Articles tagged with Microarray Analysis
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A phase 1/2 trial found microarray patches to be safe and induce strong immune responses in children, with over 90% protected from measles. The method could help achieve high population immunity levels required to control childhood diseases.
Researchers developed a single-assay approach using exome sequencing data to detect large-scale pathogenic mutations, detecting 91 previously undetectable mutations. This shift could enable earlier diagnoses and save the NHS vital resources.
A pilot study proposes a promising global genomic assay for diagnosing molecular subtypes in pediatric B-ALL, leading to more accurate diagnosis and targeted treatment options. RNA sequencing analysis accurately identified subtypes in all known cases and determined genetic subtype in 79% of previously unknown cases.
A new study validates Low-Pass Genome Sequencing (LP GS) as a robust and cost-effective alternative to Chromosomal Microarray Analysis (CMA) for prenatal diagnosis. LP GS detects six additional Copy Number Variations (CNVs) in cases with negative CMA results, highlighting the importance of sequencing depth in its detection sensitivity.
Researchers have identified KIAA0930 as a key factor causing muscle atrophy in cancer cells, which could lead to the development of new anti-cachexia therapies. The study found that KIAA0930 knockdown cells showed increased muscle mass and weight compared to control cells.
A comprehensive European allergy atlas has been compiled, revealing regional and climate-related differences in sensitisation to allergens. The study found varying sensitisation patterns across Europe, with certain regions having lower sensitivity to house dust mites and higher sensitivity to peanut and fruit allergens.
Researchers developed predictive models using serum microRNAs to identify patients at risk of requiring early palliative care. The study used serum samples from 178 patients with various types of cancer and found that miRNA-based models had higher accuracy than clinical models in predicting referral to a palliative care unit.
A genetic test known as chromosomal microarray analysis (CMA) may be able to identify the cause of Sudden Infant Death Syndrome (SIDS) or its counterpart in older children, known as Sudden Unexplained Death in Childhood (SUDC). CMA identified deletions or duplications of DNA segments in 14% of deceased infants and toddlers up to 28 mon...
A study of 137 children with early-onset psychosis found that over 70% had copy number variants, a common cause of neurodevelopmental disorders. The research suggests that chromosomal microarray testing can bring closure to families and improve treatment outcomes.
Researchers from Arizona State University investigate autoantibodies in healthy individuals, revealing their pervasiveness and role in human health and disease. The findings aim to improve diagnostics and therapeutics for a range of illnesses.
A new genomic platform has been developed to study the mouse epigenome, allowing researchers to analyze 285,000 epigenetic control points. The system uses microarrays to detect changes in DNA methylation sites and has been validated using archival specimens.
Researchers found that miR-133b levels were significantly lower in FAP-associated Desmoid tumors than in sporadic Desmoid tumors, while SIRT1 mRNA levels were up-regulated. A negative correlation between miR-133b and SIRT1 was observed, suggesting a novel mechanism underlying progression of FAP-associated Desmoid tumor.
A newly developed genotyping chip can help establish and maintain genetic diversity in reef restoration efforts. The chip allows researchers to genetically identify corals and their symbiotic algae, enabling conservation biologists to track coral diversity and compare samples.
Research found that miR-133b levels were significantly lower in FAP-associated Desmoid tumors than in sporadic Desmoid tumors. SIRT1 mRNA levels were up-regulated in FAP-associated Desmoid tumor, suggesting a novel mechanism underlying progression.
The HD-MAP vaccine shows significantly enhanced immune responses compared to standard intramuscular injection, with faster onset kinetics and higher overall immune responses. The patch is stable for up to 12 months at temperatures as high as 40°C, providing potential for easy distribution without refrigeration.
Astronauts may have access to fresh salads in space, but the microgravity environment affects plant growth. Researchers compared two transcriptomic approaches to understand how plants adapt, finding that RNA-Seq and microarray chips have relative advantages.
A new measurement chip has been developed to detect Legionella pneumophila, a deadly bacterium that causes pneumonia. The chip uses microarray analysis and can identify the specific subtype of the pathogen present within 34 minutes.
Researchers at Arizona State University have created a high-throughput technology that can produce up to 1,000 doses of antimicrobial treatments within a week. The system uses synthetic antibodies, or synbodies, which are made from short protein fragments and can be quickly screened against a large number of pathogens.
A novel drug delivery system using a microarray patch has been developed for HIV pre-exposure prophylaxis (PrEP), which could increase adherence among at-risk women and others. The patch contains tiny projections that painlessly deliver a drug, providing weeks or months of protection against infection.
