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Discovery: One of the deleted genes linked to Williams syndrome is responsible for mitochondrial function and regulation in the brain’s nerve cells

Researchers found that the deletion of the Gtf2i gene impairs mitochondrial organelle formation and function, leading to abnormal cell behavior and neurodevelopmental pathologies. This discovery sheds light on the mechanism behind Williams syndrome, a rare genetic disorder characterized by cognitive and social impairments.

SourceTel-Aviv University·JournalCommunications Biology·DateJan 10, 2024

UMass Chan researchers identify molecular link between gut bacteria and excitatory brain signaling in C. elegans

Researchers established a molecular link between specific B12-producing gut bacteria and acetylcholine production in C. elegans, a neurotransmitter important to memory and cognitive function. A diet rich in these bacteria reduced seizure-like behavior in mutant worms by restoring excitatory/inhibitory balance.

SourceUMass Chan Medical School·JournalNature Cell Biology·TypeExperimental study·DateJan 4, 2024

Distinct sex differences persist in countries with higher standards of living

Despite improved living conditions, sex differences in personality, verbal skills, and negative emotions are larger in countries with higher standards of living. Women tend to benefit more from these improvements, exhibiting greater altruism and cooperative ability, while men show better cognitive skills but at a smaller advantage.

SourceKarolinska Institutet·JournalPerspectives on Psychological Science·TypeMeta-analysis·DateJan 3, 2024

Caffeine highs and lows footballers should be aware of

Research by Staffordshire University found that caffeine can improve short pass accuracy but negatively affect decision-making and long pass accuracy. The study suggests that coaches may need to adjust training strategies to account for caffeine's effects on young soccer players.

SourceStaffordshire University·JournalBehavioural Brain Research·TypeRandomized controlled/clinical trial·DateDec 11, 2023

Brain waves usually found in sleep can protect against epileptic activity

Researchers at University College London have discovered that slow waves typically present during sleep can also occur during wakefulness in people with epilepsy, potentially protecting against increased brain excitability. These 'wake' slow waves decrease the impact of epileptic spikes on brain activity and may protect against seizures.

SourceUniversity College London·JournalNature Communications·TypeExperimental study·DateNov 30, 2023

OCD therapy retrains the brain

A new study finds that exposure and response prevention (EX/RP) therapy for OCD improves cognitive control by strengthening connections between brain networks. This breakthrough sheds light on the mechanisms underlying EX/RP's effectiveness in treating OCD, paving the way for targeted therapies.

SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateNov 29, 2023

Breakthrough study shows exercise improves cognitive health for people with Down syndrome

A breakthrough study found that light exercise can improve cognitive health in adults with Down syndrome, leading to improved information processing and attention. After just eight weeks of walking, participants showed significant increases in physical fitness and reductions in errors during cognitive assessments.

SourceAnglia Ruskin University·JournalInternational Journal of Environmental Research and Public Health·DateNov 29, 2023

Long COVID happens in nursing homes, too

A new study reveals that COVID-19 can leave a lasting impact on older adults living in nursing homes, causing them to need more help with daily activities and experience a decline in brain function. The study found that those who tested positive for COVID had effects that lasted up to nine months.

SourceMichigan Medicine - University of Michigan·JournalJournal of the American Geriatrics Society·TypeData/statistical analysis·DateNov 21, 2023

New studies of brain activity explain benefits of electroconvulsive therapy

Researchers propose a new hypothesis that ECT alleviates depression symptoms by increasing aperiodic activity in the brain. Aperiodic activity helps boost inhibitory activity, slowing down neuronal cycles and effectively controlling how neurons turn on and off. The studies also found similar effects in magnetic seizure therapy.

SourceUniversity of California - San Diego·JournalTranslational Psychiatry·DateNov 15, 2023

The autism-linked gene SYNGAP1 could impact early stages of human brain development, USC study reveals

A new USC study reveals that variants of the autism-linked gene SYNGAP1 can disrupt early brain development in the cortex, a region involved in higher-order cognitive functions. The research found that disease-causing variants of SYNGAP1 alter the cells' cytoskeletons and lead to disorganized neural circuits.

SourceKeck School of Medicine of USC·JournalNature Neuroscience·TypeExperimental study·DateNov 9, 2023

Brain imaging identifies biomarkers of mental illness

A new study has identified a brain connectivity variate that predicts psychiatric disorders in adolescents. The finding provides evidence for a transdiagnostic brain-based measure underlying individual differences in developing psychiatric disorders in early adolescence.

