Articles tagged with Genome Engineering
Researchers at KAUST have developed a new genome engineering approach allowing accurate integration of large genetic sequences into plants. This method opens new avenues for agricultural biotechnology, synthetic biology, and plant-based biomanufacturing.
The partnership aims to develop genomic tools addressing large-scale problems in health and the environment, combining research strengths across UC San Diego's departments. The collaboration will accelerate discovery and drive real-world impact, leveraging CRISPR technology and microbiome-editing tools.
Researchers identified a precise gene edit that lowers cadmium in rice grains while maintaining yield and essential mineral nutrients. The OsNramp5 I441T mutation selectively limits cadmium translocation, reducing grain cadmium by 48% without compromising zinc or manganese uptake.
A new Europe-wide survey found broad public support for fertility treatment and reproductive research in the UK, Netherlands, Spain, and Italy. The study suggests that public understanding and opinion on these topics continue to develop, with areas where public views are not yet settled identified.
Researchers at Nara Institute of Science and Technology developed a practical, non-genetically modified brewing yeast that produces over nine times higher intracellular ornithine levels than the original yeast. The improved yeast retained normal brewing performance, making it suitable for value-added fermentation.
Scientists have developed a genome engineering platform that enables simultaneous gene knockout, base substitution, insertion, deletion, duplication, and inversion in a single framework. The TRIM platform integrates multiple desirable traits by combining gene knockout with prime editing-based sequence modification.
Recent advancements in animal models, organoid models, and bioengineered organoids have provided new tools for studying primary sclerosing cholangitis. These models replicate the effects of bile retention and inflammation, enabling studies of disease mechanisms, drug screening, and preclinical evaluation.
A new approach, called INSTALL, enables non-toxic DNA integration in multiple human cell types and successfully inserts large genetic payloads in mice, offering a promising solution for genetic therapies. The study's findings have the potential to broaden the applicability of genome editing therapies.
A novel plant-based approach uses lettuce chloroplasts to produce functional GLP-1 peptides, paving the way for more affordable and better-tolerated oral medications. This method bypasses hurdles such as manufacturing cost, delivery system, and side effects associated with conventional approaches.
The journal explores the convergence of computational biology, artificial intelligence, and healthcare innovation, with a focus on precision medicine and enhanced patient care. Submissions are accepted from researchers, clinicians, and technologists on topics such as AI in medicine, computational genomics, and drug discovery.
Kobe University scientists have engineered bacteria to produce a group of compounds with promising pharmacological activities. The breakthrough uses a rational design strategy to create a platform for industrial production of drug candidates.
Researchers used genome sequencing to identify blight-resistant trees with high American chestnut ancestry, preserving the species' ecological and cultural importance. The approach, known as genomic selection, allows breeders to predict resistance and make better decisions earlier in the breeding process.
Researchers at Monash University have developed an AI-powered approach to create highly accurate and specific anti-CRISPR molecules, enabling faster development of gene editing tools for various applications. This breakthrough addresses the inconsistent performance and safety risks associated with CRISPR technology.
Researchers from New England Biolabs and Yale University have developed a first fully synthetic bacteriophage engineering system using the High-Complexity Golden Gate Assembly platform. This method simplifies strain engineering techniques, allowing for rapid creation of tailored therapeutic strains to overcome antibiotic resistance.
Scientists at the Salk Institute have discovered a new mode of epigenetic targeting in plant cells, where specific DNA sequences guide DNA methylation patterns. This finding has major implications for understanding epigenetic regulation and could inform future strategies for epigenetic engineering.
A team of plant biotechnologists at Texas Tech University has developed a groundbreaking method to accelerate crop creation, bypassing the time-consuming process of tissue culture. The new technique enables plants to grow new shoots directly from wounded tissue, eliminating the need for traditional lab-based regeneration steps.
Researchers at the University of Texas at Austin have developed a novel gene-editing method that can correct multiple disease-causing mutations simultaneously. This approach uses bacterial retrons to protect the microbes from viral infection and has shown promising results in correcting scoliosis-causing mutations in zebrafish embryos.
Researchers from Mass General Brigham developed a bespoke CRISPR-Cas9 gene-editing enzyme to correct the genetic error causing multisystemic smooth muscle dysfunction syndrome, a rare condition associated with stroke and death in childhood. The therapy extended survival four-fold in mouse models of MSMDS.
A research team developed a new method to precisely edit DNA by combining genetic engineering with artificial intelligence. The technique enables accurate modeling of human diseases and lays the groundwork for next-generation gene therapies.
