Chronic disease medications impair the body's ability to regulate core temperature, increasing the risk of heat-related illness in elderly patients. Exercise and improved fitness levels can help mitigate these effects, but bodily impairments from chemotherapy and medications may limit exercise capacity.
A novel study found that consuming two oz-eq portions of animal-based versus plant-based protein foods results in different EAA bioavailability. The study, conducted by scientists at Purdue University, included young and older adults, with no differences in EAA bioavailability between age groups.
Research identifies key molecular signatures and pathways contributing to skeletal muscle strength loss in females with estrogen deficiency. The study found parallel patterns of inhibition and activation across various signaling pathways, including AMPK and calcium signaling.
A new study found that cumulative exposure to extreme heat can worsen cognitive health, particularly among Black older adults and residents of disadvantaged neighborhoods. Researchers analyzed data from nearly 9,500 U.S. adults ages 52 and older, finding a link between high heat exposure and faster cognitive decline in these groups.
Researchers found that participants with MCI performed significantly worse on a test of four types of decision-making abilities compared to those without. The study's findings have broad implications for choices about finances, health care, and other daily decisions.
Scientists have discovered that SARS-CoV-2 can infect cells using multiple entry points beyond ACE2, explaining its ability to jump between species. This finding highlights the need for continued monitoring of coronaviruses and their potential to cause future pandemics.
A new study reveals that patients hospitalized with COVID-19 had a higher in-hospital mortality and persisted at 30 days, 90 days, and 180 days after discharge. The risk of death was nearly twice that observed in those who were discharged alive from an influenza-related hospital admission.
Researchers propose a novel theory of aging that suggests cell competition is a key factor in the process. The selective destruction theory (SDT) proposes a mechanism of aging that is independent of accumulating damage and consistent with epigenetic rejuvenation.
Researchers found that adults who experienced violence, financial stress, or separation from parents as children were more likely to experience physical and cognitive impairments. Adverse childhood experiences can have lifelong consequences, including difficulty walking, carrying out daily activities, and problems with memory.
A large head-to-head comparison study of the Moderna and Pfizer-BioNTech vaccines found that the Moderna vaccine was associated with a slightly lower risk of adverse events for older adults. The study also showed that the Moderna vaccine was linked to a 4% lower risk of pulmonary embolism and a 15% lower risk of diagnosed COVID-19.
A new study published in JAMA Ophthalmology found that vision problems are more common in older adults with dementia. The study of nearly 3,000 older adults showed that even mild vision issues were associated with a higher risk of dementia.
The American College of Physicians recommends starting colorectal cancer screening at age 50 for asymptomatic adults with average risk. The guideline aims to balance benefits and harms of screening in this population. Screening in younger adults may not offer significant net benefit due to lower incidence rates.
A recent study by Tufts University researchers found that myo-inositol in human breast milk increases synaptic connections between neurons, indicating stronger brain connectivity. This finding could lead to improved infant formulas and better brain health outcomes for adults with certain psychiatric conditions.
A new study by Beth Israel Deaconess Medical Center reveals that older adults who belong to sexual and gender minorities experience higher rates of frailty, starting at younger ages, compared to non-OSGM participants. The research highlights the need for early geriatric assessment among OSGM and potential targets to mitigate frailty.
Researchers discovered that adult and aged mice demonstrated improved performance in behavioral tasks after environmental enrichment, with MSK1 playing a vital role. The study highlights the importance of MSK1 in converting positive experiences into cognitive benefits across the lifespan.
A new study from UC Davis Health found that volunteering in late life is associated with better executive function and episodic memory. Those who volunteered several times per week had the highest levels of executive function, potentially serving as a simple intervention against Alzheimer's disease and associated dementias.
A Michigan Medicine study in Texas found that 61.4% of older adults with cognitive impairment are still driving, but one-third of caregivers have concerns about their care recipient's ability to drive safely. Researchers emphasize the need for open discussions between caregivers and healthcare professionals to ensure safety.
A study of 2,226 US participants found significant racial differences in post-retirement cognitive decline. White men experienced the most pronounced decline, whereas Black women showed minimal loss. College attendance was linked to greater cognitive decline after retirement.
A new study found that COVID-19 vaccines significantly reduced dementia-related deaths in long-term care and nursing homes, with a 77% decrease in the second year. However, deaths among those living at home did not decline as much, with only a 16% reduction.