SourceElsevier·JournalBiological Psychiatry·TypeImaging analysis·DateNov 9, 2023

Brain health in over 50s deteriorated more rapidly during the pandemic

Researchers found that cognitive decline quickened by 50% in the first year of the pandemic, with factors like loneliness, depression, and decreased exercise contributing to the impact. The study suggests that lockdowns had a lasting effect on brain health in people aged 50+, raising concerns about increased risk of dementia.

SourceUniversity of Exeter·JournalThe Lancet Healthy Longevity·TypeObservational study·DateNov 1, 2023

New clues to early development of schizophrenia

Researchers have discovered axonal dysregulation in the prenatal brain as a mediator of genetic risk for schizophrenia. The study used induced pluripotent stem cells and three-dimensional brain organoids to identify key genes involved, including CYFIP1, which is highly expressed in microglia.

SourceElsevier·JournalBiological Psychiatry·TypeExperimental study·DateOct 24, 2023

Is it ok to press the snooze button?

A study of 1,732 adults found that 69% used the snooze function or set multiple alarms. Snoozing resulted in lost sleep but prevented awakening from slow-wave sleep. In a second study, 30 minutes of snoozing improved cognitive performance.

SourceWiley·JournalJournal of Sleep Research·DateOct 18, 2023

Study examines role of working memory, cognitive functions in English learners learning to write

Researchers found that working memory was the most significant predictor of writing ability among English learner students. Cognitive functions such as phonological awareness and oral language development were also important, but only working memory consistently predicted higher scores in writing.

SourceUniversity of Kansas·JournalJournal of Experimental Child Psychology·TypeExperimental study·DateOct 17, 2023

On-Yee Lo, PhD, receives NAM Healthy Longevity Catalyst Award for work on brain stimulation to improve physical and cognitive functions in older adults

Dr. On-Yee Lo receives $50,000 seed funding to develop personalized non-invasive brain stimulation targeting shared networks to improve physical and cognitive functions in older adults. The project aims to demonstrate direct evidence that modulating between-network connectivity can be linked to changes in physical and cognitive behaviors.

Life satisfaction may not enhance cognitive functioning among some older adults

A new study suggests that life satisfaction has limited benefits for cognitive function in older adults experiencing health or socioeconomic challenges. High life satisfaction was associated with increased cognitive functioning among most individuals, but it was less beneficial for those with low SES, poor health, or adverse psychologi...

SourceBoston University School of Public Health·JournalSSM - Mental Health·TypeSurvey·DateSep 28, 2023

NTU Singapore scientists find new evidence to explain how we pay attention

Researchers uncover clues about how chemicals released by brain cells regulate our attention span, finding that two neurotransmitters work together in a precise sequence to regulate signal transmission. This discovery could lead to new treatments for neurological conditions associated with concentration difficulties.

SourceNanyang Technological University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateSep 21, 2023

Contributions to white matter injury in Alzheimer’s disease

Researchers highlight microvascular contributions to white matter injury in Alzheimer's disease, sparking calls for exploration of connections between AD, WM injury and cerebral small vessel disease. The study emphasizes the critical need to define mechanisms and diagnostic features of mixed vascular and AD neuropathological change.

SourceImpact Journals LLC·JournalAging-US·TypeCommentary/editorial·DateSep 12, 2023

Targeted ultrasound can change brain functions for up to an hour after intervention

A new study suggests that transcranial ultrasound stimulation can be used to change specific types of activity within the brain, paving the way for targeted treatments of mental health conditions. The research found that TUS induced significant changes in GABA concentration and altered communication between brain regions.

SourceUniversity of Plymouth·JournalNature Communications·TypeExperimental study·DateSep 12, 2023

Educational attainment protects against a genetic risk factor for Alzheimer’s disease

Researchers found that individuals with a genetic mutation linked to early-onset Alzheimer's disease had slower cognitive decline if they had higher education levels. The study also revealed that the APOE e4 mutation, which significantly increases risk for sporadic Alzheimer's disease, was less detrimental to cognitive function in thos...

SourceMass General Brigham·JournalNature Communications·TypeObservational study·DateAug 30, 2023

Prevalence of disabilities for older Black & White Americans plummeted from 2008 to 2017

The study found a significant decline in the prevalence of serious later-life cognitive impairments among Black Americans, narrowing racial disparities. However, racial disparities persisted in activities of daily living and functional limitations. Improved air quality may have contributed to the narrowing of disparities in cognitive i...

SourceUniversity of Toronto·JournalAging and Human Development·TypeSurvey·DateAug 29, 2023