Articles tagged with Immunology
A new study from Texas A&M University reveals that circadian disruptions change the structure of mammary glands, weaken immune defenses, and fuel aggressive breast cancer. Disabling an immune checkpoint molecule called LILRB4 helps restore the immune system's ability to fight back.
Recent advances in immunotherapy have transformed multiple myeloma treatment, offering durable survival benefits. Emerging targets such as regulatory T cells, myeloid-derived suppressor cells, and tumor-associated macrophages are being explored to enhance treatment efficacy.
A new class of engineered extracellular vesicles can induce antigen-specific regulatory T cells, potentially paving the way for next-generation therapies for autoimmune and allergic diseases. The system uses peptide-MHC complexes to display disease-relevant antigens, allowing for precise control over immune responses.
Researchers outline breakthrough strategies to address poor infiltration of CAR-T cells into solid tumor microenvironments. Vascular normalization and chemokine modulation enhance T cell penetration, while combination therapies with chemotherapy and oncolytic viruses amplify results.
Researchers have identified an effective strategy to reduce structural liver damage and improve hepatic vascular function in cirrhosis. Blocking the PAF-R receptor can help rebalance immune and inflammatory responses within the liver.
Scientists have created a detailed single-cell map of asymptomatic dengue virus infections, revealing distinct immune responses that help protect individuals from the virus without symptoms. The findings could guide the development of safer and more effective dengue vaccines.
Alveolar macrophages, once seen as peacekeepers in the lung, can actually fuel inflammation during allergic reactions. These cells send signals that attract other immune cells, leading to worsened allergic reactions and potentially life-threatening conditions like asthma.
Research from the University of Basel found that individual genetic differences can make antibody-based therapies ineffective in some people. The study analyzed thousands of genetic sequences and discovered a large number of naturally occurring variations in amino acid sequences, which can render treatments ineffective.
Researchers have developed an ultrasensitive liquid biopsy platform to predict and monitor immunotherapy response in advanced cancer patients. The study shows that lower levels of circulating tumor DNA (ctDNA) at baseline are associated with better progression-free survival and overall survival.
A new artificial intelligence model, ImmunoMatch, predicts correct protein pairings within antibodies, potentially strengthening the immune system. This could lead to new therapeutic treatments for various diseases.
A new diagnostic method using AI and genetic information can accurately identify pneumonia in critically ill patients, distinguishing between infectious and non-infectious causes. The model has been shown to reduce inappropriate antibiotic use by over 80% and could lead to faster diagnosis and improved patient outcomes.
Researchers at UVA Health System discover how traumatic brain injury increases Alzheimer's risk and find a potential prevention strategy using a hollowed-out virus to deliver repair supplies. The approach could help limit neurodegeneration and potentially prevent other neurological diseases.
Researchers developed a new way to stimulate the immune system to attack tumor cells by blocking an immune checkpoint. They created multifunctional molecules called AbLecs, which combine a lectin with a tumor-targeting antibody, and showed they could boost the immune response to cancer cells.
A study by University of Zurich researchers has shed light on the mechanisms that maintain homeostasis with mucosal fungi. The team discovered that the fungus Candida albicans uses a toxin called candidalysin to survive in the mouth, and that interleukin 17-mediated immunity prevents it from growing out of control.
A novel diagnostic approach enables rapid detection of both antibiotic resistance and high virulence in Klebsiella pneumoniae, a microorganism driving the global antibiotic resistance crisis. This breakthrough could support timely, targeted therapy and strengthen infection-control strategies in healthcare settings.
Researchers review how haplo-HSCT overcomes HLA barriers to restore immune homeostasis, with up to 30% GVHD rates reduced. Donor immune cells can be re-educated to accept recipients' bodies as 'self', highlighting a process of immune remodeling.
MIT researchers have found a new way to create solid particles of highly concentrated antibodies, suspended in a solution, which can be injected using a standard syringe. This advance could make antibody treatments more convenient and accessible for patients, particularly older people with difficulty visiting hospitals.
The study found that the investigational vaccine produced an immune response in 74% of participants and was safe and well-tolerated. A Phase 2 study is planned to evaluate the vaccine's efficacy, offering new hope for triple-negative breast cancer treatment.
Researchers develop comprehensive method to connect diseases with underlying genetic machinery, revealing intricate gene networks that influence complex traits. The new technique provides actionable insights into how specific genes affect cell functions, shedding light on biological mechanisms and potential therapeutic targets.
Research found that anxiety symptoms reduce circulatory NK cells and sub-populations, while insomnia symptoms decrease total NK cells. This could lead to impaired immune function and increased disease susceptibility.
