Articles tagged with Drug Addiction
A recent UC San Diego study has found that e-cigarette use does not help smokers stay off cigarettes, but rather increases the risk of relapse. Former smokers who switched to e-cigarettes were more likely to relapse compared to those who remained tobacco-free.
A study published in JAMA Network Open found that nearly three-fourths of U.S. adults with buprenorphine use did not misuse the medication in 2019, trending downward between 2015-2019 despite increased treatment. The research highlights the need to expand access to proven treatment approaches like buprenorphine therapy to reduce misuse.
A recent study found that fully vaccinated individuals with substance use disorders have a significantly higher risk of breakthrough COVID-19 infection compared to the general population. The study, published in World Psychiatry, revealed that patients with cocaine and cannabis use disorder had the highest risks.
Scientists at Temple University will explore the therapeutic potential of KLS-13019, a CBD analog that shows promise as an opioid alternative. The Phase 2 SBIR grant aims to test the compound's effects on rat models of neuropathic pain, shedding light on its safety and efficacy.
Researchers found that methamphetamine, cocaine, and nicotine withdrawal share similar features in mouse brains, including reduced modularity and increased functional connectivity. This reorganization may contribute to the addictive nature of psychostimulants.
A University of Minnesota Medical School study found that nicotine withdrawal can lead to overeating high-calorie foods, possibly linked to the brain's opioid system. This connection may hinder smoking cessation and increase the risk of relapse, emphasizing the need for better understanding the factors driving cravings for unhealthy food.
Overdose deaths involving methamphetamine rose 180% from 2015 to 2019, outpacing increases in methamphetamine use. Riskier patterns of use, including frequent use and co-use with other substances, contributed to the surge. Diverse populations, particularly American Indians/Alaska Natives and young adults, are disproportionately affected.
A new study by University of Bath psychologists suggests that Spice, a synthetic drug, is more harmful than cannabis and causes more severe withdrawal symptoms. Participants who tried to quit Spice reported experiencing sleep issues, irritability, and low mood, among other symptoms.
A study from OHSU found that almost 8% of patients with opioid use disorder died within 12 months of hospital discharge, comparable to those who suffered heart attacks. The researchers highlight the need for comprehensive addiction care and destigmatizing healthcare systems.
A study found that only about 2-2.5% of individuals with alcohol dependence in Sweden receive alcohol medication, highlighting unequal provision of treatment across sociodemographic factors and co-morbid conditions. The research suggests low knowledge among physicians and patients, as well as preference for psychological treatment over...
A recent NIH-supported study highlights alarming disparities in opioid overdose deaths among non-Hispanic Black individuals in the US. The rates increased by 38% from 2018 to 2019, with Kentucky and Ohio experiencing the largest increases. The research emphasizes the need for community-based interventions addressing these disparities.
Researchers reviewed 79 studies on neurocognitive impairments and brain abnormalities associated with nonfatal opioid overdoses in humans. The findings suggest a link between overdose, cognitive impairment, and brain changes, which could influence attention span, memory, and executive function.
Researchers discovered that a brain area traditionally thought to specialize in old habits also plays a role in learning new actions. The study found that the dorsolateral striatum is involved in consolidating action learning immediately after the new action has been learned.
Researchers found a spike in prescription opioid and anti-anxiety sedative consumption, while illicit drug use plummeted during the early pandemic. The study used wastewater analysis to track community-wide habits and anxiety levels.
A new study from Simon Fraser University found that nearly 60% of people experiencing homelessness and serious mental illness in Metro Vancouver have had a criminal conviction. The study identified factors associated with criminal convictions, including irregular income assistance payments, drug addiction, and psychiatric hospitalization.
A study published in Science Advances reveals a previously unknown mechanism behind compulsive alcohol use, which may be targeted by medication. A small group of nerve cells in the central amygdala promote alcohol use despite negative consequences.
A systematic review found evidence that non-invasive brain stimulation can reduce smoking frequency in nicotine-dependent smokers. High-frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex was associated with the greatest reduction in smoking frequency.
A new study recommends making methadone more widely available through office-based visits with primary care physicians to improve access and convenience for patients with opioid use disorder. This could reduce transportation costs and enhance treatment retention rates, but further research is needed to confirm its effectiveness.
Recent Mayo Clinic research reveals a significant increase in opioid overdose-related emergency department visits during the COVID-19 pandemic. Opioid overdoses accounted for 1 in every 313 visits, up from 1 in every 400 visits in previous years.
A non-toxic derivative of tetanus neurotoxin improves depression symptoms in rat models, lasting two weeks. Hc-TeTx inhibits serotonin transport by binding to neurotrophin receptors, suggesting potential for treating neurodegenerative diseases.
