Researchers at the University of Wisconsin-Madison have created an antibody that selectively links to a protein on highly aggressive brain cancer cells, causing them to light up in PET scanners. This breakthrough could lead to improved diagnosis and treatment of glioblastoma multiforme, a deadly form of brain cancer.
SourceUniversity of Wisconsin-Madison·JournalProceedings of the National Academy of Sciences·DateNov 9, 2015
A possible solution to the inflammatory side effects of Alzheimer's immunotherapy has been discovered by researchers from the University of Southampton. They engineered three new antibodies that preserved immunotherapeutic activity while reducing inflammation.
SourceUniversity of Southampton·JournalActa Neuropathologica·DateNov 5, 2015
Researchers discovered that introducing a specific strain of bacteria into mice with melanoma boosted their immune systems to attack tumor cells. The findings suggest that manipulating gut bacteria can improve immunotherapy outcomes, providing a new approach to treating cancer.
SourceUniversity of Chicago Medical Center·JournalScience·DateNov 5, 2015
Researchers discovered that anti-PlGF antibody treatments, such as aflibercept, may slow the progression of dry age-related macular degeneration. The study found that PlGF actually worsened retinal damage in mice, but an anti-PlGF treatment provided protection against light-induced degeneration.
SourceAssociation for Research in Vision and Ophthalmology·JournalInvestigative Ophthalmology & Visual Science·DateNov 3, 2015
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A study by Rice University researchers has solved a long-standing mystery about the storage and secretion of blood-clotting factor VIII. The protein is both stored and secreted from a specialized organelle in endothelial cells, which line the walls of blood vessels.
Researchers can improve research and reduce costs by replacing animal-derived antibodies with modern technologies like recombinant antibodies and aptamers. This switch has the potential to save tens of thousands of animals from suffering in laboratories.
SourcePeople for the Ethical Treatment of Animals (PETA)·JournalBiotechnology Advances·DateOct 26, 2015
Researchers have found that a deadly fish virus, viral hemorrhagic septicemia virus (VHSv), is still circulating in Lake Winnebago, Wisconsin. Despite efforts to slow its spread, the virus can survive in infected fish, potentially leading to future outbreaks.
SourceUniversity of Wisconsin-Madison·JournalJournal of Clinical Microbiology·DateOct 23, 2015
Researchers have discovered a candidate target for a dengue virus transmission-blocking vaccine, which interferes with the virus's infection of mosquitoes. The target protein, CRVP379, is required during DENV infection in mosquito cells and whole mosquitoes, and its expression levels correlate with the level of DENV infection.
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers at The Scripps Research Institute have discovered a way to convert leukemia cells into cancer-killing immune cells using a rare human antibody. The induced NK cells can detect and eliminate cancer cells, offering a potential new therapy for leukemia and possibly other cancers.
SourceScripps Research Institute·JournalProceedings of the National Academy of Sciences·DateOct 19, 2015
A team of Caltech biologists has created a non-surgical approach to deliver long-term contraception using a single shot, rendering animals infertile for up to two months. The technique targets the 'master regulator of reproduction,' gonadotropin-releasing hormone (GnRH), neutralizing its effects and preventing conception.
SourceCalifornia Institute of Technology·JournalCurrent Biology·DateOct 6, 2015
A team of researchers from the University of Pennsylvania School of Medicine has elucidated the structure of a protein complex at its root, which may hold therapeutic potential for treating heparin-induced thrombocytopenia (HIT). The study found that an antibody called RTO disrupts this complex, preventing platelet activation and clot ...
SourceUniversity of Pennsylvania School of Medicine·JournalNature Communications·DateOct 6, 2015
A team of researchers found that sialic acid reduces antibody-induced cell killing, offering potential treatment for autoimmune diseases. Antibodies with this sugar structure are detectable more frequently in healthy individuals than those with autoimmune diseases.
SourceUniversity of Zurich·JournalJournal of Clinical Investigation·DateOct 6, 2015
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A new approach using DNA nanomachines can detect specific antibodies in five minutes, enabling rapid and affordable point-of-care diagnostics for infectious diseases like HIV. This technology promises to reduce healthcare costs and treatment initiation delays.
SourceUniversity of Montreal·JournalAngewandte Chemie·DateOct 6, 2015
Researchers develop rapid and efficient method to target protein modification, enabling precise attachment of synthetic molecules. This technique has potential applications in antibody-drug conjugates for tumor therapy, outperforming existing methods.
