Articles tagged with Drug Addiction
Researchers found that alcohol helps synchronize GABA cells, increasing dopamine release and dependency. The study provides new insights into the mechanism of addiction and could lead to targeted pharmacological treatments.
A recent editorial emphasizes the importance of evidence-based treatment for opioid use disorder (OUD), highlighting the benefits of medications like methadone, buprenorphine, and naltrexone. Experts stress that these treatments should be evaluated like any other chronic illness, free from unnecessary regulations and biases.
A new study found that cardiac surgery was associated with a 56% reduction in mortality, while in-hospital addictions counselling resulted in a 72% reduction. Both interventions showed significant benefits for patients who inject drugs with first-episode endocarditis.
The Society for Neuroscience presents Dr. Michael Bruchas with the Jacob P. Waletzky Award, recognizing his research on stress biology and opioid signaling in drug addiction. His work has advanced our understanding of neural circuits and cell biology critical to developing new treatments.
The $1.5 million grant will allow Brown, RIDOC and partners to expand MAT treatment for high-risk individuals, addressing gaps in the existing program. Over three years, the team aims to treat over 300 additional Rhode Island residents with opioid use disorders.
Scientists have made a major advance in understanding how heroin addiction develops by studying the brain circuits that lead to its powerful addictive effects. The discovery of dopamine neurons' role in reinforcing heroin's effects could help refine addiction treatment and develop less addictive painkillers.
Researchers identified the paraventricular thalamus as a key player in tracking important details for animals to learn. The study's findings suggest that the brain can adapt its focus on good and bad outcomes based on context, which could lead to new treatments for drug addiction.
A study of 9,449 university students found that opioid misuse linked to lower GPAs and increased impulsivity. Risk factors identified include living off campus and early age of sexual activity.
Research reveals that a single dose of cocaine can irreversibly alter brain circuits surrounding neurons associated with addiction. This discovery may lead to the development of medications targeting the extracellular matrix to reverse addiction.
A new study by George Mason University found an estimated 2,035 emergency department visits from e-cigarette explosion and burn injuries between 2015-2017, underscoring the need for improved surveillance and regulation. The devices contain harmful substances like nicotine and ultrafine particles, posing serious health risks.
Experts warn that Brexit will affect the UK's ability to tackle the illicit drugs trade due to exclusion from the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). The EMCDDA plays a crucial role in surveillance, data exchange, and policy-making, posing substantial risks to public health and safety.
A study published in PNAS reveals that an ancient retrovirus, HK2, is more frequently found in drug addicts and associated with addiction. The virus integrates near a gene involved in dopaminergic activity, manipulating nearby genes and predisposing individuals to addictive behavior.
A new study by Centre for Addiction and Mental Health suggests that an inhaled form of a high blood pressure medication may treat certain types of anxiety as well as pain. The treatment uses a short-acting nasal spray called amiloride, which targets physiological changes in brain functioning linked to anxiety and pain sensitivity.
A recent study by Boston Medical Center found that only 24% of youths receive FDA-approved medications for opioid use disorder within three months of diagnosis. Patients who receive medication are more likely to remain in treatment compared to those who only receive behavioral health services.
The Journal of Addictions Nursing special issue provides a unique nursing perspective on the opioid crisis, highlighting research topics and expert views. The publication presents seven original research papers addressing various aspects of OUD, including medication-assisted treatment, overdose prevention, and stigma reduction.
The Stanford model analyzes opioid use and addiction among Americans, projecting a decline in deaths if doctors reduce prescriptions by 25% over 10 years while expanding treatment programs. The researchers aimed to provide policymakers with 'what-if' scenarios to address the crisis.
A recent survey found that nearly a third of college students knew someone who overdosed on painkillers or heroin, while 20.5% said they know someone addicted to pain medication. The study highlights the collateral damage of the opioid epidemic on those closely tied to users.
A study by Rutgers Brain Health Institute discovered that the hypothalamus' 'orexin' neurons play a key role in controlling food motivation. Orexin blockers have shown promise in reducing binge-like eating episodes, providing new hope for treatment options.
A study published in EMBO Reports reveals that the Maged1 gene plays a key role in controlling addictive behavior. Researchers found that mice lacking the gene are unresponsive to cocaine and exhibit reduced dopamine release, indicating a promising new entry point for understanding drug addiction mechanisms.
Current opioid epidemic responses neglect to account for gender-specific factors, including pain sensitivity and treatment outcomes. Women are disproportionately affected by opioid addiction, with increased risk of overdose deaths and limited access to effective treatment options.
