A new study published in the Journal of Experimental Medicine showed that a fast-tracked stroke drug, 3K3A-APC, protected mice from injury to the brain's white matter, a leading cause of dementia. The drug may also be effective in slowing down progression of cognitive impairment.
A study of 2,800 patients with COVID-19 examined the rate and factors associated with post-discharge blood clot risk. The researchers found that certain factors, including age and use of blood thinners, increased the risk of developing a blood clot after hospital discharge.
A two-year follow-up of participants found that those who had both their mitral valve and tricuspid valve repaired at the same time experienced better outcomes, including less progression to moderate or severe leakage. This study provides high-level evidence for surgeons on how to perform tricuspid valve repair in these patients.
Researchers compared milvexian with enoxaparin for prevention of blood clots in knee replacement surgery patients. Milvexian resulted in better clot protection without increased bleeding risk. The study suggests a safer oral anticoagulant alternative for preventing blood clots.
A new trial shows that the novel surgical device venous external support (VEST) may improve outcomes of coronary bypass grafting using leg veins by preventing intimal hyperplasia, a key factor in vein graft failure.
Research suggests women with lingering COVID-19 symptoms experience heart rate irregularities during physical exertion, leading to delayed recovery and reduced exercise tolerance. Targeted rehabilitation programs are needed to manage these consequences in women with persistent heart and lung problems.
A recent study published in JAMA Internal Medicine investigated the incidence of cerebral venous sinus thrombosis (CVST) after post-vaccination. The researchers found that the rate of this rare adverse effect is significantly higher than pre-pandemic rates, prompting consideration of vaccine effectiveness in preventing COVID-19.
A comprehensive patient blood management program implemented at Mayo Clinic reduced allogenic transfusion use by 33% and improved hospital length of stay and adverse events. The program's multi-faceted approach included education efforts, computerized order entry processes, and analytics to inform decision-making.
Researchers identified six human blood proteins, including serum albumin and immunoglobulin G, in the red paint of a 1000-year-old gold mask. The presence of bird egg proteins suggests the use of a binding material to preserve the paint on the metal surface.
Lactate sensors in wearables aim to monitor athletes' exertion levels, but the connection between sweat and blood lactate remains unclear. Researchers propose improvements to electrochemical sensors and develop an epidermal patch containing a lactate biosensor.
Researchers found that a screening blood test for major blood clots in the lungs is still useful for ruling out pulmonary embolism in COVID patients, with low D-dimer levels indicating no clot presence. The test can help avoid more expensive and invasive diagnostic tests, reducing patient safety risks.
Researchers at QUT identified causal genetic links to three blood metabolite levels that increase migraine risk. These findings could lead to the development of compounds that target metabolite levels and prevent migraines.
A plasma biomarker panel identified a combination of sTNFR1, sTNFR2, cystatin C, and eGFR that discriminated between patients with worsening or low risk of chronic kidney disease after three years. This combination was particularly effective at identifying those with very low risk of subsequent kidney dysfunction.
A study at Stockholm University has discovered a novel, eco-friendly feeding trap that can be deployed to control mosquito populations. The trap uses a beetroot-based mix with added toxins, which attracts and kills female mosquitoes, while leaving male mosquitoes unaffected.
Scientists at DZNE and UMG identified three microRNAs in the blood that correlate with mental fitness and cognitive decline. The biomarker is associated with an increased risk of Alzheimer's disease within two years, offering potential targets for therapy and early warning signs.
A recent study published in the American Journal of Clinical Nutrition found that consuming whole fat milk has no negative impact on children's health. The research, which involved 49 healthy children aged four to six, showed that both groups consumed similar amounts of calories and fat.
Researchers evaluated D-Dimer blood test to rule out blood clots in COVID-19 patients, finding it effective. The study also highlighted the importance of timely diagnosis and treatment to prevent complications.
A University of Minnesota Medical School-led study found that patients on blood thinners before having COVID-19 were admitted less often to the hospital and had reduced deaths. The use of blood thinners also benefited hospitalized COVID-19 patients regardless of medication type or dose.
Researchers found that people living at high altitudes have a lower risk of stroke and stroke-related death. The study suggests that adaptation to low oxygen conditions may help protect against stroke damage. A protective window between 2,000 and 3,500 meters was identified, with less protection seen above this altitude.
A study published in BMJ Open found a significant link between asymmetric brain arteries and the likelihood of developing a cerebral aneurysm. The research suggests that MRI and CT angiograms can be used to screen people with asymmetrical brain arteries for cerebral aneurysms, providing a new tool for monitoring those at risk.
