Articles tagged with Immunology
A multidisciplinary research framework is needed to explore links between evolved tolerance to pathogens and their spillover into humans. Hosts can live with pathogens for long periods, creating conditions perfect for spillover, according to a new review.
Researchers at Osaka University found that E-NTPD8 regulates luminal ATP levels, which affects immune cells and promotes inflammation in colitis. Depletion of neutrophils improved symptoms, highlighting the enzyme's role in preventing severe colitis.
Researchers at MD Anderson Cancer Center presented new findings on novel therapeutic approaches, including cell therapy for solid tumors and antibody drug conjugates targeting TROP2. The therapies achieved partial responses in six patients, with an overall response rate of 35.3% and disease control rate of 70.6%.
Researchers at Kanazawa University have identified a new vaccine platform that targets liver cells to induce anti-malaria immunity. The AAV8 vaccine platform was found to be more effective in eliciting a T cell-mediated response in the liver, providing sterile protection against malaria in a murine model.
A study found that elevated mucosal-associated invariant T (MAIT) cell activation is strongly correlated with poor immune coordination and increased mortality in severe COVID-19 patients. In contrast, focused immune responses driven by interferon-alpha are associated with survival.
Researchers at Karolinska Institutet discovered that B cells choose between cell fates to balance acute and memory responses. This understanding could optimize vaccines against viruses or other pathogens.
A small trial found that the low-dose Moderna vaccine generated long-lived T cell immunity comparable to natural infection. The presence of cross-reactive T cells enhanced immune response in younger and older patients alike.
Researchers have created bispecific antibodies that target multiple regions of the SARS-CoV-2 spike protein, neutralizing virus variants and protecting hamsters from clinical disease. The new treatments may be especially effective against emerging variants due to their binding mechanism.
Researchers have identified nine FDA-approved drugs that can effectively suppress SARS-CoV-2 replication in human cells. These compounds have been shown to be safe in humans and could potentially provide an alternative treatment for COVID-19 patients.
Researchers found that viral fossils in Australian marsupials are used to make non-coding RNAs that protect against outside infection. The study suggests that these viral fossils may be helping to immunize animals, potentially providing a mechanism similar to vaccination.
Researchers found that patients with a rare genetic condition may develop chronic inflammatory bone diseases due to an impaired response to interferon gamma. The study suggests that this impairment leads to excessive osteoclast proliferation and increased bone resorption, causing multifocal osteomyelitis.
Researchers have created a new technology to enhance therapeutic antibodies' ability to attack blood cancer cells by leveraging the human immune system. This approach combines IgM and IgG antibodies, resulting in a single molecule with increased complement activation.
A recent study has found that pregnancies complicated by sepsis are associated with a higher risk of cesarean delivery, postpartum hemorrhage, and preterm delivery. Researchers recommend increased prenatal surveillance for patients with sepsis and other serious infections to mitigate these risks.
Researchers found that prior exposure to common cold coronaviruses boosts the body's immune response to SARS-CoV-2, with cross-reactive T cells recognized by the immune system. The study's findings suggest a protective effect against severe disease and improved vaccine efficacy in younger individuals.
The FDA has granted orphan drug status to Octagam 10%, the first and only IVIg treatment for adult dermatomyositis. The therapy is expected to become the first treatment option for adults with this rare disease, which affects approximately 10 out of every million U.S. residents.
Researchers found that high levels of complement protein Ba are a reliable indicator of transplant-associated thrombotic microangiopathy development, contrary to previous reports. The study's findings provide hope for developing prophylactic treatments to prevent the disease.
A new study in mice reveals that mild maternal infections during pregnancy can promote enhanced immunity in offspring, but also increase susceptibility to inflammatory disorders. The research found that the mother's immune response to infection affected epigenetic changes in the fetal intestinal epithelium stem cells.
Researchers have developed a new adaptive radiotherapy strategy called PULSAR, which combines radiation and immunotherapy to improve tumor control. The approach uses artificial intelligence to personalize treatment plans, allowing oncologists to replan cancer treatment in under 30 minutes.
Long-term kidney transplant survival rates in the US have increased significantly over the last three decades, with five-year survival rates for deceased and living donors rising from 66.2% and 79.5%, respectively, in 1996-1999 to 78.2% and 88.1% in 2012-2015.