SourceLudwig-Maximilians-Universität München·JournalAngewandte Chemie·DateSep 28, 2015
Genetic mutations in Ebola virus appear to block antibody-based treatments from warding off infection. The mutations, or 'escape variants,' have implications for the continued development of therapeutics to treat Ebola virus disease, which has claimed over 11,000 lives in West Africa.
SourceUS Army Medical Research Institute of Infectious Diseases·JournalCell Reports·DateSep 11, 2015
A team of researchers from the USA, England, Australia, and Germany will collaborate on a three-year project to better understand the information processing in germinal centres of lymph nodes. The goal is to gain insights into antibody formation and develop targeted therapeutics for infections.
SourceHelmholtz Centre for Infection Research·DateSep 2, 2015
Patients with autoimmune hepatitis who present with cirrhosis at first diagnosis and those with SLA/LP antibodies have a higher risk of relapse, liver transplant, and reduced life expectancy. The presence of SLA/LP antibodies is linked to poor overall and liver transplant-free survival.
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Study finds that certain IgG3 and IgG4 donor-specific HLA antibodies correlate with distinct patterns of antibody-mediated injury to transplanted organs. Patients with mostly IgG3 antibodies have a higher likelihood of organ rejection soon after transplantation, while those with mostly IgG4 antibodies experience delayed rejection.
SourceAmerican Society of Nephrology·JournalJournal of the American Society of Nephrology·DateAug 20, 2015
Researchers developed a paper-based device that changes color to detect Ebola, yellow fever, or dengue viruses. The test takes minutes and doesn't require electricity, providing a potential solution for remote, low-resource areas.
A team of scientists at Scripps Research Institute has devised an improved method to engineer therapeutic proteins into antibodies, which can persist long enough to be useful. The technique mimics evolution and harnesses the power of large numbers to select rare junction segments that allow inserted proteins to fold and function normally.
SourceScripps Research Institute·JournalChemistry & Biology·DateAug 13, 2015
Scientists have successfully tested a new tumor diagnosis method that uses molecular spies to detect diseased cells and visualize tumors. The method, which combines antibody-based detection with pre-targeting technology, has the potential to improve cancer treatment by using internal radiation.
SourceHelmholtz-Zentrum Dresden-Rossendorf·JournalChemical Science·DateAug 3, 2015
The HVTN 505 study found that the candidate vaccine induced polyreactive antibodies recognizing both HIV and intestinal microbes. These non-specific antibodies may decrease vaccine effectiveness against HIV.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalScience·DateJul 30, 2015
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Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A licensed technology measures anti-HLA antibody secretion from memory B cells, improving kidney transplant efficiency and preventing rejection. Researchers found high-risk patients using this technique, which complements existing antibody measurement methods.
SourceIDIBELL-Bellvitge Biomedical Research Institute·JournalKidney International·DateJul 30, 2015
A study published in PLOS Pathogens found that older individuals are more susceptible to West Nile virus due to impaired immune responses. The researchers discovered that older mice had delayed antibody responses, reduced helper T cells, and lower chemokine levels, leading to higher viral loads and increased brain damage.
A new database, Histone Antibody Specificity Database, has been launched to improve the accuracy of histone antibodies used in epigenetics research. The database provides validated test results for over 100 commonly used antibodies, allowing researchers to select reliable options for their experiments.
SourceVan Andel Research Institute·JournalMolecular Cell·DateJul 23, 2015
A new online portal provides a robust online interactive database to address the 'antibody crisis' in molecular biology. The Histone Antibody Specificity Database allows scientists to find reliable antibodies for their research with higher confidence, using validated test results.
SourceUniversity of North Carolina Health Care·JournalMolecular Cell·DateJul 23, 2015
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A phase 2 trial found that AS03 and MF59 adjuvants increased immune responses to an inactivated H7N9 influenza vaccine, with AS03-adjuvanted formulations inducing the highest antibody response. The study suggests AS03 as a first-line adjuvant for H7N9 vaccines in adults.
Researchers at Rockefeller University discovered that high affinity B cells divide faster during the antibody selection process, giving them an advantage. This discovery builds on earlier work and may have important implications for improving vaccines and understanding lymphomas.
SourceRockefeller University·JournalScience·DateJul 16, 2015
A University of Toronto research team discovered a new link between the genetic cause of ALS and its pathology, suggesting that C9orf72's mislocalization leads to TDP-43 buildup. This breakthrough offers new avenues for research and potential treatment or cure.
SourceUniversity of Toronto·JournalAnnals of Neurology·DateJul 15, 2015
Researchers have discovered a subset of plasma cells in the bone marrow that serve as an immune archive, preserving a catalog of how the body responded to measles and mumps viruses in childhood. These long-lived cells can provide valuable insights for vaccine designers aiming to create long-lasting antibodies.