A new study has identified unique genetic codes in the placenta that could detect pregnancy complications earlier than current tests. The researchers found specific biomarkers in maternal blood that indicate placental health and fetal well-being, allowing for real-time assessment throughout pregnancy.
Patients with dementia presenting with shortness of breath were less likely to be tested for pulmonary embolism compared to those without dementia. Clinical signs and risk factors, such as elevated heart rate, were also evaluated differently in patients with dementia.
A large epidemiology study found associations between higher HDL and apoA1 levels with a lower risk of ALS. Lower LDL and apoB levels were also linked to decreased risk. These findings may support population screening and preventative therapy for ALS.
SourceBMJ Group·JournalJournal of Neurology Neurosurgery & Psychiatry·TypeObservational study·DateSep 13, 2021
The study found large reductions in uninsurance and improvements in blood pressure and blood sugar control among Hispanic and Black patients after Medicaid expansion. The first five years of expansion were associated with significant benefits for these populations.
A mechanical engineering faculty-researcher at RIT is developing a microfluidic device to improve the detection of drug-resistant bacteria in blood, which can cause severe infection and death. The goal is to detect these strains early, allowing for prompt treatment and recovery.
Researchers examined changes in life expectancy after allogeneic blood or marrow transplantation over four decades. The study found improved survival rates and reduced risk of death among transplant recipients.
A recent study found that individuals with COVID-19 are at a higher risk of developing phlebitis and thrombophlebitis, as well as blood clots in the leg and lung. The study also identified associations between general COVID-19 susceptibility and increased blood clot events and circulatory diseases.
A new study from Uppsala University found that genetic tests are more accurate than traditional blood tests in determining the risk of cardiovascular diseases. The study analyzed data from 500,000 subjects and discovered a significant link between blood group genetics and coagulation proteins.
Researchers found Prozac reduces lipid concentrations in monkey brains, linked to potential side effects in young patients. The study suggests dietary changes may alleviate adverse effects by influencing lipid synthesis.
A clinical trial shows that full-dose blood thinner treatment reduced the need for organ support and improved hospital outcomes in moderately ill COVID-19 patients. However, this benefit was not seen in critically ill patients requiring intensive care.
Researchers at the University of Basel developed a breath test to measure treatment success in epilepsy patients. The test provides immediate results without requiring a blood sample, allowing doctors to adjust medication quickly and precisely tailored to individual patients' needs.
Researchers analyzed patient specimens and clinical trial data from thousands of patients to assess the importance of immune cell molecules called Fc gamma receptors (FCGRs) in the therapeutic efficacy of two antibody drugs. High levels of FCGR2B on tumor cells were found to prevent rituximab efficacy, while obinutuzumab was not impact...
A world-first study found that cancer patients receiving chemotherapy intravenously have more than double the risk of developing a blood clot or thrombosis if the vein is too small and the catheter occupies more than 45% of the vein. Researchers identified specific limits on catheter-to-vein ratios to reduce risks for cancer patients.
Researchers compared various race-free equations and found that removing race adjustments increases eGFR values for Black patients, leading to more chronic kidney disease stage reclassifications. Blending or direct removal of race coefficients resulted in decreased eGFR estimates.
Researchers analyzed Neandertal and Denisovan genomes to identify blood groups, confirming their African origin and Eurasian dispersal. The study also found evidence of low genetic diversity and possible demographic fragility, shedding light on the disappearance of Neandertals.
A study analyzing ancient DNA has uncovered new information on the blood types of Neanderthals and Denisovans. The analysis reveals consistent African origins and increased vulnerability to diseases affecting fetuses and newborns, confirming previous evidence of low genetic diversity leading to eventual demise.
A proposed Canadian Immunization Services model could provide a coordinated approach to vaccination across the country, addressing fragmentation in data sharing, vaccine procurement, and supply chain management. The independent not-for-profit corporation would be funded by provinces, territories, and potentially the federal government.
A scientific review suggests a disruption in blood clotting and immune system may contribute to psychosis development. The researchers propose that an imbalance of these systems leads to inflammation, which contributes to the development of psychosis.
A novel body tissue adhesive incorporating snake venom has been developed to stop life-threatening bleeding in seconds. The 'super glue' works with visible light and offers 10 times the strength of existing fibrin glue, cutting blood clotting time in half.
Middle- to older-aged adults who eat at least three servings of whole grains daily have smaller increases in waist size, blood pressure, and blood sugar levels over time. Whole grains may protect against heart disease by reducing these risk factors.
