Articles tagged with Gene Expression
Researchers found that healthy individuals vary in gene expression levels in circulating blood cells, with some genes used at varying levels depending on time of day and age. Despite these differences, the study revealed remarkable similarity in the genes used among the subjects.
A study of 74 patients with non-classic cystic fibrosis revealed that nearly a third had no detectable changes in their CFTR genes, sparking debate about the role of epigenetics and alternative causes. The findings may lead to improved diagnosis and treatment options for these patients.
Researchers at UT Southwestern Medical Center have discovered a protein called Homeodomain-Only Protein (HOP) that regulates heart growth from fetal stage to adulthood. HOP helps control the balance of cardiac cell proliferation and differentiation, with disrupted levels leading to abnormal heart development.
Researchers found that human embryonic germ cells and their specialized daughter cells maintain correct 'imprinting,' a way cells determine gene expression. This is critical information for the safe clinical use of these cells in treating diseases.
A study identified three gene expression patterns correlated with survival after chemotherapy, which outperformed the International Prognostic Index. The patterns revealed aspects of tumor biology affecting treatment response, including immune system involvement and tumor cell division.
A study found that hereditary BRCA1 and BRCA2 ovarian cancers have similar gene expression profiles to sporadic ovarian cancers. The research suggests shared molecular mechanisms between hereditary and sporadic ovarian carcinogenesis exist.
Researchers analyzed gene expression profiles from thousands of lymphoma biopsy samples to identify predictive genes that can predict patient response to treatment and survival rates. The study found that a formula created from 17 key genes could accurately classify patients into four groups with varying five-year survival rates.
Researchers aim to find new targets in the brain to prevent and treat Alzheimer's and Parkinson's diseases using Serial Analysis of Gene Expression (SAGE) technology. The $2.75 million funding will support Columbia University's technology transfer and commercialization efforts.
Researchers found that diabetes causes a phase shift in the heart's circadian clock, leading to changes in gene expression and potentially disrupting the synchronization between stimulus and response. This alteration may contribute to contractile dysfunction and increased risk of heart failure in patients with diabetes.
Hopkins researchers identified a nine-fold increase in expression of the AMACR gene in prostate cancers, making it a promising early marker and potential drug target. Overexpression patterns were also found in precancerous lesions, highlighting the gene's potential for non-invasive detection and prevention.
The Society for Women's Health Research has published proceedings from its Second Annual Conference on Sex and Gene Expression. The conference explored topics such as sex differences in embryonic development, cognitive functions, and mitochondrial DNA. Researchers from various backgrounds shared their findings contributing to the emerg...
A unique gene has been identified as a regulator of stem cell growth, suggesting that embryonic and adult stem cells share key genes and properties. This discovery could lead to the development of new therapies for cancer patients in need of stem cell transplants.
The RNA Invader assay directly detects gene expression levels without sample contamination, allowing for accurate quantification of small changes in biologically significant genes. This technology also discriminates between nearly identical RNA sequences, enabling researchers to identify specific targets with consistency.
The RNA Invader assay directly detects gene expression levels from crude cell samples, eliminating costly and time-consuming steps. This technology allows for precise quantification of small changes in biologically significant genes.
Researchers developed a tissue culture system that mimics normal cell growth, allowing them to study gene transfer techniques in greater detail. They found that cancer cells can be easily infected while normal cells are poorly infected, suggesting a potential target for gene therapy.
Researchers at Rosetta Inpharmatics used Flexjet DNA microarray technology to analyze the role of changes in chromosome number on gene expression, showing large-scale biases that affect cellular processes. The study provides a novel tool for evaluating aneuploidy and its potential applicability to human cancer cells.
A study using robotic microarray technology has identified 55 genes involved in cardiac hypertrophy, including 30 previously unassociated genes. The research also discovered eight genes associated only with recovery from hypertrophy, providing new insights into the complex relationship between heart stress and gene expression.
A Cedars-Sinai researcher has identified a gene associated with malignancy in brain, liver, breast, colon, kidney, and reproductive organs, but not in healthy adults. The discovery could lead to the development of a method to block the gene's expression using antisense technology, potentially stopping cancer before it spreads.
Researchers at Ohio University develop a faster gene function identification system using a nonviral gene expression system in zebrafish, reducing identification time from three years to two days. The technique allows scientists to study gene function without destroying the gene, making it valuable for studying genetic disease.
A University of Illinois geneticist criticizes the misuse of genetics in society, citing the controversial book 'The Bell Curve' as an example. Jerry Hirsch argues that the field has been misunderstood and mishandled, leading to flawed conclusions about intelligence and racism.
Researchers at Ohio University have developed a nonviral gene therapy system that can express genes outside the nucleus of a cell, making it easier to deliver disease-fighting genes to tumor cells. This system has been successfully used in cell cultures and mouse models to promote anti-cancer activity.
Researchers at Ohio University found evidence that memory loss with aging may be connected to malfunctioning genes controlling spatial memory. The study identified unique DNA sequences in old mice brains, which could lead to the development of therapies targeting age-related cognitive decline.
Kristen Kroll's innovative technique enables the mass production of genetically modified frogs, allowing researchers to study embryonic development in unprecedented detail. By disabling specific signaling pathways, scientists can pinpoint precise stages of tissue and organ formation.