Articles tagged with Routes Of Administration
Researchers developed biodegradable particles with microscopic needles to improve skin absorption of drugs delivered through patches or creams. The technology increased intradermal drug delivery up to 37-fold for three different drugs.
Researchers at UH College of Pharmacy are developing breakthroughs to combat sepsis, a leading cause of hospital deaths, and diseases such as Alzheimer's and sickle cell disease. A dual-action nanomedicine has shown a 100% survival rate in preclinical trials for sepsis treatment.
Researchers at the University of Houston have discovered adding salt can help release therapeutic material from endosomes, improving delivery efficiency for mRNA vaccines and gene therapies. The simple strategy overcomes a major obstacle in gene medicine, potentially making these therapies more efficient and accessible worldwide.
Researchers are developing snail-inspired soft robots to deliver targeted therapy directly to tumor sites in bowel cancer patients. The robots aim to increase drug bioavailability and reduce off-target toxicity., Transforming colorectal cancer treatment by enabling precise drug release at tumour sites.
Researchers at Lehigh University and the Cleveland Clinic are developing a nonsurgical therapy for pelvic organ prolapse using drug-delivering nanoparticles. The treatment aims to delay or reverse matrix degradation, reducing the severity of POP in patients with earlier stages of the disorder.
Researchers at Stanford University developed a new delivery platform that allows drugs to be stored and delivered in much higher concentrations, enabling quicker and smoother injections. The new formulation method has been tested on three different proteins and reached concentrations exceeding 500 mg/mL.
Researchers at University of Bath have developed a system that can transport therapeutic proteins across the gut wall and into the bloodstream, enabling medication delivery via pill. The new technology has shown consistent delivery rates, with potential to transform lives of patients who currently inject themselves daily.
Researchers validated panels of antibodies targeting clinically relevant nucleic acid modifications to visualize antisense oligonucleotides in both in vitro and in vivo studies. The tools enable detection of modified nucleic acids irrespective of sequence, facilitating multiple clinical and pre-clinical workflows.
Scientists at Xi'an Jiaotong-Liverpool University developed a new nanoparticle capable of carrying high doses of chemotherapy drugs while staying stable for extended periods. This innovation could make treatments more effective and reduce side effects.
A new study found that over 40% of children who underwent complicated appendicectomy recovered faster and had fewer complications when cared for in the home following surgery. This model of care reduced hospital time by 35% and saved families and hospitals over $1,400 per day.
Researchers created optimized DNA hydrogels with fewer nucleic acids, achieving efficient and sustained drug release. The new hydrogel units showed prolonged persistence of at least 168 hours post-administration in mice, contributing to anti-tumor effects.
A study by the University of Gothenburg found that Swedish pharmacy personnel report a deteriorating patient safety climate. Pharmacists gave lower ratings for teamwork, job satisfaction, and management, with only 37% having a positive outlook on working conditions. The study suggests that changes in the work environment, including inc...
A new study reveals that opioid smokers die at two-thirds the rate of injectors, likely due to reduced transmission of HIV and hepatitis C. However, smoking opioids carries a substantial overdose risk and should not be misconstrued as safe.
Researchers found that intravenous administration of immunomodulatory nanoparticles after TBI can limit inflammatory cell infiltration and reduce behavioral decline and lesion size. The treatment was shown to be safe without noticeable toxicity in mice.
Researchers found that omitting the bolus-specific 5-fluorouracil (5-FU) portion from common chemotherapy regimens improves tolerability without sacrificing treatment effectiveness. The study of 11,765 patients shows no decrease in overall survival but a notable reduction in cytopenias.
The new guidelines from the Surgical Infection Society offer updated recommendations for antimicrobial agent selection, source control, and treatment of specific pathogens. These evidence-based guidelines aim to improve clinical outcomes and reduce mortality rates from intra-abdominal infections globally.
Pharmaceutical companies exploited a loophole in the DEA's monitoring system, leading to an oversupply of opioids in communities. The study highlights the impact on Black communities, where overdose deaths tripled from 2014 to 2020. High supply chain complexity played a key role in evading regulations.
Researchers review cell-based therapies for comprehensive sepsis management, highlighting the potential of mesenchymal stem cells and innate immune cells like macrophages. The review also emphasizes the need for further studies on optimal dosage, administration routes, and storage methods to maximize efficacy and safety.
A groundbreaking study demonstrates that intradermal administration of naked mRNA induces robust vaccination against SARS CoV-2 in mice and primates. The novel approach avoids the use of lipid nanoparticles, which can cause adverse reactions, allowing for multiple doses over a lifetime.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
The AAGBI has published new guidance on safe injection practice, highlighting the importance of prefilled and labelled syringes to avoid medication errors. The guidance recommends standardization of fit-for-purpose physical structure and medicine storage, as well as exploring technological solutions to reduce errors.
Researchers at California Polytechnic State University have developed a novel method for storing biological materials such as RNA and proteins in a solid-state, resembling a pill or tablet that dissolves in water for on-demand use. This innovation overcomes current limitations in storage and handling, making it easier to access these m...
A study suggests that ketamine nasal spray is a convenient alternative to intravenous infusion for treating refractory chronic migraine. The treatment showed promise in reducing daily headaches and improving quality of life, with most participants reporting 'very effective' results.
Researchers at the University of Texas M. D. Anderson Cancer Center have developed a novel approach to administer intrathecal and intravenous immunotherapy to treat leptomeningeal disease (LMD) in melanoma patients, showing promising results in improving survival rates and quality of life for some patients.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers developed an AI tool using natural language processing and machine learning to identify people who inject drugs in electronic health records. The model accurately identified PWIDs in 1,000 records from 2003-2014, significantly improving clinical decision making and resource allocation.
Researchers have engineered probiotic bacteria to produce the dopamine precursor L-DOPA, a potential treatment for Parkinson's disease. The new approach eliminates side effects and reduces treatment complications, offering a promising alternative to existing treatments.
A new study suggests that mixing cannabis with tobacco increases the risk of dependence and decreases motivation to quit. Cannabis users who prefer non-tobacco routes have higher odds of seeking help to use less cannabis and tobacco, indicating a lower risk of psychological dependence.
A study found reformulated ER oxycodone has significantly lower abuse rates through non-oral routes of administration. Data from 140,496 individuals assessed for substance abuse treatment showed a 20-month reduction in abuse rates.
A study found that most non-ICU patients receiving intravenous proton pump inhibitors (PPIs) had inappropriate indications or routes of administration. The researchers highlighted the need for restrictions on IV PPI use to improve both clinical and cost impacts.
Researchers review vitamin C absorption and metabolism, suggesting re-evaluation of its use in treating cancer. New insights reveal differences between intravenous and oral administration routes.