Articles tagged with Aging Populations
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A novel ensemble learning model has achieved an accuracy of 96 percent in predicting mild cognitive impairment and dementia in older drivers. The two most influential driving variables are the right to left turn ratio and the number of hard braking events.
A community-integrated intermediary care (CIIC) model in Thailand reduces caregiver burden by 39.4% and improves seniors' functional ability, while also providing formal care and technical training for family caregivers.
A recent study found that metformin users had distinct DNA methylation profiles compared to non-users, potentially revealing its role in longevity. The research identified several pathways related to delirium and aging, highlighting the need for further investigation into metformin's mechanism of action.
Researchers examined three epigenetic age acceleration measurements and found inverse associations with lung cancer risk in men and younger participants. However, these findings did not support a positive association between epigenetic age measures and lung cancer risk in the study.
Research finds that older workers who are motivated to grow and develop at work, as well as those in organizations that encourage learning, are more likely to stay. An age-inclusive environment also aids in retention by mitigating age stereotypes and removing barriers for training participation.
Salk scientists discovered that when telomeres become very short, they communicate with mitochondria, triggering an inflammatory response. This process destroys cells that could become cancerous, preventing cancer formation. The findings highlight the importance of studying interactions between telomeres, mitochondria, and inflammation.
A new study found Black South Africans who migrated to find work reported better emotional well-being and were at lower risk for depression after the move. The research may help policymakers tailor mental health resources to underprivileged migrants and those seeking economic mobility.
According to hyperfunction theory, menopause is also a disease. Aging is a quasi-programmed disease that can be partially treatable by rapamycin. The author suggests that slowing aging may delay the onset of diseases like prostate cancer, obesity, and hypertension.
A study found that stock photography sites have limited representation of diverse populations, particularly people with darker skin tones and lower socioeconomic status. This limitation makes it challenging for organizations to develop effective communication tools to reach these groups.
Researchers found that clearance of p16Ink4a-positive cells did not impact β-cell mass, but improved β-cell function and proliferative capacity in a subset of HFD mice. The targeted subpopulation of β-cells is non-proliferative and non-SASP producing.
Researchers analyzed over 500,000 patient records and found that patients diagnosed at age 70 were nearly twice as likely to be passed over for post-surgical radiation therapy. This significant gap in treatment recommendations suggests that cognitive heuristics play a major role in physician decision-making.
A new study led by the University of California San Diego found that daily walking and moderate-to-vigorous physical activity significantly reduced the risk of developing mild cognitive impairment or dementia in senior women. With each additional 1,865 steps per day, the risk was lowered by 33%, while moderate-to-vigorous physical acti...
Researchers found that the F-box gene FBXC-58 is a novel mediator of dietary restriction effects on extending the health span of Caenorhabditis elegans. FBXC-58 prevents muscle aging and extends longevity through an S6 kinase-dependent pathway.
In a mouse model of laser-induced CNV, RORα expression was highly increased in the choroidal/RPE complex post-laser, while loss or inhibition of RORα worsened CNV with increased lesion size and vascular leakage. RORα negatively regulates pathological CNV development by modulating angiogenic response and inflammatory environment.
A recent study from West Virginia University found that states permitting nurse practitioners to exercise full practice authority (FPA) tend to have a more diverse and racially aligned NP workforce. In FPA states, Black NPs serve 2.8% more Black Medicare beneficiaries than in non-FPA states.
A recent study found that social support has a significant impact on depression risk, particularly in individuals with high genetic risk scores. The research used data from two groups: first-year doctors and recently widowed older adults, showing that those who gained social support during stressful times had lower depressive symptoms.
A new twin study by Karolinska Institutet suggests that the same genes may be behind both cardiometabolic diseases and dementia. The study found that individuals with multiple cardiometabolic conditions had a significantly increased risk of developing dementia.
A study by Plamen Nikolov and Shahadath Hossain found that access to retirement plans can lead to significant adverse effects on cognitive functioning among the elderly. The researchers discovered that pension benefits and retirement resulted in reduced cognitive performance, particularly among females.
A recent study by North Carolina State University found that adult children in separated families receive substantially less emotional, material, and instrumental support from their parents. This often results in disadvantages for these children due to limited access to resources. The study also highlights the importance of providing a...
A new study finds epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV. Participants showed accelerated biological age and different brain activity patterns compared to controls, suggesting a link between biological aging and neural function in PWH.