Researchers found that a type of echocardiogram can predict which COVID-19 patients are most at risk of developing atrial fibrillation, a condition that increases the risk of heart failure and stroke. Patients with high levels of certain biomarkers in their blood also showed increased risk.
Researchers at Johns Hopkins Medicine report a potential noninvasive biomarker for tracking gene editing therapies in early-stage Huntington's disease. By measuring blood volume in the brain, they found that suppressing the mutant huntingtin gene can normalize altered arteriolar blood volumes and delay or prevent symptom development.
A longitudinal study of 358 diabetics found that proteins ANGPT1, TNFSF12, and FGF20 are associated with slower kidney decline. These proteins may help identify individuals at higher risk of diabetic kidney disease, enabling earlier interventions and treatment.
A recent study has made a breakthrough in understanding the process that leads to pulmonary embolism, a condition that kills over 2,000 people in the UK each year. Researchers have identified a protein called fibrin as crucial in stabilizing clots and preventing fragments from breaking loose.
A new study published in Neurology found that trying more than one time to remove blood clots during endovascular treatments for ischemic strokes was associated with increased disability and brain damage. Researchers suggest aiming for a single attempt at removal with new devices, highlighting the need for further development.
The NIH ACTIV-4B trial found that not treating certain symptomatic but stable outpatients with anticoagulant or antiplatelet therapy may be the best course of action, suggesting a very low rate of thrombotic complications. This recommendation has immediate implications for prophylactic treatment and management of mild COVID-19 symptoms.
Researchers successfully engineered yeast to produce spermidine, a natural molecule that induces autophagy, in hopes of addressing age-related diseases. The production yield reached 2.3 grams per liter, paving the way for fermentation-based manufacture of polyamines and their analogues.
A new study highlights the high risk of kidney failure and cardiovascular complications in patients with primary nephrotic syndrome, particularly those with focal segmental glomerulosclerosis. Adults with this condition are 19.63 times more likely to develop kidney failure over a median follow-up period of 4.5 years.
Researchers found that COVID-19 patients have higher levels of pro-clotting VWF molecules and lower levels of anti-clotting ADAMTS13. This disruption leads to severe blood clots, which can be life-threatening.
A new device that fits over a person's ears can measure real-time changes in blood alcohol levels through the skin. The device collects gas released through the skin and uses an ethanol vapour sensor to calculate ethanol concentrations.
A study published in Environment International found high levels of lead in indigenous people living in Peruvian Amazonia, with the highest concentrations found near oil extraction areas. The research, led by Cristina O'Callaghan-Gordo, highlights the need for urgent action to address the potential health effects on these communities.
Women are more likely to experience acute aortic dissection with older age and different presenting symptoms, leading to delayed diagnosis and treatment. The study highlights the need for sex-directed strategies to improve outcomes in female patients.
A clinical trial found an implantable device is more than three times more effective in detecting atrial fibrillation in ischemic stroke patients. The device could prevent disabling strokes by almost 70% if detected early.
A new study published by the American Heart Association found that adults with OCD were more than three times as likely to experience an ischemic stroke, with the greatest risk among older adults. Researchers also discovered that medications used to treat OCD did not increase the risk of stroke.
A study published in Nature Metabolism found that specific proteins in the blood can predict an individual's trainability and response to exercise. The researchers identified 147 proteins related to cardiorespiratory fitness, which improved their ability to predict an individual's change in VO2max.
The research team found that tenascin-C plays a crucial role in damaging vision cells following ischaemia. In mice without tenascin-C, retinal function improved after ischaemic damage, and fewer photoreceptors died.
A new study on the 25 million-year-old fossil skull of Aetiocetus weltoni reveals that it had both teeth and baleen in adulthood. The discovery provides evidence of a major shift in feeding behavior from raptorial carnivory to filter-feeding, and sheds light on the evolution of modern baleen whales.
A study of 1,095 patients with COVID-19 found abnormal blood-oxygen levels and breathing rates are strong predictors of poor patient outcomes. Researchers recommend monitoring for these signs at home or seeking medical attention earlier to potentially save lives.
A new study published in JAMA Network Open found that a game-based program increased physical activity levels among diabetes patients by an average of 503 steps per day. The program used wearable devices and digital scales with personalized goals to encourage competition, collaboration, or support from family members.
A new type of coronary artery stent is being developed with ultra-low profile struts and a smart surface that can help improve healing and prevent blood clots. The stents aim to reduce the risk of restenosis and thrombosis, which occur in 3-10% of cases.