The American Society of Human Genetics recognizes Dr. Harry Dietz for his work on Marfan Syndrome, Dr. Eric Green for his leadership in advancing human genetics and genomics, Dr. Mike Talkowski for his pioneering contributions to cytogenetics and genomic medicine, and Dr. Elizabeth Bhoj for her extensive work in translational genetics.
A team of scientists proposes using gene editing to restore lost genetic diversity in endangered species, enabling them to adapt to future environmental changes. The approach could complement traditional conservation methods and attract new investors and expertise.
Researchers developed an AI-informed method for rapid protein evolution, integrating structural and evolutionary constraints. The approach, AiCE, outperforms traditional methods in predicting high-fitness mutations, enabling efficient protein redesign and applications in precision medicine.
Researchers at the University of Sydney developed a biological 'artificial intelligence' system called PROTEUS, which can accelerate cycles of evolution and natural selection to create molecules with new functions in weeks. The system has potential applications in finding new medicines and improving gene editing technology like CRISPR.
Researchers found that a single synonymous mutation in a gene drives cucumber elongation by altering RNA structure and function. This breakthrough has significant implications for crop breeding programs and may lead to the development of precision-crop improvement techniques.
Researchers argue that deliberate full extinction might be acceptable in rare cases, but only with careful consideration of ecological and moral implications. The study calls for robust ethical safeguards and inclusive decision-making frameworks to guide the use of genetic modification technologies.
Researchers at MIT engineered bacteria to produce unique wavelengths of light that can be detected using hyperspectral cameras. This technology could enable the development of bacterial sensors for agricultural applications, such as monitoring crop health and detecting pollutants.
The new AI model leverages hypergraphs to quickly and accurately identify therapeutic gene targets for diseases. HIT outperformed existing models in all tested metrics, demonstrating its accuracy in classifying therapeutic gene targets with great precision.
The final synthetic chromosome unlocks new possibilities in metabolic engineering and strain optimisation, enabling the generation of genetic diversity on demand. The achievement represents a major milestone in synthetic biology and has important implications for future genome engineering projects.
Researchers have developed a new sorghum variant that can outperform soybeans in oil production, with great potential as a clean source of renewable fuel. The 'push-pull-protect' strategy successfully engineered sorghum lines to accumulate up to 5.5% TAG in their leaves and 3.5% dry weight in their stems under field conditions.
Researchers found that soil contains antibiotic resistance genes that can be transmitted to humans, making it a pressing public health threat. The study reveals how these genes spread through the environment and highlights the importance of understanding soil ecosystems to control antibiotic resistance.
Researchers developed a new tool called SigRM to analyze single-cell epitranscriptomics data, enabling the study of RNA modifications in individual cells. This can provide valuable insights into gene regulation and its impact on health and disease, particularly in complex conditions like cancer.
Scientists at Gladstone Institutes have discovered a diverse range of retrons that can edit DNA more quickly and efficiently than current methods, including CRISPR. The new retrons showed high editing rates in both bacteria and human cells, with some performing 10-fold better than the gold-standard retron.
Researchers at Osaka Metropolitan University used CRISPR/Cas9 to create a strain of Euglena that produces wax esters with shorter carbon chains, improving their cold flow and suitability as a biofuel feedstock. This breakthrough could potentially replace petroleum-based production of wax esters with biological sources.
A century-old experiment has pinpointed the genes behind barley's adaptability, enabling its continued survival in rapidly changing environments. Researchers identified key genes that enable flowering at optimal times, allowing crops to thrive despite increased temperatures and droughts.
A study led by Cesar de la Fuente and his team has uncovered sequences for infection-fighting molecules in the genomic data of extinct species. These ancient β-defensins may lead to the creation of new antimicrobial therapies, including antibacterial, antifungal, and antiviral treatments.
Researchers at FAU aim to identify signatures of natural selection in the human genome, understanding its role in adaptation and disease. The $1.8 million NIH grant will develop powerful tools for complex modes of adaptation from genetic data.
Researchers at the University of Hawaii have developed a new gene editing technology that can efficiently deliver healthy genes to the body. This method addresses limitations of current methods and has shown success rates of up to 96%, potentially leading to faster and more affordable treatments for various genetic diseases.
The University of Illinois has been awarded $15 million from the NSF to establish a new iBioFoundry, which will integrate synthetic biology, laboratory automation, and artificial intelligence. This facility aims to advance protein and cellular engineering, promoting sustainable biomanufacturing processes.
