Researchers from Amsterdam UMC and Copenhagen University have found that a chemofree drug-combination therapy is more effective than traditional chemotherapy in treating CLL, resulting in reduced side effects and improved patient outcomes. The study, the largest ever conducted on CLL, involved 920 fit patients and showed that treatment...
SourceAmsterdam University Medical Center·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateMay 10, 2023
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Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Blinatumomab immunotherapy significantly improves the survival rate of babies with aggressive acute lymphoblastic leukemia (ALL), from 66% to 93%, while reducing side effects. The treatment is now standard for babies worldwide.
SourcePrincess Máxima Center for Pediatric Oncology·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateApr 26, 2023
A study of 7807 children found no increased risk of brain tumours, leukemia, or lymphoma after a single CT scan. However, exposure to 4 or more scans before adulthood significantly increases the risk of intracranial tumours, leukemia, and non-Hodgkin lymphoma
SourceCanadian Medical Association Journal·JournalCanadian Medical Association Journal·TypeObservational study·DateApr 24, 2023
Children with acute lymphoblastic leukemia (ALL) who live in extreme poverty are at a significantly higher risk of relapse and have difficulty adhering to treatment. The study highlights the need for clinicians and researchers to assess financial hardship and adherence to treatment to improve outcomes.
SourceAmerican Society of Hematology·JournalBlood·DateApr 18, 2023
A study by Linköping University researchers found that blood stem cells from leukemia patients remain in the bone marrow, but become defective over time, leading to long-term effects on blood formation. This discovery may explain why many leukemia survivors experience blood cell function disorders later in life.
SourceLinköping University·JournalHaematologica·TypeExperimental study·DateApr 5, 2023
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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers discuss cortactin's impact on cancer progression by modulating the Wnt5a/ROR1 signaling pathway. Cortactin expression is found in various cancers, including breast and chronic lymphocytic leukemia, suggesting its potential role in promoting metastasis.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateApr 4, 2023
Scientists from USC Stem Cell laboratory discovered a mechanism linking leukemic mutations to varying disease potentials, identifying RNA splicing regulator Rbm25 as a critical factor. The study found that over-contributing clones of blood stem cells produce excessive myeloid cells, leading to potential leukemia development.
SourceKeck School of Medicine of USC·JournalBlood·TypeExperimental study·DateMar 23, 2023
Researchers at Lund University discovered a novel mechanism linking RNA splicing to the development of leukemia in myelodysplastic syndrome patients. The study highlights the critical role of core spliceosome component SF3B1 and its regulation by N6-methyladenosine (m6A) modification, which provides a
SourceLund University·JournalMolecular Cell·DateMar 21, 2023
Researchers found that consuming vitamin A or its analogs can help prevent painful pancreas inflammation in children and young adults with acute lymphoblastic leukemia (ALL) during chemotherapy treatment. The study revealed that only 1.4% of patients developed pancreatitis when taking vitamin A, compared to 3.4% without it.
SourceCincinnati Children's Hospital Medical Center·JournalScience Translational Medicine·TypeData/statistical analysis·DateMar 15, 2023
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A team of researchers has discovered a potential therapeutic that can synergize with existing drugs to more effectively kill certain leukemia cells. The therapy targets a DNA repair protein and shows promise in clinical trials.
SourceAmerican Society for Biochemistry and Molecular Biology·JournalMolecular & Cellular Proteomics·TypeExperimental study·DateMar 8, 2023
A study of 2.2 million Danish children found certain maternal infections during pregnancy increased childhood leukemia risk among offspring. The findings suggest potential implications for etiology and preventive measures.
SourceJAMA Network·JournalJAMA Network Open·DateFeb 20, 2023
Researchers have successfully converted pluripotent stem cells into hematopoietic stem and progenitor cells using optimized transcription factors. The resulting PSC-derived cells generated all types of white blood cells in mice without giving rise to tumors or leukemias, suggesting a promising future for PSC-based transplant therapies.
