Articles tagged with Aging Populations
Researchers will investigate immune system differences between men and women to better understand neurodegenerative diseases. The study aims to identify why certain neurological diseases primarily affect males or females, and how this difference impacts disease progression.
Scientists at NTU Singapore have found that a stress response in cells, when 'switched on' at a post-reproductive age, could be the key to slowing down aging. The study showed that this stress response extended the lifespan of roundworms fed a high-glucose diet.
A new study found that timely treatment of depression can reduce the risk of dementia by about 30% in certain patient groups. The study, published in Biological Psychiatry, analyzed data from over 350,000 participants and found that depression elevated the risk of dementia by 51%, but treatment reduced this risk. Those with increasing ...
New research from UC San Francisco found that senescent cells promote normal repair and healing in damaged tissues, contradicting the long-held view that they are purely detrimental. The study used senolytics to kill senescent cells and found that injuries healed more slowly. However, the researchers also discovered that senescent cell...
A 14% decrease in live births was observed in Europe nine months after the start of the COVID-19 pandemic and first lockdowns. The decline may be linked to lockdowns rather than COVID-19 infection, with countries experiencing longer lockdowns having lower birth rates.
Researchers found that participants with long COVID had a lower peak oxygen rate and irregular breathing patterns during exercise tests, indicating reduced exercise capacity. This decline was equivalent to a 40-year-old woman's expected exercise capacity dropping to that of a 50-year-old woman.
A study in C. elegans suggests that disrupting meiosis in reproductive cells accelerates aging and triggers a decline in healthspan, similar to humans. The research highlights the importance of reproductive fitness for overall health, with potential applications for early detection and treatment of age-related diseases.
A University of California, Berkeley study found that aging and environment are more important than genetic variation in affecting gene expression. As individuals age, their gene expression profiles diverge, making genetics less useful in predicting which genes are ramped up or down.
A study published in the Journal of the American Geriatrics Society found that individuals with type 2 diabetes who exhibit psychological resilience experience fewer hospitalizations, better physical functioning, and a lower likelihood of becoming frail. Psychological resilience also appears to mitigate aging-related concerns.
Researchers found that cataract surgery patients experienced fewer systemic complications than those undergoing other low-risk procedures, even without anesthesia experts present.
A new study found that fewer Asian, Black, and Hispanic patients qualify for anti-amyloid monoclonal antibody treatments, which may slow Alzheimer's progression. The treatment's effectiveness depends on the presence of amyloid plaques, with lower incidence in minorities.
Scientists at UC San Francisco's Neuroscape Center have developed video game interventions that improve key aspects of cognition in aging adults, including short-term memory, attention and long-term memory. The games use adaptive closed-loop algorithms to challenge players, keeping them engaged while adapting difficulty levels.
Researchers find nematodes have two independent ageing processes, one determining movement cessation and the other death time, correlated with each other. This challenges the concept of a single biological age measure indicative of overall health.
A recent study highlights the importance of physical exercise, social relationships, and passion in maintaining brain health. By adopting these three factors, individuals can improve their cognitive function and reduce the risk of age-related decline.
A recent study published in BMC Biology found that normal variation in dietary patterns affects the aging process. The researchers identified key patterns of specific nutrients associated with minimal biological aging, emphasizing the need for a holistic approach to nutrition and aging. The findings suggest that balanced nutrient intak...
Healthy older adults exhibit greater mental well-being despite poorer cognitive performance than younger adults. The study reveals that neural mechanisms underlying these findings may inspire new therapeutic interventions to promote healthy brain function.
Researchers analyzed data from over 25,000 US adults in a clinical trial and found that vitamin D3 and omega-3 fatty acid supplementation had no effect on frailty scores. Healthy lifestyle habits such as regular exercise and the Mediterranean diet are recommended for preventing frailty instead.
A new study of 1.9 million adults found that young-onset type 2 diabetes is associated with a substantially higher relative risk of cardiovascular disease and death. Individuals diagnosed with early-onset T2D aged 40 or younger had five times more likelihood to develop heart disease, seven times more likely to be hospitalized with hear...
Researchers from Tokyo Metropolitan University have developed a method to directly measure the strength of skeletal muscle myotubes by analyzing wrinkles formed on an elastic substrate when stimulated with electric pulses. This new technique is more sensitive than existing measures and has great potential for accelerating drug discover...