Researchers discovered that infant nasal organoids divide faster and have different cell types than adult ones, making them more susceptible to RSV infection. The findings suggest that infants' bodies respond with a less coordinated defense against the virus, leading to severe airway blockages and mucus production.
A study by Van Andel Institute scientists found that reducing calorie intake helps cancer-fighting immune cells do their jobs more effectively. The researchers discovered that a low-fat, high-protein diet given once a day promotes the formation of ketones, which act as a cellular fuel for T cells to become more effective tumor fighters.
The Pew Charitable Trusts has funded seven new biomedical research collaborations, bringing together 14 renowned scientists to tackle pressing problems in human health. These interdisciplinary projects will accelerate discoveries and advance understanding of human biology and disease.
NEJM Clinician curates highly relevant clinical insights from over 150 peer-reviewed journals to give physicians clear guidance without the noise. The weekly publication delivers summaries and commentary in a concise, 30-minute read, helping healthcare providers stay informed and confident in their decisions.
Researchers present phase 1 study results of rapcabtagene autoleucel, a rapid CAR-T cell manufacturing platform that reduced production time to under two days. The treatment showed a manageable safety profile and promising antitumor activity, with complete remission rates ranging from 70% to 100% in patients.
A new organ-on-a-chip platform recapitulates age-dependent immune responses, allowing for more accurate testing of cancer vaccines in older adults. The platform reveals functional differences in immune responses between young and old lymphocytes, which are not detectable with traditional 2D cultures.
Researchers at MD Anderson have made significant discoveries in the treatment of rare bile duct cancers, with zanidatamab showing promising results. Additionally, a study identified RASH3D19 as a target to overcome treatment resistance in KRAS-mutant cancers.
Scientists created the first comprehensive map of neutrophils using next-generation sequencing technologies, revealing a stable architecture despite individual cells' short lifespan. This discovery opens new avenues for guiding immunity toward healing and facilitating translation to clinical studies.
A study from the Ragon Institute of Mass General Brigham, MIT and Harvard found that immune cells called CD8+ T cells play a crucial role in controlling HIV. Researchers discovered that having these CD8+ T cell features before treatment was most important for achieving remission.
Researchers at the University of Gothenburg discovered that grey seal milk contains approximately 33% more sugar molecules than breast milk, including unique and powerful compounds against disease-causing bacteria. These findings could lead to improved infant formula and potential applications in human health.
Researchers at MIT discovered how an immune system molecule, interleukin-1 beta, triggers a brain circuit to shut down social behavior in mice. The study found that the molecule activates neurons in the dorsal raphe nucleus, leading to social withdrawal and lethargy.
Researchers discovered that the gut's epithelial cells can translate nerve signals into molecular instructions, such as cytokines, to coordinate immune responses. This system is closely linked to feeding behaviour and daily biological rhythms, suggesting a link between disrupted circadian patterns and 'civilisation diseases' like chron...
Researchers have discovered that rhesus macaques shed TIGIT from immune cell surfaces when exposed to plasmin, a natural enzyme involved in blood clot breakdown. This creates a soluble form of TIGIT that can still bind anti-TIGIT monoclonal antibodies, potentially leading to misleading safety and efficacy data for human trials.
Researchers at LJI have discovered a cellular driver that leads to the development of tissue-resident memory T cells, which specialize in defending specific organs. The study found that GPR25 sustains TGF-\u00b2 signaling, promoting differentiation and transformation into these specialized immune cells.
A new study suggests that pairing modest antiviral therapies with immune modulation can restore damaged tissues and lung function after severe influenza infection. The findings offer a potential foundation for future clinical strategies to improve outcomes in severe acute respiratory disease.
Two first-in-class antibodies, C01 and C04, have been developed to inhibit inflammation in autoimmune diseases by blocking the high-affinity IgG receptor FcγRI. The antibodies were discovered using a unique immunization method and exhibit higher affinity for FcγRI than human IgG.
Scientists have created a complex tissue model of human bone marrow using only human cells, replicating the cellular complexity of the body's 'blood factory'. This breakthrough reduces the need for animal experiments in blood cancer research and potentially enables personalized therapies.
Researchers at UC Santa Barbara propose a cyst-targeted therapy using monoclonal antibodies to interrupt the runaway growth of fluid-filled sacs in polycystic kidney disease. The treatment, targeting a driver of cyst progression, shows promise in slowing or reversing the disease with minimal side effects.
A new study found that patients with advanced basal cell carcinoma may benefit from receiving immunotherapy earlier, with a significant increase in objective response rate. Researchers explored adding relatlimab to nivolumab and saw promising results in overcoming resistance to single-agent anti-PD-1.
