Articles tagged with Edema
A team of researchers led by Rice University bioengineer Omid Veiseh is developing a first-of-its-kind regenerative treatment aimed at restoring damaged lymphatic vessels and potentially curing lymphedema. The therapy, called ELIXIR, uses engineered human retinal pigment epithelial cells to rebuild broken lymphatic vessels.
Optic disc edema progression in spaceflight predicted using optical coherence tomography imaging, suggesting crew members without ODE on day 30 unlikely to develop concern on day 150. This technology offers opportunity for predicting ODE magnitude during longer missions.
Researchers found 11 cases of laryngeal edemas in patients after tisagenlecleucel infusion, with higher doses and CAR-positive cells linked to increased risk. Steroid administration showed promise in early management without affecting therapy effectiveness.
High-flow nasal oxygen was found to be more effective than noninvasive ventilation in preventing endotracheal intubation or death within 7 days in four of five patient groups with acute respiratory failure. However, the results were sensitive to analysis models and may require further study in specific patient populations.
Researchers have developed a suite of parameters that can be used to quantitatively measure different physical characteristics of the lung. The parameters were found to be highly sensitive and specific for diagnosing fibrosis and edema in an animal model, using only five necessary parameters.
New research reveals a cocktail of approved drugs can quickly reduce brain swelling and improve outcomes in animal models of brain injury. The study suggests reopening lymph nodes as an emergency pressure release valve for the brain, addressing cerebral edema as the leading cause of TBI-related deaths.
A study comparing radiologist and AI performance in interpreting 2,000 chest X-rays found that AI tools achieved moderate sensitivity but high false-positive rates. Radiologists outperformed AI in detecting the absence of disease, especially for complex cases.
Researchers developed an AI model to estimate best-corrected visual acuity from fundus photographs in patients with diabetic macular edema, achieving accuracy within one to two lines on a standard chart. The study's findings support the potential of AI in clinical settings, with opportunities for further improvement.
Swimming-induced pulmonary oedema (SIPE) is a relatively little known hazard associated with open water swimming. Risk factors include older age, long distances, cold water, and female sex. SIPE can occur in fit and healthy individuals, highlighting the importance of awareness and prevention.
Researchers at Charité – Universitätsmedizin Berlin have discovered a cystic fibrosis drug effective in laboratory experiments, raising hope it can treat pneumonia regardless of the pathogen. The study found that CFTR plays a key role in pulmonary edema and that a CFTR modulator, ivacaftor, can prevent this condition.
A novel algorithm uses near-infrared spectroscopy to estimate intracranial pressure (ICP) based on hemoglobin levels. The research validates the accuracy of this method using invasive ICP data.
A NIH-funded study found that patients with retinal vein occlusion experience significant visual acuity gains, but require long-term monitoring and treatment. After five years, many participants retained an average of three lines of improvement in their visual acuity.
Researchers have identified a new family of proteins in blood vessels that prevent fluid from entering the lungs, offering a potential new avenue for treating acute respiratory distress syndrome. Stimulating these bitter taste receptors has been shown to provide protection against fluid leak into the lung.
Researchers found that scorpion venom triggers a systemic neuroimmune reaction leading to pulmonary edema and cardiac alterations. Administration of corticosteroids, such as dexamethasone, can quickly inhibit the inflammatory process and prevent death in mice.
Swollen neurons are less likely to exhibit overactivity associated with long-term TBI complications. Researchers propose a more nuanced approach to managing cerebral swelling, potentially leading to better outcomes for patients with traumatic brain injuries.
A new study at Boston Medical Center found that the common treatment bevacizumab for diabetic macular edema is less effective for Black patients compared to white and Hispanic individuals. This disparity underscores the importance of increasing diversity in clinical trials to develop treatments tailored to all patient groups.
Researchers developed a novel ultrasound technique that quantifies lung scarring and detects lung fluid in rats, showing promise for assessing pulmonary fibrosis and edema. The non-invasive method could reduce costs and improve patient care by providing accurate, measurable assessments of lung health.
Researchers warn against treating COVID-19 lung injury like high altitude pulmonary edema (HAPE), citing differences in underlying mechanisms and necessary treatments. Long-term supportive care, including mechanical ventilation, may be needed to overcome underlying inflammation.
Joint capsule edema and thickness at the axillary recess are useful predictors of stiff shoulders in patients with rotator cuff tears. MRI findings also show associations between tear size, location, and preoperative passive range of motion.
Researchers have discovered that the glymphatic system goes awry during a stroke, promoting brain cell drowning and swelling. This finding may lead to novel interventions to reduce stroke severity and improve outcomes.
