Articles tagged with Delirium
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A recent study by Indiana University researchers found that young African-American adults are less susceptible to delirium in the ICU compared to Caucasians of the same age group. The study, which analyzed data from over 2,000 adults, also revealed differences in medication use and disease severity between racial groups.
New research identifies C-reactive protein as a potential biomarker for post-operative delirium, enabling preventive measures to safeguard patient health. Increased CRP levels before and after surgery are linked to higher risk of developing delirium.
Researchers analyzed data from 19 studies on hospitalized patients and found that antipsychotic medications did not reduce new cases of delirium. The study suggests that these medications may not affect the duration or severity of delirium, and more research is needed to understand their effectiveness in treating delirium.
A recent review of medical literature found no significant effect of antipsychotics on delirium incidence, duration, or mortality. The study analyzed data from 19 studies and concluded that there is no compelling signal to support routine use of antipsychotic medications for delirium prevention.
A study published in Neurology found that certain antibiotics are associated with delirium, a condition characterized by mental confusion and hallucinations. Researchers identified three types of brain problems related to antibiotics, including seizures, psychosis, and impaired muscle coordination.
A UCLA study reveals that cancer surgery significantly increases the risk of injuries and age-related health issues in older patients, leading to prolonged hospital stays, increased healthcare costs, and a higher risk of death. The study highlights the importance of discussing potential events with doctors before surgery.
Delirium occurs frequently in elderly GI surgery patients, often due to advanced age and poor physical health. Patients with postoperative delirium tend to experience longer hospital stays and increased mortality rates.
Dr. Sharon K. Inouye has received the 2015 M. Powell Lawton Award from the Gerontological Society of America (GSA) for her significant contributions to gerontology. Her work focuses on delirium prevention and treatment, and she has developed evidence-based interventions such as the Hospital Elder Life Program (HELP), which has been sho...
Researchers have developed a two-item bedside test for detecting delirium, which takes an average of 36 seconds to perform and has a sensitivity of 93 percent. The test uses simple questions to assess cognitive function and can help doctors catch the condition earlier.
A study found that major postoperative complications significantly contribute to prolonged hospital stays, while delirium contributes to adverse outcomes including length of stay, institutional discharge, and rehospitalization. Delirium was found to exert the highest attributable risk compared with other adverse events.
A study published in JAMA Surgery found that postoperative delirium significantly increases adverse outcomes in older adults, including prolonged hospital stays and institutional discharge. Delirium alone exerts the highest risk of adverse outcomes at the population level compared to other major surgical complications.
Researchers identified the hectic emergency department environment and lack of baseline cognitive state as major barriers to delirium recognition. Doctors emphasized the need for a rapid screening test and a 'physician-proof' dementia screening tool to improve detection rates.
A new study by Johns Hopkins Medicine researchers found that developing delirium in the ICU increases hospital stays and risk of dying, with risks doubled for brain dysfunction. The study also suggests potential causes of delirium include medication use and inflammation outside the brain.
A major systematic review of ICU delirium studies found a strong association between brain dysfunction and adverse outcomes, including high mortality rates and post-discharge cognitive impairment. Delirium was identified in 32% of critically ill patients, leading to a two-fold increase in hospital death risk.
A new study found that 48% of hip fracture patients experienced delirium during hospitalization, leading to significantly longer hospital stays and higher costs. The study suggests that reducing the rate of delirium would simultaneously increase quality of care while decreasing costs for elderly patient care.
A meta-analysis of 14 studies suggests that non-medication interventions can significantly reduce the risk of delirium and falls among older patients. These interventions include nutrition and hydration improvement, exercise, therapeutic activities, and re-orientation strategies.
A meta-analysis of multicomponent nonpharmacological interventions found significant reductions in delirium incidence and falls among hospitalized older patients. These strategies also trended toward decreases in length of hospital stay and institutionalization, suggesting a potential cost savings of over $16 billion annually.
The Wake Up and Breathe program significantly reduced delirium in critically ill patients, while also decreasing sedation levels and coma prevalence. However, the study found a trend towards increased duration of mechanical ventilation.
Older adults at risk of delirium following surgery due to preoperative pain and depressive symptoms. The study found a significant interaction between pain and depressive symptoms, increasing delirium risk by two-fold.
A new three-minute diagnostic assessment, 3D-CAM, detects delirium with greater-than-90-percent specificity and sensitivity, particularly in patients with dementia. The test has the potential to significantly improve detection of this common and morbid condition in vulnerable older hospital patients.