Researchers developed a new epigenetic biomarker, GrimAge version 2, which leverages two DNAm-based estimators of plasma proteins to predict mortality risk. The study found that GrimAge 2 outperforms existing clinical biomarkers in predicting mortality across multiple racial/ethnic groups and associations with age-related conditions.
A study followed over 7,000 Canadians for three years to find that being female, physically active, and not obese were key to maintaining excellent health. Factors such as high income and social support also played a crucial role in optimal aging.
Researchers found that participants who lived alone and reported strong cohesion with their neighbors had a similar risk of death compared to those living with others. Living alone is associated with various poor health outcomes, including depression, cardiovascular disease, dementia, and premature death.
Researchers from Nagoya University found that 5G network telemedicine is effective in providing telerehabilitation and teletreatment in a remote community. The study showed that 5G transmitted high-definition images with low latency, reducing the need for physical therapist visits and improving patient outcomes.
The Global Roadmap for Healthy Longevity aims to design societies that benefit both older and younger individuals. Investing in the health, well-being, and purpose of older adults can yield great rewards for all ages, fostering productive lives, social capital, and a sense of fulfillment.
Researchers found that a one-year increase in retinal age was associated with a 10% higher risk of incident kidney failure over 11 years. Retinal age gap, a non-invasive biomarker based on retinal imaging, may help identify people at elevated risk for kidney failure.
Researchers found that glutaminase inhibitor BPTES selectively eliminates senescent dermal fibroblasts, improving skin aging phenotype by increasing collagen density and cell proliferation. The study suggests BPTES as a potential therapeutic agent for skin aging, offering new treatment options.
Researchers at the University of Gothenburg found that using warmer brain irrigation fluid can halve the number of repeat operations needed to remedy bleeding under the cranium. This method involves replacing room temperature irrigation fluid with body temperature fluid, resulting in a significant reduction in surgical interventions.
A daily cup of black tea could help reduce extensive abdominal aortic calcification (AAC) and lower cardiovascular risk late in life. Flavonoid intake from other sources like fruits, nuts, and dark chocolate may also offer protection.
The SuperAgers Family Study aims to identify genetic and biological factors of healthy aging. The study will provide insights for decades to come, assisting researchers in developing new therapies.
Researchers are exploring how aging affects communication between bone and muscle, finding that imbalance can lead to muscle loss, falls, and bone fractures. They aim to develop novel interventions to restore this balance, potentially treating osteoporosis and sarcopenia.
A new study found racial and ethnic disparities in brain aging among middle-age and older adults. In late life, Latinx and white adults experienced more pronounced brain aging, while Black adults showed accelerated brain aging in midlife.
A University of Gothenburg study finds that light physical activity can lead to milder symptoms and improved survival rates for patients with intracerebral hemorrhage. The research shows a clear link between physical activity and reduced severe symptoms, as well as higher survival rates compared to those who are less active.
Researchers found drastic differences in microglia marker Iba1 and factors influencing Sirt1 levels and activity between elder groups. Preserving microglia and Sirt1 functional efficiency is crucial for longevity.
A new poll finds that more than half of people over 50 have helped at least one person over 65 with various tasks, including health care needs, home repairs, and finances. The experience can be rewarding but also challenging, especially for those helping individuals with complex needs.
Researchers have identified a class of lipids called SGDGs that decline in the brain with age and may have anti-inflammatory effects. These findings could lead to new therapeutic interventions for age-related neurological diseases. Further research will be needed to explore the role of SGDGs in human neuroinflammation.
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
Researchers will investigate immune system differences between men and women to better understand neurodegenerative diseases. The study aims to identify why certain neurological diseases primarily affect males or females, and how this difference impacts disease progression.
Scientists at NTU Singapore have found that a stress response in cells, when 'switched on' at a post-reproductive age, could be the key to slowing down aging. The study showed that this stress response extended the lifespan of roundworms fed a high-glucose diet.
A new study found that timely treatment of depression can reduce the risk of dementia by about 30% in certain patient groups. The study, published in Biological Psychiatry, analyzed data from over 350,000 participants and found that depression elevated the risk of dementia by 51%, but treatment reduced this risk. Those with increasing ...
New research from UC San Francisco found that senescent cells promote normal repair and healing in damaged tissues, contradicting the long-held view that they are purely detrimental. The study used senolytics to kill senescent cells and found that injuries healed more slowly. However, the researchers also discovered that senescent cell...
