Articles tagged with Melanoma
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Researchers discover DNA methylation marker that influences PD-L1 expression on cancer cells, shedding light on why new therapies don't work for some patients. The findings suggest epigenetic therapies could be used in combination with immunotherapy to treat melanoma patients.
A University of Colorado Cancer Center study shows that combining radiosurgery with immunotherapy, especially PD-1 inhibitors, can significantly improve cancer control and overall survival in melanoma patients. The study found that patients treated with anti-PD-1 therapies had a median brain metastasis-free survival of not reached, whe...
A recent study published in Clinical Cancer Research found that older melanoma patients are more likely to respond to anti-PD1 immunotherapy compared to younger patients. Researchers analyzed data from 538 patients with melanoma treated with pembrolizumab and found a 13% decrease in progression rates for each decade of life.
The ILLUMINATE-204 trial shows an overall response rate of 38% with 2 complete responses, suggesting a promising strategy for treating patients with metastatic melanoma unresponsive to PD-1 therapy. The combination regimen is generally well-tolerated, with fewer than a quarter of patients experiencing immune-related toxicities.
A deep learning convolutional neural network (CNN) outperforms experienced dermatologists in diagnosing skin cancer, detecting 95% of melanomas at level I. The CNN's performance improves with additional clinical information, highlighting its potential as an aid for physicians.
Research presented at the European Congress on Obesity shows that obesity surgery is associated with a 61% fall in malignant melanoma risk and a 42% drop in skin cancer risk. The study suggests that weight loss in individuals with obesity can reduce the risk of deadly melanoma, which has steadily increased in many countries.
Researchers aim to develop a virtual biopsy tool that can guide patient care without the need for invasive skin cuts. The technology uses multiphoton microscopy and machine learning techniques to provide high-quality images of melanin, enabling doctors to diagnose melanoma more accurately.
A new study found that daily aspirin use is associated with a nearly double risk of melanoma in men compared to those who do not take aspirin. In contrast, women taking daily aspirin did not have an increased risk of melanoma. Researchers suggest increasing patient education about sun exposure and skin checks for high-risk individuals.
A team of melanoma experts at Moffitt's Center of Excellence will investigate the causes and drivers of acral melanoma, a rare form of skin cancer affecting African-Americans. The three-year grant aims to develop better prevention and treatment strategies for this aggressive disease.
A USC study reveals teenage minorities in Los Angeles are struggling with tanning addiction, associated with marijuana abuse and obsessive-compulsive disorder. The condition is more prevalent among Native Hawaiian and Pacific Islanders, highlighting the need for targeted education and services.
A combination of XL888, a HSP90 inhibitor, and vemurafenib, a BRAF inhibitor, was found to be safe and effective in treating advanced melanoma patients, with 75% experiencing a response. The treatment resulted in manageable toxicities and durable responses.
Researchers found that married patients with melanoma are more likely to present with early-stage tumors and undergo sentinel lymph node biopsies, leading to better patient outcomes. The study analyzed over 52,000 patients with no distant metastases from 2010 to 2014.
Researchers identified a novel therapeutic vulnerability in NRAS mutant melanoma, using a combination of BET and MEK inhibitors. The combination treatment showed potent anti-tumor effects and prolonged survival in mice with melanoma resistant to targeted therapies and immunotherapies.
Researchers at University of Texas M. D. Anderson Cancer Center discovered a rare pre-existing mutation in PIK3CA that causes rapid drug resistance in melanoma patients. The study found that this mutation was present in the tumor before treatment and rapidly expanded after treatment, leading to swift disease progression.
Researchers found that repurposed leukemia drugs can inhibit the secretion of pro-metastatic cathepsins in melanoma. This is due to ABL kinases increasing activity, which regulates transcription factors and induces gene expression. The study also showed that approved leukemia drug inhibitors prevent metastasis.
Research finds obese male patients treated with targeted or immune therapies live significantly longer than those with a normal BMI. The 'Obesity Paradox' suggests that obesity may improve survival in men with metastatic melanoma, contradicting prior assumptions about the impact of weight on cancer outcomes.
Researchers from Saarland University conducted a systematic meta-analysis of studies on sunbed use and malignant melanoma. While they found an association between the two, they identified significant methodological shortcomings in earlier studies. Moderate solarium use was not shown to increase the risk of malignant melanoma.
Researchers found that patients who received a combination of BRAF and MEK inhibitors before and after surgery had a six-fold increase in time to progression compared to standard-of-care surgery. The study suggests that presurgical targeted therapy may improve outcomes for patients with high-risk stage 3 melanoma.
Researchers at the University of Pennsylvania have identified a new therapeutic target for melanoma, G protein-coupled estrogen receptor (GPER), which shows promise in combination with anti-PD-1 inhibitors. Activation of GPER may explain why women who have been pregnant have better survival outcomes when facing deadly skin cancer.
