Articles tagged with Immunology
Researchers created a comprehensive human T cell reference for 68 subtypes and states, alongside the STCAT tool, achieving 28% higher accuracy than existing methods. The tool allows users to browse T cell expression profiles and analyze customized scRNA-seq data.
A team of researchers has identified a novel oncometabolite that accumulates in tumors and impairs immune cells' ability to fight cancer. The study highlights how the metabolic environment of tumors influences T cell function, opening new possibilities for improving cancer immunotherapy by targeting tumor metabolism.
Researchers from the International Institute of Molecular and Cell Biology in Warsaw discovered a crucial role of enzyme TENT5A in extending poly(A) tails of therapeutic mRNA molecules, making them more stable and effective. Macrophages play a key role in vaccine effectiveness, capturing and neutralizing 'intruders' after administration.
Researchers developed fluorescent polyionic nanoclays that can be customized for medical imaging, sensor technology, and environmental protection. These tiny clay-based materials exhibit high brightness and versatility, enabling precise tuning of optical properties.
Researchers have found that a specific protein modification to the immune protein MDA5 can block viral replication and reduce heart inflammation. The study's findings could lead to the development of broad-spectrum antiviral treatments that target multiple viruses.
Tulane University scientists developed a handheld device to deliver rapid and accurate tuberculosis diagnoses in under an hour. The device, called the lab-in-tube assay (LIT), can detect Mycobacterium tuberculosis DNA in saliva, blood, and sputum samples, offering a cost-effective tool for improving TB diagnoses in resource-limited areas.
Research reveals pregnancy-induced immune shifts affecting disease susceptibility and delivery outcomes, with adaptations in T cells, B cells, and monocytes identified across stages.
A recent study published in Cell revealed that a specific intestinal immune cell prevents food allergies by breaking the threshold between friend and foe in the gut. Researchers at WashU Medicine identified this cell as RORγt+ dendritic cells, which maintain tolerance to harmless food allergens, preventing allergic reactions.
Scientists at Nano Life Science Institute developed engineered EVs that activate immune cells inside tumors, enhancing immune responses while reducing harmful side effects. The breakthrough could lead to more targeted and effective cancer therapies with fewer side effects.
T cells with low Bach2 levels accumulate in affected areas, leading to chronic symptoms. Modulating Bach2 levels may help reduce atopic dermatitis chronicity.
Researchers at Karolinska Institutet have developed a new method to diagnose COPD by analyzing protein levels in nasal lavage. The study found that elevated IL-26 levels can indicate an early phase of the disease, and may lead to new treatment strategies targeting this cytokine.
Researchers found that NADPH oxidase 2/ reactive oxygen species pathway exacerbates periodontitis in mice with colitis. NOX2 inhibitors reduce ROS levels and inflammation, suggesting a potential therapeutic approach for patients with both conditions.
Researchers developed a new approach to strengthen NK cells' fight against tumors by using CRISPR/Cas9 to eliminate the SMAD4 gene, making them resistant to TGF-β and Activin A molecules. The modified cells showed greater capacity to control tumor growth in both laboratory models and mice.
Researchers found that ultrafine bubble showers significantly suppressed inflammation in mice with atopic dermatitis caused by external factors. The treatment also improved skin protective barrier proteins. However, no significant effects were seen in mice with atopic dermatitis caused by genetic factors.
A research team at Tokyo University of Science has identified two new tetranins in spider mite saliva that reduce reproduction and increase defense responses in plants. The findings have potential for organic farming techniques and more resilient crops, contributing to sustainable agriculture and enhanced food safety.
Researchers found that pancreatic cancer cells gain a survival edge by carrying copies of critical cancer genes on circular pieces of DNA outside chromosomes. The discovery highlights the importance of targeting extrachromosomal DNA in treating the disease.
A recent study published in the Journal of Experimental Medicine reveals that plasma cells are programmed from birth to migrate to protected sites in the body, where they produce large amounts of antibodies. High expression of integrin β7 is an excellent marker for these cells' ability to home to the bone marrow.
Research finds that certain viral antibodies and genetic risk factors can increase MS risk, with elevated antibody levels combined with a specific gene variant associated with strong increased risk. The study also identifies potential biomarkers for early diagnosis.
A new study found that white blood cells that remember past inflammation events are quick to overreact, raising the risk of blood clots. Researchers discovered that these immune cells, called myeloid cells, have increased blood-clotting activity long after the initial inflammatory event.
A team of researchers has identified a critical signaling pathway involved in the recruitment of CD8+ T cells into atherosclerotic plaques. This discovery provides new potential therapeutic strategies for cardiovascular diseases.
