Articles tagged with Lipids
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Researchers found that very long-chain meibum is essential for preventing dry eye disease. Mice with deleted Elovl1 gene developed cloudy corneas and signs of dry eye disease after five months.
Researchers at Saint Louis University have discovered a link between elevated chlorinated lipids and severe outcomes in sepsis patients. The study found that high levels of these lipids can predict acute respiratory distress syndrome and death within 30 days, suggesting they may serve as an early warning sign of the condition.
A University of Iowa study reveals how excess fat in the heart's mitochondria leads to impaired energy production and cardiac damage. Researchers found that lipid overload causes small, misshapen mitochondria that don't produce energy efficiently.
Researchers found that mTOR stimulates liver tumor formation through increased lipid synthesis. The study shows how mTORC2 promotes the new synthesis of fatty acids and lipids in hepatocytes, enabling rapid cell growth and energy production.
Researchers at Columbia University developed a new microscopy technique to track fatty acids in living cells, revealing that saturated fats cause hardened membrane patches that can lead to cellular damage. In contrast, unsaturated fats can 'melt' these patches, suggesting potential therapeutic strategies for lipid disorders.
A new review article examines the effectiveness of lipid-based products, including liposome lid sprays and emulsion eye drops, in treating dry eye disease. The studies found that these products provide immediate relief of symptoms and improve the structure and stability of the tear film lipid layer.
Researchers found that topical application of Resolvin E1 on gum tissues prevented and treated gum disease, while also reducing the likelihood of advanced arterial plaque rupture. The study suggests effective preventive and therapeutic treatments for heart disease and gum disease without unwanted side effects.
Researchers found that long-term yerba mate supplementation reduced body weight and improved blood lipid levels, as well as insulin resistance in obese mice. The study suggests that yerba mate may be a safe and effective way to manage weight and related metabolic disorders.
Researchers found that fruit flies raised on a low protein diet during early life lived more than twice as long as those fed throughout on a standard diet. Adult flies release toxic lipids from their skin, which were less toxic if they ate a low-protein diet earlier in life.
Researchers at UC Berkeley and University of Toronto have discovered lipid mediators that may halt glaucoma progression. The study found that lipoxins A4 and B4 secreted by astrocytes can stop retinal ganglion cell degeneration, offering a potential treatment for this neurodegenerative disease.
Researchers found that lipids produced by Bacteroidetes bacteria have a unique chemical signature and can cause inflammation in blood vessels. The study links these bacterial lipids to atherosclerosis and may lead to early diagnosis of heart disease.
Researchers from TU Graz developed the 'Lipid Data Analyzer' tool, which can identify lipids at a detailed structural level more precisely and reliably than previous solutions. The tool detected over 100 novel lipid species and can be flexibly adapted for other metabolic products such as sugars.
Scientists discover that velvet worm slime consists of a mix of proteins and fatty acids, forming nanoglobules that harden into stiff filaments when exposed to shear forces. These fibers have tensile stiffness similar to Nylon and can be dissolved in water again within hours.
Researchers discovered that muscle cell lipid composition varies with the time of day, influenced by a biological clock, which could help regulate insulin sensitivity. This variation is linked to type 2 diabetes development.
Scientists have created Algal droplet bioreactors on a chip that can screen millions of cells for improved growth rates and lipid content. The technology holds promise for accelerating the discovery of super algal strains that can efficiently produce biofuels, potentially making commercial-scale production a reality.
Researchers discovered that impairing the partnership between brain cells leads to neurodegeneration. Apolipoprotein APOE4 was found to mediate lipid droplet accumulation, increasing oxidative stress and breaking protective mechanisms. This study provides new insights into Alzheimer's disease.
Researchers found that gut bacteria regulate lipid uptake by hacking into the circadian clocks in gut cells. The microbiome helps establish the essential molecular link NFIL3, which regulates body composition and metabolism. This discovery may lead to new strategies to fight obesity.
Researchers at University of Utah Health found that boosting levels of acylcarnitines, a new lipid source for brown fat, restores youthful ability to adapt to cold in older mice. This discovery could lead to a therapy for cold sensitivity and potentially aid in obesity prevention.
Researchers identified lipid accumulation mechanism in oocytes, limiting in vitro bovine embryo success. Excessive fat buildup impairs embryo development and viability.
Scientists have created a method to build bridges between organelles in living cells, allowing for controlled manipulation of communication between subcellular compartments. This breakthrough could lead to breakthroughs in understanding cell function and developing new treatments for diseases.
