Articles tagged with Immunology
A UCLA study finds that DNA copy-number changes enable melanoma cells to resist immune attacks, leading to tumor relapse. The researchers suggest a strategy to make tumors more prone to self-destruction after immune attacks, potentially extending the effectiveness of immunotherapy.
Researchers explore manganese's impact on cancer immunotherapy, highlighting its potential to boost anti-tumor effects and induce immunogenic cell death. The review aims to synthesize findings on the cGAS-STING pathway and Mn's overall role in immune checkpoint therapy.
Scientists discovered profound and specific changes in T cells as people age, leading to weaker immune responses to vaccines. This insight opens the door to designing more effective vaccines by compensating for age-related cellular changes.
Researchers at the University of Missouri are exploring the use of extracellular vesicles to target lung cancer. By manipulating these tiny messenger particles, scientists can deliver specific instructions to kill cancer cells while sparing healthy ones.
The Allison Institute's third annual scientific symposium featured a panel discussion with five Nobel laureates, highlighting breakthroughs in cancer vaccines, immunotherapy, and immunology research. The event also recognized scientific achievement and leadership through award presentations.
A new study shows that eosinophils, typically linked to allergies, play a protective role against Candida infections by recognizing the fungus and releasing proteins that stop its growth. This discovery opens the door to new therapies that could strengthen natural defenses against life-threatening fungal infections.
Researchers have developed vitamin-engineered nanoplatforms that can overcome tumor heterogeneity and therapeutic resistance. These platforms integrate immunomodulation, precision drug delivery, and diagnostic capabilities, enabling targeted therapy and early detection of cancer.
Salk Institute researchers have determined the structure of HIV's integrase protein during its newly discovered function, enabling the development of better HIV therapeutics. The study reveals a surprising flexibility in the protein's architecture, which can interact with both DNA and RNA, paving the way for new integrase-targeting drugs.
A genetic mutation previously associated with skin disorders like psoriasis also affects the intestine, leading to reduced gut motility and increased vulnerability to bacterial infections. This finding broadens our understanding of the connection between genetics, immune signaling, and gastrointestinal health.
A new Alliance trial is exploring the effectiveness of a combination of targeted therapy and immunotherapy for patients with advanced adrenocortical carcinoma, a rare and aggressive cancer. The study aims to improve disease control and quality of life for patients with limited treatment options.
The Stowers Institute has appointed its first AI Fellow, Sumner Magruder, to harness the potential of artificial intelligence in biological research. He will collaborate with researchers to design new algorithms and unlock insights from large datasets.
UofL Health – Brown Cancer Center oncologists and researchers will continue developing novel therapies using patients' own immune system to defeat cancer. The center's faculty and research facilities support clinical trials that bring new treatments to patients.
Researchers at Cincinnati Children's propose a unified approach to understand blood cell formation, identifying rare cell populations and gene regulatory networks. This breakthrough advances targeted therapies and stem cell engineering.
University of Missouri researchers are helping farmers prevent disease outbreaks by teaching biosecurity practices, such as hand sanitizing and wearing farm-dedicated shoes. They also provide guidance on safe composting methods to dispose of dead livestock, reducing the risk of disease spread.
A*STAR researchers discovered that mosquito saliva not only transmits the virus but also influences how the body's immune system responds to chikungunya infection. Sialokinin, a bioactive peptide in Aedes mosquito saliva, binds to neurokinin receptors on immune cells and suppresses monocyte activation.
Researchers found that ATG9A helps prevent inflammation by promoting autophagy-mediated cleanup of inflammatory proteins in skin cells. This mechanism limits TNF-driven STING activation and ZBP1-dependent cell death, preventing severe skin disease.
A study found that higher thymic health is associated with better outcomes in cancer patients treated with immunotherapy, including a 35% lower risk of cancer progression and 44% lower risk of death. Thymic health may serve as a non-invasive biomarker of adaptive immune competence in various cancers.
A comprehensive guide describes the effects of spaceflight on the immune system, including microgravity, cosmic radiation, and sleep disruptions. The study provides integrated mechanistic insights into how these stressors alter immune physiology, with potential relevance in aging research.
A study published in the Journal of Intensive Medicine found that moderate-dose corticosteroids improve sepsis patient recovery rates by stabilizing immune cells and reducing inflammation. The treatment also shows protective effects on the heart and vascular system, preventing cardiovascular failure and organ damage.
Researchers developed a novel technology to attach 'fake targets' to tumor cells, enabling immune cells to attack regardless of antigen presence. The Univody platform showed promising results in animal models, suppressing tumor growth and triggering broader immune activation.
Han Xiao, a pioneer in medicinal chemistry, has been awarded the David W. Robertson Award for his contributions to therapeutic discovery. His research focuses on developing chemical tools to probe and manipulate biological systems, with a focus on cancer therapy.