Research reveals that even a single night of sleep deprivation can alter the profile of immune cells, similar to those found in individuals with obesity. This suggests that the immune system is highly sensitive to sleep patterns and may contribute to long-term inflammatory states and increased risk of disease.
A new study introduces Mal-ID, a machine learning framework that analyzes immune receptor datasets to identify disease signatures. It achieved high classification accuracy in distinguishing six distinct disease states with a multiclass AUROC score of 0.986.
Researchers have discovered double negative memory B cells, a novel subset of immune cells that are more dysfunctional when in close contact with tumors. These cells may be a useful diagnostic marker and a potential target for developing new immunotherapies.
Three early-career scientists, Dr. Omar Abudayyeh, Dr. Caleb Lareau, and Dr. Yuzhong Liu, are awarded $150,000 grants for their innovative research on human immunology, vaccine discovery, and cancer immunotherapy. Their proposals aim to advance our understanding of the immune system and develop new treatments for deadly diseases.
A study published in The Journal of Immunology found that supplementing maternal diet with vitamin E during pregnancy can reduce the development of food allergy and anaphylaxis in newborn mice. This potential breakthrough could help address the alarming increase in peanut allergy among children.
Researchers at Salk Institute discover SSRIs like Prozac regulate immune response, preventing sepsis in mice. The findings suggest a potential new use for the popular drug, which could lead to life-saving treatments and enhanced global preparedness for pandemics.
Researchers found that people with diabetes are more likely to develop antibiotic-resistant strains of Staphylococcus aureus, which can spread rapidly and evade treatment. Controlling blood sugar levels through insulin use may be key in preventing antibiotic resistance.
Researchers at University of Melbourne and Pfizer discover new insights into a dual-target drug that may supercharge cancer-fighting immune cells, potentially leading to improved outcomes for breast cancer patients. The study found that this approach can enhance anti-tumor immunity by intratumoral CD8+ T cells.
Researchers discovered immune cells that can recognise influenza (flu) viruses even as they mutate, providing a potential solution to the annual updates of flu vaccines. The study found that certain T cells, which play a critical role in fighting infections, can detect multiple flu strains, even those that have evolved over a century.
Researchers at Fujita Health University have developed a novel therapy using mesenchymal stem cells to treat inflammatory eye diseases, reducing inflammation and promoting tissue repair. The study found that adMSC injections effectively reduced inflammation in mice with GVHD without long-term complications.
Researchers at TUM found that cystic fibrosis causes changes in the immune system as early as birth, leading to frequent inflammation and infections. These changes are not affected by CFTR modulator therapies.
Researchers at the University of Melbourne have identified a rare type of immune cell, called stem-like T cells, that holds the key to maintaining powerful, long-term immune responses. ID3+ T cells have the remarkable ability to resist burnout and maintain a powerful immune response over time.
Research from RIKEN Center for Integrative Medical Sciences found that infant gut bacteria are associated with food sensitivities and allergies, particularly to eggs. The study suggests that probiotic supplements, such as Bifidobacterium, may help prevent food allergies in at-risk infants.
Researchers study mucosal mast cells in IgE-mediated food allergy, revealing their role in immune response and potential therapeutic targets. The study sheds light on molecular mechanisms involved in food allergies and offers new avenues for medication development.
The ISS National Lab sponsored over 100 payloads to the orbiting laboratory, achieving the second-highest annual total. The lab also published a record 51 peer-reviewed articles in FY24, advancing scientific discovery and innovation.
Researchers developed MUNIS, a deep learning tool that predicts CD8+ T cell epitopes with high accuracy, potentially accelerating vaccine development. The tool was validated using experimental data from influenza, HIV, and EBV, demonstrating its potential to streamline vaccine design.
A study found that Lrrk2 regulates macrophage functions and immune responses by promoting the M1 phenotype through IFN-γ signaling. This enhances bacterial clearance but also raises potential therapeutic strategies targeting immune pathways for immune-related disorders.
A new study published in Cell reveals significant differences in the immune response of children and adults to cancer, with potential implications for targeted therapies. The research shows that children's tumours are generally less inflammatory and have fewer mutations, making them appear less foreign to their immune system.
The study provides insights into the roles of microglia in neurodegenerative diseases, revealing nine transcriptionally distinct subpopulations. The GPNMB-high Lipo.DAM signature is associated with Alzheimer's Disease and Multiple Sclerosis, and may hold relevance for immune-based therapies.
Researchers discover immune cells regulate blood sugar levels by stimulating glucagon production in the pancreas. This complex neuroimmune-hormonal circuit reveals a new way the body maintains stable glucose levels, especially during periods of low energy.
The International Alliance for Primary Immunodeficiency Societies has partnered with Rockefeller University Press to launch the Journal of Human Immunity, an open-access journal focused on human immunity and inborn errors of immunity. The journal aims to provide a platform for groundbreaking research and attract top-tier submissions.