A team of archaeologists discovered lipid-based biomarkers for whole wheat in a frozen Bronze Age container, providing new insights into the spread and exploitation of cereal grains. The finding has significant implications for studying early farming practices in Eurasia.
Muscles require energy to perform daily movements, and researchers have found a pathway that regulates fuel delivery based on activity level. The discovery is dependent on circadian rhythms and could impact obesity in humans.
A new study published in Current Biology found that bacterial cells are limited by their ability to produce fat, which affects their growth and size. The research, conducted at Washington University in St. Louis, used a novel approach to understand the role of biosynthesis in cell-size regulation.
A Clemson University graduate discovered that certain toxicants can disrupt the maturation of Daphnia magna by altering lipid levels, affecting development and reproductive rates. The study found that triclosan and atrazine can lead to stunted growth and altered lipid allocation in newborns.
Researchers found that knocking out a key enzyme improved post-heart attack healing and reduced chronic inflammation. The study suggests that a short-term dietary excess of polyunsaturated fatty acids may also play a role in promoting healing.
A Japanese research team has discovered the mechanism behind oil synthesis in microalgae cells, which could contribute to the development of more efficient biofuels. The findings revealed that adding seawater increases the production of triacylglycerol, a key component of oil.
Arbuscular mycorrhizal fungi can obtain lipids from their host plants, which are essential for their growth and reproduction. This discovery highlights the importance of lipid transfer in these symbiotic relationships, suggesting that AM fungi depend on their hosts for survival and nutrient uptake.
Researchers identify genes involved in lipid uptake as critical for TRM cell function, revealing a key dependency on fatty acids. Targeting these lipids could enable selective removal of TRM cells, offering new therapeutic opportunities for autoimmune diseases.
Lipid nanoparticles (SLNs) have shown increased effectiveness in delivering nucleic acids, with advantages including protection against degradation and boost to transfection process. Researchers are exploring their application in treating various diseases, including degenerative disorders of the retina, infectious diseases, and cancer.
Researchers identified cardiolipin, a mitochondrial lipid, as a potential target for reducing Parkinson's symptoms. Blocking the FASN protein increased cardiolipin levels and improved mitochondrial function, providing new insights into the disease.
Researchers discovered that a vitamin D metabolite inhibits proteins regulating lipid production, opening new treatment opportunities for diseases linked to vitamin D deficiency. The study's findings suggest potential therapeutic applications for synthetic analogs of the metabolite.
Researchers analyzed prefrontal cortex lipids in humans and monkeys to identify key differences. They found that human brains had a greater range of lipid concentrations during the first year of life, with many changes occurring after childhood.
A fatty molecule thought to be unique to flowering plants has been found in bacteria from the Adriatic Sea, solving a 20-year-old paleontological mystery. The discovery challenges the assumption that isoarborinol's presence indicates land and flowering plant life.
Researchers at Mayo Clinic have identified a key protein, Rab10, that helps hungry liver cells locate and break down fat for energy. This discovery could lead to new treatments for fatty liver disease.
A new study reveals an efficient means of attaching lipids to peptides, which can improve the molecules' drug-delivery capabilities. This breakthrough enables peptides to be more druglike, overcoming issues with poor absorption and breakdown.
A team of researchers has successfully developed liquid-crystalline nanostructures that protect antimicrobial peptides, allowing them to target and destroy bacteria without being degraded. This innovative approach could provide a new weapon in the fight against antibiotic-resistant superbugs.
A University of Cincinnati study found that gut bacteria influences intestinal mast cells' activation and fat absorption. The research suggests a novel role for the gut microbiome in promoting lipid absorption.
Researchers found that certain lipid mediators can delay the onset and progression of heart failure. The lack of standard drugs stimulating these mediators suggests a need for re-evaluation of current treatment protocols to improve disease outcomes.
A recent study published in Diabetologia found that intensified and multifaceted treatment of patients with type 2 diabetes and known vascular damage can extend their lifespan by approximately 8 years. The treatment involved a combination of behavioural education, medication, and lifestyle modifications.
A team of researchers from the University of Alaska Fairbanks made a groundbreaking discovery after analyzing stable isotopes and lipid residues at prehistoric hearths along the Tanana River. The study found that early Alaskans' diets were more complex than previously thought, with salmon and freshwater fish playing a prominent role.
Researchers have developed a new technology called Cholestosomes that can encapsulate insulin and deliver it orally without degrading. The vesicles are made of naturally occurring lipid molecules and can pass through the stomach intact, allowing for high bioavailability and effective insulin delivery.
