Articles tagged with Aging Populations
Researchers found that combining BCL-2 inhibitors can selectively eliminate senescent cells, improving efficacy and reducing toxicity by targeting high-MCL-1 expressing subpopulation of cells. This synergistic approach enables lower doses of drugs to be used, overcoming resistance to monotherapy.
Queen ants live much longer than workers by generating an anti-insulin protein that blocks aging pathways. This protein enables pseudoqueens, female worker ants that become queens, to reproduce and live longer without aging.
A study of 641 participants found that midlife and older Hispanic/Latinx adults were more likely to experience prolonged loneliness, with 16% persistently lonely. The researchers suggest that culturally important familism was disrupted by social distancing, and reduced access to transportation and community activities may contribute to...
A recent study published in the Journal of Aging and Physical Activity found that higher levels of light physical activity and moderate-to-vigorous physical activity were associated with lower risk of death. In contrast, higher sedentary time was linked to increased mortality risk, regardless of genetic predisposition for longevity.
A recent study by Florida Atlantic University found that only seven out of 50 largest US cities have strong evacuation plans in place, highlighting a need for improvement in preparing for natural disasters. The study suggests that cities with experience in major hurricanes tend to develop stronger plans.
Tyler Golato will present his latest research on the topic of Decentralized Science, focusing on early learnings and future hopes. The conference aims to discuss the most pressing obstacles in finding efficacious interventions for aging.
Dr. Varun Dwaraka will present his latest research on epigenetic clocks and their use as a diagnostic tool for various disease states, including aging. The presentation highlights recent clinical trial insights from the use of epigenetic clocks to test pharmacologic and clinical interventions.
Joe Betts-LaCroix will present his latest research on reprogramming, parabiosis, and autophagy, exploring their commonalities in the context of aging biology. The conference aims to discuss the most pressing obstacles in finding efficacious interventions for aging.
Lou Hawthorne will present his latest research on clearing progeronic soluble factors using NaNots at the conference. The study aims to develop treatments for major diseases such as cancer and inflammatory conditions like sepsis and 'inflamm-aging'.
Marco Quarta will present his latest research on the biology of aging at the world's largest aging research for drug discovery conference. The presentation focuses on single cell AI-enabled discovery of cellular senescence and targeted senolytic drug development.
Ann Beliën will present her latest research on Platform-based clinical development in aging at the 9th Aging Research & Drug Discovery conference. The conference aims to discuss the most pressing obstacles in finding efficacious interventions for aging, bringing together experts from academia and industry.
A study by UCSF found that routine depression screening in primary care increased rates from 40.5% to 88.8%, capturing previously undertreated groups. Screening disparities virtually disappeared for older patients, Black/African Americans, and non-English speakers.
Ann Beliën, CEO and Founder of Rejuvenate Biomed, will present her latest research on platform-based clinical development in aging. Her company has evolved from a discovery company to a clinic stage company under her leadership with over 20 years of experience in drug development.
Researchers discovered that face centering, not saliency, plays a key role in guiding attention to faces in videos as people age. The findings have implications for children's television programming and the diagnosis of autism spectrum disorder.
Research reveals that nursing homes in disadvantaged neighborhoods have lower clinical staff hours compared to those in more well-off areas. This disparity is particularly pronounced for registered nurses and physical therapists.
Researchers analyzed data from over 3,000 participants and found no association between electrocardiogram measures and telomere length. The study suggests that ECG prolongation is age-dependent but not a marker of biological aging.
Researchers identify LINE-1 RNA as a key player in premature aging, revealing its role in progeria and potential therapeutic targets. By inhibiting LINE-1 RNA, scientists reverse signs of aging and extend lifespan in mice.
A 12-month exercise program improved physical functioning and aerobic exercise capacity in adults with CKD stages G3b-4. The program, which included resistance and aerobic exercise, showed no significant impact on cardiovascular risk factors.
A Kessler Foundation neuroimaging study found that older individuals reported less state fatigue and showed greater brain activation to combat fatigue. The study also revealed women show greater resilience when faced with a fatiguing task, highlighting age and gender differences in fatigue responses.
Staff turnover affects both residents and their families, compromising the quality of care. Continuity of nursing home staff and leadership is essential for delivering personalized care, as frontline workers deliver 90% of care. Researchers emphasize the need to attract and retain well-trained staff who enjoy working with older adults.