SourceEmory Health Sciences·JournalImmunity·DateJul 15, 2015
Vanderbilt University Medical Center researchers have developed a large panel of antibody treatments against chikungunya, a flu-like illness with debilitating joint pain. The antibodies can be used to treat infected individuals early in the infection, potentially preventing severe symptoms.
SourceVanderbilt University Medical Center·JournalCell Host & Microbe·DateJul 8, 2015
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers discovered a link between autoimmune diseases and Long QT syndrome, a potentially life-threatening heart condition. Screening and counseling are now recommended for patients with certain medications or abnormal electrolytes.
SourceSUNY Downstate Health Science University·JournalCirculation·DateJul 6, 2015
A new study found that a test can predict which rheumatoid arthritis patients will fail to respond to biologic drugs. Detecting low drug levels and anti-drug antibodies in the bloodstream can help adjust treatments.
SourceUniversity of Manchester·JournalArthritis & Rheumatology·DateJul 3, 2015
Researchers discovered a human antibody specific to dengue virus serotype 2 that protects mice from the virus, regardless of administration timing. The antibody may act as both a preventative and therapeutic agent by locking viral envelope proteins on the surface, preventing them from entering host cells.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateJul 2, 2015
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers developed a new method to map critical chemical tags on proteins, enabling better understanding of protein formation and function. The technique allows pinpointing phosphates' location and studying unstable amino acids like histidine.
A team led by Associate Professor Shee-Mei Lok at Duke-NUS Medical School discovered an antibody that neutralizes dengue virus serotype 2 (DENV-2), making it harder to kill. The finding could help develop dengue therapeutics and is a significant step towards addressing the global dengue pandemic.
SourceDuke-NUS Medical School·JournalScience·DateJul 2, 2015
A Stanford study found that narcolepsy may be triggered by a combination of genetic predisposition and infection, particularly with the H1N1 virus. Researchers discovered elevated antibodies in patients who received the Pandemrix flu vaccine, which was associated with an increased risk of narcolepsy.
SourceStanford Medicine·JournalScience Translational Medicine·DateJul 1, 2015
Researchers at Scripps Research Institute identify new immune molecules that protect against deadly Marburg virus, a relative of Ebola virus. The study provides ingredients needed to develop treatments for future Marburg outbreaks.
SourceScripps Research Institute·JournalPLOS Pathogens·DateJun 29, 2015
Researchers at The Wistar Institute identified specific mutations in H3N2 viruses that made the 2014-2015 flu vaccine less effective. Antigenic drift, a phenomenon where viruses accumulate mutations to evade immune response, was found to be a key factor.
SourceThe Wistar Institute·JournalCell Reports·DateJun 25, 2015
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A single mutation in the H3N2 virus helped it evade the immune system's defenses, making last year's flu vaccine less effective. Researchers have identified this mutation as a key factor in the mismatch between the vaccine strain and circulating strains.
Researchers uncover detailed information on AnAPN1 protein shape and antibody binding sites, enabling the design of more effective mosquito-based vaccines. This breakthrough may lead to a reduced number of infected mosquitoes and eventual disease eradication.
SourceMonash University·JournalNature Structural & Molecular Biology·DateJun 16, 2015
Zhiqiang An received a grant to research how tumors evade therapy, aiming to develop countermeasures for improved immunotherapy success and reduced mortality. The focus is on a type of leukemia affecting tens of thousands in the US.
SourceUniversity of Texas Health Science Center at Houston·DateJun 15, 2015
Researchers found that patients positive for HPV16 E1, E4-7, L1, L2, and E2 antibodies had better overall and progression-free survival compared to those negative. This suggests that these antibodies may be used to identify patients at risk of oropharyngeal cancer recurrence and death.
SourceAmerican Association for Cancer Research·JournalClinical Cancer Research·DateJun 15, 2015
Scientists developed ICeChIP, a new technique to calibrate chromatin immunoprecipitation (ChIP) experiments with an internal standard. This improves accuracy and reproducibility in epigenetic studies, enabling comparisons between experiments and discovery of new findings, including the prevalence of bivalency in stem cells.
SourceUniversity of Chicago Medical Center·JournalMolecular Cell·DateJun 4, 2015
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers discovered that Hepatitis C virus variants work together, sacrificing some to protect others from the immune system. This complex interaction, known as antigenic cooperation, could alter vaccine and treatment strategies.