Researchers at the University of Texas Medical Branch developed a treatment that reduces drug-seeking behaviors in rats by restoring serotonin signaling. This finding offers new hope for treating drug addiction and related health issues such as depression and schizophrenia.
A new study by Scripps Research scientists found that activating GPR139, a receptor linked to alcohol addiction, can significantly decrease drinking in alcohol-addicted rats. The researchers also discovered that the drug helps mediate physical pain associated with withdrawal in severe cases of alcohol addiction.
Researchers found that rats who chose alcohol showed similarities to human alcohol addiction diagnostic criteria, including continued use despite negative consequences. The study identified a gene expression change in the amygdala region of the brain as key to understanding this behavior.
A study by the National Institute on Drug Abuse found that patients receiving methadone or buprenorphine had a significantly lower risk of death from opioid overdose. The study analyzed data from over 17,000 adults in Massachusetts who survived an overdose between 2012 and 2014.
Researchers found significant reductions in all-cause and opioid-related mortality among overdose survivors taking methadone or buprenorphine. However, only three out of ten overdose survivors receive these medications.
A recent study found that up to seven percent of patients develop a persistent habit after being prescribed opioids following surgery. To address this issue, experts recommend enhanced care coordination between surgeons and primary care physicians to identify patients at risk of developing opioid addiction.
Researchers at Scripps Research Institute will study genetic factors behind oxycodone and cocaine addiction using a unique, genetically diverse rat model. The five-year grants will allow for the creation of shared tissue banks for researchers worldwide to use in addiction studies.
A new study finds that a hospital-based addiction medicine team significantly reduces burnout and frustration among healthcare providers, while improving patient engagement and care. The team's approach fundamentally reframes substance use disorder as a treatable chronic disease.
Researchers used optogenetic tools to activate neurons linked to ejaculation in male fruit flies, revealing a rewarding experience. The study suggests that the brain processes ejaculation as a natural reward, influencing motivation and addiction risk.
A recent review article emphasizes the need for further clinical studies on neonatal abstinence syndrome (NAS) to develop evidence-based assessment, diagnosis, and treatment guidelines. Non-pharmacologic interventions like breastfeeding and rooming-in have shown positive short-term results, but larger, multi-site trials are necessary.
Scientists developed a potent new medicine to fight addiction by blocking an enzyme, resulting in higher GABA levels and reduced dopamine release. The new compound, CPP-115, is 10 times more efficient than vigabatrin and has fewer side effects.
A study found a 60.5% reduction in mortality among recently released inmates who were on medication for addiction treatment before their release, compared to the previous year. The program, launched in 2016, linked inmates with community centers and supportive care after release.
Researchers at Oregon State University found that symptoms of alcoholism make it difficult for patients to take naltrexone, a medication approved to treat alcohol use disorder. The study suggests that ongoing daily contact with the patient is crucial to improving adherence, particularly after heavy drinking episodes or strong cravings.
A new study from UT scientists finds that buprenorphine, a drug used to treat opioid addiction, can impair the ability of obese mice to vary their breathing. This discovery may encourage similar studies in humans, who also need to achieve tasks like climbing stairs and respond to challenges such as disease and surgical stress.
A new Tel Aviv University study published in Addiction found that only eight out of 100 smokers benefit from taking smoking cessation medications after a year. The researchers conclude that policymakers should find better methods to help smokers quit and prevent young people from starting to smoke.
Researchers identified G-CSF as a key player in the development of cocaine addiction, altering mice's desire for the drug but not other rewards. Manipulating G-CSF in the brain's reward center could reduce addiction-like behaviors, paving the way for new treatments.
Recent breakthroughs aim to help those struggling with opioid use disorders by providing interim treatments and safer prescription options. Interim therapies can get people medication sooner, reducing the risk of overdose and infection, while safer opioids may mitigate respiratory suppression and addiction.
A high prevalence of complications related to opioid use disorders has been seen in emergency radiology patients, with skin and soft tissue infections, respiratory issues, and back pain being common. Imaging results often provided critical information to aid management plans and reduce mortality rates.
A recent study found that most smokers feel regretful about their habit and are addicted to cigarettes. The researchers suggest that measures reducing smokers' discontent and improving subjective well-being could be considered in cost-benefit analysis of proposed regulations.