SourceInternational Society for Stem Cell Research·JournalStem Cell Reports·DateFeb 16, 2023
A new protein degrader, AK-2292, shows promise against STAT5, a key player in leukemia and other cancers. By targeting the protein's degradation, researchers have overcome previous challenges in designing small molecule inhibitors.
SourceMichigan Medicine - University of Michigan·JournalNature Chemical Biology·TypeExperimental study·DateFeb 15, 2023
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Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers at Harvard's Wyss Institute developed a method to fine-tune CAR-T cell stimulation using artificial antigen-presenting scaffolds. This approach enhances consistency and potency of resulting CAR-T cell products, allowing for better cancer treatment outcomes.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalNature Communications·TypeExperimental study·DateFeb 10, 2023
Researchers at VCU Massey Cancer Center have discovered a novel combination therapy that dramatically suppresses the growth of AML cells, including those resistant to venetoclax. The dual mTORC1/2 inhibitors synergistically enhance AML cell death when paired with venetoclax.
SourceVirginia Commonwealth University·JournalClinical Cancer Research·DateFeb 7, 2023
Pusan National University researchers have identified a novel gene, SURF4, that regulates cell death and differentiation in acute myeloid leukemia (AML). The study found that suppressing SURF4 expression increases cell differentiation, cell death, and accumulation of ROS, leading to arrested tumor growth in mice.
SourcePusan National University·JournalCancer Communications·TypeExperimental study·DateJan 31, 2023
A new study standardizes the use of optical genome mapping (OGM) for patients with blood cancers, demonstrating its potential as a frontline test for diagnosing hematologic malignancies. OGM outperforms existing tests in detecting cancer-causing gene variants and identifying additional information that can improve patient outcomes.
SourceMedical College of Georgia at Augusta University·JournalJournal of Molecular Diagnostics·DateJan 17, 2023
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Researchers from Hospital Universitario 12 de Octubre and Josep Carreras Institute create a cell therapy based on STAb cells for T-Cell Acute Lymphoblastic Leukemia (T-ALL), a rare disease with few treatment options. The new therapy offers an alternative to CAR-T therapies, which have limitations in treating this type of leukemia.
SourceJosep Carreras Leukaemia Research Institute·JournalBMJ·TypeExperimental study·DateJan 16, 2023
A comprehensive study of childhood leukemia's genetic diversity provides insights into personalized therapy. Researchers identified distinct groups based on drug sensitivity profiles, which significantly impact prognosis.
SourceSt. Jude Children's Research Hospital·JournalNature·DateJan 5, 2023
The E1910 trial found that adding blinatumomab to standard front-line consolidation chemotherapy improved overall survival and kept most patients in remission. The treatment, which targets malignant B cells, demonstrated its effectiveness in patients with a good prognosis after an initial round of chemotherapy.
A new treatment protocol has been shown to significantly reduce the risk of aggressive childhood leukemia returning after chemotherapy. The ALL-11 protocol, which includes an extra year of maintenance chemotherapy for children with specific genetic mutations, has improved five-year survival rates and quality of life for these patients....
SourcePrincess Máxima Center for Pediatric Oncology·TypeRandomized controlled/clinical trial·DateDec 10, 2022
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Gene variants associated with leukaemia produce 'rogue' killer T cells that drive autoimmune diseases, according to a new study. These rogue cells can cause autoimmune disease even at low levels, highlighting the connection between leukaemia and autoimmunity.
SourceGarvan Institute of Medical Research·JournalImmunity·TypeExperimental study·DateNov 28, 2022
A team of researchers discovered that the gut microbiome plays a critical role in driving granulopoiesis, a process formation of granulocytes, in mice models. The study found that alterations in the gut microbiome composition induced by neutropenia stimulate reactive granulopoiesis via interleukin 17A secreted by T cells, promoting neu...