Researchers developed the 3D-CAM test, a short and structured diagnostic assessment to diagnose delirium. The test was highly sensitive and specific, with a sensitivity rate of 96% and specificity rate of 98%. Additionally, a study found that clinicians often remain unaware of patients' central venous catheters in place, posing a patie...
A University of Utah study reveals benzodiazepines increase ICU mortality by 9.1% compared to propofol. Patients treated with benzodiazepines spent more time on mechanical ventilation and were at higher risk for complications like delirium.
A randomized controlled trial found that melatonin supplementation had no effect on reducing delirium in elderly patients undergoing hip fracture surgery. The study suggests that melatonin may not be effective in preventing postoperative delirium, and further research is needed to compare its effects with antipsychotics.
Two Regenstrief Institute investigators, Michael LaMantia and Noll L. Campbell, have received NIH career development awards to study delirium recognition in emergency departments and the adverse cognitive effects of medications in older adults. Their projects aim to improve care and management of older adults with delirium.
Critically ill patients receiving steroids in the ICU are significantly more likely to develop delirium, with up to 80% of ventilated patients at risk. Minimizing steroid use may reduce delirium and its long-term impact on functional recovery and cognitive function.
Researchers developed a new scoring system, CAM-S, to measure delirium severity in older adults, which is associated with hospital mortality rates of up to 33% and estimated annual healthcare costs of over $182 billion. The study found that length of hospital stay increases with delirium severity, as well as mean hospital costs.
A new delirium severity score helps predict hospital outcomes in patients with delirium. The Confusion Assessment Method (CAM) scoring system is validated for predicting adverse outcomes, including prolonged hospital stay and functional decline. Additionally, a US survey shows that obesity contributes to the dramatic increase in diabet...
A new UK study found that continued statin use may help prevent delirium in critically ill patients who received statins before hospital admission. The study used a validated delirium screening tool and showed a significant lower risk of delirium associated with statin administration.
Delirium in older patients is frequently overlooked due to the lack of screening tools in emergency departments. The condition can lead to prolonged hospital stays, increased mortality rates, and a higher risk of developing dementia. Researchers call for the development of emergency department-specific screening instruments to improve ...
A novel role for S100β has been identified as a biomarker for delirium duration in critically ill patients, which may have implications for refining treatment in intensive care units. Delirium duration is associated with increased mortality rates, and higher levels of S100β on day 1 or day 8 are linked to longer delirium duration.
A Vanderbilt study found that 74% of patients with respiratory failure, cardiogenic shock, or septic shock developed delirium in the hospital, leading to dementia-like brain disease even a year after discharge. Cognitive deficits persisted for up to 12 months in both older and younger patients.
Researchers found that patients with pre-existing dementia who developed delirium while hospitalized had a 25% chance of dying within 30 days. Early detection and treatment of delirium can improve patient functioning and reduce mortality rates.
Researchers tested haloperidol, a commonly used antipsychotic, in 141 critically ill patients on artificial ventilation. The study found that haloperidol had no effect on reducing delirium or mortality rates, but may help reduce sedation requirements. Non-pharmacological interventions are more effective in preventing delirium.
A new two-minute assessment tool has been developed to help hospital staff identify patients at risk of developing delirium, a condition characterized by severe confusion and disorientation. The tool, termed AWOL, uses elements that can be assessed quickly in the fast-paced environment of a hospital.
A study found that nearly half of older adults undergoing surgery with general anesthesia developed delirium in the postanesthesia care unit (PACU), with 45% of patients experiencing delirium. Delirium is linked to decreased cognitive function and an increased risk of nursing home admission. The study suggests that even brief episodes ...
A team of doctors and nurses at Johns Hopkins Hospital implemented interventions to improve patient sleep quality, reducing delirium by 54% in ICU patients. The study suggests that simple measures can have a significant impact on patient outcomes and recovery from intensive care.
A new trauma program at St. Michael's Hospital has shown significant improvements in outcomes for elderly patients admitted for trauma. The program, which provides geriatric consultations within 72 hours of admission, has reduced the risk of delirium by 10% and decreased the likelihood of discharge to long-term care facilities.
A randomized controlled trial found that daily sedation interruption did not improve outcomes, including duration of mechanical ventilation, among critically ill patients. The study also revealed increased use of opioids and benzodiazepines in the interruption group.
Delirium is a common acute condition with significant short- and long-term effects on cognition and function. A systematic evidence review identified risks, prevention options, and prognoses related to delirium, emphasizing the need for effective management strategies.