Researchers at the University of Huddersfield have developed a new approach to combat cancer treatment challenges by creating self-assembled drugs with high specificity towards human cancer cells. The breakthrough demonstrates unprecedented anti-cancer activity and selectivity in laboratory testing.
Early childhood bilharzia damages psychometric measures, cognitive skills, and executive function in children, leading to disadvantaged educational attainment; treatment with praziquantel can reverse detrimental effects within 6 months.
Researchers identified two lectins, Clec4g and CD209c, that strongly bind to the SARS-CoV-2 Spike protein, blocking viral entry into cells. These findings hold promise for developing robust therapeutic interventions against circulating variants.
Scientists discovered beige fat cells mediate subcutaneous fat's brain protection and provide anti-inflammatory effects. Beige fat transplantation restored cognitive function in obese mice with dementia-like behavior.
A large study found that COVID-19 infection during pregnancy is associated with a higher risk of very preterm birth and all preterm births. People of color face disproportionate infection risk while pregnant. Researchers recommend vaccination to reduce COVID-19 infection and prevent preterm birth.
A study found that SARS-CoV-2 antibodies remained stable or increased in healthcare workers seven months after infection, indicating potential protection from pre-existing antibodies against common cold coronaviruses. The results suggest that individuals with higher levels of anti-HCoV IgG and IgA had lower susceptibility to COVID-19.
Scientists identified five human monoclonal antibodies that can neutralize multiple beta-coronaviruses by targeting a conserved structure in the spike protein. These antibodies showed promise in reducing viral load and enhancing immune responses in hamsters, providing potential inspiration for broadly protective vaccines.
A KAIST study found that specific macrophages play a key role in lung damage during COVID-19. The research provides new insights into dynamic immunological changes and could lead to more precise use of immunosuppressive agents.
Researchers discovered that mRNA-1273 vaccine-induced antibodies are a correlate of protection against SARS-CoV-2 infection in non-human primates. The study found that these antibodies, particularly in the lower airways, offer protection against severe disease by reducing viral replication.
A substance from Saussurea controversa has been found to promote bone regeneration by stimulating the conversion of stem cells into osteoblasts. The calcium chelidonate was tested in vitro and in vivo, showing non-toxic effects and increased viable stem cells at low doses.
A new COVID-19 pooling test method, P-BEST, has been developed to identify all positive subjects, including asymptomatic carriers, in a single round of testing. The algorithmic method increases testing efficiency and reduces costs, making it ideal for conducting carrier screening when infection rates are low.
A case series describes immunologic features of mild and moderate COVID-19 in pediatric patients, highlighting distinct clinical characteristics. The study found that hospitalized children with COVID-19 exhibit unique immune responses, which may inform treatment strategies.
A researcher at Penn State is testing the efficacy of common disinfectants against viruses. The study aims to determine the optimal contact time for sanitizing surfaces to reduce the spread of COVID-19.
A recent study found that 3% of NHS hospital staff may be carrying the SARS-CoV-2 virus without realizing they are infected. This could lead to transmission to co-workers, family members, and patients. Regular testing for all staff is crucial to prevent infection spread.
A new DNA test can diagnose chlamydia infection in koalas within 30 minutes, providing on-the-spot results and allowing for quicker treatment decisions. The test, developed using the LAMP method, targets a specific sequence of DNA in the bacteria and has been successfully trialled at Currumbin Wildlife Hospital.
Researchers analyzed 385 patients with transplant glomerulopathy to identify distinct features and outcomes, developing a tool for clinicians to predict health outcomes. The study may help individualize treatments for patients at high risk of transplant failure.
University of Otago researchers have discovered a way to culture cynomolgi malaria parasites, which are almost identical to vivax malaria. This breakthrough could help eliminate the relapsing form of human malaria, a major public health concern worldwide.
Researchers discovered a potential way to prevent mosquito-borne diseases like Zika and dengue by targeting the sphingolipid pathway in the midgut. This approach could stall viral replication and prevent transmission to humans.
Drs. Henry Boom and Moses Joloba at Case Western Reserve University and Makerere University, respectively, have received a $1.5 million five-year grant to strengthen Ugandan biomedical research capacity. The program aims to provide PhD-level training in microbiology and immunology to talented young Ugandan scientists.