SourceHokkaido University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateNov 21, 2022
Researchers found that MK256 induced differentiation and maturation in leukemia stem cells, inhibiting proliferation of AML cell lines. The study also showed dose-dependent inhibition of the STAT pathway in both in vitro and in vivo studies.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateNov 10, 2022
Scientists have discovered that leukemia cells can change their DNA read-out to evade treatment, making them harder to treat. The study identified key genetic changes that allow cancer cells to survive and relapse.
SourcePrincess Máxima Center for Pediatric Oncology·JournalBlood·TypeExperimental study·DateNov 1, 2022
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DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A multistate study found that mRNA COVID vaccines were less effective in immunocompromised adults, with protection rates ranging from 34% to 71% after multiple doses. The study emphasizes the importance of non-pharmaceutical interventions, such as masks and antibody treatment, for additional protection against severe COVID-19.
Researchers investigated the possible connection between maternal obesity and an increased risk of acute lymphoblastic leukemia in children. Changes in fetal epigenetics, insulin-like growth factor profiles, and immune cell populations have been proposed as potential explanations for this association.
SourceUniversity of Minnesota Medical School·JournalLeukemia Research·TypeMeta-analysis·DateSep 28, 2022
Researchers engineered immune cells to control two major complications of leukemia treatment: graft-vs-host disease and cancer relapse. The approach, using a protein called OX40, showed promise in animal models, protecting against both conditions without severely impairing the immune system.
SourceBaylor College of Medicine·JournalBlood·TypeExperimental study·DateSep 27, 2022
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Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers at the University of South Australia are using new technologies to speed up blood cancer diagnosis and treatment. The project aims to identify genetic variants that cause cancer, enabling clinicians to provide targeted treatments and improve patient management.
SourceUniversity of South Australia·TypeData/statistical analysis·DateSep 27, 2022
The NCCN Annual Congress on Hematologic Malignancies will address key findings on chronic lymphocytic leukemia management and CAR T-cells in diffuse large B-cell lymphoma. The event also features updates on immunotherapies in multiple myeloma treatment.
SourceNational Comprehensive Cancer Network·DateSep 27, 2022
Researchers found that 12% of cancer survivors lived in poverty, experiencing negative effects on physical and mental health. Financial burden of cancer care persists years after diagnosis, leading to poor health outcomes and increased mortality.
SourceMedical College of Georgia at Augusta University·JournalJCO Oncology Practice·DateSep 15, 2022
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers have found that delivering a cellular metabolite via tiny particles called nanoliposomes can augment the beneficial effects of certain anti-leukemia drugs in models of acute myeloid leukemia. The study also uncovered several mechanisms behind these effects.
Researchers found that gut commensal bacteria enhance the pathogenesis of a tumorigenic murine retrovirus by upregulating genes that suppress the immune response. This ability to evade the immune system allows tumors to develop and progress in mice infected with the virus.
SourceUniversity of Chicago·JournalCell Reports·TypeExperimental study·DateSep 13, 2022
Scientists discover that methotrexate causes oxidative damage to the cerebrospinal fluid and choroid plexus, leading to cognitive impairment. Adding antioxidants to the CSF may protect against this damage, offering a potential treatment for 'chemo brain'. Researchers are exploring other chemotherapy drugs and testing antioxidant treatm...
SourceBoston Children's Hospital·JournalNeuron·DateSep 13, 2022
A recent study published in Frontiers in Pediatrics suggests that modern immunotherapies, such as CAR-T cell therapy, could replace traditional stem cell transplantation for high-risk ALL patients. The review also discusses the importance of reducing long-term side effects, including organ damage and secondary cancers.
SourceSt. Anna Children's Cancer Research Institute·JournalFrontiers in Pediatrics·DateSep 7, 2022
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers sequenced 2,574 pediatric ALL patient samples, identifying 376 significantly mutated genes that potentially drive cancer development. The study provides a foundational guide for physicians and scientists to understand disease development and improve treatment outcomes.
