Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
The new international doctoral programme, RAMP-UP, aims to improve regenerative medicine and ATMPs in Europe by training 55 doctoral students from academia, healthcare, and industry. The programme has the potential to revolutionise healthcare with advanced therapies for genetic diseases and cancers.
A recent study found that the average duration of ADHD medication for children and adolescents is more than three years. Long-term effects in children have not been sufficiently studied due to limited data on the safety of marketed ADHD medicines.
GLP1-RA treatment is associated with improvements in quality of life, restrained eating, and emotional eating behavior. The treatment also provides reassurance regarding its psychiatric safety profile.
Researchers have identified conditions under which ultra-high dose rate carbon ion beams can spare normal cells while maintaining tumor control, opening new possibilities for safer radiotherapy. The study reveals a cell-sparing effect under normoxic conditions using higher linear energy transfer values.
A breakthrough all-oral treatment for a rare but deadly strain of sleeping sickness is now available, revolutionizing care for patients in endemic countries. Fexinidazole Winthrop has been approved for use in several African countries and is being distributed by WHO, offering a safer alternative to existing treatments.
A 72-week clinical trial found tirzepatide to be more effective than semaglutide in reducing body weight and waist circumference. The study demonstrated that tirzepatide's dual mechanism of action, mimicking both GLP-1 and GIP hormones, is key to its superior performance.
Researchers found that phospholipids in ascites fluid disrupt immune cell function, particularly NK cells, leading to impaired anti-tumor activity. Blocking these lipids can restore NK cell activity, providing a promising therapeutic target.
Researchers investigated the efficacy of a combination of atorvastatin and dexamethasone in treating patients with subacute subdural hematoma (sASDH). The study found significant symptom improvement and no recurrence or progression of symptoms in all five patients treated with this regimen. Non-surgical interventions for sASDH are ofte...
Researchers discovered 500 cryptic peptides found only in pancreatic tumors, which could be targeted by vaccines or engineered T cells to attack the cancer. The peptides were identified using immunopeptidomics and shown to slow down tumor growth in mice.
Researchers found that patients taking HIV drugs called NRTIs are substantially less likely to develop Alzheimer's disease. The study, led by Jayakrishna Ambati, analyzed data from two large health insurance databases and determined a significant reduction in Alzheimer's risk among patients on NRTIs.
Researchers from Mass General Brigham presented key findings from multiple innovative studies on gene and cell therapy, focusing on rare diseases, brain cancer, and neurodegenerative disorders. The studies explored strategies to improve care delivery and accelerate translation from lab to clinic, with potential breakthroughs in treatin...
Researchers investigated the clinical outcomes of concurrent TTFields therapy with CRT in patients with newly diagnosed glioblastoma, finding no significant difference in survival outcomes compared to adjuvant therapy. The study also showed comparable safety profiles for both treatment groups.
This study found a decline in racial and ethnic disparities in receipt of ERBB2-targeted therapies among older Medicare beneficiaries with ERBB2-positive breast cancer. The narrowing of disparities may be attributed to changes in healthcare practices or policies over time.
A cross-sectional study finds a doubling in nicotine pouch past-30-day use and an increase in pouch plus e-cigarette dual use, leading to decreased exclusive e-cigarette use among US 10th and 12th graders. Prioritizing surveillance, regulation, and prevention strategies is crucial for addressing pediatric nicotine pouch use.
Researchers at TUM developed an AI-powered algorithm to predict kidney damage in prostate cancer patients undergoing lutetium-177 PSMA therapy. Early detection could enable personalized treatment adjustments to prevent organ damage.
A new AI model developed by Uppsala University accurately diagnoses multiple sclerosis (MS) with an overall accuracy of 90%, identifying the transition from relapsing-remitting to secondary progressive MS in almost 87% of cases. This enables earlier diagnosis, reducing the risk of patients receiving ineffective medicines.
Researchers identified risk factors for sudden unusual mental or somatic experiences, including past psychedelic use, reality distorting practices, and extensive spiritual practice. These findings can help clinicians diagnose and treat associated suffering, and inform the development of practical guidelines.
Researchers developed an automated machine learning program to identify potential cardiovascular incidents and fall/fracture risks based on bone density scans. The algorithm shortened screening time and found moderate to high AAC levels in 58% of older individuals, placing them at high risk of heart attack and stroke.
A cohort study of pregnant individuals with opioid use disorder found that buprenorphine treatment was associated with improved maternal and infant outcomes. The study highlights the need to improve access to treatment nationwide for these patients.