A study published in Cell Stem Cell found that mitochondrial dynamics regulate the dormant state of adult muscle stem cells, which are essential for tissue stability. The researchers discovered that the protein OPA1 regulates this process and its depletion leads to severe muscle stem cell defects.
Queen ants live much longer than workers by generating an anti-insulin protein that blocks aging pathways. This protein enables pseudoqueens, female worker ants that become queens, to reproduce and live longer without aging.
Researchers found that combining BCL-2 inhibitors can selectively eliminate senescent cells, improving efficacy and reducing toxicity by targeting high-MCL-1 expressing subpopulation of cells. This synergistic approach enables lower doses of drugs to be used, overcoming resistance to monotherapy.
A study of 641 participants found that midlife and older Hispanic/Latinx adults were more likely to experience prolonged loneliness, with 16% persistently lonely. The researchers suggest that culturally important familism was disrupted by social distancing, and reduced access to transportation and community activities may contribute to...
A recent study by Florida Atlantic University found that only seven out of 50 largest US cities have strong evacuation plans in place, highlighting a need for improvement in preparing for natural disasters. The study suggests that cities with experience in major hurricanes tend to develop stronger plans.
A recent study published in the Journal of Aging and Physical Activity found that higher levels of light physical activity and moderate-to-vigorous physical activity were associated with lower risk of death. In contrast, higher sedentary time was linked to increased mortality risk, regardless of genetic predisposition for longevity.
Joe Betts-LaCroix will present his latest research on reprogramming, parabiosis, and autophagy, exploring their commonalities in the context of aging biology. The conference aims to discuss the most pressing obstacles in finding efficacious interventions for aging.
Lou Hawthorne will present his latest research on clearing progeronic soluble factors using NaNots at the conference. The study aims to develop treatments for major diseases such as cancer and inflammatory conditions like sepsis and 'inflamm-aging'.
Marco Quarta will present his latest research on the biology of aging at the world's largest aging research for drug discovery conference. The presentation focuses on single cell AI-enabled discovery of cellular senescence and targeted senolytic drug development.
Ann Beliën will present her latest research on Platform-based clinical development in aging at the 9th Aging Research & Drug Discovery conference. The conference aims to discuss the most pressing obstacles in finding efficacious interventions for aging, bringing together experts from academia and industry.
A study by UCSF found that routine depression screening in primary care increased rates from 40.5% to 88.8%, capturing previously undertreated groups. Screening disparities virtually disappeared for older patients, Black/African Americans, and non-English speakers.
Tyler Golato will present his latest research on the topic of Decentralized Science, focusing on early learnings and future hopes. The conference aims to discuss the most pressing obstacles in finding efficacious interventions for aging.
Dr. Varun Dwaraka will present his latest research on epigenetic clocks and their use as a diagnostic tool for various disease states, including aging. The presentation highlights recent clinical trial insights from the use of epigenetic clocks to test pharmacologic and clinical interventions.
Ann Beliën, CEO and Founder of Rejuvenate Biomed, will present her latest research on platform-based clinical development in aging. Her company has evolved from a discovery company to a clinic stage company under her leadership with over 20 years of experience in drug development.
Researchers discovered that face centering, not saliency, plays a key role in guiding attention to faces in videos as people age. The findings have implications for children's television programming and the diagnosis of autism spectrum disorder.
Researchers analyzed data from over 3,000 participants and found no association between electrocardiogram measures and telomere length. The study suggests that ECG prolongation is age-dependent but not a marker of biological aging.
Researchers identify LINE-1 RNA as a key player in premature aging, revealing its role in progeria and potential therapeutic targets. By inhibiting LINE-1 RNA, scientists reverse signs of aging and extend lifespan in mice.
Research reveals that nursing homes in disadvantaged neighborhoods have lower clinical staff hours compared to those in more well-off areas. This disparity is particularly pronounced for registered nurses and physical therapists.
A 12-month exercise program improved physical functioning and aerobic exercise capacity in adults with CKD stages G3b-4. The program, which included resistance and aerobic exercise, showed no significant impact on cardiovascular risk factors.
A Kessler Foundation neuroimaging study found that older individuals reported less state fatigue and showed greater brain activation to combat fatigue. The study also revealed women show greater resilience when faced with a fatiguing task, highlighting age and gender differences in fatigue responses.
Staff turnover affects both residents and their families, compromising the quality of care. Continuity of nursing home staff and leadership is essential for delivering personalized care, as frontline workers deliver 90% of care. Researchers emphasize the need to attract and retain well-trained staff who enjoy working with older adults.