A new technology bridges clinical pathology assessment, high-content analysis, and 3D cell cultures, allowing rapid, automatable, and multiplex readouts. This technique is applied to mixed arrays made up of spheroid models from various cell lines, demonstrating its potential for safety and efficacy testing and model optimization.
Researchers at TUM developed a new molecular method to investigate the function of thousands of proteins in parallel. They identified hundreds of previously unknown interactions among proteins using DNA-printed protein arrays, which enabled them to study protein functions more efficiently. The new method has the potential to accelerate...
By combining FTIR spectroscopy with microarrays, researchers can extract detailed information about protein structures and bonding, allowing for precise quantification and analysis of proteins in minute amounts. This breakthrough enables label-free detection and high-throughput analysis of hundreds of proteins in a few minutes.
A recent study published in Experimental Biology and Medicine identified over 4,000 genes with altered expression in dying neurons, including those involved in cell death, survival regulation, and oxidative phosphorylation. This breakthrough opens doors to future research on novel players regulating neuronal survival and death.
Researchers identified differential gene expression in proximal and distal nerve segments of rats with sciatic nerve injury, revealing changes in cell differentiation, cytokinesis, and immune response. The study provides insights into Wallerian degeneration and offers a platform for studying nerve injury and repair.
Researchers have developed a innovative technique called immunosignaturing to capture disease complexity, offering a marked improvement in detection over traditional methods. The technique uses a microarray to profile antibodies circulating in blood, demonstrating high accuracy in identifying multiple diseases.
Molecular methods have improved identification of war wound infections, revealing new insights into microbial species associated with successful and unsuccessful healing. The study found that certain bacteria are linked to poor wound healing, while others are associated with successful recovery.
Researchers at UNSW Australia developed a novel lab-on-a-chip device using non-volatile ionic liquids to overcome evaporation issues. The device has potential applications in environmental monitoring, medical diagnosis and process control.
Researchers at Stanford University developed a microarray to identify cytokines, chemokines, and other proteins targeted by SLE patients' autoantibodies. They found that patients with high levels of autoantibodies against B cell activating factor (BAFF) experienced more severe symptoms.
A multicenter prospective clinical study is investigating the effects of chromosomal abnormalities found prenatally through microarray analysis on developmental delays and birth defects. Researchers aim to share genetic variances with parents during pregnancy, providing them with detailed genetic counseling.
Scientists have developed a palm-sized microarray platform that can grow up to 1,200 individual cultures of fungi or bacteria. This technology has the potential to accelerate drug discovery for treating various types of infections.
A new study suggests a safer and more informative noninvasive test for detecting chromosomal defects in the fetus, using fetal DNA in the mother's blood. The method offers a cost-effective alternative to traditional invasive procedures, reducing risks of infection and potential harm to the fetus.
A new method of prenatal testing using microarray technology is providing physicians with more comprehensive results than conventional karyotyping, according to George Washington University researchers. The study found that microarray analysis can identify additional abnormalities not detectable by karyotyping, allowing for earlier int...
A new microarray analysis has proven 40% more effective in identifying genetic causes of stillbirth than traditional karyotyping testing. The study, conducted by researchers at the University of Texas Medical Branch, provides strikingly more information for families seeking closure.
A new genetic test using microarray analysis has been shown to detect clinically relevant information more effectively than the current standard method of prenatal testing. Microarray also identified additional abnormalities not detected by karyotyping in cases with advanced maternal age or positive screening results.
A new study has documented the experiences of women receiving abnormal prenatal chromosomal microarray testing results, revealing a range of negative reactions. The research highlights the importance of providing emotional support and nuanced counseling to help parents navigate the ambiguities of genetic testing.
The Gene Expression Commons enables researchers to see the whole picture of gene expression in a sample, overcoming limitations of DNA microarray technology. By analyzing collections of thousands of publicly available DNA microarray experiments, scientists can compare absolute levels of expression among many genes in each cell type.
Researchers are developing protein microarray technology to identify early signs of diseases such as diabetes and cancers. This technique allows for the simultaneous analysis of thousands of proteins, facilitating high specificity and reduced cost.
The Amniochip technology uses microarray technology to detect genetic syndromes with a diagnostic resolution 100 times greater than conventional techniques. This reduces the waiting time for results to 48 hours, compared to three weeks with traditional methods.
A University of Arizona study found that spaceflight alters gene expression in mice, potentially leading to increased cell death and compromised immune systems. The research suggests that long-duration space missions to destinations like Mars may require new strategies to mitigate these effects.