A multicenter study found that radiologically unstable plaque, particularly intraplaque hemorrhage, significantly increases the risk of ischemic stroke and ocular symptoms in patients with symptomatic mild carotid stenosis. Surgical intervention, such as carotid endarterectomy, may be a protective factor for these patients.
Patients who develop epilepsy after a traumatic brain injury are at an increased risk of premature death, with a mortality rate 1.8 times higher than those without epilepsy. The study also found that the risk of developing epilepsy is highest in the first year after the injury.
A randomized clinical trial suggests that metformin can be an effective treatment for symptomatic knee osteoarthritis in people with overweight or obesity. The study's results support the use of metformin for this condition, but further confirmation is needed in larger clinical trials.
Research reveals subpar healthcare services in Global South cities, with frequent medicine shortages and inadequate long-term condition management. Innovative policy approaches are needed to balance public service expansion and private subsidies to improve access and equity for marginalized populations.
A study of nearly 11,000 individuals found that men with panic disorder are more vulnerable to developing problematic drinking behaviors than women, potentially due to self-medication. The research highlights the need for sex-specific assessment and intervention strategies in treating comorbid conditions
A survey study found that more than 1 in 7 adults carried medical debt in 2023, with 1 in 3 forgoing mental health care the following year. Medical debt may exacerbate treatment gaps by raising thresholds for seeking care and eroding patient trust.
Researchers developed fluorescent polyionic nanoclays that can be customized for medical imaging, sensor technology, and environmental protection. These tiny clay-based materials exhibit high brightness and versatility, enabling precise tuning of optical properties.
The University of Missouri is partnering with a consortium to design and license a new research reactor, NextGen MURR, which will produce critical medical isotopes for cancer treatment. The project aims to enhance Missouri's role as a leader in nuclear science and medical research.
Dr. Rhonda Winegar investigates the effectiveness of music therapy in supporting neurological care, including its ability to reduce anxiety and depression in Alzheimer's patients. Her research also highlights its potential to regulate heart rate and blood pressure, as well as improve motor function in individuals with Parkinson's disease.
The USA Center for Rural Public Health Preparedness is leading a four-year project to identify and overcome obstacles in adopting the latest trauma triage guidelines. The goal is to produce guidelines that are equally useful and relevant for anyone, whether they are in urban or rural areas.
Researchers developed an AI model that creates synthetic fibrosis patterns to aid in treating atrial fibrillation. The system accurately mimics real heart scarring and enables clinicians to test different treatment approaches on digital models before performing procedures.
A new analysis of the SURMOUNT-1 trial found that around two-thirds of participants regained only 5% or less of their lowest weight over three years. The study suggests that most patients receiving tirzepatide had a relatively stable weight journey, with limited weight regain after reaching their nadir weight.
A new class of antibiotic has been shown to be effective in treating MRSA infections, with a daily dose of epidermicin NI01 demonstrating equal efficacy to the current standard of care. The findings justify further pre-clinical development and could lead to new gel-type therapies for skin infections.
Researchers at The University of Texas at San Antonio are working on a new AI tool to improve lives after brain injury. They plan to analyze data from 3,000 veterans and develop an interactive dashboard for clinicians to use, providing insights that could revolutionize treatment.
The American Heart Association will strengthen and expand Hawaii's stroke system of care, reducing death and disability rates from stroke in rural populations. The initiative aims to enhance coordination among emergency responders, hospitals, and healthcare providers.
A study found that smaller embryos already hatching are more likely to be chromosomally normal. This insight helps fertility clinics select better embryos during IVF, particularly for women over 35 or those undergoing PGT-A.
A new NIH study found that children born in lower-opportunity neighborhoods are more likely to experience repeated asthma flares requiring emergency care. Non-Hispanic Black children have the highest incidence rates of severe childhood asthma, also known as asthma with recurrent exacerbations (ARE).
A new AI tool called MindGlide can extract key information from brain images to measure damaged areas and highlight subtle changes in MS patients. The tool performed better than other AI tools and expert clinical analysis, enabling researchers to unlock valuable insights into multiple sclerosis.
A meta-analysis of randomized clinical trials found that glucagon-like peptide-1 receptor agonists (GLP-1RAs) were associated with a statistically significant reduction in all-cause dementia. Cardioprotective glucose-lowering therapies, however, did not show an overall reduction in dementia risk.
Research reveals that GLP-1RAs and SGLT2i medications significantly reduce the risk of Alzheimer's disease and related dementias in people with type 2 diabetes. No significant difference was found between these two treatments.