SourceGeorgia Institute of Technology·JournalProceedings of the National Academy of Sciences·DateMay 26, 2015
Researchers have discovered a novel antibody insecticide that targets the African malaria mosquito, offering an alternative control strategy to halt the spread of the disease. The antibodies work by targeting a key component of the mosquito's nervous system, killing over 90% of infected insects within a day.
SourceThe Company of Biologists·JournalJournal of Experimental Biology·DateMay 20, 2015
A novel antibody, Ab926, has been discovered that can prevent E. coli from attaching to human cell surfaces and also dislodge bacteria already attached. This antibody works by binding to the side of the FimH pocket, rather than directly competing with free-floating mannose.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalPLOS Pathogens·DateMay 14, 2015
A Case Western Reserve University researcher has won a $500,000 NSF CAREER grant to develop tiny sensors capable of detecting insecticides in Lake Erie or determining subtypes of human cancers. The technology combines antibodies with plant viruses to create a large surface area for targeting pollutants or cancer cells.
Scientists at MIT created a new cancer therapy that activates both the innate and adaptive immune systems to attack tumors. The treatment combines an antibody drug with IL-2, which boosts immune responses, resulting in complete tumor disappearance in 80-90% of mice.
SourceMassachusetts Institute of Technology·JournalCancer Cell·DateApr 14, 2015
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Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers at Texas Biomedical are exploring a novel mechanism for Filovirus detection using llama antibodies, which could lead to more sensitive diagnostic tools for Marburg and Ebola viruses. The goal is to develop streamlined tests that can detect all known and emerging strains of these viruses.
SourceTexas Biomedical Research Institute·DateApr 9, 2015
A Phase 1 trial of VSV-ZEBOV, an experimental Ebola vaccine, found it safe and elicited robust antibody responses in all 40 healthy adults who received it. The vaccine showed a favorable safety profile with mild or moderate fever experienced by 30% of participants.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalNew England Journal of Medicine·DateApr 1, 2015
Researchers found that camel antibodies protected uninfected mice from MERS and helped infected mice expunge the disease. The study suggests these antibodies might be therapeutic for MERS patients and protect uninfected household members and healthcare workers.
SourceAmerican Society for Microbiology·JournalJournal of Virology·DateMar 30, 2015
Researchers at CRT and Bioinvent are developing antibodies targeting OX40 and 4-1BB, 'co-receptors' that stimulate killer T-cells. The goal is to reverse tumour cell suppression of immune responses, allowing the immune system to fight cancer.
Researchers at NYU College of Dentistry are working with Rheonix, Inc. on a Phase II grant to develop an affordable point-of-care test for HIV/AIDS detection in remote areas. The test aims to detect both antibodies and viral RNA in a single specimen within under one hour.
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CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A multivalent vaccine candidate induced broad antibody responses in trial participants, including to non-vaccine strains, suggesting a possible solution to evading immunity. The study provides evidence that VLP-based vaccines may overcome antigenic drift, but further development and clinical trials are needed for a vaccine suitable for...
Researchers report significant recovery after a single dose of an experimental treatment targeting interleukin-23, a key immune signaling protein in psoriasis. The study found nearly all patients experienced dramatic improvement in their symptoms, with an average 80% reduction in skin lesions.
SourceRockefeller University·JournalJournal of Allergy and Clinical Immunology·DateMar 13, 2015
Researchers found increased pocket depth and clinical attachment loss in patients with rheumatoid arthritis, highlighting the link between gum disease and joint inflammation. The study also identified Porphyromonas gingivalis antibodies as biomarkers for identifying patients who may benefit from periodontal treatment.
SourceInternational Association for Dental, Oral, and Craniofacial Research·DateMar 12, 2015
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Researchers have successfully treated dogs with hemophilia using a mutant human protein with unusually high blood-clotting power. The treatment eliminated pre-existing antibodies and reversed the bleeding disorder in two years without causing thrombosis or immune reactions.
SourceChildren's Hospital of Philadelphia·JournalBlood·DateMar 12, 2015
Recent research suggests that irisin, believed to travel from muscle to fat tissue after exercise, may not exist in humans. New tests used in previous studies found antibodies were poorly vetted and nonspecific, leading to false positive results.
SourceDuke University·JournalScientific Reports·DateMar 9, 2015
A new study has identified antibodies targeting dopamine D2 receptors and NMDA glutamate receptors in children experiencing their first episode of psychosis. This finding suggests that autoimmunity may play a role in the development of psychosis, offering hope for new treatment approaches.
SourceElsevier·JournalBiological Psychiatry·DateMar 5, 2015