Researchers developed MemTrax, a continuous recognition test for advanced cognitive impairment screening. The test quickly and accurately quantifies memory processing, storage, and retrieval, providing precise assessments of severity and rate of change over time.
A team of scientists at Harvard Medical School has identified six chemical cocktails that can restore cellular aging and rejuvenate human cells. The study builds upon the discovery of Yamanaka factors, which can convert adult cells into induced pluripotent stem cells, raising hopes for treating age-related diseases and injuries. The im...
Researchers investigated hepatic hydrogen sulfide production in a mouse model of Hutchinson-Gilford Progeria Syndrome (HGPS) and found reduced H2S levels in RC-fed mice, with partial rescue on high-fat diet. This study suggests that accelerated aging in HGPS may be partially explained by reduced hepatic H2S levels.
A new study suggests that reduced brain gray matter volume may mediate the association between glycemia and depression. Researchers observed a significant correlation between elevated glycosylated hemoglobin levels, reduced GMV, and depression in a large cohort of participants.
A large US study of over half a million adults found that BMI was not significantly linked to increased all-cause mortality in most cases. The study suggests that further research is needed to fully understand the relationship between BMI and mortality risk, particularly among younger adults.
A large clinical trial found that monthly vitamin D supplements reduced the risk of major cardiovascular events such as heart attacks by 9% in older adults. The study involved over 21,000 Australians aged 60-84 and showed a significant reduction in heart attack rates, but no difference in stroke rates.
New smart pants based on fiber optic sensors can track various types of physical activities in the clinic or at home, detecting signs of distress. The sensing approach achieved 100% accuracy in classifying activities and has several advantages, including low-cost and reliability.
Significant reductions in nicotine dependence were found among U.S. adults with cigarette use from 2006 to 2019, particularly among those 50 years and older. Tobacco cessation strategies tailored to age and comorbidities are needed for this population.
A global study predicts a significant increase in hip fractures worldwide by 2050, with the number projected to nearly double compared to 2018. The study highlights a post-fracture treatment gap in fracture prevention, particularly for men, leading to increased mortality and dependency.
The University of Central Florida has launched a five-year program to increase diversity among student researchers focused on health disparities in aging. The INTREPID program aims to provide hands-on learning, promote an affinity toward older adults, and create a sense of community through socialization.
A new UK survey study led by Lancaster University found that 6.6% of the population aged 16 and over changed their reported sexual identity over a six-year period. The research challenges the assumption that sexual identity mobility declines with age, revealing that it is as prevalent among over-65s as young people.
A recent study published in JAMA Network Open explores the association between adverse childhood experiences and epigenetic aging in midlife. The research found that early life experiences can accelerate biological aging, which may contribute to various health outcomes in middle-age adults.
The Endocrine Society will discuss emerging technology and diabetes research, including a scientific statement on hormones and aging. Researchers will share studies on various aspects of endocrinology, such as PCOS, obesity, and endocrine-disrupting chemicals.
Researchers investigate whether pregnant mothers' exposure to toxic metals affects kidney development in their babies, which may set the stage for chronic kidney disease. The team aims to identify key combinations of metal mixtures that could have detrimental effects on developing kidneys.
Researchers explore ED visits as a continuum of care, evaluating frailty in older adults and deprescribing medications. The studies aim to improve subsequent care through better communication between emergency departments and primary care doctors.
A nationwide VR research project is working to create diverse groups of participants to reflect real-world social dynamics. The Virtual Experience Research Accelerator (VERA) aims to provide researchers with access to large, reliable, and diverse groups for various VR research projects.
A recent study published in Calcified Tissue International found that heavy drinkers are at risk of muscle loss and frailty. The research, which analyzed data from the UK Biobank, suggests that consuming 10 units or more of alcohol per day can lead to lower muscle mass, even when adjusted for body size and other factors.
A UC Riverside-led study created a virtual village to connect older people living with HIV, reducing social isolation and depression. The virtual space provided health, community-based, and personal resources, facilitating positive connections and friendships.
Rodlescia Sneed aims to scale up the Chronic Disease Self-Management Program for older adults in state prisons, analyzing factors that influence effectiveness. She seeks to maximize program use in prisons and determine maximum effectiveness through user manual creation and future R01 grant testing.
Researchers tested zoledronic acid's effects on cellular senescence using multiple approaches. The study found that zoledronic acid killed senescent cells with minimal effects on non-senescent cells and reduced circulating SASP factors, including CCL7, IL-1β, TNFRSF1A, and TGFβ1.
