Articles tagged with Lungs
A Michigan Medicine study found that pulmonary embolism death rates remained unchanged over the past decade, with higher mortality rates among men, Black patients, and those from rural areas. The study analyzed over 100,000 deaths related to pulmonary embolism between 2006 and 2019.
A new study reveals that boys who smoke in their early teens may damage the genes of their future children, leading to increased risks of developing asthma, obesity, and low lung function. Researchers investigated epigenetic profiles of 875 people aged 7-50 and found changes associated with fathers' teenage smoking.
A nationwide study found that modern blood thinners (NOACs) reduce the risk of serious bleeding by up to 45 percent compared to traditional drug Waran. Apixaban, a NOAC substance, is associated with a lower risk of bleeding in both short and long-term treatment.
A National Institutes of Health-supported study suggests that adults with obesity may benefit from extracorporeal membrane oxygenation (ECMO) when in intensive care for respiratory failure. The study found lower mortality rates among patients with obesity who received ECMO compared to those without, contradicting previous concerns.
Researchers found significant reductions in microbiome diversity among people with severe symptoms soon after infection. The oral microbiomes of people with shorter cases changed in consistent ways during infection, while those with long cases changed in many different ways.
A new NIH study found that high levels of certain minerals and metals in environmental water supplies may increase the risk of nontuberculous mycobacteria pulmonary infections in people with cystic fibrosis. The presence of sulfate, vanadium, and molybdenum was positively associated with increased incidence of lung infections.
HSE biologists explain how coronavirus evolves from Wuhan variant to Omicron, highlighting the crucial role of microRNA molecules in the process. The study found that substitutions in the viral genome disrupted microRNA binding regions, leading to the emergence of more contagious and resilient strains.
Researchers discuss the essential role of macrophages in metastatic growth of lung colonies in melanoma, highlighting their importance in clearing challenges to tissue integrity and promoting growth-related processes. The authors emphasize the need for targeted therapies against macrophages to combat untreatable metastasis.
A new University of Michigan poll suggests that nearly half of older adults do not know about the new RSV vaccines, while some groups show much less interest in getting the vaccine. The virus poses a significant risk to older adults with lung or immune system conditions, and those who live in nursing homes.
SARS-CoV-2's nucleocapsid protein (N) uses human body temperature to replicate, binding to RNA motifs at specific spatial folds. The study reveals new functions and potential targets for antiviral drugs.
Researchers found that dietary AHR ligands from cruciferous vegetables, such as kale and broccoli, maintain a healthy barrier in the lungs and prevent infection. The study shows that AHR activity is essential for lung barrier integrity during viral infections.
Researchers found that the flu blocks lung liquid secretion, allowing staph to infect lungs. Treatment with a CFTR-activating drug like ivacaftor restores liquid secretion and protects against staph infection.
A new imaging method developed by UC researchers can identify specific lung infections in real time, reducing diagnosis time from 2-3 days to hours. The method uses injectable probes that light up under a nuclear imaging machine, enabling faster treatment for critically ill patients.
A study by Duke University researchers has found microplastics in the fats and lungs of two-thirds of marine mammals, suggesting that ingested plastics can travel into tissues. The presence of polymer particles and fibers in whales' fat and organs may cause harm, including hormone disruption.
Researchers at West Virginia University are tracing the cause of diabetic heart disease using diabetic animal models to examine mitochondrial function. They hope to understand how faulty protein import affects the mitochondria and explore potential treatments to improve energy production and reduce cardiovascular risk.
A network meta-analysis found that breathing training combined with aerobic exercise, and yoga training, enhance lung function in adults with asthma. The study highlights the importance of integrating appropriate exercise training into asthma management plans.
A large study published in ERJ Open Research found that people with low levels of vitamin K in their blood are more likely to have poor lung function and experience respiratory issues. The research suggests that vitamin K may play a role in keeping lungs healthy, but further studies are needed to confirm this link.
Researchers at TUM develop an RNA agent for a lung spray that slows macrophage activity, reducing lung inflammation and fibrosis. The active substance RCS-21 is delivered via an inhaler through a special sugar molecule, showing promise in treating acute inflammatory lung damage.
Critically ill children on ventilator support can experience patient-ventilator asynchrony (PVA), which worsens outcomes. Researchers are using machine learning to develop a common set of definitions and measurements for PVA in pediatric patients, aiming to minimize risks and improve clinical outcomes.
Researchers found that clinical strains of Aspergillus fumigatus differ significantly from environmental strains in amino acid synthesis. The fungus appears to shape the lung microbiome to its advantage, surviving on vital metabolites produced by other microorganisms.