Researchers at Penn State found that melanoma patients who received immunotherapy with beta blockers lived significantly longer than those without, with five years survival rates of 70% vs. 25%. The study suggests reducing physiological stress with beta blockers can improve the effectiveness of immunotherapy.
Researchers at the University of East Anglia have discovered that combining an immunosuppressive arthritis drug, leflunomide, with a melanoma treatment may enhance its effectiveness. The study found that the combination almost completely stopped the growth of a melanoma tumor in mice.
A recent study examined the skin cancer history and habits of active Florida firefighters. The research found that 4.5% of participants had skin cancer, with a significantly higher frequency of melanoma (0.7%) compared to the general U.S. population. Non-work-related sun exposure may be contributing to this increased risk.
Researchers at Georgia State University have developed a blood test that can diagnose two types of cancer, lymphoma and melanoma, using mid-infrared spectroscopy. The test has shown promising results in differentiating between healthy mice and those with tumorous conditions, and could potentially be used for screening humans.
A study from Karolinska Institutet found that family members without an inherited CDKN2A mutation still have a higher risk of developing melanoma. This phenomenon, called phenocopy, is attributed to other risk-modifying genes or environmental factors within the families.
A novel compound omaveloxolone has been shown to restore immune response in patients with melanoma, improving antitumour responses when combined with checkpoint inhibitors. The study found a 57% overall response rate in patients who had not received prior checkpoint inhibitor treatment.
A study by UMMS researchers has identified a protein called GDF6 as a primary role in metastatic melanoma, found to be expressed in 80% of human melanomas and correlated with increased melanoma growth and spread. The findings offer new therapeutic potential for treatment-resistant skin cancer.
A team of McMaster University graduates has developed a skin cancer detection device called The sKan, which creates a thermal map on the region of interest on the skin. The device is made up of 16 temperature-sensitive components and assists physicians in detecting melanoma by providing quantitative information about skin spots.
A study found circulating tumor cells (CTCs) associated with relapse in stage IV melanoma patients, suggesting a potential predictor for high-risk disease progression via liquid biopsy. CTCs were detected in approximately 40% of advanced stage melanoma patients and linked to faster relapse rates.
A University of Colorado Cancer Center study finds a genetic change called ALK-fusion in a patient sample of a melanoma subtype called mucosal melanoma. Treated with FDA-approved drugs, the tumor responded dramatically. The study suggests that these non-sun-exposed melanomas may be more susceptible to targeted treatments.
A new Cleveland Clinic study emphasizes the significance of prompt treatment in stage I melanoma, with patients treated within 30 days showing better survival rates. Delayed treatment beyond 90 days led to significantly worse outcomes, especially among older patients and those with comorbidities.
Researchers found a strong association between certain beneficial gut bacteria and improved response to immunotherapies in patients with metastatic melanoma. The beneficial bacteria, including three specific species, were found to prime the immune system to attack cancer cells more effectively.
A new study found that delays in melanoma surgery are common among Medicaid and privately insured patients, highlighting the need for better access to specialty care. The likelihood of surgical delay decreased when dermatologists performed operations or made diagnoses.
A study found that Medicaid patients experienced surgical treatment delays more frequently than those with private insurance for melanoma surgeries. Non-white patients and those without dermatologist referrals also faced longer wait times.
A study using temporary tattoos helped medical students develop a greater understanding of skin cancer and empathy for patients. The study found that wearing a realistic tattoo provided a powerful experience, allowing students to consider the person behind the illness.
A recent study published in the Journal of Health Communication found that illustrations are more effective than photos in helping people spot problematic moles during skin self-examinations. The research uses eye-tracking technology to show that participants fixate on atypical moles longer with illustrated visuals, leading to increase...
The COMBI-AD trial found that combination dabrafenib and trametinib therapy doubled relapse-free survival in stage III BRAF-mutant melanoma patients. The treatment was also shown to improve overall survival, distant metastases-free survival, and freedom from relapse.
The CheckMate 238 trial demonstrated that adjuvant nivolumab is superior to standard of care ipilimumab in patients with high-risk stage III/IV melanoma, resulting in improved relapse-free survival and reduced side effects. Nivolumab's benefits were observed across various patient subgroups.
Researchers from Boston University School of Medicine discovered that enhancing palmitoylation in the variant MC1R protein of redheads can reduce cancer risk for melanoma. This finding offers a potential alternative strategy to prevention by reducing sun exposure, which has been the focus of public health work.
Early FDG-PET/CT scanning can accurately predict melanoma patients' response to immune checkpoint inhibitor therapy, providing a more effective treatment approach. The study developed criteria with high sensitivity, specificity, and accuracy, identifying a small increase in tumor uptake as an indication of responsiveness.