A 14% decrease in live births was observed in Europe nine months after the start of the COVID-19 pandemic and first lockdowns. The decline may be linked to lockdowns rather than COVID-19 infection, with countries experiencing longer lockdowns having lower birth rates.
Researchers found that participants with long COVID had a lower peak oxygen rate and irregular breathing patterns during exercise tests, indicating reduced exercise capacity. This decline was equivalent to a 40-year-old woman's expected exercise capacity dropping to that of a 50-year-old woman.
A study in C. elegans suggests that disrupting meiosis in reproductive cells accelerates aging and triggers a decline in healthspan, similar to humans. The research highlights the importance of reproductive fitness for overall health, with potential applications for early detection and treatment of age-related diseases.
A University of California, Berkeley study found that aging and environment are more important than genetic variation in affecting gene expression. As individuals age, their gene expression profiles diverge, making genetics less useful in predicting which genes are ramped up or down.
A study published in the Journal of the American Geriatrics Society found that individuals with type 2 diabetes who exhibit psychological resilience experience fewer hospitalizations, better physical functioning, and a lower likelihood of becoming frail. Psychological resilience also appears to mitigate aging-related concerns.
A new study found that fewer Asian, Black, and Hispanic patients qualify for anti-amyloid monoclonal antibody treatments, which may slow Alzheimer's progression. The treatment's effectiveness depends on the presence of amyloid plaques, with lower incidence in minorities.
Scientists at UC San Francisco's Neuroscape Center have developed video game interventions that improve key aspects of cognition in aging adults, including short-term memory, attention and long-term memory. The games use adaptive closed-loop algorithms to challenge players, keeping them engaged while adapting difficulty levels.
Researchers found that cataract surgery patients experienced fewer systemic complications than those undergoing other low-risk procedures, even without anesthesia experts present.
Researchers find nematodes have two independent ageing processes, one determining movement cessation and the other death time, correlated with each other. This challenges the concept of a single biological age measure indicative of overall health.
A recent study highlights the importance of physical exercise, social relationships, and passion in maintaining brain health. By adopting these three factors, individuals can improve their cognitive function and reduce the risk of age-related decline.
A recent study published in BMC Biology found that normal variation in dietary patterns affects the aging process. The researchers identified key patterns of specific nutrients associated with minimal biological aging, emphasizing the need for a holistic approach to nutrition and aging. The findings suggest that balanced nutrient intak...
Healthy older adults exhibit greater mental well-being despite poorer cognitive performance than younger adults. The study reveals that neural mechanisms underlying these findings may inspire new therapeutic interventions to promote healthy brain function.
Researchers analyzed data from over 25,000 US adults in a clinical trial and found that vitamin D3 and omega-3 fatty acid supplementation had no effect on frailty scores. Healthy lifestyle habits such as regular exercise and the Mediterranean diet are recommended for preventing frailty instead.
A new study of 1.9 million adults found that young-onset type 2 diabetes is associated with a substantially higher relative risk of cardiovascular disease and death. Individuals diagnosed with early-onset T2D aged 40 or younger had five times more likelihood to develop heart disease, seven times more likely to be hospitalized with hear...
Researchers from Tokyo Metropolitan University have developed a method to directly measure the strength of skeletal muscle myotubes by analyzing wrinkles formed on an elastic substrate when stimulated with electric pulses. This new technique is more sensitive than existing measures and has great potential for accelerating drug discover...
A study published in Cell Stem Cell found that mitochondrial dynamics regulate the dormant state of adult muscle stem cells, which are essential for tissue stability. The researchers discovered that the protein OPA1 regulates this process and its depletion leads to severe muscle stem cell defects.
Researchers found that combining BCL-2 inhibitors can selectively eliminate senescent cells, improving efficacy and reducing toxicity by targeting high-MCL-1 expressing subpopulation of cells. This synergistic approach enables lower doses of drugs to be used, overcoming resistance to monotherapy.
Queen ants live much longer than workers by generating an anti-insulin protein that blocks aging pathways. This protein enables pseudoqueens, female worker ants that become queens, to reproduce and live longer without aging.
A study of 641 participants found that midlife and older Hispanic/Latinx adults were more likely to experience prolonged loneliness, with 16% persistently lonely. The researchers suggest that culturally important familism was disrupted by social distancing, and reduced access to transportation and community activities may contribute to...