A study by Pavel Horký and colleagues has discovered that low levels of methamphetamine in freshwater rivers can elicit addiction in wild brown trout. The fish exhibited withdrawal symptoms when switched to clean water, suggesting addiction was present. Methamphetamine contamination in waterways poses a significant threat to aquatic life.
A new study found that many younger adult dental patients are taking medications, highlighting the importance of reviewing medication histories. Medications such as antidepressants and opioids can increase the risk of dry mouth, tooth decay, and tooth loss.
Researchers found that individuals with childhood trauma experienced a stronger desire for morphine and felt more euphoric after taking the opioid drug. In contrast, those without childhood trauma were more likely to dislike the effects and feel dizzy or nauseous.
A recent UCLA clinical trial has shown encouraging results in helping daily smokers who are also heavy drinkers quit smoking and cut down their alcohol intake. The study found that nearly 36% of participants had quit smoking, with varenicline alone showing a highly encouraging quit rate.
A Rutgers study suggests that individuals with high sensation-seeking traits may be more susceptible to drug addiction due to a genetic predisposition. High-sensation-seeking rats showed stronger motivation for cocaine, making them more prone to developing addictive behavior.
A new study by RAND Corporation reveals that half of all patient-months of buprenorphine treatment are prescribed by just 4.9% of physicians and other providers, highlighting the potential for targeted efforts to increase medication treatment capacity in rural areas.
One in five pharmacies in the US refuse to dispense buprenorphine, a vital medication for opioid use disorder patients. This study highlights the need for reduced stigma and increased collaboration between pharmacists and healthcare providers.
A study by Indiana University researchers found that access to local health-related laws in Indiana counties is limited due to outdated or non-existent online databases. The study aimed to build a comprehensive database of local laws, highlighting the importance of standardized online systems for policy surveillance and transparency.
The global street drug supply has changed dramatically, with heroin and cocaine now cut with up to 17 pharmaceutically active and potentially toxic adulterants. This trend poses significant risks to public health and safety, particularly for high-risk groups during the COVID-19 pandemic.
A study published in JAMA Network Open found that over 60% of US adults who vape are interested in quitting, with former cigarette smokers having the highest intentions. Despite e-cigarettes being seen as a potential tool for smoking cessation, many users struggle to quit, and current treatments may not be effective for all users.
A team of neurobiologists identified a brain region, subthalamic nucleus, that predicts addiction in rats. Abnormal activity in this region was observed in future addicted individuals before punishment exposure.
A new study published in Addiction highlights the effectiveness of daily e-cigarette use in aiding smoking cessation. The research found that daily e-cigarette users were over five times more likely to achieve abstinence from tobacco smoking for one month compared to those using no quitting aids.
Patients taking buprenorphine for opioid use disorder who also take benzodiazepines experience a 40% lower risk of overdose, according to research published in The American Journal of Psychiatry. This finding suggests that buprenorphine can protect patients from overdose even when taking benzodiazepines.
The opioid overdose epidemic in the US is fueled by restricted access to evidence-based treatments, with only 18% of individuals receiving effective medications. Proposed exemptions aim to expand access, but more changes are needed to address the crisis.
A recent study found that over half of primary care clinics in nine states refuse to accept opioid patients due to perceived stigma. Clinics gave more favorable responses when patients mentioned their last doctor had retired, suggesting systemic biases influence decision-making.
A new study found that naltrexone use decreases the risk of hospitalization due to alcohol use disorder, while benzodiazepine use is associated with increased mortality and hospitalization. Only about a fourth of persons diagnosed with AUD used any medications, highlighting under-utilization of treatment options.
A new treatment combining naltrexone and bupropion shows promise in reducing methamphetamine use disorder, with a response rate of 13.6% compared to 2.5% in placebo groups. The therapy also led to reduced cravings and fewer adverse effects.
A 10-year study found that individuals with high sensitivity to alcohol's pleasurable effects are more likely to develop an alcohol use disorder. Higher sensitivity, not tolerance, is linked to increased risk and addictive behavior.
Researchers are using cutting-edge MRI sensors to map brain responses to drugs of abuse and identify genes that promote neuron survival. They plan to apply this technology to study Parkinson's disease, hoping to uncover new therapeutic targets.
Researchers found that almost two-thirds of light smokers (1-4 cigarettes/day) and a quarter of those smoking less than weekly were addicted. The study suggests that clinicians should consider lighter smokers for treatment, as they may still require assistance to quit.
