Articles tagged with Mesenchymal Stem Cells
Researchers have developed a new biological treatment that targets inflammation-driven scarring after a heart attack, aiming to reduce the risk of heart failure. The treatment uses donated human bone marrow-produced exosomes to dampen inflammation and promote healing.
Researchers have discovered a hidden network of specialized mesenchymal support cells in the intestine that work together to maintain its inner lining. The study found four distinct populations of cells with unique genetic programs, each occupying specific locations and influencing stem cell activity and immune responses.
Researchers have explored how human mesenchymal stem cells can help repair brain injury in children born preterm. The PREMSTEM project has investigated the use of h-MSCs to address brain injury caused by early-life birth, with promising results showing a positive impact on brain damage and inflammation.
Researchers at Mayo Clinic found that transplanting patients' own stem cells into their veins can help prevent inflammation and vein narrowing in patients with end-stage kidney disease. This could extend the time before dialysis is required, reducing healthcare costs and improving patient outcomes.
Researchers have discovered a specialized mesenchymal-endothelial crosstalk that supports angiogenesis and osteogenesis, enabling periodontal bone regeneration. This communication network between mesenchymal stem cells and endothelial cells drives tissue repair and regeneration, holding promise for dental therapeutic strategies and bro...
Researchers found that telomerase inactivation in immune cells or connective tissue cells slows tumor growth, but creates conditions for aggressiveness. In contrast, endothelial cell preservation suppresses metastasis.
Researchers at The Hebrew University of Jerusalem have found that mesenchymal stem cell secretions can help protect mammary cells from stress while increasing milk fat production. This breakthrough could lead to healthier cows and richer, creamier milk without the need for additives or heavy processing.
Researchers at MD Anderson have made significant progress in treating non-small cell lung cancer (NSCLC) by combining chemotherapy, immunotherapy, and surgery. They found that pre-surgical combination therapy showed promising results, with high rates of pathological complete response and major pathological response.
A study reveals that APPswe promotes osteogenic differentiation of mesenchymal stem cells by regulating the Notch pathway, while its extracellular segment blocks cell proliferation and migration. This suggests a potential role for APPswe in bone formation and treatment of bone loss in Alzheimer's patients.
Researchers from Yokohama National University have developed a method to fabricate complex oriented tissues with multiple directionality using 3D printing. This technique utilizes flow to orient collagen fibers and cells, allowing for the creation of fine, micro-oriented structures in both horizontal and vertical directions.
A new study found that mesenchymal stem cell-derived extracellular vesicles significantly enhance survival and facilitate substantial peripheral blood recovery in mice exposed to high-dose irradiation. The treatment promoted hematopoietic recovery, with increases in red blood cell, platelet, white blood cell, and hemoglobin levels.
Researchers investigated the role of Notch1 in regulating BMP-2 induced chondrogenic differentiation and endochondral ossification. They found that Notch1 signaling promotes osteogenic, chondrogenic, and angiogenic differentiation of MSCs.
Aging individuals experience bone loss despite physical activity, highlighting the importance of MSCs in regulating bone mechanoresponse. The new 3D bone marrow analog reveals that trabecular volume affects MSC response to mechanical signals, with higher strains associated with older densities and increased F-actin production
A novel subset of progenitor cells, called high-risk MSCs, reside in the stroma and promote DNA damage and tumor growth. These cells play a critical role in the initiation of ovarian cancer, particularly in older women or those with BRCA mutations.
Researchers found that Shh significantly promotes BMP9-induced osteogenic differentiation of mesenchymal stem cells, leading to enhanced ectopic bone formation. The study suggests that Shh may augment BMP9-induced osteogenesis by activating essential transcription factors.
The PREMSTEM Conference will present cutting-edge research on neonatal brain repair, focusing on human mesenchymal stem cells as a potential therapy for preterm birth-related brain injury. Associate Professor Atul Malhotra's keynote address will highlight successes and lessons learned from his ongoing stem cell-based therapy trials.
Researchers developed MSCs with aloe emodin-loaded nanoparticles and IFN-γ pretreatment, which inhibited CD4+T cell activation and reduced inflammation in mouse models. The combination also preserved pancreatic structure and function, holding promise for clinical application.
Researchers at Fujita Health University have developed a novel therapy using mesenchymal stem cells to treat inflammatory eye diseases, reducing inflammation and promoting tissue repair. The study found that adMSC injections effectively reduced inflammation in mice with GVHD without long-term complications.
Researchers identified early cellular changes associated with Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy (MDPL) syndrome, a rare genetic aging disorder. MDPL syndrome is characterized by premature aging of mesenchymal stem cells, which can form tissues like bone and fat.
The study, published in Aging, introduces a new therapy for osteoarthritis that uses extracellular vesicles derived from fat tissue to repair damage caused by aging cells. The treatment showed strong therapeutic effects in both cellular and mouse preclinical studies, reducing inflammation and DNA damage markers in human joint cells.