A fully automated minilab developed by Munich researchers can quickly identify antibiotic residues in milk, providing a fast and simple solution to the current laborious and expensive testing method. The system takes just under six minutes to produce a result, reducing production losses and disposal costs for the dairy industry.
Researchers successfully used a new technique to pinpoint changes in one cell type that flagged the likelihood of kidney-transplant recipients rejecting their new organs. The algorithm enabled doctors to better identify the onset of cancers, genetic disorders, and other problems by analyzing whole-blood samples.
A study by Garvan Institute of Medical Research reveals epigenetic changes in prostate cancer cells, silencing nearly 3% of the genome and targeting tumor suppressor genes, making treatment far more complex than imagined.
Researchers at Scripps Institute create a novel screening technique for large compound libraries, enabling efficient identification of high-affinity protein ligands. The innovative approach combines bead display and microarray analysis, allowing for rapid comparison of binding affinity without tedious re-synthesis.
Two new software programs, caCORRECT and omniBioMarker, have improved the identification of cancer biomarkers from gene expression data. The certified tools remove noise and artifacts, and identify valid biomarkers for personalized cancer treatment.
Researchers demonstrate that Affymetrix Gene platform can analyze differential splicing activity, comparable to Exon arrays, providing added value to existing data. The new statistical method, FIRMAGene, uses adjacent poorly fitting probes to calculate differential expression.
A novel digital gene-expression profiling technique is gaining traction, offering a fully quantitative approach to gene-expression analysis. The method has been shown to provide robust and comparable expression profiling data, making it an attractive alternative to traditional microarray-based platforms.
Researchers identified gene subnetworks that distinguished patient groups and uncovered new genes associated with breast cancer. These findings may lead to more accurate diagnostics and prognosis for various types of cancer, including leukemia, prostate cancer, and lung cancer.
Researchers at University of California, Irvine have identified a modified vaccinia virus Ankara (MVA) as a potential alternative to the existing smallpox vaccine. MVA produced similar antiviral responses in human and animal studies, suggesting its safety and effectiveness. The study marks a significant advancement in developing a safe...
A recent study integrates lipid metabolic profiling with gene expression analysis, demonstrating the synergistic power of combining metabolic profiling with proprietary microarray analysis methods. The results show that Por can be considered an enzyme critical for proper functioning of lipid mobilization in the mouse liver.
A new microarray technology enables fast and accurate enrichment of thousands of targeted genomic regions for high-throughput sequencing. This method replaces PCR-based approaches, allowing for the resequencing of entire genomes or specific genes in a cost-effective and efficient manner.
Researchers have developed a method to discern most genetic activity of a tumor from radiology scans, enabling personalized medicine and non-invasive diagnosis. This approach could revolutionize cancer treatment by providing unique characteristics of each patient's disease.
Researchers at Baylor College of Medicine found that chromosomal microarray analysis is remarkably sensitive in detecting abnormalities in individual chromosomes, identifying the source of problems in many cases. The technique improved detection rates by up to 12% compared to traditional methods.
A recent study identified common flaws in oncology microarray studies, including inadequate methods to account for false-positive findings. Researchers provide guidelines to improve the quality of analysis and reporting of such studies, aiming to validate scientific findings through replication.
A study in fruit flies reveals how genes respond to alcohol, offering insights into human susceptibility to abuse. The researchers found that exposure to alcohol modifies the expression of many genes in flies, some of which are also present in humans.
Genomatix Software GmbH has appointed a distributor in China, Beijing ZGZ Science and Technology Development Co., Ltd., to expand its market presence. This partnership is significant for Genomatix, with over 1,800 researchers in China subscribed to its free services.
The National Human Genome Research Institute has awarded $54 million to three Centers of Excellence in Genomic Science over five years. These grants will support innovative research projects at the University of Washington, Yale University, and California Institute of Technology.
Researchers at the Salk Institute found that specific plant hormones activate different factors rather than a common target, contradicting the long-held assumption that they converge on a central growth regulatory module. This discovery was made using gene-chip technology and analysis of microarray data from the AtGenExpress project.
A large-scale cross-platform study of research microarrays has uncovered high concordance across platforms, addressing a crucial issue in biomedical research. The study, led by Winston Patrick Kuo, used 10 different microarray platforms and two QRT-PCR approaches to compare gene expression measurements.
The HHMI Physician-Scientist Early Career Award program provides flexible funding and time for young physicians to pursue research careers. Thirteen awardees have made impressive contributions to various fields, including genomics, proteomics, and cancer research.
A new study uses high-resolution genomic microarrays to detect small rearrangements in chromosomes that cause rare birth defects. The technology allows for rapid and precise diagnosis, providing a target for future therapies.