Research found that one in 50 citations in top immunology journals were critical in nature, criticizing specific sections or limitations. Negative citations came from close academics but at a significant distance geographically, highlighting social cost of criticism.
Researchers at the University of Leicester have developed an 'electronic nose' that can rapidly detect C. difficile infections by identifying unique chemical fingerprints. This technology holds promise for faster diagnoses and tailored treatment options.
L. Barth Reller, a renowned clinical microbiologist, has been recognized with the 2012 TREK Diagnostic ABMM/ABMLI Professional Recognition Award for his outstanding contributions to the field. He is also an accomplished mentor and trainer of medical microbiologists, having mentored 38 fellows who now hold leadership positions globally.
The FASEB MARC Program has announced the travel award recipients for IMMUNOLOGY 2012, supporting underrepresented minority students and postdoctorates in biomedical research. This year's 25 awards total $41,250, aiming to increase diversity in the field.
The Faculty of 1000 awarded $250 travel grants to 74 Associate Faculty Members who submitted six or more evaluations in 2011. The highest number of evaluations came from Faculties of Cell Biology, Immunology, Neuroscience, and Anaesthesiology & Pain Management.
The FASEB MARC Program has awarded $9,900 to underrepresented minority students and postdoctorates attending the AAI 2011 Advanced Course in Immunology. The program aims to increase diversity in biomedical and behavioral research.
The FASEB MARC Program aims to increase the number of underrepresented minorities engaged in biomedical research, with a total of $1,650 awarded this year. Dr. Patricia B. Lodato from University of Maryland School of Medicine has been selected as the recipient of the FASEB MARC Travel Award.
A study found that individuals with asymptomatic herpes simplex virus type 2 (HSV-2) infection can still shed the virus, highlighting a high risk of transmission to unsuspecting sexual partners. This poses a significant concern for public health and patient management.
The FASEB MARC Program has announced 37 travel award recipients for the 98th Annual Meeting of The American Association of Immunologists. These awards aim to promote diversity in biomedical research by supporting junior faculty and students from underrepresented minority groups.
Researchers have discovered that polymers of amino acid lysine can block the propagation of prions, halting their spread in test tubes and cultured cells. In animal models, mice treated with polylysines showed improved symptoms, longer survival, and lower prion levels
Dr. J. John Cohen is recognized for his work in demystifying science for non-scientists through public programs like Mini Med School, which has inspired similar programs globally. His research on apoptosis and teaching awards have further solidified his commitment to making science accessible.
The 'Cleanair' system reduces building energy consumption by up to 25%, saving CO2 emissions and improving indoor air quality. Lab tests have proven its effectiveness in removing various pollutants, including particles, viruses, and volatile organic compounds, making it a game-changer for asthmatics and overall health.
Researchers developed an immunological purification method to detect synacthen in low concentrations, providing a gap-closing solution for drug testing authorities. This new test confirms the presence of the protein and produces a unique chemical fingerprint.
John Sherris is recognized for his tireless advocacy and leadership in clinical microbiology, including development of standardized susceptibility testing. He also holds an honorary medical degree from Karolinska Institute and has published a highly regarded textbook on medical microbiology.
A Stanford study reveals a connection between archaea abundance and gum disease severity, affecting about one-third of Americans. The research found that more than one-third of patients with chronic periodontitis harbored archaea in their diseased subgingival spaces but not elsewhere.
Researchers at New York Medical College are exploring bacterial antibiotic resistance in salmon aquaculture and developing new diagnostic tests for Lyme disease. The studies aim to improve understanding of the diseases and test new methods for prevention and control.
Dr. Blossom A. Damania has been awarded the $50,000 Gertrude B. Elion Cancer Research Award for her research on tumor virology and Kaposi's sarcoma-associated herpesvirus (KSHV). This award recognizes her groundbreaking work in deciphering how the virus can transform cells into malignancies.
Dr. Hultgren's work on pilus genetics, biosynthesis and structure has contributed significantly to understanding bacterial adhesions critical to pathogenesis. His research applications have led to recognition nationally and internationally.
A rare lung disease thought to affect only people from Japan, China, and Korea has been diagnosed in five US patients with no Asian ancestry. Long-term antibiotic use can effectively treat the condition, but mortality rates remain high if left untreated.