Breast cancer cells can live for years in bone marrow after remission, leading to disease recurrence in approximately 40% of patients. A study found that mesenchymal stem cells support the cancer cells by donating essential proteins, making them more aggressive and drug-resistant.
Mesenchymal stem cells (MSCs) show promise in delivering treatments directly to cancer cells and boosting the immune system's fight against cancer. However, ongoing research highlights challenges related to MSC behavior, including variability in their effects and potential to create conditions that support tumor growth.
Researchers from IBEC have improved understanding of how MSCs sense environment viscosity, a key factor in differentiation into different tissue types. Viscosity affects cell behavior and promotes differentiation into softer tissues like cartilage.
Researchers developed a novel method to enhance the efficacy of MSC-based therapy for articular cartilage repair by adding ascorbic acid during MSC expansion. The addition improved chondrogenic differentiation, reduced cell heterogeneity, and showed a robust shift in metabolic profile.
A $1.9 million NIH grant will support research on closing cellular gaps, with implications for wound healing and cellular regeneration therapies. The goal is to develop a theoretical understanding of the process, enabling control over individual factors and potential applications in regenerating heart cells.
Texas A&M researchers are investigating the use of extracellular vesicles to deliver immune-suppressing proteins, potentially reducing the immune system's attack on insulin-producing beta-cells. The goal is to develop a novel treatment for type 1 diabetes, which currently has only lifelong insulin therapy as an approved option.
A UofL cardiologist is leading a Phase II clinical trial of a new stem cell therapy for heart failure, the first in the US to use intravenous delivery. The trial aims to determine whether one or multiple doses of mesenchymal stem cells improve health and quality of life for patients.
MSCs have demonstrated potential in treating severe COVID-19 cases by mitigating a cytokine storm, relieving pulmonary symptoms, and promoting organ recovery. MSC therapy also holds promise for managing influenza infections by counteracting inflammation and promoting lung tissue repair.
Researchers explore Extracellular signal-regulated kinase 5 (Erk5) and its unique structures regulating autophosphorylation and transcription. Erk5 is involved in angiogenesis, neurogenesis, energy metabolism, tumor growth, and metastasis, making it a potential target for cancer treatment.
Researchers review cell-based therapies for comprehensive sepsis management, highlighting the potential of mesenchymal stem cells and innate immune cells like macrophages. The review also emphasizes the need for further studies on optimal dosage, administration routes, and storage methods to maximize efficacy and safety.
Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been shown to alleviate acute liver failure by inhibiting hepatocyte apoptosis and regulating macrophage polarization. This study suggests that hUC-MSC-based cell therapy may serve as an alternative option for patients with liver failure.
New findings in The American Journal of Pathology indicate that periostin promotes esophageal squamous cell carcinoma progression by enhancing cancer and stromal cell migration in cancer-associated fibroblasts. Periostin may be a promising therapeutic target for treating ESCC.
Researchers at Mayo Clinic have developed an immunotherapy strategy that combines chimeric antigen receptors with mesenchymal stromal cells, known as CAR-MSCs. This approach shows potential in targeting inflammatory disease sites more precisely and improving immunosuppression and healing outcomes for autoimmune diseases.
Researchers discovered a new type of stem cell that can regenerate cartilage in arthritic mice, offering potential for treating osteoarthritis. The stem cells, derived from human pluripotent stem cells, were found to efficiently generate new cartilage when transplanted into the knees of OA mice.
A recent study published in Nature Medicine calls into question the effectiveness of stem cell therapy for treating knee pain. While some patients showed improvement, there was no significant advantage found in using stem cell therapies compared to corticosteroid injections over a one-year period.
Researchers developed a ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle hybrid system to treat rheumatoid arthritis. This approach provides both immediate pain relief through ROS scavenging and long-term immune tolerance by delivering immunomodulatory cytokines.
Researchers found that apoptotic cells induce apoptosis in neighboring hair follicle cells during the regression cycle. The study proposes a mathematical model of the hair follicle regression cycle, which suggests that the dermal papilla plays an essential role in initiating apoptosis.
A new biomimetic chip has been developed to simulate the human gastric mucosa, combining organoid and organ-on-a-chip technologies. The biochip replicates mechanical stimulation and cell-to-cell interactions, mimicking key features of the human stomach's defense mechanisms.
A systematic review and meta-analysis of 195 clinical trials found that cell therapy can reduce the risk of death from COVID-19 by 60%. The studies, conducted in 30 countries between January 2020 and December 2021, used various types of cells, including mesenchymal stem cells and natural killer cells.