Researchers analyzed Medicaid databases to identify predictors of timely enrollment in treatment for opioid use disorder among Medicaid recipients. Prior overdose, alcohol use disorder, and back problems were associated with non-enrollment, while frequent emergency room visits or primary care provider visits were linked to timely enrol...
A study by USF Health found that resident physicians are interested in treating opioid addiction but lack the knowledge and skills to prescribe buprenorphine. The survey also revealed that only 3% of residents were currently waivered, highlighting a need for increased training and support.
A study published in JAMA Network Open found that reducing nicotine levels in cigarettes decreases addictiveness, particularly among those with mental illness and socioeconomic disadvantage. The research suggests that lower nicotine content could lead to policy changes benefiting all smokers, especially the most vulnerable.
A University of Guelph study finds that sweetened coolers with high-fructose corn syrup can promote harmful alcohol consumption among teenagers. The researchers suggest that these beverages act as a gateway to introduce young people to alcohol, increasing the likelihood of binge drinking.
A novel study by Keck Medicine of USC researchers reveals a potential new opioid medication that can slow the progression of osteoarthritis while easing pain. The medication, which activates the kappa opioid receptor, has been shown to preserve cartilage in joints and alleviate pain with reduced risk of addiction.
Researchers at the University of Alabama at Birmingham have identified a complex gene program that regulates brain changes in response to cocaine. By using single-nucleus RNA sequencing approaches, they found that only a small fraction of neurons in the nucleus accumbens were transcriptionally responsive to cocaine administration.
Researchers found that individuals with stronger connections between frontal cortex and striatum in two distinct brain networks were more resilient to drug addiction. These brain circuits are involved in goal-directed behavior and habit regulation, suggesting potential strategies for preventing or treating addiction.
A joint research team has identified dopamine D2 receptors in cholinergic interneurons as a key factor in susceptibility to cocaine addiction. The study found that DRD2 overexpression and reduced cell activation in ChINs contribute to the development of cocaine addiction.
A new study shows that financial incentives can increase the number of emergency department physicians trained to prescribe buprenorphine, a potentially life-saving medication for opioid overdose. By offering reimbursement and a $750 incentive, 89% of physicians were fully trained in six weeks.
Laws punishing pregnant drug abusers are ineffective in reducing substance use during pregnancy, instead decreasing treatment admissions by 29% and referrals to healthcare professionals by 18%. The study found no significant reduction in babies born with withdrawal symptoms or exposed to narcotics.
A recent study found that nearly two-thirds of teens and young adults use e-cigarettes due to social factors, despite widespread knowledge of the risks. The survey, conducted by the University of Michigan's MyVoice study, also revealed that most respondents believe vaping is dangerous and can lead to substance use.
Researchers at the University of California, Irvine have discovered a key receptor for dopamine called D2R that intervenes in cocaine's modifying functions in the striatum. Disrupting D2R signaling may lead to new therapeutic strategies for treating cocaine addiction.
A survey of primary care physicians found that one-third did not support the use of medications to treat opioid use disorder (OUD), despite conclusive evidence. The researchers urge policy changes to increase the acceptance of and willingness to prescribe medications for OUD among primary care physicians.
Researchers at UArizona College of Medicine identified prolactin as a key factor in women's pain sensitivity. The study suggests new therapies targeting the prolactin system could greatly benefit women suffering from functional pain syndromes, such as migraines and fibromyalgia.
A new study published in Clinical Infectious Diseases shows that treating opioid use disorder with medications within 30 days of discharge from the hospital due to injection drug use-related endocarditis improves health outcomes. Those who received medication had a reduced risk of overdose and rehospitalization within a year.
A commonly used anti-psychotic medication has been linked to potentially adverse changes in brain structure, particularly a thinning of the cortex. The study found these changes were more prominent in elderly participants and those who experienced relapse of psychotic symptoms.
A new study shows that individuals with opioid use disorder who receive medication and residential treatment after detox have lower mortality rates. The research highlights the importance of ongoing treatment to increase survival chances.
Researchers have re-engineered a plant-derived compound to reduce morphine-seeking behaviors in mice, preventing relapse to opioid addiction. The new molecule inhibits a protein receptor involved in heroin dependence and prevents stress-induced relapse.
Researchers found that opioid dependence leads to permanent neuro-adaptations in the central nucleus of the amygdala, affecting pain transmission and GABA receptor activation. Normalizing nociceptin levels resulted in reduced opioid consumption, suggesting the peptide as a promising target for opioid use disorder treatment.
Buprenorphine use has more than doubled nationwide between 2009 and 2018, with increases seen across most age groups. However, a notable decline was observed among 15-24-year-olds, who experienced a 20% decrease in treatment rates.