A new study published in the European Journal of Ageing found that having a partner had a greater impact on reducing loneliness among older adults during the pandemic's first wave. Not having a partner was the most significant factor, with those without a partner experiencing a higher risk of moving into loneliness.
Researchers at NTU Singapore and Cuprina have developed a new clinical-grade collagen made from discarded bullfrog skin, which is leapfrogging from the lab bench to clinics soon. This sustainable innovation aims to reduce waste and provide an affordable yet effective wound-care solution.
A study of 1,813 older women found that accelerated biological aging is associated with lower odds of living to be 90 years old and maintaining physical and cognitive function. Slower age acceleration was linked to a reduced risk of mortality.
A Dartmouth-led research team will assess the effectiveness of visit information provided to older adult patients and caregivers in improving quality of life. The CHRONICLE Trial aims to determine whether audio recordings or written summaries are more effective in sharing healthcare visit information.
A new study has developed cut-off points to measure handgrip strength in the general population, considering gender, body height, and aging. Low handgrip strength is linked to increased mortality risk and may indicate underlying health conditions such as heart and lung problems.
The study found that engaging in physical activity reduced the decline in global and domain-specific cognitive function over time, particularly in women. The researchers recommend highlighting the benefits of physical activity to promote brain health and encourage patients to participate. Dr. Geda and Dr. Krell-Roesch are joint recipie...
A study published in CMAJ found that patients who received care from physicians speaking their primary language had shorter hospital stays and fewer falls and infections. Francophones had a 24% lower risk of death, while allophones had a 54% lower risk.
A new study found that the fourth COVID-19 vaccine reduces the risk of death among elderly individuals in long-term care facilities by 72%. The study, which included approximately 40,000 residents, also showed a significant reduction in hospitalizations and infections.
Researchers are developing a health scorecard to predict dementia risk using brain scans, genetics, and biomarkers. The study will analyze diverse populations between ages 65-90, providing insights into contributing factors like diabetes or hypertension that can be addressed to modify the risk.
A recent study found that older adults in later-born generations are more likely to have multiple chronic health conditions than prior generations. This trend may lead to increased strain on the well-being of older adults and medical insurance systems, particularly as the US population ages. The researchers suggest that sociodemographi...
A new study published in eClinicalMedicine found that older men experiencing frequent bad dreams were twice as likely to be diagnosed with Parkinson's disease. The researchers suggest that dream changes could serve as an early warning sign for the condition, which may develop years before characteristic symptoms appear.
A straightforward questionnaire, called the Attentional Failure during Driving Questionnaire (AFDQ), has been developed to assess older drivers' ability to drive safely. The study found that repeated attentional challenges were a key predictor of crashes among older drivers.
Ian David Hickson will present his research on chromosome instability and its role in driving human disease, with a focus on developing novel therapeutic strategies to target difficult-to-treat cancers. The conference aims to bridge clinical, academic, and commercial research to find practical solutions to extending healthy lifespan.
Dr. Björn Schumacher will discuss his research on genome stability and its impact on aging and disease, using C. elegans as a model organism. His work aims to contribute to the development of future strategies to prevent age-related diseases.
João Pedro de Magalhães, a renowned expert in aging research, will present his latest work on data-driven approaches in longevity pharmacology. The presentation aims to bridge the gap between genotype and phenotype, a major challenge in understanding the ageing process.
A recent SFU study found that 79% of Vancouver residents have access to a grocery store within a 15-minute walk, while 99% can reach one via cycling. However, there are inequities in access across populations and neighbourhoods, disproportionately affecting children, older adults, and racialized populations.
A new clinical study published in Cell Reports Medicine found that daily intake of postbiotic Urolithin A improved muscle strength by 12% in middle-aged adults. The supplement supported the cells' ability to renew their powerplants, the mitochondria, during the aging process.
A new study finds that having three or more children is negatively correlated with late-life cognition, with the effect strongest in Northern Europe. The researchers suggest that this may be due to financial stress and reduced social interaction, leading to potential cognitive deterioration.
Dr. Blagosklonny discusses the potential of combining rapamycin with other modalities to live long enough to benefit from future discoveries in cellular reprogramming. He emphasizes that Altos Labs needs to develop rapamycin-based drug combinations to achieve additional decades of life extension, potentially within 3-5 years.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.