Researchers have discovered two major mechanisms that contribute to the high risk of complications from lung infections in individuals with Down syndrome: poor ciliary function, which impairs the respiratory tract's ability to clear mucus and viral particles, and immune hyper-reactivity, which leads to an overactive immune response. Th...
A new study by UCSF found that half of participants with extensive tobacco exposure had persistently high respiratory symptoms, yet performed well in COPD tests. The study highlights a gap in effective care for tobacco-exposed individuals and emphasizes the need for broader definition of smoking-related lung disease.
Researchers found that human senescent fibroblasts trigger progressive lung fibrosis in immunodeficient mice by inducing paracrine senescence and pro-fibrotic activities. The study also suggests that senolytic compounds like navitoclax can ameliorate lung fibrosis induced by senescent human fibroblasts.
A UBCO researcher says Canada is falling behind in developing effective intervention programs to stop young people from beginning to vape. The study analyzed government-funded campaigns and found that many relied on telling teens about physical health harms, which may not be enough to prevent vaping uptake.
A new study found that babies with food allergies are more likely to develop asthma and have reduced lung function by six years of age. Early life food allergy was associated with an increased risk of both conditions, even if the allergy resolved or persisted.
Researchers identified a new class of molecules capable of preventing excessive inflammation in severe COVID-19. Blocking the link between peptide C5a and its cellular receptor reduced lung damage and other complications in mice. This finding suggests that antagonists of C5aR1 could be useful for treating severe COVID-19.
A new study published in Radiology found that AI can use data from low-dose CT scans of the lungs to improve risk prediction for death from various causes. The study used data from over 20,000 individuals and found that body composition measurements derived from lung screening LDCT were strong predictors of mortality.
The July issue of CHEST journal features 49 articles on clinically relevant topics, including disability rights and life-sustaining treatment. The journal offers complementary web resources, such as visual abstracts, to expand the reach of its research.
Workers cutting, grinding, and polishing artificial-stone slabs for countertops are developing silicosis due to high concentrations of silica and polymer resins. Researchers call for public health measures, including banning the product and improving worker safety.
Extracellular vesicles from fibrotic lungs can activate dormant fibroblasts in healthy lungs, initiating fibrosis development and spreading. The study's findings support the potential use of EVs as a targeted drug therapy platform to slow fibrosis progression and improve patient outcomes.
A new study found that omega-3 fatty acids, particularly docosahexaenoic acid (DHA), are associated with reduced lung function decline and better lung health. The research supports the inclusion of omega-3 fatty acids in the diet to promote lung health.
A recent study found that PCSK9 inhibitors may impair lung function in some patients, while statins have a protective effect on the brain, increasing hippocampus volume which may reduce dementia and depression risk. The study used genetic data from 340,000 UK Biobank participants.
The Omicron subvariant BA.5 efficiently infects lung cells due to a mutation in the spike protein, enabling efficient entry and fusion with lung cells. This finding suggests that future SARS-CoV-2 variants may regain the ability to cause severe illness in risk patients and people with insufficient immunity.
The American College of Chest Physicians has launched CHEST Pulmonary, a new online publication dedicated to pulmonary and sleep medicine. The journal features original research, case series, and reviews on various topics, including implementation science and artificial intelligence applications.
Researchers are studying ways to update pulse oximeter technology to address limitations including overestimation in patients with darker skin tones and motion artifact. The goal is to improve the accuracy of oxygen saturation readings, particularly for diverse groups and in multiple settings.
Researchers found that a triple combination therapy of elexacaftor, tezacaftor, and ivacaftor improves lung function and reduces inflammation in patients with cystic fibrosis. The treatment's positive effects last over 12 months, offering hope for better management of the disease.
Researchers at CU Anschutz Medical Campus have found that vaping nicotine during pregnancy can be detrimental to the baby, disrupting bone and lung development. The study suggests that nicotine in e-cigarettes is just as harmful as that in traditional cigarettes.
Researchers at KIT have developed nanoparticles that can carry antibiotics directly to the lungs, increasing drug concentration and reducing resistance. The nanocarriers, containing Bedaquilin or BTZ-043, overcome biological barriers and show effectiveness in treating multidrug-resistant tuberculosis.
A study published in Radiology found that AI algorithms with high diagnostic accuracy improved radiologists' detection of lung cancers on chest X-rays. High-accuracy AI led to more frequent changes in reader determinations, suggesting increased human trust in AI.
Researchers found that when a patient's congestive heart failure is mentioned during the initial check-in process, emergency room physicians are less likely to test for pulmonary embolism, potentially leading to delays in diagnosis. This anchoring bias can delay crucial testing and diagnosis of deadly medical conditions.