Researchers at the University of Chicago developed a potential new PCOS treatment using mesenchymal stem cell-derived extracellular vesicles, which can lower androgen hormone activity and stabilize ovarian function. This approach offers a better safety profile and potential for wide-scale applications compared to conventional methods.
Researchers discovered ovarian mesenchymal progenitor cells that improve aged ovarian function and extend reproductive lifespan. By transplanting functional mesenchymal cells, the study shows an efficient approach to postpone ovarian aging.
A new drug delivery method utilizes polymer-stabilized crystals to deliver antioxidants to stem cells, minimizing variation in drug release and extending the duration of effectiveness. This technology can be applied to various cell cultures and potentially other hydrophilic drugs, disease models, and methods applications.
Scientists create a subcellular omics toolkit to study organelle diversity and communication in stem cells. The tool enables the identification of similar cell types, leading to more precise therapies for various diseases.
Researchers found that immune-modulating cells may slow the expansion of bulges in the aorta by creating a less-inflammatory environment. A second study discovered evidence that a COVID-19 infection promotes the enlargement of abdominal aortic aneurysms, which are extremely dangerous and potentially fatal if they rupture.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
Scientists discovered that inhibiting microRNA-141-3p can reduce chronic inflammation, muscle loss, and bone degradation in aged mice. By blocking this tiny RNA, researchers found improvements in the spleen's immune response, lower levels of pro-inflammatory proteins, and a more youthful profile in bones and muscles.
Researchers found that senescence-associated exosomes (SA-EXOs) from MSCs induce fibrosis and activate invasive characteristics in neighboring cells via the TGF-β pathway. SA-EXOs play a large role in cancer-related fibrosis, and their unique miRNA content influences myofibroblast phenotypes.
Researchers at Mayo Clinic found that a dissolvable plug delivering stem cells can heal single-tract fistulas in patients with Crohn's disease. The treatment has shown durable results with minimal side effects, offering hope for patients with refractory perianal fistulas.
Researchers investigated manuka honey's potential to resist bacterial infections and promote bone growth in collagen scaffolds. Higher concentrations of honey led to decreased bone health, while soaked scaffolds showed improved results.
A novel form of chemoimmunotherapy has been proven to be a promising treatment for canine cancer, extending the lives of terminally ill dogs. The therapy uses modified Mesenchymal Stem Cells carrying a potent 'kill-switch' that induces anti-cancer immunity and improves quality of life.
A research team led by Professor Kwang-Hyun Cho at KAIST has developed a fundamental technology to revert metastatic lung cancer cells to a non-metastatic state. This breakthrough could lead to the elimination of drug resistance and metastatic potential in cancer cells, while increasing their responsiveness to chemotherapy.
The Cleveland Clinic is developing a stem cell treatment for complex regional pain syndrome, a debilitating disease that causes chronic pain, using human mesenchymal stem cells (hMSC). The research has long-term potential for providing patients an alternative to addictive opioid treatments.
A new study reveals a previously unrecognized level of heterogeneity and specialization of endothelial and mesenchymal cells in the bone marrow. By integrating single-cell gene expression data, researchers identified 14 endothelial and 11 mesenchymal subclusters, providing insights into blood stem cell self-renewal and differentiation
A KAUST-developed nanotechnology platform uses tiny iron wires that bend in response to magnetic fields to accelerate bone cell formation. Bone-forming stem cells grown on the moving substrate transform into mature bone much faster than usual, potentially paving the way for more efficient regeneration of bone.
Researchers have developed a unique 3D printed system to harvest mesenchymal stem cells from bioreactors, which can be used for various treatments. The system combines microfluidics and 3D printing to process adult stem cells, potentially making stem cell therapies more widely available.
The study found that mice lacking both Runx1 and Runx2 in CAR cells showed a significant reduction of HSPCs and immune cells, along with an increase in fibrosis. The researchers suggest that Runx1 and Runx2 may be potential targets for the diagnosis and treatment of myelofibrosis.
A recent study published in NPJ Regenerative Medicine found that large bone injuries trigger a repair strategy recapitulating elements of skeletal formation in utero. The gene Sonic hedgehog (Shh) plays a necessary role in healing central regions, while small-scale fractures heal through a distinct program.
A team from the Terasaki Institute for Biomedical Innovation has created a method to repair tendons using silk fibroin scaffolds, which showed improved healing and regeneration of injured tendons. The scaffold combines silk fibroin with GelMA to promote cell attachment, growth, and differentiation.
Researchers have discovered a novel nano-therapy that prevents bronchopulmonary dysplasia (BPD) in premature babies. The therapy uses tiny particles released by mesenchymal stromal cells, which travel to the brain and lungs, reducing damage and improving lung and brain health.
Researchers at Johns Hopkins Medicine found that certain stem cells have built-in tracers made of sugars that can track their movement in living tissues. The discovery could streamline and advance restorative research for diseases of the brain.