Articles tagged with Lungs
Researchers found a shared genetic trait that predicts a higher risk of small lung vessel disease and its severe form, pulmonary arterial hypertension. This discovery could lead to personalized treatments for patients with limited oxygen response.
The Pirola variant of SARS-CoV-2 has rediscovered an entry pathway into lung cells that was previously used by earlier variants, which may promote the development of pneumonia. The virus uses the cellular enzyme TMPRSS2 for entry and is resistant to most therapeutic antibodies.
The BA.2.86 omicron subvariant can infect human lung cells more efficiently than previous omicron variants, raising concerns about potential severe disease symptoms. While bivalent mRNA vaccines can neutralize BA.2.86, the efficiency is reduced, emphasizing the importance of getting a newer booster vaccine.
Researchers developed nanosensors that can be inhaled and detected in urine, offering a potential alternative to CT scans for early lung cancer detection. The diagnostic system shows high specificity and sensitivity in detecting stage 1 or 2 lung tumors.
Researchers found that higher levels of omega-3 fatty acids in the blood plasma were associated with better lung function and longer survival without needing a lung transplant. This was consistent regardless of smoking history or cardiovascular disease.
A study in the JAMA Network Open found that Hispanic and American Indian individuals with breast, colorectal, lung, and prostate cancer were undercaptured in the National Cancer Database, but representation improved over time. Further investigation is needed to understand where these populations seek cancer care.
A Learning Health System model is being developed to increase organ donation and reduce disparities in access to transplantation. The project, led by Hennepin Healthcare Research Institute, will use data tools to track progress and improve equity in organ donation across the US.
Researchers identified Benidipine as a compound promoting the death of cigarette smoke-induced senescent lung cells, improving lung emphysema. The dihydropyridine family of calcium channel blockers constitutes a new class of senolytics that could improve lung diseases.
A 12-week beetroot juice supplement reduced systolic blood pressure by 4.5mmHg and increased walking distance by 30 meters in COPD patients. The nitrate-rich supplement improved cardiovascular risk markers, suggesting potential benefits for everyday life and heart disease prevention.
Researchers at the University of Seville have developed a bioinspired PEM fuel cell design that improves the distribution of liquid water inside these batteries. This approach has the potential to significantly enhance the efficiency and durability of PEM fuel cells, leading to more efficient and sustainable energy systems.
Researchers have discovered that immune cells play a crucial role in directing the growth of human lung tissue during development, revolutionizing our understanding of early lung development. The findings also suggest that early immune disturbances could manifest as pediatric lung disease.
The study found that solely the omicron variant influences cell cycle genes, leading to increased p21 expression and a senescence-associated secretory phenotype. This results in premature cellular senescence, potentially contributing to the reported cytokine storm and development of long-COVID.
A novel study has implicated granulocyte colony-stimulating factor (G-CSF) in both bronchopulmonary dysplasia and retinopathy of prematurity, making it a promising therapeutic candidate. G-CSF deficiency was shown to protect against these diseases, suggesting wide-ranging protection.
A new study from Gladstone Institutes has greatly expanded the scientific body of knowledge about how the body responds to too much oxygen. The research highlights a particular protein, MYBBP1A, that may play a central role in regulating cells' response to hyperoxia.
Researchers found SARS-CoV-2 viruses persisting in lung cells for up to 18 months post-infection, despite undetectable upper respiratory tract presence. The study suggests a link between innate immunity failure and virus persistence.
A new experimental model, human precision-cut lung slices (hPCLS), was used to study lung disease mechanisms and understand treatment response. The team leveraged single-cell genomics to analyze cell activity in hPCLS after specific treatments.
Researchers at Temple University Health System report that the BASHIR Endovascular Catheter reduces blockages in lung arteries and correlates with improved right ventricle function, suggesting better survival outcomes. The catheter also shows significantly lower bleeding rates compared to other devices.
Researchers at UC Riverside found that SARS-CoV-2 entry varies among different species and tissue types, highlighting the need for thorough investigations into viral entry mechanisms. The study's findings suggest that targeting TMPRSS2 may not be effective in preventing COVID-19 infection in mink.
Research at the Radiological Society of North America annual meeting found that marijuana smokers are 12 times more likely to develop centrilobular emphysema compared to non-smokers. Combined marijuana and cigarette smoking increased the risk of breathing difficulties and other serious respiratory symptoms.
A study of over 2.9 million patients found that gender concordance was associated with lower mortality for female patients, but higher mortality for male patients. The quality of surgical care provided by female surgeons is equivalent to or slightly better than that provided by male surgeons.