Researchers discovered a previously unknown cellular communication method between neurons and immune cells in neuropathic pain. Blocking this method could prevent neuropathic pain without side effects.
A new rat model of drug addiction, requiring daily puzzle-solving for cocaine reward, still produced substance use disorder symptoms. In contrast to traditional models, the rats relied on flexible problem-solving to maintain their addiction, contradicting the widely-held view that habit is necessary.
A new study at Vanderbilt University Medical Center uses a blood test to personalize treatment for smokers. The study found that patients who are 'normal' metabolizers of nicotine respond better to varenicline (Chantix), while those who are 'slow' metabolizers do as well with a nicotine patch.
The American Thoracic Society editorial emphasizes the need for effective tobacco control measures, citing the court-ordered publication of corrective statements by major US tobacco companies. The statements acknowledge the addictive nature of nicotine and the lethal effects of smoking on human health.
A new systematic review of evidence suggests that primary care physicians and their teams can provide effective addiction care using anti-opioid medication. The studies found that patients had the highest chance of successful treatment when working with a team of non-physicians, including nurse case managers.
A new study by Matthew Wanat found that more dopamine is released when waiting for a reward, highlighting the importance of timing in decision-making. The research could provide valuable insights into understanding drug addiction, which hijacks brain regions where dopamine is released.
A study of 11 addiction treatment professionals reflects the increase in prescription drug addictions and staff-related challenges following Hurricane Katrina. The disaster led to the creation of emergency preparedness plans, but participants expressed frustration with federal help conditions.
A Boston hospital is conducting a study on the use of lorcaserin to treat cocaine addiction, targeting serotonin receptors in the brain. The goal is to reduce cravings and rewards associated with cocaine use, with the potential to provide a real game-changer for treatment options.
Chronic cocaine users exhibit impaired learning and memory in the ventromedial prefrontal cortex, making it hard for them to form new associations and quit using the drug. This finding highlights potential limitations of extinction-based therapy in treating addiction.
A new study found that opioid prescription use increased significantly between 1999 and 2014, driven by patients taking medication for 90 days or longer. Long-term use was associated with greater risk for addiction and overdose, as well as concurrent use of benzodiazepines.
A six-year Canadian study found that 39% of Ontario adults with IDD were dispensed antipsychotic medication, with 29% not having a documented psychiatric diagnosis. The study highlights the need for better prescribing practices and monitoring to ensure appropriate use in this vulnerable population.
A survey found that many physicians are unwilling to increase their use of buprenorphine, citing lack of time and reimbursement as major concerns. Providing access to counseling services for patients and mentoring for physicians could help boost prescription rates.
A new study reveals that a small group of physicians in Ontario prescribe the majority of medications used to treat opioid addiction. High-volume prescribers see large numbers of patients daily and bill the province hundreds of thousands of dollars annually.
Researchers found that prenatal alcohol exposure alters the brain's reward system, making individuals more susceptible to addiction. The study suggests that endocannibinoids play a critical role in this process, leading to increased sensitivity to drugs of abuse and decreased dopamine neuron function.
Fowler has made significant contributions to brain research, developing the radiotracer F-18-FDG to measure brain glucose metabolism non-invasively in humans. Her work has facilitated advances in the study of the human brain and malignant tumor detection.
The Consensus Document from the American Society of Addiction Medicine (ASAM) offers practical guidance on drug testing in various clinical settings. It emphasizes that drug testing should be widely used to monitor adherence and abstinence, but also serves as a therapeutic tool rather than a punitive one.
Cuts to addiction services in England have led to a surge in drug-related deaths and increased pressure on the NHS. The Royal College of Psychiatrists is calling for more training posts and no further cuts to addiction services.
A Penn study found that even small quantities of opioids prescribed for minor injuries increase the risk of long-term use. The research suggests that laws limiting opioid prescription pill amounts may help address the opioid epidemic.
Researchers discovered compounds in areca nuts that target addiction-related brain receptors, potentially treating nicotine cravings without side effects. The new molecules could offer a safer alternative to existing smoking cessation drugs like Chantix.
A review of 13 studies found that mixing energy drinks with alcohol increases the risk of injury due to masked intoxication effects. Researchers warn that this practice poses a serious public health concern, and more research is needed to confirm findings.
Researchers at Salk Institute find that changing dopamine levels can alter upcoming choices, suggesting new avenues for treating Parkinson's and OCD. The study uses advanced techniques to measure dopamine concentration in mice brains, revealing a tight association between brain chemistry and decision-making.