SourceSt. Jude Children's Research Hospital·JournalNature Genetics·TypeExperimental study·DateSep 1, 2022
A KAUST-led research team identified two drug treatments that boost the activity of molecules involved in cell adhesion, enhancing the ability of blood-forming stem cells to enter the bloodstream and produce new blood. This breakthrough could lead to improved bone marrow transplant success for leukemia patients.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalBlood Advances·DateAug 25, 2022
Researchers developed a method to produce generic CAR T cells from induced pluripotent stem cells (iPS cells), which could be produced at scale for multiple patients. The new cells showed enhanced anti-tumor activity and comparable efficacy to current clinical-grade cells.
SourceBoston Children's Hospital·JournalCell Stem Cell·DateAug 4, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Leukemia cells exploit metabolic pathways to evade programmed cell death, but researchers identified a weak spot in acute lymphoblastic leukemia that can be targeted with experimental drugs. Inhibiting glutathione metabolism induces ferroptosis, leading to the death of malignant lymphocytes.
SourceJosep Carreras Leukaemia Research Institute·JournalRedox Biology·TypeExperimental study·DateAug 1, 2022
A study found that a majority of online pharmacies selling imatinib, a chronic myeloid leukemia therapy, are uncertified and operate unsafely. Patients may face risks of nonadherence, treatment failures, and adverse events if they use these pharmacies.
SourceNational Comprehensive Cancer Network·JournalJournal of the National Comprehensive Cancer Network·TypeSystematic review·DateJul 28, 2022
Researchers have discovered eight potential leukemia-killing compounds that target mitochondria, inducing mitophagy to weaken cancer cells. The compounds showed significant synergy with existing chemotherapy drugs, offering a deadly one-two punch against leukemia.
SourceRice University·JournalLeukemia·TypeExperimental study·DateJun 30, 2022
Researchers discovered a rare type of thymocyte cell, known as EADN, which can transform into leukemia in some patients. The discovery could lead to personalized treatments for each person's unique cancer case.
SourceUniversity of Missouri-Columbia·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJun 27, 2022
A joint study by Finnish and US researchers has found a new combination of drugs that is effective against T-acute leukaemia, with temsirolimus and dasatinib showing enhanced synergistic effect. The therapy has shown promise in eradicating leukaemia cells in zebrafish and human disease.
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GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A groundbreaking study using cellular barcoding in mice reveals that blood cells originate from two independent sources: hematopoietic stem cells and embryonic multipotent progenitor cells. These findings have significant implications for understanding blood cancers, bone marrow transplant, and the aging immune system.
SourceBoston Children's Hospital·JournalNature·DateJun 15, 2022
A new study explains how leukemia cells can transform into harmless immune cells through epigenetic changes, potentially leading to novel therapies for blood malignancies. The METTL3 gene is identified as a key controller of this process.
SourceJosep Carreras Leukaemia Research Institute·JournalLeukemia·TypeExperimental study·DateJun 9, 2022
Researchers discovered that leukemia-initiating cells in MLL-rearranged B-ALL can switch between two metabolic states, which makes them difficult to target. Targeting the quiet, stem cell-like state curbs the leukemia by forcing the cells back to an active proliferation state.
SourceBoston Children's Hospital·JournalCell Reports·DateJun 1, 2022
A new study reveals a gene called KLF4 that normally suppresses tumor formation but is reprogrammed in acute promyelocytic leukemia, an aggressive type of blood cancer. Overexpressing KLF4 can suppress the growth of cancerous cells and reverse the effects of the disease.
SourceCenter for Genomic Regulation·JournalGenes & Development·TypeExperimental study·DateApr 20, 2022
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Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers at the University of Sussex have discovered a potential new target for treating acute myeloid leukaemia (AML) by understanding how two oncoproteins interact within cancer cells. The study found that beta-catenin and Wilms Tumour 1 proteins physically interact, impacting each other's oncogenic signalling activity.
SourceUniversity of Sussex·JournalHaematologica·DateApr 20, 2022
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
SourceUniversity of California - Los Angeles·JournalNature·TypeObservational study·DateApr 13, 2022
A study by University of Helsinki researchers found that the immune system attacks itself in rare type of blood cancer. The immune system plays a role in the development and growth of cancer cells, making current therapies less effective.