Researchers have engineered a living material resembling human phlegm to study polymicrobial biofilms in cystic fibrosis patients. The material, which grows 3D biofilms in a controlled manner, will help experts understand how these structures form and develop effective treatments.
A recent study published in Nature Communications reveals that disrupted NAD(H) homeostasis is a key factor in tuberculosis pathogenesis. The researchers found that the glycolytic pathway can be selectively inhibited using an LDH enzyme with mostly LDHA subunits, which preferentially converts pyruvate to lactate and NADH to NAD+.
The November issue of CHEST journal features cutting-edge research on asthma, COPD, diffuse lung disease, and thoracic oncology. A new guideline provides updated recommendations for patients with stable COPD, while home spirometry is shown to be less consistent than clinic spirometry in monitoring lung function in patients with asthma.
Researchers aim to identify contaminants in ash, soil, and surface waters from the Maui fire, posing risks to human health. The study will also help educate communities on the presence and risk of contaminants, informing prevention measures for future fires.
Researchers developed soft, miniaturized wearables that continuously track subtle body sounds wirelessly across the body. The devices offer new functionalities and provide highly accurate, real-time evaluation of patient health.
Researchers discovered COVID-19 causes epigenetic scars in lung tissue that lead to hyperinflammation and fibrosis. These changes are associated with increased interferons and chemokines, promoting inflammation.
A large-scale study found that low-dose CT screening increases the 20-year survival rate of lung cancer patients from 18.6% to 81%, with Stage I cancers having an even higher long-term survival rate of 95%. Early detection through annual screening can effectively cure lung cancer in the long term.
A new study published in Radiology shows that patients diagnosed with lung cancer via CT screening have a 20-year survival rate of 81 percent, significantly higher than the average five-year survival rate for all lung cancer patients. Early detection through routine screening can lead to a cure if found early.
Researchers at Brigham and Women's Hospital analyzed data from over 7,500 patients to discover that suspected bronchiectasis in smokers is associated with a higher risk of mortality. The study suggests that lung imaging can help identify this condition, leading to improved patient care.
A new study by RCSI University of Medicine and Health Sciences found that boosting levels of a deficient protein improves survival rates for people with severe alpha-1 antitrypsin deficiency. The research, which tracked health data from over 600 patients, showed a clear survival benefit from augmentation therapy.
Dr. Marlene Rabinovitch, a renowned pediatric cardiologist, will receive the 2023 Research Achievement Award for her groundbreaking research on PAH treatment. Her discoveries have led to the identification of neutrophil elastase as a trigger for inflammatory responses and the potential use of immunosuppressant FK506 to restore lung blo...
Researchers identify immune cells responsible for some hard-to-treat asthma cases, particularly in men who develop asthma later in life. These cells can cause severe inflammatory responses and do not respond to treatment.
Researchers identify cytotoxic CD4+ tissue-resident memory T cells as potential asthma triggers, particularly in older male patients. These cells can cause severe inflammatory responses and make treatment challenging.
The Center for Advancing Point of Care Technologies (CAPCaT) has received a five-year, $8.9 million award from the NIH to develop innovative point-of-care health technologies. The program aims to address heart, lung, blood and sleep disorders in underserved populations.
A recent VA study analyzed electronic health records of over 5.9 million veterans to provide insights into COVID-19 mortality rates. The research found that absolute numbers of deaths were higher in younger age groups and healthier individuals, despite older adults experiencing the highest rate of excess mortality.
A new study reveals that innate CD8+ lymphocytes play a crucial role in limiting tuberculosis infection, and an inflammatory molecule called Interleukin-15 could be used to boost vaccine efficacy. Researchers found that these cells create a 'bottleneck' preventing bacteria from establishing active infection.
Researchers at UCSF found a feedback loop between immune protein IL-31 and nerve cells, which dials back nearby inflammation and promotes skin healing. This discovery could lead to new treatments for conditions like eczema, allergies, and asthma by targeting the nervous system's role in regulating the immune response.
A University at Buffalo-led research team has developed molecules that can transport chloride ions across cell membranes, increasing airway surface liquid and restoring normal mucus clearance in cystic fibrosis cells. The synthetic anion binders offer a new potential treatment for the chronic disease.
Scientists have discovered a TB vaccination strategy that prevents lung infection in monkeys infected with SIV, despite the vaccine being contraindicated for people living with HIV. The results show promise for protecting people with HIV against TB, which is the leading cause of death among them.
A new AI tool developed by Brazilian researchers can detect potentially cancerous lung nodules in CT reports, missing a crucial early diagnosis. The NLP tool achieved an accuracy rate of 97% in identifying suspicious nodules.
