Articles tagged with Excretory System
Researchers have identified a way to strengthen bladder cells' ability to eliminate hidden bacteria, reducing recurrent UTIs. OM-89 increases lysosomal acidification and enzyme activity, allowing antibiotics to reach and kill bacteria more effectively.
A new study found that bladder infections after brain injury worsen cognitive problems, with post-injury UTIs altering brain immune cells. This research suggests that bladder infections may exacerbate TBI outcomes, highlighting the need for infection prevention strategies to improve long-term recovery.
Researchers have discovered a previously overlooked group of bladder nerves that help detect urinary tract infections and trigger the body's response to clear them. These nerves, located close to the bladder lining, act as an early warning system that springs into action during a UTI, helping to reduce severity and spread of infection.
A novel treatment approach combining phage therapy and fecal microbiota transplantation has shown promise in treating recurring urinary tract infections. The study, published in Nature Microbiology, found that the treatment reduced UTI episodes and improved quality of life for patients.
A recent study found that cranberry juice enhanced the antibiotic activity of fosfomycin against 72% of uropathogenic E. coli strains, while suppressing resistance-related mutations. The findings suggest that natural compounds in cranberry juice may be a useful frontier in fighting antibiotic resistance.
A study published in Frontiers in Ecology and Evolution found that optimal birth weight for minimal kidney damage during extreme endurance events is around eight pounds. Individuals with lower or higher birth weights may face a greater risk of kidney stress or damage.
A USC team has created a neuroprosthetic device that can restore coordinated bladder control in small animal models, proof of concept for a future treatment that could transform lives after spinal cord injuries. The device targets the dorsolateral funiculus region of the spinal cord to mimic the natural signals that trigger the need to...
A phase 2 study led by NYU Langone Health showed that adding pembrolizumab to standard chemotherapy and radiation with surgery allowed 60% of patients to avoid bladder removal for up to two years post-treatment. This breakthrough treatment offers hope to patients with muscle-invasive urothelial cancer of the bladder.
Weill Cornell Medicine researchers will explore novel combination therapies to address the gap in treatment options for patients with advanced urinary tract cancers. The study aims to understand how inherited genetic alterations and tumor-acquired mutations cooperate to disrupt DNA repair and drive cancers of the urinary tract.
A clinical trial is underway to assess the safety and efficacy of the UroActive implant for stress urinary incontinence in men. The trial aims to improve quality of life and provide a better treatment option compared to current SUI treatment.
Researchers found a significant link between type 1 diabetes and an increased risk of bladder cancer, with people being 4.29 times more likely to develop the disease. The new analysis controlled for tobacco smoking, a factor that obscured the heightened risk in earlier studies.
USC Stem Cell scientists have developed a blueprint for generating specific kidney cell types on demand, holding immense value for preclinical studies of new therapeutics and congenital kidney diseases. The team successfully created lab-grown proximal tubule cells that can absorb sugar and protein, respond to chemotherapy drugs, and pr...
A USC research team has made a groundbreaking discovery about the human spinal cord's role in bladder control. The study used functional ultrasound imaging to observe real-time changes in blood flow dynamics during bladder filling and emptying, revealing areas where activity is correlated with bladder pressure.
Scientists developed a material that can stick to tumors, pumping out chemotherapy drugs for days, minimizing impact on healthy tissue. Early results show great promise for reducing clinical treatments and improving patient outcomes.
A new review recommends combining enfortumab vedotin with pembrolizumab as the first-line therapy for advanced urothelial cancer, offering a more effective and better-tolerated alternative to traditional chemotherapy.
A recent study at the University of Jyväskylä found that central adiposity increases the risk for stress urinary incontinence in middle-aged women. Larger fat mass and waist circumference are key factors associated with this increased risk, highlighting the importance of body composition in understanding pelvic floor disorders.
A joint research team from POSTECH and Hanyang University developed a personalized stimulation control mechanism using evoked compound action potential feedback mechanisms to treat urinary disorders. This technology enables precise adjustment of tibial nerve stimulation in real-time, based on individual nerve responses, improving patie...
A new study published in Annals of Internal Medicine found that AI diagnostic and treatment recommendations were more accurate than those made by physicians in a virtual urgent care setting. In 77% of cases, AI recommendations were rated as optimal, compared to 67% for physicians' decisions.