Researchers discovered that the protein PIN1 drives bladder cancer by triggering cholesterol synthesis, which fuels out-of-control cell growth. A combination of statins and a PIN1 inhibitor effectively blocks tumor growth in mice, offering a promising therapeutic approach for this deadly disease.
Scientists at Salk Institute discovered that removing bile acid-creating protein BAAT and adding bile acid UDCA controls tumor growth in mice with liver cancer. UDCA supplements may be a quick solution to improving liver cancer patient outcomes.
Researchers designed metallo-supramolecular complexes that selectively bind to MPXV mRNA G4, modulating A5L protein expression and immune response activation. These findings highlight the significance of G4s in viral immunodominant protein expression and offer potential avenues for developing antiviral therapeutics.
Research led by University of Pittsburgh scientists found that exposure to long-wavelength red light reduces blood clots in humans and mice. The study's findings have the potential to reduce deaths and disabilities caused by blood clots worldwide.
The Howard Hughes Medical Institute has named 25 new Hanna Gray Fellows, investing up to $1.5 million in each scientist for eight years. This support enables them to pursue challenging questions at the forefront of their fields, driving progress in areas like cancer treatment and animal evolution.
Researchers profiled gene features and immunoregulatory ceRNA in ischemic stroke, identifying 11 distinct immune cell-related genes. The expression of HECW2 was positively correlated with specific lncRNAs through miRNAs, suggesting a potential biomarker and therapeutic target.
Researchers at the Allen Institute have developed a new approach called CryoSCAPE, which stabilizes blood samples to preserve molecular composition and lower costs. This technology will enable broader participation in research studies and clinical trials for underserved communities.
Neuroscientist Professor Raz Yirmiya reveals a vital link between inflammation and depression through groundbreaking research. His work suggests that both activation and suppression of the immune system can trigger depressive symptoms, highlighting the need for personalized treatment approaches.
A recent study found that host genetics, particularly major histocompatibility complex (MHC) class-II polymorphisms, drives individual differences in influenza vaccine response. The research also presents a novel vaccine platform that broadens antibody and T cell responses against diverse influenza subtypes.
A University of Toronto study discovered a new communication pathway between the gut and lung, highlighting the role of a little-known protozoan in shaping immune responses. The study found that this microbe can worsen airway inflammation in allergic asthma but provide protection against respiratory infections.
Scientists at Goethe University Frankfurt have discovered a new way to tailor natural killer cells to target leukemia cells, improving their efficacy. The researchers used CRISPR/Cas9 gene editing to disable an immune checkpoint, allowing the modified cells to attack cancer cells more effectively.
Researchers at RCSI University of Medicine and Health Sciences have discovered that macrophages, a type of immune cell, work differently throughout the day due to the body's internal clock. This daily rhythm determines when immune cells are most efficient at detecting threats and mounts a response.
Researchers at Tokyo University of Science found that kaempferol increases RALDH2 levels in dendritic cells, promoting regulatory T-cell development and reducing inflammation. The study suggests that flavonoids like kaempferol may serve as natural remedies to alleviate allergic symptoms.
Researchers at Salk Institute establish a novel framework for the relationship between nutrition and cell identity. They found that a nutritional switch from acetate to citrate plays a key role in determining T cell fates, shifting them from active effector cells to exhausted cells.
Mirror bacteria, synthetic organisms with reversed molecular shapes, may impair immune defenses in humans, animals, and plants. The researchers call for a global discussion to chart a path towards better understanding and mitigation of potential risks from these organisms.
The University of Arizona Health Sciences has received a second vote of support from Maricopa County, doubling its investment in the Center for Advanced Molecular and Immunological Therapies (CAMI) to $8 million. CAMI will accelerate novel therapies for cancers, autoimmune conditions, and infectious diseases, including COVID-19.
The Cul3/Diap2/Dredd axis plays a crucial role in mediating Drosophila's antimicrobial immune defense. The study identifies Cul3 as a key regulator of this pathway, enhancing the E3 ubiquitin ligase activity of Diap2 and regulating the ubiquitination modification of Death-related caspases.
The Pew Charitable Trusts has funded eight teams of researchers to conduct interdisciplinary biomedical research projects. These partnerships aim to advance scientific discovery and improve human health by combining expertise in cell biology, immunology, neuroscience, and genetics.
A prestigious professorship in immunology has been established at the Walter and Eliza Hall Institute, continuing Sir Gustav Nossal's groundbreaking work on immune tolerance. The position aims to nurture new generations of researchers and advance understanding of immune diseases such as lupus and rheumatoid arthritis.