Research in mice shows that the glymphatic system floods the brain during a stroke, triggering severe swelling and cell death. This discovery could lead to new treatment strategies focused on restoring blood flow and inhibiting the spread of depolarization.
A new AI algorithm developed by researchers can analyze retinal images to predict which patients with diabetic macular edema are likely to respond to anti-VEGF therapy. The algorithm achieved an 87% accuracy rate in predicting treatment response, offering a potential breakthrough in personalized medicine.
Researchers at Wyss Institute for Biologically Inspired Engineering developed an AAV-based gene therapy that targets leaky lung cells by overexpressing the CD98hc protein. This approach shows great promise in reducing vascular leakage and improving lung function, offering a new hope for treating pulmonary edema.
A new study finds that severe sleep apnea is a risk factor for treatment-resistant diabetic macular edema, a complication of diabetes causing vision loss or blindness. Patients with severe sleep apnea were more likely to experience worsening eye disease and require multiple treatments.
A new study found that closely monitoring patients with diabetic macular edema who have good vision can be an acceptable initial strategy, with prompt treatment starting if vision worsens. The two-year study showed similar visual acuity outcomes among groups receiving aflibercept injections, laser photocoagulation, or observation.
A new study finds that starting treatment before vision loss is unnecessary for most people with diabetic macular edema. Close monitoring of the condition is essential to determine when treatment should begin.
The LIMPRINT study found that chronic edema significantly impacts health-related quality of life in patients, particularly those with leg swelling. The condition is often neglected and difficult to treat, affecting a large portion of the population.
A newly developed model of central retinal vein occlusion in mice demonstrates the protective effects of adrenomedullin (ADM) and its receptor activity-modifying protein RAMP2. The study suggests that the ADM-RAMP2 system could be a novel therapeutic target for treating retinal vein occlusion, which affects millions worldwide.
A comparative clinical trial found that delivering corticosteroids directly into the eye is more effective than injecting them adjacent to the eye in treating uveitic macular edema. The treatment led to significant reductions in macular edema and improvements in visual acuity, with intravitreal triamcinolone and dexamethasone implant s...
Researchers found intravitreal treatments to be superior to periocular injections in reducing macular edema and improving visual acuity. The study suggests shifting towards intravitreal corticosteroid injections for treating uveitic macular edema.
Young recreational and elite athletes often accumulate excess fluid in bone marrow around joint connecting spine to pelvis. Magnetic resonance imaging detects this excess fluid in healthy individuals, raising debate about diagnostic thresholds for axial spondyloarthropathy.
A recent study found that intense physical activity did not significantly increase bone marrow edema in healthy people, challenging previous hypotheses about the role of mechanical stress in rheumatic diseases. MRI lesions were present in a significant proportion of healthy active individuals, regardless of exercise intensity.
A clinical trial funded by the National Eye Institute shows that monthly eye injections of Avastin improve visual acuity on average from 20/100 to 20/40, comparable to Eylea. Macular edema decreased significantly in both groups, with higher resolution rates in the Eylea group.
Researchers found that using red-channel images improved the detection of diabetic macular edema, a complication of diabetes leading to blindness. The study suggests that this method could offer a clear-cut advantage in under-served groups with high rates of diabetic eye disease.
A new study found that neuropilin 2 deficiency leads to excessive and prolonged fluid build-up after inflammation, causing edema. The research also revealed a novel hypothesis that endogenous Semaphorin 3F protein inhibits vascular permeability and edema.
A new device that monitors lung fluid accumulation reduces heart failure-related hospitalizations by over half and death rates by 39% compared to standard care. Patients who used the Edema Guard Monitor took medication earlier, preventing pulmonary congestion from reaching advanced stages.
A two-year clinical trial found that Eylea (aflibercept) performed better than Avastin (bevacizumab) in participants with moderate or worse vision loss, while Lucentis (ranibizumab) yielded similar gains. The study confirmed the effectiveness of all three drugs for diabetic macular edema treatment.
A clinical trial funded by the National Institutes of Health found that Lucentis is highly effective in treating proliferative diabetic retinopathy, improving vision by about half a line on an eye chart compared to laser therapy. The study also showed lower rates of complications such as vitrectomy and serious systemic adverse events.
Researchers led by Johns Hopkins Medicine discovered that three drugs, Eylea, Avastin, and Lucentis, are effective in treating diabetic macular edema. Eylea performed better than the other two drugs when vision loss was moderate to severe.
A national study found Eylea effective in improving eyesight for individuals with poor vision due to diabetic macular edema. The condition affects an estimated 7.7 million people in the US, and treatment options are limited, making informed decisions crucial.