A new study published in the European Journal of Ageing found that having a partner had a greater impact on reducing loneliness among older adults during the pandemic's first wave. Not having a partner was the most significant factor, with those without a partner experiencing a higher risk of moving into loneliness.
Researchers at NTU Singapore and Cuprina have developed a new clinical-grade collagen made from discarded bullfrog skin, which is leapfrogging from the lab bench to clinics soon. This sustainable innovation aims to reduce waste and provide an affordable yet effective wound-care solution.
A study of 1,813 older women found that accelerated biological aging is associated with lower odds of living to be 90 years old and maintaining physical and cognitive function. Slower age acceleration was linked to a reduced risk of mortality.
A Dartmouth-led research team will assess the effectiveness of visit information provided to older adult patients and caregivers in improving quality of life. The CHRONICLE Trial aims to determine whether audio recordings or written summaries are more effective in sharing healthcare visit information.
A new study has developed cut-off points to measure handgrip strength in the general population, considering gender, body height, and aging. Low handgrip strength is linked to increased mortality risk and may indicate underlying health conditions such as heart and lung problems.
The study found that engaging in physical activity reduced the decline in global and domain-specific cognitive function over time, particularly in women. The researchers recommend highlighting the benefits of physical activity to promote brain health and encourage patients to participate. Dr. Geda and Dr. Krell-Roesch are joint recipie...
A study published in CMAJ found that patients who received care from physicians speaking their primary language had shorter hospital stays and fewer falls and infections. Francophones had a 24% lower risk of death, while allophones had a 54% lower risk.
A new study found that the fourth COVID-19 vaccine reduces the risk of death among elderly individuals in long-term care facilities by 72%. The study, which included approximately 40,000 residents, also showed a significant reduction in hospitalizations and infections.
Researchers are developing a health scorecard to predict dementia risk using brain scans, genetics, and biomarkers. The study will analyze diverse populations between ages 65-90, providing insights into contributing factors like diabetes or hypertension that can be addressed to modify the risk.
A recent study found that older adults in later-born generations are more likely to have multiple chronic health conditions than prior generations. This trend may lead to increased strain on the well-being of older adults and medical insurance systems, particularly as the US population ages. The researchers suggest that sociodemographi...
A new study published in eClinicalMedicine found that older men experiencing frequent bad dreams were twice as likely to be diagnosed with Parkinson's disease. The researchers suggest that dream changes could serve as an early warning sign for the condition, which may develop years before characteristic symptoms appear.
A straightforward questionnaire, called the Attentional Failure during Driving Questionnaire (AFDQ), has been developed to assess older drivers' ability to drive safely. The study found that repeated attentional challenges were a key predictor of crashes among older drivers.
Ian David Hickson will present his research on chromosome instability and its role in driving human disease, with a focus on developing novel therapeutic strategies to target difficult-to-treat cancers. The conference aims to bridge clinical, academic, and commercial research to find practical solutions to extending healthy lifespan.
Dr. Björn Schumacher will discuss his research on genome stability and its impact on aging and disease, using C. elegans as a model organism. His work aims to contribute to the development of future strategies to prevent age-related diseases.
João Pedro de Magalhães, a renowned expert in aging research, will present his latest work on data-driven approaches in longevity pharmacology. The presentation aims to bridge the gap between genotype and phenotype, a major challenge in understanding the ageing process.
A recent SFU study found that 79% of Vancouver residents have access to a grocery store within a 15-minute walk, while 99% can reach one via cycling. However, there are inequities in access across populations and neighbourhoods, disproportionately affecting children, older adults, and racialized populations.
A new clinical study published in Cell Reports Medicine found that daily intake of postbiotic Urolithin A improved muscle strength by 12% in middle-aged adults. The supplement supported the cells' ability to renew their powerplants, the mitochondria, during the aging process.
A new study finds that having three or more children is negatively correlated with late-life cognition, with the effect strongest in Northern Europe. The researchers suggest that this may be due to financial stress and reduced social interaction, leading to potential cognitive deterioration.
Dr. Blagosklonny discusses the potential of combining rapamycin with other modalities to live long enough to benefit from future discoveries in cellular reprogramming. He emphasizes that Altos Labs needs to develop rapamycin-based drug combinations to achieve additional decades of life extension, potentially within 3-5 years.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Scientists have discovered a master gene that programs ear hair cells into either outer or inner ones, enabling the development of these cells to restore hearing. This breakthrough could provide a previously unavailable tool to create specific hair cells and improve treatments for age-related hearing loss.