SourceUniversity of Helsinki·JournalNature Communications·DateApr 11, 2022
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Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Dr. Philip D. Greenberg has been elected as the American Association for Cancer Research President-Elect for 2022-2023. He will work to harness advances in cancer research and translate them for patient benefit, with a focus on addressing disparities in minority engagement.
SourceAmerican Association for Cancer Research·DateApr 5, 2022
Researchers discovered that a genetic mutation causing odd-shaped nuclei may lead to earlier diagnosis and treatment of certain leukemias. The study found that the loss of nuclear Lamin B1 induces defects in nuclear morphology and genome instability, setting the stage for cancer.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalCell Stem Cell·TypeExperimental study·DateApr 4, 2022
Ira Mellman, PhD, is being honored with the 2022 AACR-CRI Lloyd J. Old Award in Cancer Immunology for his seminal work on dendritic cell function and its impact on atezolizumab and neoepitope vaccines. His research has made a major impact on cancer immunology and has the potential to stimulate new directions.
SourceAmerican Association for Cancer Research·DateApr 1, 2022
Hokkaido University scientists have identified CDK6 as a promising target for treating adult T-cell leukemia/lymphoma (ATLL) with the drug palbociclib. The combination of palbociclib with everolimus also showed significant tumor growth reduction and minimal side effects in mice models.
SourceHokkaido University·JournalBlood·TypeExperimental study·DateMar 31, 2022
Research at Universidad Complutense de Madrid found that tumour cells from childhood acute lymphoblastic leukaemia (ALL) can hide in the subventricular neurogenic niche, causing relapses and preventing new neurone generation. This discovery may explain cognitive and sensory alterations in ALL survivors.
SourceUniversidad Complutense de Madrid·JournalHaematologica·TypeExperimental study·DateMar 30, 2022
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GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A CHOP-led study found bortezomib significantly improved overall survival in children and young adults with newly diagnosed T-cell lymphoblastic lymphoma. The trial also showed that intensifying the chemotherapy regimen allowed for elimination of radiation in nearly all patients, resulting in excellent outcomes.
SourceChildren's Hospital of Philadelphia·JournalJournal of Clinical Oncology·DateMar 10, 2022
Scientists at the Princess Máxima Center for Pediatric Oncology discovered a new combination treatment strategy for childhood T-cell acute lymphoblastic leukemia (T-ALL) by analyzing protein activity. The study found that blocking specific proteins, such as LCK and SRC, in combination with an overactive chain reaction of INSR/IGF-1R, k...
SourcePrincess Máxima Center for Pediatric Oncology·JournalNature Communications·TypeExperimental study·DateFeb 25, 2022
Researchers at UNC Lineberger Comprehensive Cancer Center have developed a new therapeutic approach using a small-molecule inhibitor of the chromatin-modulatory enzyme EZH2 to target aggressive cancer cells. The treatment also targets cMyc, a prominent cancer-causing factor, and shows profound tumor killing effects.
SourceUNC Lineberger Comprehensive Cancer Center·JournalNature Cell Biology·TypeExperimental study·DateFeb 24, 2022
Researchers have identified a group of clinical signs that can be paired with genetic testing to better inform the timing of more aggressive treatment for leukemia patients. The study used a mouse model to understand how genetic mutations trigger bone marrow failure and life-threatening complications.
SourceUniversity of Wisconsin-Madison·JournalScience Advances·TypeExperimental study·DateFeb 22, 2022
Scientists at Stanford University and SLAC National Accelerator Laboratory have created a molecular cage to study the structure of KIX, a protein used by AML cancer cells. The technique has successfully imaged KIX with cryo-EM, revealing new insights into its function and potential targets for therapy.
SourceDOE/SLAC National Accelerator Laboratory·JournalACS Central Science·TypeExperimental study·DateFeb 11, 2022
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Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.