A clinical trial comparing Eylea (aflibercept), Avastin (bevacizumab), and Lucentis (ranibizumab) for diabetic macular edema found that Eylea provided greater visual improvement, especially in patients with moderate vision loss. The study enrolled 660 participants and showed similar results when starting vision was mild.
A new study led by USC Eye Institute finds that ranibizumab may help reduce cases of blindness by 75 percent among Hispanic and non-Hispanic whites with diabetic macular edema. The treatment could potentially save the sight of thousands of working-age individuals suffering from diabetic eye disease.
A study of 1,038 adults with diabetes found that diabetic macular edema (DME) prevalence is 3.8% overall, with higher odds among non-Hispanic black patients and those with longer diabetes duration and higher hemoglobin A1c levels.
Researchers found that ADC values accurately reflect changes on the injured side but not on the uninjured side, indicating a delay in pathological changes. This study suggests that ADC measurements may not be reliable for detecting cytotoxic edema on the unaffected brain tissue after traumatic brain injury.
A new study suggests that lung ultrasound can accurately detect pulmonary edema in pregnant women with preeclampsia, allowing for timely intervention and reducing the risk of respiratory failure. This non-invasive test has the potential to improve patient outcomes and reduce mortality rates associated with preeclampsia.
A new study reveals that nearly half of Americans with diabetes are unaware of the link between the disease and visual impairment, while only six in ten have had their eyes fully examined. The research highlights the need for improved patient education and access to eye care specialists to prevent vision loss.
Researchers found that changes in occludin and connexin 43 expression are consistent with the development of brain edema, reflecting its pathogenesis. The study's findings may lead to better treatments for intracranial diseases.
Thioperamide significantly decreases brain water content and malondialdehyde levels while increasing histamine levels and superoxide dismutase activity, preventing oxidative damage and brain edema. Thioperamide's effects are mediated by postsynaptic H1 receptors.
Researchers discovered that lungs with fluid in the lungs no longer pump water out as believed, but instead pump it in. This finding has important implications for treating lung edema, a common symptom of heart disease.
A large retrospective cohort study found that thiazolidinedione use may increase the risk of diabetic macular edema (DME) at 1-year and 10-year follow-up evaluations. The association was strongest among patients taking thiazolidinediones in combination with insulin.
A randomized controlled trial found that bevacizumab treatment improved visual acuity and reduced symptoms of diabetic macular edema compared to traditional macular laser therapy. The study suggests a potential long-term benefit of bevacizumab in managing persistent DME.
A study of a rare neurodegenerative disease has uncovered a mechanism that destabilizes the homeostatic balance of brain cells, leading to fluid accumulation. The discovery identifies a protein GlialCAM as an ion channel subunit regulating chloride ions and potentially paving the way for new treatments.
Martina Navratilova, a former tennis champion, was hospitalized with pulmonary edema after climbing Mount Kilimanjaro. The study highlights the risks of acute mountain sickness and high-altitude pulmonary edema among climbers of high peaks.
This special issue of Progress in Cardiovascular Diseases explores the connections between high-altitude medicine and low-altitude diseases. Studies have elucidated fundamental mechanisms involved in lung edema and hypoxic pulmonary hypertension, while also detecting vascular dysfunction in humans.
A comparative-effectiveness study confirms that ranibizumab eye injections in combination with laser therapy result in dramatic visual improvement for patients with diabetic macular edema. The treatment demonstrates substantial visual benefits, including a 50% improvement rate and prevention of blood vessel leakage.
A nationwide study found that treating diabetic macular edema with ranibizumab eye injections, plus laser treatment if needed, results in better vision than laser treatment alone. At the one-year follow-up, nearly 50% of patients had substantial improvement in vision.
Researchers tested mecamylamine, a topical drug, in a human clinical trial to treat diabetic macular edema. The study showed significant improvement in vision and biological effects in the retina in approximately 40% of participants.
A study published in the World Journal of Gastroenterology found that early enterostomy closure via endoscopy significantly reduces hospital stay duration and stoma closure time. The researchers used endoscopic examination to determine optimal closure timing, concluding it's a useful predictor for this procedure.
Researchers found that a 1-milligram dose of triamcinolone significantly improved vision in some patients with retinal vein occlusion. The treatment also showed superior safety compared to existing laser therapies. However, grid photocoagulation remained the preferred option for those with blockages in smaller branches of the vein.
Researchers found that bevacizumab significantly improved vision in diabetic patients with macular edema, with 51.8% of eyes showing improvement after 24 months. Additionally, the treatment controlled cystoid macular edema after cataract surgery, with most eyes improving and remaining stable.