Resolvins and maresins, naturally produced omega-3 fatty acid molecules, regulate subsets of white blood cells that play a central role in inflammation. The findings suggest these molecules may be useful for treating chronic inflammatory and autoimmune diseases.
Researchers at VIB-KU Leuven have unraveled the mechanism by which DYT1 dystonia causes cellular defects, linking it to dysregulation of lipids. The findings may lead to new medical approaches to overcome this poorly understood condition.
Research suggests removing drug use barriers to effective hep C treatment for opioid-addicted patients. The elbasvir-grazoprevir treatment showed high sustained virologic response rates in a randomized trial. In contrast, lipid screening evidence is lacking for younger adults.
A £1.3m grant will enable Cardiff University and partners to further develop the LIPID MAPS resource, advancing global lipidomics research. The project aims to discover new lipids involved in disease processes and preserve a widely-used classification system.
Researchers found that bumble bees selectively forage among plant species based on the nutritional quality of their pollen. The study identified specific plant species with high protein-to-lipid ratios as preferred by bumble bees.
Researchers have identified five types of lipid, or fatty acids, that exist as droplets inside the cells of female chickens' sperm storage tubules. These lipids may be released into the sperm storage tubules and improve the sperm's survival. The study provides insight into how certain female animals are able to store sperm long-term.
A new lipid, LPA, has been found to regulate lymphocyte motility in narrow lymph nodes. LPA enables efficient movement through spaces jammed with immune cells and stromal cells. This discovery may lead to novel strategies for controlling immune responses.
Researchers discovered that breast cancer cells require fatty acids from the extracellular environment to proliferate. LIPG enzyme is crucial for tumor growth, and its inhibition may lead to more efficient chemotherapy treatments.
The American Society for Biochemistry and Molecular Biology honored prominent researchers with various awards, including the Herbert Tabor Research Award, FASEB Excellence in Science Award, and ASBMB Plenary Lectures. These recognition include notable scientists such as Robert G. Roeder, Bonnie L. Bassler, Peter Walter, Charles Brenner...
Researchers at Washington University in St. Louis discovered that cancer cells can synthesize lipids from non-glucose sources, contradicting the long-held glucose hypothesis. This finding raises questions about diagnostic methods and treatment strategies for cancer.
Two unique enzymes, AIG1 and ADTRP, have been discovered that play a role in metabolism and inflammation, potentially targeting type 2 diabetes and inflammatory disorders. The enzymes are moderately inhibited by lipase inhibitors, suggesting they may be used to boost FAHFAs, which normalize glucose levels and reduce inflammation.
Researchers at Stanford University developed a machine to mimic the surface of the eye, allowing for systematic testing of tear film behavior on contact lens surfaces. This innovation could lead to more comfortable contact lenses that protect users from painful dry eye symptoms.
A new study found that exposure to bisphenol S, a chemical used in BPA-free products, can encourage the formation of fat cells. Researchers created a human cell model and tested the effects of BPS exposure on fat cell metabolism.
A study published in Nature Medicine found that fuel-starved light receptors contribute to the development of age-related macular degeneration. The researchers discovered that photoreceptors need lipids, not just glucose, to function properly and that blocking a specific receptor can prevent abnormal vessel growth.
Researchers found that photoreceptors use both glucose and lipids as fuel substrates, debunking previous scientific beliefs about the cause of abnormal blood vessel growth leading to blindness. This discovery opens new therapeutic avenues for retinal diseases such as AMD.
Researchers discovered that saposin B binds to the anti-malarial drug chloroquine, potentially leading to toxicity due to prolonged binding instead of removing damaged lipids. This finding opens up new avenues for investigating saposin B's role in other conditions, such as lysosomal storage diseases.
Researchers have developed a new analytical tool that can identify 'isomers' in lipid molecules, which may lead to the early diagnosis of cancer. The method uses tandem mass spectrometry and the Paternò-Büchi reaction to pinpoint the location of double bonds in lipids.
A new biorefinery process developed by NREL has significantly improved ethanol production from algae, with a yield of 126 gallons of gasoline equivalents per ton of biomass. The process, called Combined Algal Processing (CAP), reduces costs by nearly $10/GGE compared to traditional methods.
Researchers at Umea University have found that the protein FGF21 redistributes fatty acids through two mechanisms, leading to improved pharmaceutical treatment options for obesity-related diseases. The study also shows that FGF21 can activate the enzyme Lipoprotein lipase, increasing the hydrolytic cleavage and uptake of blood lipids.