Researchers have developed an innovative antibody-based enzyme switch called 'Switchbody', which is activated upon antigen binding. The switch's mechanism relies on a 'trap-and-release' process, offering new opportunities in diagnostics and therapeutics.
Researchers have identified a protein complex that drives T cell exhaustion in tumors and show that disrupting it can revive exhausted anti-tumor CTLs. The study's findings offer new hope for improving the efficacy of cancer immunotherapy.
Researchers found that immune cells in the gut follow an atypical pathway to produce antibodies providing long-term protection against viruses. The study could help guide the development of better vaccines for respiratory viruses like influenza and SARS-CoV-2.
Researchers have made breakthroughs in overcoming immune reactions behind human rejection of transplanted pig kidneys, paving the way for more successful clinical trials. The study reveals three major immune responses against the pig kidney and identifies potential biomarkers as early-warning systems for rejection.
A combination of immunotherapy drugs shows improved response rates and long-lasting tumor suppression in patients with mismatch repair-deficient and microsatellite instability-high cancers. The results broaden treatment options for these biologically aggressive cancers.
A 47-year-old man from New Jersey died after consuming beef due to a tick-borne meat allergy caused by the Lone Star tick's alpha-gal sugar. Researchers identified the allergy and its link to fatal anaphylaxis, urging physicians to investigate severe abdominal pain after eating red meat in areas with high Lone Star tick populations.
Researchers developed a 'humanized' model of aortic valve calcification, enabling testing of potential treatments. The breakthrough could lead to new therapies to stop or reverse calcium buildup, improving outcomes for people with heart disease.
A new study identifies fatty acid elongase ELOVL5 as a key promoter of inflammation resolution in the lungs. The research reveals that ELOVL5 works through a dual mechanism to dampen inflammatory pathways and generate pro-resolving lipid signals.
A team of researchers led by Dr. Michele Ardolino is bridging scientific fields to unlock the mechanisms behind effective immune responses in cancer patients. They will study the interactions between the immune system, nervous system, and gut microbiome to design more personalized treatment strategies.
Researchers at the University of Pittsburgh have developed a skin patch test that can detect antibodies associated with COVID and flu infections. The test uses carbon nanotubes and is orders of magnitude more sensitive than existing tests.
Research at Amsterdam UMC found that early HIV treatment improves immune system function in the short term but leads to dysregulation in the long term. After six months of treatment, the immune system functions similarly to that of people without HIV, but this improvement is temporary and does not last beyond three years.
A study published in Chinese Medical Journal identified tumor-promoting keratinocytes linked to HPV infection and poor prognosis. These cells were found to interact with immune cells, promoting tumor proliferation and differentiation.
A recent review in the Chinese Medical Journal uncovers how circulating tumor cells evade immune elimination, highlighting their interactions with immune cells and blood components. The study suggests new therapeutic targets, including anti-platelet therapy and immune checkpoint inhibitors, to combat cancer metastasis.
A randomized clinical trial has shown that rituximab is effective in preventing relapses and reducing the need for corticosteroids in adults with relapsing nephrotic syndrome. The study involved 66 adult patients treated with either rituximab or a placebo, with impressive results at the 49-week follow-up.
Scientists have discovered that immune cells shed their glycocalyx layer to move into tissues, changing the understanding of inflammatory skin diseases like psoriasis. This finding may lead to new approaches in developing drugs targeting immune cell movement and treating infections and inflammatory diseases.
MIT researchers use messenger RNA to activate an immune pathway in nearby immune cells, triggering the destruction of tumors. The approach combines existing immunotherapy drugs and avoids side effects associated with large doses of STING activators.
Researchers have visualized intricate dynamics of heart cell interaction during repair, revealing how immune cells guide connective tissue and prevent overgrowth of scar tissue. The study provides a critical foundation for future research aimed at reducing scar formation and maintaining the heart's pumping capacity.
Two landmark international studies published in The Lancet and Nature Medicine expose the need for faster recognition, better diagnostics, and personalized treatment pathways to combat pneumonia and sepsis. Irish ICUs face a shortage of beds, with implications for delayed care and increased mortality.
A UCLA study finds that DNA copy-number changes enable melanoma cells to resist immune attacks, leading to tumor relapse. The researchers suggest a strategy to make tumors more prone to self-destruction after immune attacks, potentially extending the effectiveness of immunotherapy.
Researchers explore manganese's impact on cancer immunotherapy, highlighting its potential to boost anti-tumor effects and induce immunogenic cell death. The review aims to synthesize findings on the cGAS-STING pathway and Mn's overall role in immune checkpoint therapy.
Scientists discovered profound and specific changes in T cells as people age, leading to weaker immune responses to vaccines. This insight opens the door to designing more effective vaccines by compensating for age-related cellular changes.