The International Society for Autism Research (INSAR) will hold its 24th Annual Meeting in Seattle, featuring 1600 posters, 28 oral sessions, and keynotes on topics such as daily challenges faced by the autism community and implementation science aimed at enhancing systems of care.
An 11-year-old Asian small-clawed otter developed left-sided paralysis after a fall, but improved with treatment for a suspected fibrocartilaginous embolus. Follow-up MRI showed a diminished lesion one year later.
The American College of Chest Physicians' CHEST Critical Care and CHEST Pulmonary journals have been indexed in Elsevier's Scopus database. This achievement is a testament to the high-quality research published in these journals, which provide open access content in pulmonary and critical care medicine.
A qualitative study reveals that migration has a complex influence on border-region emergency medical services, leading to more injuries and deaths. Increased federal funding is needed to support the work of local EMS clinicians, who are struggling with unsustainable strain.
Despite free treatment in many countries, TB patients incur catastrophic costs due to hospitalization and lost income. A systematic review found that these costs can be prohibitively high for individuals in low-, middle-, and high-income settings.
A new study by McGill University researchers sheds light on the disruption of calcium transport in the brain's AMPA receptors, linking it to autism and intellectual disability. The findings could pave the way for treatments targeting these receptors, offering hope for patients with related neurological disorders.
Researchers used mice to examine the activity of two neuronal proteins linked to autism. They found that a natural balance between MDGA2 and BDNF maintains normal neuron activity, but disruption can lead to ASD-like symptoms. This study suggests MDGA2 and BDNF as promising therapeutic targets for future treatments.
A large population survey found that nearly 1 in 10 people in Great Britain experienced NHS-related harm due to treatment or care received, and lack of access to care. The study highlights significant inequities in rates and impact of harm, with disadvantaged groups experiencing higher rates and more severe impacts.
A centralized notification pathway increased hypertension treatment in individuals with left ventricular hypertrophy. This study highlights the potential of leveraging underutilized cardiovascular data to enhance healthcare delivery.
The Pediatric Long COVID Extension for Community Healthcare Outcomes (ECHO) program has successfully trained nearly 100 healthcare professionals across the US, equipping them to diagnose and manage long COVID in children. The program aims to bridge access gaps and empower community providers.
A new virtual reality-based system shows promise in improving psychiatric diagnosis by differentiating between common mental health conditions. The system uses immersive scenarios and physiological measurements to elicit emotional responses, suggesting enhanced diagnostic accuracy.
Researchers at Mayo Clinic are conducting a study to understand the factors that contribute to rapid progression of dementia in patients with Alzheimer's disease and Related Dementias. The team aims to identify biomarkers and disease-modifying targets that can improve diagnosis and treatment outcomes for these patients.
Three UVA Engineering faculty members, Scott T. Acton, Gustavo Kunde Rohde and Shannon Barker, have been named to the 2025 class of the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows. They are recognized for their contributions to biomedical engineering research, innovation, teaching and leadership.
The Finerenone Trial found that sudden death was the primary cause of higher cardiovascular mortality in patients with heart failure and mild or preserved ejection fractions. The study suggests that finerenone may not significantly impact cardiovascular mortality, but its effects on overall mortality are unclear.
A study published in JAMA Cardiology found that finerenone was effective in treating heart failure, regardless of the presence of atrial fibrillation. New-onset atrial fibrillation was linked to a substantially increased risk of adverse outcomes.
The American Heart Association has launched a new certification program for hospitals dedicated to optimizing heart failure treatment, reducing readmissions. The Heart Failure Center Certification aims to enhance patient outcomes and promote evidence-based treatments.
A cohort study found semaglutide use is associated with a higher risk of nonarteritic anterior ischemic optic neuropathy in people with diabetes. However, the retrospective design limits the study's ability to establish causality, necessitating further research.
A new study from Queen Mary University of London reveals substantial financial burdens on patients and concerns over the reliability of information in the fertility sector. The research highlights a need for regulatory action to ensure clinics provide accurate cost information and treatment options.
Researchers at Lancaster University discovered a new type of vaccine-specific scepticism, where some people perceive COVID-19 vaccines as 'not a vaccine' compared to MMR. This phenomenon may also apply to the flu vaccine, highlighting the need for clear public health messaging.
A new digital 'translator' for brain studies enables researchers to map the brain in a standardized way, facilitating discoveries and treatments for various disorders. The open-source software allows for the comparison of brain imaging data with widely used brain atlases, promoting commonalities across findings.
A cohort study suggests that many comatose patients who died after withdrawing life-sustaining therapy had recovery potential. Experts emphasize the need for novel solutions to avoid deaths based on biased prognostication or incomplete information.