Researchers developed an innovative gene-writing technology based on R2 retrotransposons, enabling efficient and precise targeted gene integration in human cells. The en-R2Tg system achieves high gene integration specificity at the 28S rDNA safe harbor site, reducing mutagenesis risks.
A new tool called TATSI enables efficient and accurate genome editing in plants, increasing the rate of targeted DNA integration by an order of magnitude. This technology has the potential to improve crop traits such as virus resistance and nutrient levels, addressing global challenges in agriculture.
Researchers at the University of Sydney have developed SeekRNA, a programmable tool that can precisely target and relocate genetic sequences with high accuracy and flexibility. This breakthrough technology surpasses current limitations of CRISPR, enabling more precise editing and reducing errors.
Researchers at Tokyo Medical and Dental University have developed a novel method for coating engineered messenger RNA molecules with polyethylene glycol (PEG), allowing selective delivery to the spleen. This breakthrough enables fine-tuned control over mRNA therapy, facilitating effective treatment of diseases previously considered inc...
Researchers at CABBI developed a computational pipeline for identifying CRISPR/Cas-facilitated integration sites, which can pinpoint neutral integration sites in two to three minutes. This tool enables researchers to efficiently locate all the needles that align with their specific criteria, transforming the genome editing process.
Researchers at Tokyo Medical and Dental University develop a genome-editing technique that decreases PMP22 protein levels in patient cells, potentially reversing CMT-related changes. The study aims to improve myelination abilities and reduce symptoms in patients with CMT type 1A.
Researchers at West Virginia University are using artificial intelligence to analyze habanero peppers and develop new methods for predicting genetic traits. The goal is to improve crop yields and prevent genetic diseases, with potential applications in human health.
A new bottom-up approach to genome synthesis in multicellular plants is proposed using the model moss Physcomitrium patens. The study discusses challenges such as genome assembly and plant transformation, highlighting recent breakthroughs and limitations that must be overcome for wider application.
Researchers propose retroelement-based gene editing as a safer alternative to CRISPR-Cas systems due to reduced risk of DNA double strand breaks and unwanted chromosomal modifications. This approach leverages endogenous mobile genetic elements, which can be programmed for targeted genomic engineering without generating DSB.
A new CRISPR-based diagnostic tool, MPXV-CRISPR, has been developed in Australia to detect the monkeypox virus with high precision and speed. The tool can detect the virus in clinical samples in just 45 minutes, making it faster than current methods.
Researchers developed a novel DNA marker-based system for identifying Japanese citrus cultivars, enabling quick detection of counterfeit fruit. The method can accurately identify cultivar-specific DNA polymorphisms within minutes, safeguarding Japan's unique citrus industry and its breeders.
Scientists have developed a method to increase the efficiency of CRISPR/Cas9 gene editing without viral material, stimulating homology-directed repair by threefold. This breakthrough improves nonviral gene editing and may lead to more efficient disease modeling and hypothesis testing.
Students participate in a genome-editing experiment to correct a mutation that causes 'GFP-itis', gaining hands-on experience with gene editing and understanding its therapeutic potential. The program aims to encourage critical thinking about the implications of germline genome editing and inspire students to pursue careers in STEM.
Researchers at CeMM Research Center discovered that the DNA mismatch repair process plays a crucial role in prime editing. By eliminating mismatch repair, they increased prime editing efficiency by 2-17-fold and improved its accuracy. This fundamental understanding brings the technology closer to clinical applications.
The center will provide a one-stop shop for custom DNA constructs, accelerating cancer research through access to state-of-the-art tools. The facility will enable transformative, large-scale experimental projects that were previously impossible for individual labs.
MIT researchers have created a new DNA writing technique called HiSCRIBE that can record interactions between cells and store spatial information. This approach offers a way to edit genes in the human microbiome, potentially revolutionizing the field of genome editing.
The Center for Behavioral Neuroscience has received a grant from NIMH to develop transgenic and gene-targeted Syrian hamsters for understanding complex social behavior. The technology will enable molecular interrogation of genes regulating social behavior, leading to progress toward better understanding of psychiatric disorders.
IBS researchers develop Digenome-seq to confirm CRISPR-Cas9's accuracy in human cells. The technique identifies on-target and off-target sequences, eliminating concerns about cancer-causing mutations.
Researchers at Whitehead Institute have developed a method to create conditional mutant mice using CRISPR/Cas, accelerating the process from years to weeks. This allows scientists to model diseases and study gene function with more efficiency.