Scientists have found that transplanting faecal microbiota from young mice into old mice can reverse hallmarks of ageing in the gut, eyes, and brain. The study suggests that gut microbes play a role in regulating some of the detrimental effects of ageing, offering a potential solution in the form of gut microbe replacement therapy.
A new study reveals that Asia and Africa have a similar aging burden to the West, with a Health-Adjusted Dependency Ratio (HADR) that indicates the impact of ill-health on dependency ratios. The HADR metric suggests that demographic age is not the only factor determining dependency, and that health levels play a significant role.
Canada's cancer rates are declining overall, but new cases and deaths are on the rise due to an aging population and growing numbers. Despite this, efforts in cancer prevention, screening, early detection, and treatment have led to improved survival rates for those diagnosed with cancer.
A new microsimulation model projects that the Japanese population will live longer and experience a decrease in years spent living with dementia. However, older women with less than a high school education are more likely to be affected by both dementia and frailty.
The 44th AChemS meeting investigates how COVID-19 affects olfactory function, leading to significant symptomology and quality of life impacts. Researchers will discuss recent findings on chemosensory testing and COVID-19, as well as the relationship between smell and depression.
Dr. Jennifer Garrison will present her latest research on Reframing Health and Aging through the Lens of Reproductive Longevity at the 9th ARDD conference. Her lab studies inter-tissue communication in systemic aging and its impact on female reproductive decline.
Researchers at Einstein Aging Study are investigating how social forces contribute to inequalities in cognitive health, particularly among Black and Hispanic Americans. The new grant will enable the tracking of over 700 Bronx adults with mobile technology to measure cognition directly as they engage in everyday activities.
Dr. Kristen Fortney will present her research on data-informed drug discovery and clinical development for therapies targeting aging at the 9th Aging Research and Drug Discovery conference. The presentation aims to unlock opportunities to treat or prevent diseases of aging by targeting molecular pathways that impact healthy human aging.
A new study found that wolves preferentially target adult moose with osteoarthritis, an age-related disease, over prime-aged adults. This selective predation helps maintain a balance in prey populations, reducing the incidence of diseases such as osteoarthritis.
A cross-racial study of 1.87 million US veterans found significant differences in dementia incidence across five racial groups, with Hispanic and Black veterans at highest risk. Rates were significantly higher for Hispanics (99%) and Blacks (55%), while Asian veterans showed a 24% increase compared to whites.
Researchers found that wealth was associated with a 19 percentage point increase in survival rates from age 65 to 85, but smoking dominated other factors in shortening lifespan. The study suggests that avoiding smoking is crucial for living longer, regardless of wealth levels.
Researchers at The University of Toledo found that low-dose lithium acts as a powerful anti-aging agent in the kidneys by blocking GSK3-beta, an enzyme associated with cellular aging. Studies showed improved kidney function and reduced albuminuria in mice and psychiatric patients treated with lithium.
Matthias Mann, Director of Proteomics and Signal Transduction at Max Planck Institute, presents latest research on Single cell and Deep Visual Proteomics for precision medicine. The conference focuses on accelerating aging research and discovery, with top-level speakers sharing groundbreaking research.
A recent study suggests that many older adults with rheumatoid arthritis are not prescribed disease-modifying medications, despite guidelines calling for early and aggressive treatment. Only 45% of patients over 65 were prescribed these medications, highlighting the need to improve prescribing practices among primary care physicians.
A University of Otago study found altering an existing assessment tool could double the capture rate of elder abuse sufferers. By adding an 'unable to determine' category, tens of thousands of older New Zealanders may be identified as victims of abuse.
Dr. Tim R Peterson's research explores the molecular cause-and-effect between infectious disease and aging, identifying a shared biochemistry that drives senescent cell formation. The presentation highlights potential applications of FDA-approved drugs in developing novel senolytics.
Dr. Joris Deelen will present his latest research on identifying and functional characterizing genetic variants linked to human longevity. The work aims to understand the efficacy of previously identified biomarkers of aging in clinical studies, using omics-based approaches such as metabolomics.
A study published in International Journal of Geriatric Psychiatry found that antidepressants were associated with a lower risk of suicide among residents aged 75+, who had a significantly increased risk if taking sleep medication or having a history of self-harm. The research highlights the need for early recognition and quality care ...
The rate of older adults treated for substance abuse increased sharply from 2000 to 2017, with a notable rise in cannabis and cocaine use. This trend is attributed to decreasing stigma around substance abuse, allowing more older adults to seek help through self-referrals.