A study published in Annals of the American Thoracic Society found that race-neutral lung function interpretation could lead to more equitable access to lung transplants for Black patients. The researchers analyzed data from over 8,900 patients and discovered that a race-specific approach resulted in lower Lung Allocation Scores (LAS) ...
The study analyzed historical data on coal miners in China, revealing a strong correlation between raw coal production, mining technology, and CWP incidence. The researchers identified key turning points in disease incidence, linked to changes in diagnostic criteria and labor management, as well as coal industry policy reforms.
COPD patients treated with dupilumab experienced rapid and sustained improvements in disease, as measured by reduced acute exacerbations, better lung function, and improved quality of life. This is the first biologic to show clinical outcomes improvement in COPD.
A recent study unveiled the doorway that SARS-CoV2 uses to slip inside cells undetected. Cholesterol clusters make up this door, allowing the virus to infect human cells. Regular exercise and mechanical force can disrupt these cholesterol aggregates, reducing the risk of infection.
Researchers found female babies with CDH have a 32% higher risk of dying within 30 to 60 days of birth compared to males. The study, using medical records from an international registry, suggests that lower birth weights for females may be linked to the disparity in survival rates.
Researchers found a link between short telomeres in ATII cells and lung fibrosis in post-COVID-19 patients. The study revealed loss of ATII cellularity and shorter telomeres concomitant with increased fibrotic lung parenchyma remodeling.
The June issue of CHEST features 49 articles on clinically relevant topics, including asthma, COPD, and critical care. The journal offers web and multimedia resources to expand the reach of its research.
Researchers found that 'concerning' CT imaging results were associated with lower clinical outcomes and shorter hospital stays in low-risk patients with acute pulmonary embolism. This suggests that emergency physicians may be managing these patients differently, leading to unnecessary hospitalizations.
Researchers at the University of Cincinnati have discovered two existing drugs that show signs of being effective in treating lymphangioleiomyomatosis (LAM), a rare and devastating lung disease. The study found that these drugs target a novel pathway dysregulated in LAM, which could lead to the development of a cure.
A University of Pittsburgh study found that TV medical dramas prompted middle schoolers to engage in discussion about vaping dangers after viewing clips featuring fictional adolescents with vaping-associated lung disease. The study suggests using entertainment television as a tool for dialogue about the health effects of e-cigarette use.
Researchers found a peptide from venomous fish Thalassophryne nattereri that controls lung inflammation and airway hyperreactivity. The molecule, TnP, inhibited cytokine production and prevented mucus-producing cell hyperplasia, making it a potential candidate for treating asthma.
Researchers created a detailed snapshot of the structure of human cilia using advanced microscopy and artificial intelligence techniques. The study found that key elements of the axoneme structure are missing in people with primary ciliary dyskinesia, leading to defective cilia and breathing difficulties.
Lung mesenchymal cells have been identified in a new experimental model, enabling the study of pulmonary diseases such as fibrosis and interstitial lung disease. The researchers used an iPSC line carrying a lung mesenchyme-specific fluorescent reporter to test growth factors and small molecules, finding that stimulating retinoic acid a...
Researchers used infected stem cells to study COVID-19's impact on organs, identifying effective anti-viral drugs for treatment. The study found distinct antiviral profiles in heart and lungs, paving the way for new therapeutic options.
Research by West Virginia University professor Sean Tu found that orphan drugs earn pharmaceutical companies almost as much as those marketed to the general public. The Orphan Drug Act incentivizes companies with tax credits, longer patent exclusivity, and easier FDA review for treating rare diseases.
Researchers at Texas Biomedical Research Institute have developed a new cell culture model to generate human alveolar macrophages, the most critical immune cells in the lungs. This model allows for easier and inexpensive investigation of lung inflammatory diseases and testing of new therapies.
The Human Lung Cell Atlas provides insights into lung biology by combining data from nearly 40 studies, revealing rare cell types and cellular differences between healthy people. The study found common cell states between lung fibrosis, cancer, and COVID-19, offering new ways of understanding lung disease.
A retrospective study found a 24% response rate to Docetaxel among patients with stage IV non-small cell lung cancer who experienced progression on immunotherapy. The median progression-free survival was 3 months, suggesting chemotherapy may still play an important role in treatment after immunotherapy failure.
Researchers have developed a therapy using nanocarriers engineered from adult skin cells that curb inflammation and tissue injury in damaged mouse lungs. The treatment has shown promise for treating acute respiratory distress syndrome (ARDS), a condition that leads to respiratory failure and puts patients on ventilators.
SMART researchers have discovered a novel combination therapy using rifaximin and clarithromycin to treat antibiotic-resistant Mycobacterium abscessus infections. The study found that rifaximin potentiates clarithromycin against M. abscessus, increasing its sensitivity and effectiveness in killing the bacteria.