Researchers developed an AI system to analyze skin lesion images and detect melanoma biomarkers, reducing unnecessary biopsies and improving early detection of deadly skin cancer. The technology provides objective data on eumelanin and hemoglobin levels, helping doctors rule out melanoma before invasive action.
A new study found that sharing personalized melanoma genomic risk information with relatives and friends can lead to increased discussions about skin cancer prevention. The study suggests that this process could encourage healthy behavior change within families.
A recent study published in JAMA Dermatology identified key features linked to amelanotic melanoma, including the absence of moles on the back, multiple freckles, and sun-sensitive traits. These characteristics may trigger doctors and patients to pay attention to pink spots that could be indicative of this type of skin cancer.
A study found that kidney transplant recipients have a higher incidence of melanoma compared to the general population, with risk factors including older age, male sex, and white ethnicity. Long-term immunosuppressive therapy contributes to this increased risk.
The University of Sussex is conducting vital skin cancer research with a new £428K grant. The project focuses on targeting the PHIP(2) protein, which is present in high amounts in melanoma and other aggressive cancers.
A new international study involving 3,500 patients found that removing all lymph nodes in the area closest to the melanoma may not provide a significant survival advantage. The study suggests that patients can be spared from complications and repeat hospitalizations if only their sentinel lymph node is removed.
Researchers found that patients with Parkinson's were four times more likely to have a history of melanoma than those without the disease. In contrast, people with melanoma had a fourfold higher risk of developing Parkinson's. The study suggests that common environmental or genetic factors may underlie both conditions.
Researchers at CNIO have developed a technique to study melanoma progression in mice, revealing unknown mechanisms and identifying new markers of metastasis. The MIDKINE protein has been identified as a key factor in melanoma metastasis, representing a new therapeutic target.
A new analysis found that delaying lymph node biopsy more than 30 days after melanoma diagnosis does not adversely affect long-term clinical outcomes. The study examined 2,483 patients and found similar results in disease-free survival and melanoma-specific survival.
A study of US pathologists reveals that melanoma diagnoses can be inaccurate and non-reproducible, particularly in the middle of the disease spectrum. The results suggest that only cases at the polar ends of the spectrum are accurately diagnosed.
New research from Swiss Tropical and Public Health Institute finds that radon increases the risk of developing malignant skin cancer, with a 50% increase in risk for 30-year-olds. The study highlights the importance of reducing residential radon exposure through appropriate house construction.
A major new study published in The New England Journal of Medicine found that completion lymph node dissection, a procedure to remove all lymph nodes near the original tumor, does not increase overall survival rates for melanoma patients. However, it can help gauge cancer spread and disease-free time.
A new robot technology reveals that the ADAM10 signalling pathway is activated during melanoma transformation, enabling a better diagnosis and potential simplification of detection methods. The research suggests avoiding cosmetic products with aluminium, which can activate this pathway.
A CNIO researcher has been funded by the Melanoma Research Alliance to study brain metastasis in melanoma, focusing on blocking cancer cell spread by targeting the microenvironment. The goal is to develop a new concept of treating metastasis in personalized medicine.
Researchers analyzed data from large-scale studies of erectile dysfunction medication users and found an overall 11% increase in melanoma risk. However, they attribute the increased risk to detection bias rather than a direct cause-and-effect link between medications and melanoma.
Researchers have discovered that FES, a protein previously linked to cancer development, actually acts as a tumor suppressor in melanoma. The study found that restoring FES expression through epigenetic drugs may provide a novel therapeutic strategy against melanoma.
The Melanoma Research Alliance awarded Dr. Neville Sanjana a grant to use CRISPR technology to identify genetic mutations causing immunotherapy resistance in melanoma. The goal is to create a list of actionable mutations for patients enrolled in melanoma immunotherapy trials.
Researchers analyzed data on 2,025 women diagnosed with stage I to IV melanoma and found no significant differences in prognosis between pregnant and non-pregnant patients. The study upends long-held beliefs about pregnancy and melanoma, showing that screening and treatment should be similar for both groups.
Researchers found significant evidence that inhibiting protein TERT may aid in diagnosis and treatment of acral lentiginous melanoma (ALM). In laboratory experiments, over 75% of ALM cancer cells were affected by a drug that inhibits TERT.
The article reviews current screening practice for melanoma in the US, highlighting risk groups and proposing full screening recommendations. The authors critically assess the USPSTF's 2016 Draft Recommendation Statement and propose evidence-based guidelines for screenings.
Researchers have identified mutations in the SF3B1 gene present in 37% of mucosal melanoma samples, which could lead to novel therapies. The study highlights the potential of targeting this gene in patients with advanced mucosal melanoma.