AIE materials have shown potential in diagnosing and treating urinary cancers, kidney disease, and infections due to their high quantum yield, excellent optical properties, and environmental responsiveness. However, challenges remain regarding stability, biocompatibility, and synthesis costs.
A recent study found that disordered eating is associated with a higher risk of symptoms of pelvic floor disorders in middle-aged women. The research revealed that consuming highly processed ready-made foods and fast food increases the risk for stress urinary incontinence, while a higher quality diet decreases the risk.
Researchers have found that UTIs cause nerves in the bladder to become hypersensitive, resulting in painful sensations and frequent urination. This new study provides a deeper understanding of how UTIs affect bladder function and offers potential new treatment options for patients suffering from recurrent UTIs or other bladder conditions.
Researchers at the University of Liverpool used AI to develop a personalised method for treating urinary tract infections, improving accuracy and reducing antibiotic resistance. The new approach uses real-time data to target specific bacterial infections, making antibiotics more effective.
Researchers found that thalattosuchian sinuses reduced during semi-aquatic phases and then diminished further as they became fully aquatic. This allowed them to develop extracranial sinuses, which might have helped drain salt glands and alleviate 'encrustation' problems.
A cohort study of children with vesicoureteral reflux found that glomerular filtration rate changes after urinary tract infections. The study used data from the Children With Vesicoureteral Reflux trial to assess estimated glomerular filtration rate changes in participants with vs without recurrent UTIs.
A new study from the University of Texas at Arlington suggests that analyzing RNA in urine can show changes in cell types, revealing early signs of cancer and other diseases. This method could help clinicians detect problems earlier when they are more easily treated without invasive procedures.
A new implant and smartphone app monitor bladder fullness in real time, offering a game-changer for people with paralysis, spina bifida, or end-stage bladder disease. The device's success has been demonstrated in small animal studies and non-human primate trials.
Researchers found that SGLT2 inhibitors reduced kidney stone rates by 30% compared to GLP1 agonists and 25% compared to DPP4 inhibitors. The study included data from 716,406 adults with type 2 diabetes who took these medications.
A study published in the Journal of Internal Medicine found that SARS-CoV-2 infection may worsen lower urinary tract symptoms in men. The research involved 17,986 men with medication for LUTS, half of whom had COVID-19, and showed a significant increase in urine retention, UTIs, and enlarged prostate issues.
Researchers have developed a lab-grown human skin model that effectively replicates mpox virus infections, providing insights into the virus's mechanisms of attack on skin cells. The study reveals how the virus causes disease and identifies potential therapeutic targets, including an antiviral drug called tecovirimat.
Researchers found that acute kidney injury does not predict worsening of kidney function trajectory in patients with CKD, suggesting that pre-existing kidney disease may be a major contributor. The study recommends focusing on flattening the eGFR slope and treating proteinuria to slow CKD progression.
The USC Stem Cell team is developing artificial kidney organoids using human stem cells and synthetic biology. They aim to create a functional kidney that resembles the real thing in function but not in form.
Researchers review current treatment updates for systemic light chain (AL) amyloidosis, highlighting the need for early diagnosis and effective maintenance therapy. The article discusses the relationship between AL amyloidosis and monoclonal gammopathy of undetermined significance (MGUS), emphasizing the importance of regular monitoring.
Researchers have discovered a new molecular mechanism for the transport and excretion of boric acid in marine pufferfish, finding that a unique gene, Slc4a11A, plays a crucial role in this process. This breakthrough opens up new avenues for understanding boric acid transport in animals.
A new study in The American Journal of Pathology found that inhibiting neuropilin 2 in smooth muscle can enhance contraction and motility of the distal colon. This could provide opportunities to regulate smooth muscle activity in patients with colonic disorders.
Researchers at the Max Planck Institute have identified a group of glucosinolate-specific transporters in the horseradish flea beetle's excretory system, enabling it to accumulate high amounts of plant toxins for defense. This mechanism allows the beetle to turn itself into a 'mustard oil bomb' and deter predators.
Researchers at Cornell University have identified a protein involved in mosquito urination, which can help control the spread of diseases like dengue fever. By blocking this protein's function, mosquitoes may be limited in their ability to survive after feeding on blood.