A study by University of California, Riverside found that older adults are less likely to ignore distractors in their surroundings while engaging in a cognitive task and an effortful physical task. This decline is greater when simultaneously performing a physical task, such as driving or carrying grocery bags.
A recent study published in Cell Metabolism found that biological age increases with stress from surgery, pregnancy, and severe COVID-19, but can be reversed upon recovery. The study used 'biological clocks' to measure the health of cells and tissue, revealing a dynamic relationship between stress and biological aging.
Joshua Chen, a Rice University doctoral alum, has won the prestigious Schmidt Science Fellowship to pursue research in synthetic biology and wirelessly programmable cell therapies for neurodegenerative diseases.
A study of 371,159 individuals aged 50 to 71 years found that a healthy low-fat diet was associated with fewer deaths from all causes, cardiovascular diseases, and cancers. In contrast, unhealthy low-carbohydrate diets were linked to significantly higher mortality rates.
Three high school students co-authored a paper using AI engine PandaOmics to discover new therapeutic targets for glioblastoma multiforme, a common and aggressive malignant brain tumor. The study identified three genes strongly correlated with both aging and glioblastoma as potential therapeutic targets.
A national pilot program evaluated the implementation of geriatric surgery standards in eight hospitals with variable sizes and resources, finding high levels of compliance. The study highlights the scalability and feasibility of the program, which aims to optimize care for older adults in a wide range of hospital settings.
A study by Osaka Metropolitan University found that social and educational indicators have a stronger impact on population decline rates than economic indicators. Increasing investment in education for children can help lower population decline rates, suggesting a potential solution to Japan's shrinking city problem.
The University of Central Florida has developed the Virtual Experience Research Accelerator (VERA), a large-scale system for extended reality human subjects research. This project aims to facilitate human subjects research and improve extended reality technologies, making them more inclusive for underrepresented groups.
A recent study found that learning multiple new tasks improves cognition in older adults, with scores increasing by two to three times. The study, which had six and 27 participants aged 66 and 69, showed that cognitive abilities continued to grow over time, reaching levels similar to those of undergraduates.
The 18th Key Symposium on Healthy Ageing and Longevity takes place in Okinawa, bringing together world experts to discuss the latest research on blue zones. The symposium aims to promote both longevity and healthy ageing to reduce age-related diseases and healthcare burden.
Researchers found that enhancing NMDAR function via increased serine racemase expression improved attention and cognitive flexibility in middle-aged rats. Upregulating serine racemase in the medial prefrontal cortex also increased glutamatergic synaptic transmission, including NMDAR activity.
Researchers found that higher selenium levels were associated with lower blood pressure and HDL concentration in middle-aged women. The study suggests that selenium may moderate the effect of genetic variants on MetS components, such as waist circumference.
Researchers found that Indigenous populations with limited food availability have slower brain aging, while industrialized populations experience faster cognitive decline. Beyond a certain point, excessive energy gain from food intake is associated with smaller brain volumes and faster aging.
A new study reveals a protein in the nervous system regulates collagen expression, potentially extending human lifespan as temperatures rise. Mutant worms with increased collagen production lived longer and looked younger than wild-type worms under warm temperatures.
Researchers found that using monoclonal antibodies within two days of a COVID-19 diagnosis reduced the risk of hospitalization or death by 39% compared to those who did not receive treatment. This finding suggests that early treatment with monoclonal antibodies significantly reduced the severity of COVID-19.
Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.
A study explores how people remain productive and find meaning in later life, revealing key lessons from experts like John Cook, Judy Woodruff, and Chris Labenz. The research highlights the importance of following one's passion and not retreating to a conventional retirement lifestyle.
A recent study found that genetic risk scores are more predictive of Alzheimer's disease in adults over 65 than age. The study used machine learning models to rank risk factors, including household income, which emerged as an important risk factor. The findings suggest considering genetic information when working on Alzheimer's disease.
Overdose mortality among people aged 65 and older has quadrupled, driven by illicit drugs like fentanyl, heroin, and synthetic opioids. Researchers call for updated Medicare coverage and harm reduction supplies to curb the trend.
A UCF research team, in partnership with the City of Orlando, aims to prevent falls among older adults through a low-cost, portable technology-based intervention. The project seeks to address public health disparities and support the development of affordable housing options.
Researchers examine how chronological and biological age impact vaccine effectiveness, finding that both factors influence immune system capacity to mount responses. The study highlights the need for further research into 'immune aging' risk and departures from healthy aging.