Researchers from Ateneo de Manila University have identified key proteins produced by Helicobacter pylori that can trigger a strong immune response. By analyzing these proteins using immunoinformatics, the team has pinpointed potential vaccine targets to prevent stomach ulcers and cancer.
A new lab-designed protein has been discovered to regulate blood glucose levels, offering a potential new treatment avenue for people with Type 1 diabetes. The substance combines insulin and glucagon into one molecule, signaling the liver to respond naturally.
This study found that TNF-α is highly expressed in asthma patients' airways and induces bronchial fibroblasts to produce inflammatory cytokines. The upregulated genes are closely related to eosinophil or neutrophil inflammation, indicating a role for bronchial fibroblasts in airway inflammation.
A study published in Aging Cell suggests that hormone replacement therapy (HRT) can help reverse changes in the immune system caused by menopause, leading to a healthier immune profile. Women taking HRT showed fewer inflammatory monocytes and stronger infection-fighting ability compared to age-matched controls.
Researchers at MIT have developed a new way to engineer CAR-NK cells that are less likely to be rejected by the patient's immune system, making them a promising treatment for cancer. The cells can destroy most cancer cells while evading the host immune system, and may offer a better safety profile than traditional CAR-T cells.
A multi-institutional study found that serially testing tumor samples can detect immune system activation in recurrent glioblastoma even when traditional imaging measures cannot. The researchers used multi-omic analysis and integrated data from various sources to show positive changes in the tumor microenvironment over time.
Researchers at The University of Osaka have identified a previously uncharacterized subset of immune cells called preTfr that play a critical role in preventing autoantibody production. In patients with severe COVID-19, these cells are significantly reduced, correlating with increased levels of harmful autoantibodies.
Three young scientists received top honors at the 2025 Blavatnik National Awards for Young Scientists, each receiving a $250,000 prize for their innovative work on critical global issues. The awards recognize exceptional scientific achievement and innovation by U.S.-based researchers under 42 years old.
Professor Sakaguchi's Nobel Prize win recognizes his groundbreaking research on regulatory T cells, crucial for preventing excessive inflammation and autoimmune reactions. His work aims to develop new treatments for autoimmune diseases, allergies, cancer, and other conditions.
A newly identified antibody, 04_A06, has been found to block 98.5% of over 300 different HIV strains in laboratory tests. In humanized mice models, the antibody reduced viral load to undetectable levels, offering a promising approach for HIV prevention and treatment.
A Wayne State University study found that prenatal Zika virus exposure leads to sex-specific changes in a baby's immune system, affecting frontline immune cells. Males are more affected, with slower growth and an exaggerated inflammatory response.
Researchers at Aarhus University used mini-organs to show that cervical epithelial cells actively detect and combat infections, with uninfected cells becoming immune-active. This discovery opens opportunities for mucosal vaccines and targeted treatments against STIs and infertility.
Researchers at La Jolla Institute for Immunology discovered that ALS is likely caused by an autoimmune reaction triggered by inflammatory CD4+ T cells targeting specific proteins in the nervous system. Anti-inflammatory CD4+ T cells may slow disease progression and prolong survival times.
The review highlights the critical roles of phospholipids in regulating immune cell migration, differentiation, and survival, as well as their regulatory effects on inflammation. Dysregulated phospholipid metabolism is linked to various diseases, including autoimmune disorders, cardiovascular disease, and cancer.
Chrysothemis Brown, an immunologist at Memorial Sloan Kettering Cancer Center, has been selected as a 2025 Freeman Hrabowski Scholar to pursue curiosity-driven research on early life immune development and tolerance. The award supports her lab's work in understanding immune tolerance and developing new treatments for immune-related dis...
Researchers have discovered myeloid cells in children's liver tumors that could be activated for treatment. This discovery provides new avenues for immunotherapy in childhood liver cancer.
Researchers identified two lymphocyte subpopulations associated with arsenic trioxide therapy for APL, the CD8 ISG T cells and NK NFκB cells, which provide new insights into its mechanism of action. ATO treatment also revitalized dysfunctional NK cells and remodelled immunoglobulin proteins.
The NF-κB signaling pathway plays a key role in regulating immune responses, inflammation, cell development, and proliferation. Research into its functions and mechanisms continues to uncover new breakthroughs in immunology and life sciences.
A study has identified KIMA, a genomic signature associated with a poor treatment response in HR+/HER2- breast cancer patients. The signature, composed of nine genes, can predict disease progression and overall survival, enabling personalized therapy selection.
A KAIST-led team has identified a gene, NR3C1, that regulates the developmental switch in astrocytes, shaping immune system reactions in adulthood. Early-life epigenetic 'memory' can predispose adult brains to excessive inflammation and disease vulnerability.