Researchers discuss lurbinectedin as a method to treat neuroendocrine tumors (NETs), with encouraging results from phase II basket studies demonstrating activity in platinum-sensitive relapsed SCLC and other malignancies. Lurbinectedin's mechanism of action involves inhibiting oncogenic transcription, promoting apoptosis and cell death.
Post-Acute Sequelae of COVID-19 research aims to track long-term health symptoms in survivors. A $3.7 million grant will support the development of self-supervised deep learning technologies to recognize post-COVID lung progression phenotypes.
A University of Melbourne research team is developing an oral therapeutic to restore the activity of common antibiotics used to treat community-acquired bacterial pneumonia. The project aims to combat antibiotic-resistant bacteria and reduce healthcare costs, with potential applications in low- and middle-income countries.
A machine learning model developed by researchers can predict lung cancer risk with an 83.9% sensitivity, identifying those who need screening for the disease. The model uses just three predictors: age, smoking duration, and pack-years of smoking, making it a simplified approach to determine high-risk populations.
Scientists have developed a trivalent vaccine candidate that provides broad and long-lasting protection against COVID-19 infection by delivering the vaccine via the nose. The vaccine triggers a strong neutralizing antibody response and protects mucosal areas, preventing disease symptoms.
A new model developed by Cleveland Clinic researchers can more accurately prioritize patients waiting for a lung transplant, taking into account their disease severity and time on the waiting list. This approach may help reduce waitlist mortality for patients with end-stage lung disease.
A University of Virginia team has developed a new analytical tool using hydrogels to cultivate vascular sprouting from mouse lung tissue, providing new insight into idiopathic pulmonary fibrosis. The research aims to understand the biomechanical and biochemical cues to blood vessels in the lungs during disease progression.
A survey by The BMJ found that patients in deprived areas have limited access to vital diagnostic tests for respiratory conditions. Despite NHS promises, GPs report 'troubling' lack of services, while Asthma + Lung UK warns of acute and long-term deterioration without timely diagnosis.
Five lung stem cell variants dominate CF lungs, causing inflammation, fibrosis, and mucin secretion. CFTR modulators fail to suppress these inflammatory variants, suggesting they as key targets for new drugs.
A new editorial paper highlights the importance of including older patients in lung cancer clinical trials, where they are often undertreated due to age-related factors. The paper emphasizes the need for increased collaboration among stakeholders to enhance enrollment and retention of older cancer patients.
A study comparing radiologist and AI performance in interpreting 2,000 chest X-rays found that AI tools achieved moderate sensitivity but high false-positive rates. Radiologists outperformed AI in detecting the absence of disease, especially for complex cases.
The 'Crystal Ribcage' technology enables scientists to study lung function at a cellular level while maintaining physiological processes. This innovation holds immense potential for understanding lung diseases and developing new treatments.
Researchers have successfully developed a robot that can autonomously navigate through living lung tissue, avoiding vital structures such as airways and blood vessels. This innovation enables surgeons to reach previously inaccessible small tumors, improving treatment outcomes for patients with lung cancer.
Preeclampsia, a major cause of maternal mortality, has increased by 37% in Texas since 2017. A new $1.47 million NIH grant will support research initiatives to address preeclampsia rates in six Panhandle counties.
A recent study by Boston Medical Center and Boston University's Center for Regenerative Medicine discovered that hemogenic endothelial cells in the fetal lung contribute to blood cell formation. This breakthrough expands our understanding of blood development and its relationship with overall health.
The September issue of the CHEST journal features research on long COVID, including a review on exercise pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2. Original studies also explore asthma treatment with albuterol-budesonide inhalers and sleep therapy using oronasal masks.
A study found that ultrasound scans performed by emergency physicians can nearly halve the time patients spend in emergency departments. This technology, known as point-of-care ultrasound (POCUS), enables faster diagnoses and treatment for suspected deep vein thrombosis (DVT).
Scientists have found that lung-resident memory B cells, critical for pulmonary immunity, require interferon-gamma produced by T follicular helper cells to differentiate. These long-lived immune cells migrate to the lungs from draining lymph nodes and lie in wait to react quickly to future infections.
Researchers have developed a new vaccination method that induces the production of antibodies in mucus, which can disable viruses. This approach has shown promising results in monkeys, suggesting that oral vaccines against SARS-CoV-2 may be more effective and popular than traditional subcutaneous vaccinations.
Research found alterations in proteins that can affect autophagy, a self-eating process of damaged cells. Healthy newborns showed individual responses to prenatal exposure to air pollution, with some more vulnerable than others. The study aims to understand the impact on breathing problems during infancy and childhood.