant women with depression or anxiety may be able to effectively manage their symptoms with medication alone.
The study found a significant increase in obesity drug prescriptions from 0.76 million in July 2017 to 1.5 million in February 2024, mirroring rising public online search activity for semaglutide and tirzepatide. This correlation highlights the real-time association between public awareness and prescription trends.
A new trial will test whether taking HMB can improve patients' physical function and quality of life. The BOOST study aims to recruit 124 patients with cirrhosis and measure its effects on liver disease, mental wellbeing, and physical function over 24 weeks.
A team of scientists at Linköping University has developed a method to anchor conductive polymers to individual living cell membranes without affecting the cell's functions. This innovation opens up new possibilities for treating neurological diseases with high precision.
Researchers at McGill University discovered a novel brain mechanism that explains why bipolar patients alternate between mania and depression. A dopamine-based 'second brain clock' controls mood shifts, operating in tandem with the body's natural sleep-wake cycle.
This study analyzed GP-patient consultations to identify treatment burdens and strategies for managing type 2 diabetes. The findings show that medication and personal resources are major components of treatment burden, emphasizing the need for tailored GP responses.
A new analysis reveals that surgery for sleep apnea may lower the risk of motor vehicle accidents compared to using a CPAP device or receiving no treatment. Patients with untreated sleep apnea had a 21% higher odds of accidents, while those undergoing surgery had 45% lower odds.
Researchers identify key brain signals prediction error and expected value to predict recovery potential in depression. They found unique brain activity patterns that could inform tailored therapy strategies, targeting specific symptoms of depression.
A recent study published in JAMA Psychiatry found that medically recommended cannabis use is associated with a higher prevalence of cannabis use disorder and more frequent use among US adults. The study suggests that medically recommended cannabis may not be effective in reducing addiction risk compared to nonmedical use.
A new longitudinal study has provided unprecedented insights into human papillomavirus (HPV) infection dynamics. The study found that non-persistent infections exhibit a plateau in viral load before rapidly declining, while chronic infections show a strong correlation between immune cells and virus production. This research could infor...