Patients with Alzheimer's who suffered delirium episodes had a sharply increased rate of mental decline for up to five years after hospitalization compared to those without episodes. The study highlights the importance of recognizing and preventing delirium, which is estimated to cost the healthcare system billions annually.
A study published in the journal Brain found that episodes of delirium increase the risk of developing new dementia eight-fold in older patients. Delirium also worsens the severity of dementia and accelerates cognitive decline in those already diagnosed with dementia.
New research establishes a link between postoperative delirium and prolonged loss of cognitive function in cardiac surgery patients. Interventions to prevent delirium may help cardiac patients avoid long-term cognitive consequences.
A Wake Forest Baptist study suggests Long QT Syndrome may cause unexplained deaths during Excited Delirium. The syndrome can be triggered by agitation, confusion, or psychiatric issues, highlighting the need for law enforcement education to prevent in-custody deaths.
A new study confirms that hospitalization and delirium in Alzheimer's patients lead to hastened cognitive decline, institutionalization, and death. Effective prevention strategies such as the Hospital Elder Life Program can mitigate this risk.
A recent study found that Alzheimer's patients who undergo hospitalization are at risk for complications such as delirium, loss of independence, and death. Researchers also highlighted the risks associated with Flavocoxid, a medical food used to treat osteoarthritis, which can cause liver injury in some patients. Additionally, screenin...
Research shows that earplugs can lower the incidence of confusion and delay cognitive disturbances in ICU patients. The use of earplugs resulted in better sleep quality, with a corresponding decrease in delirium risk by over 50%.
Researchers developed a mouse model of delirium, finding that systemic inflammation triggers short-term memory disturbance, which is reversed by treatment with donepezil. The study reconciles two long-standing hypotheses, shedding light on the condition's causes and potential treatments.
A study at Duke University Medical Center confirms an association between sleep apnea and post-surgical delirium, a condition with serious health consequences. Researchers found that patients with obstructive sleep apnea were more likely to develop delirium after surgery.
A new study published in Infection Control and Hospital Epidemiology found that patients moved into isolation during hospitalization are nearly twice as likely to develop delirium. The researchers suggest that underlying illness may be the cause of this association.
A new national plan aims to improve care for patients with delirium, a poorly understood condition that affects millions of Americans. The plan outlines four goals: improving clinical care, educating healthcare providers, investing in research, and developing a network of delirium professionals.
A systematic review of delirium biomarkers found that clinicians are not using these chemical indicators to diagnose or treat patients with delirium. Biomarkers linked to delirium provide a window into the disease process, enabling better recognition and management of the condition.
Researchers found that elderly residents in long-term care facilities who were evacuated during a severe summer storm experienced delirium, cognitive changes, hospitalizations, and death. The study highlights the need for nurses to be aware of the potential difficulties older adults may experience during disasters.
A review of 4,431 patients from six countries found that older adults with cognitive impairment often face challenges in emergency departments due to lack of assessment tools and inadequate care. The authors highlight the need for more research and development of a clinically relevant screening tool to address these issues.
A prospective study found that smoking significantly increases a woman's risk for peripheral artery disease (PAD), which can cause pain and discomfort. The study also suggests that smoking cessation reduces the risk, but even after 20 years of abstention, the risk remains elevated.
A new intervention using cognitive activities is being tested to help patients with delirium superimposed on dementia. The study, funded by the National Institutes of Health, aims to improve physical function and resolution of delirium.
Delirium is a growing concern in hospitals, affecting over 7 million Americans annually and causing prolonged hospital stays, increased mortality risk, and vulnerability to Alzheimer's disease. Researchers are calling for improved monitoring and treatment strategies to reduce the delirium burden by half within two decades.
Temporary combativeness in anesthetized children may be prevented by reducing epinephrine production with specific drugs, according to a medical expert. This can improve post-surgery experience for both children and their families.
Researchers aim to improve nurses' assessment skills to better detect delirium in patients with dementia, reducing drug treatments and improving outcomes. The five-year project will integrate electronic medical records and provide decision-making support to encourage evidence-based practices.
A review analyzing previous research found delirium in older patients increases risk of death, dementia, and institutionalization. The study controlled for age, illnesses, and severity, confirming the association independent of these factors.
A new study by Johns Hopkins researchers suggests that limiting the depth of sedation during procedures could safely cut the risk of postoperative delirium by 50 percent. Lighter sedation was associated with a one-day reduction in the duration of delirium in those patients who still emerged from surgery confused and disoriented.