Researchers at CU Anschutz discovered a genetic program within lymphatic endothelial cells that enables storage and archival of antigens, helping the immune system remember infections. This understanding could lead to improved vaccines and therapies by fine-tuning immune memory.
Researchers identified genetic modifications that can improve the efficacy of chimeric antigen receptor (CAR)-T cell treatment for multiple myeloma and other cancers. The study used CRISPR screening to pinpoint genes that influenced T cell function and survival in culture and in a preclinical model of multiple myeloma.
Australian scientists have discovered how T follicular helper cells tailor their behavior to different infections, paving the way for improved vaccine design and targeted therapies. The study sheds light on a molecular 'instruction manual' guiding antibody production and long-term immunity.
The University of California - Riverside is receiving a $2 million grant to investigate how gut microbes interact with their human hosts to influence health. The research aims to create next-generation probiotics that strengthen the gut microbiome, improve vaccine effectiveness, and prevent infections.
Ensemble projections suggest vaccinating high-risk groups reduces disease burden, while broader vaccine availability saves more lives. Averted COVID-19 burden due to vaccination is robust across immune escape scenarios.
Researchers discovered a mechanism through which melanoma cells adapt to two proliferative states, with alterations in iron metabolism playing a central role. Targeting iron homeostasis and organelle crosstalk may offer innovative strategies to prevent tumor progression and overcome resistance.
Dr. Carl Nathan's groundbreaking research has advanced our understanding of innate immunity, tuberculosis, and cancer. His discovery of macrophage-activating factor (MAF) and its role in driving immune responses has led to the development of new treatments for previously intractable diseases.
Researchers developed a fusion protein that blocks the 'do not attack' signal and selectively activates tumor-fighting immune cells. The molecule, combining an IL-2 variant with a PD-1 antibody, induces a multifaceted anti-tumoral T cell response in human lung cancer patients.
Mass General Brigham has identified key areas of innovation in medicine, including gene editing, immune system modulation, AI-powered care, and organ transplantation. The 'Big Ideas in Medicine' aim to transform diagnosis, treatment, and prevention of disease with next-generation technologies.
Researchers have identified a secreted form of a protein called Clever-1 that systemically suppresses T cells essential for fighting cancer. The investigational anti-Clever-1 antibody, bexmarilimab, directly inhibits the release of sClever-1, potentially predicting treatment resistance and paving the way for new combination treatments.
The Blavatnik Regional Awards recognize exceptional postdoctoral researchers in Life Sciences, Physical Sciences & Engineering, and Chemical Sciences. Veena Padmanaban, Valentin Crépel, and Xiao Xie are this year's winners, honored for groundbreaking discoveries in cancer cell biology, condensed matter physics, and chemical biology tools.
The Alliance for Clinical Trials in Oncology will host a public webinar showcasing key findings from the 2025 ASCO Annual Meeting. Researchers will discuss latest information on colorectal, squamous cell, and renal cell cancers.
Research has shown that lymph nodes provide the right environment for stem-like T cells to survive, multiply, and produce killer cells. Preserving lymph nodes could strengthen immune responses and increase the effectiveness of immunotherapy. The study's findings have important implications for cancer therapy.
A study published in eBioMedicine identified a specific immune response that controls Oropouche virus infections and prevents neurological damage. B cells produce antibodies quickly, helping to neutralize the virus and prevent its spread to the central nervous system.
A chemically modified STn glycoconjugate vaccine has been developed with enhanced antitumor immunity, demonstrating substantial resistance to enzymatic degradation and inducing potent T-cell responses. The vaccine induces functional antibodies capable of initiating both CDC and ADCC against STn-positive tumor cells.
Researchers at UMass Amherst found that certain T-cells have an inherent ability to remember past viral foes, which could lead to next-generation cancer vaccines. This 'immunological memory' is crucial for the body's immune response and can be harnessed for targeted therapies.
Researchers have identified a key immunoregulatory mechanism in aspergillosis, where the dendritic cell receptor limits the host's response to fungal infections. Neutrophils play a crucial role in clearing fungal hyphae, and Dcir regulates their degranulation activity, which is essential for killing pathogens.
Research by University of Pittsburgh scientists discovered that damaging telomeres can lead to dysfunctional T cell function. To combat this, they developed a targeted antioxidant approach that rescued T cell function, opening the door for novel therapies in cancer immunotherapies.
A new computational tool called scODIN simplifies single-cell analysis by automating cell type identification in scRNA-seq data. It allows users to define specific cell subsets at different levels of detail and recognizes cells with intermediate phenotypes or transitional states, capturing complexity missed by traditional methods.