Articles tagged with Memory Disorders
A study led by Duke Health found that a short course of the Alzheimer's drug donepezil can reverse structural and genetic brain changes caused by alcohol exposure in rats. This reverses dendritic spine density, affecting learning and memory. The research identifies a specific gene target for potential repair.
A team of University of Pennsylvania neuroscientists developed a system to monitor brain activity and trigger stimulation responsively, improving learning and memory performance. The study found that precisely timed electrical stimulation can reliably enhance memory function in patients with memory loss.
Researchers at Ohio State University Wexner Medical Center conducted a study on a brain pacemaker to slow the decline of problem-solving and decision-making skills in patients with Alzheimer's disease. The deep brain stimulation (DBS) implant improved cognitive, behavioral, and functional abilities in patients.
Researchers at Mayo Clinic discovered that electrical stimulation of the lateral temporal cortex enhances word recall, making it easier for patients to remember previously viewed words. The study suggests potential new treatment devices for memory and cognitive deficits.
Researchers found that early personality changes can lead to noticeable behavior problems, including depression and anxiety. The study suggests that diagnosing these early changes could help develop earlier treatments for Alzheimer's disease.
A new study by UCLA researchers found that daily consumption of curcumin improved memory and mood in people with mild, age-related memory loss. The study, which involved 40 adults aged 50-90, showed significant improvements in cognitive power and reduced amyloid and tau signals in the brain.
Research by neuroscientists at New York University uncovers neural circuits that may be intact but improperly tuned, leading to inflexibility in learning new information. The study sheds light on the cognitive deficit characteristic of Fragile X syndrome, which impairs memory use in multiple ways.
Adolescents with OCD experience widespread learning and memory problems, affecting daily functioning and school performance. Researchers found impaired cognitive flexibility and goal-directed control, highlighting the need for structured environments to support their development.
Dr. Chiaravalloti will test the modified Story Memory Technique's impact on new learning and memory abilities in older adults with mild cognitive impairment. The study aims to improve daily functioning and quality of life for this population.
Scientists at UC San Diego report that distinct, sparse sets of hippocampal neurons encode episodic memories, recollections of past events. The findings provide significant insights into the mechanisms of memory and have implications for health-related reasons, including Alzheimer's disease.
A new guideline from Mayo Clinic suggests that exercise can help people with mild cognitive impairment, which is an intermediate stage between normal aging and dementia. Twice-weekly workouts of 30 minutes or less may slow down the progression of symptoms.
Researchers found that direct electrical stimulation of the human amygdala can enhance next-day recognition of images, with a significant boost in memory performance. The study used low-level current and showed an improvement in memory recall for patients with epilepsy and average memory performance.
Researchers found that overexpressing FKBP1b restored gene expression in hippocampal neurons, improving water maze performance and reversing age-related memory impairments in rats. The study suggests addressing FKBP1b deficiency may be a new avenue for countering age-related memory loss.
A study by Temple University researchers found that mice fed canola oil daily suffered impaired working memory and increased amyloid plaques, indicative of neuronal damage. The findings suggest that long-term consumption of canola oil may be detrimental to brain health.
Researchers found that six weeks of intense exercise improved high-interference memory, a type of memory that allows us to distinguish between similar objects. Participants who experienced greater fitness gains also showed increased brain-derived neurotrophic factor (BDNF), supporting the growth and function of brain cells.
Researchers found that a specific G protein linked to dopamine receptors plays a role in both forming and erasing memories. The study suggests that the brain has an 'optimization process' that whittles away unnecessary memories, allowing for better function.
A study by McMaster University neuroscientists found that even mild trauma from contact sports can disrupt the production of new neurons in the hippocampus, a region critical to memory. Temporary memory losses were observed in concussed athletes, while scores improved after a reprieve from their sport.
A study published in Nature Communications reveals that membralin plays a crucial role in regulating the cell's machinery for producing beta-amyloid, the protein responsible for neuronal death in Alzheimer's disease. The researchers found that membranes with lower levels of this protein are associated with increased neurodegeneration a...
The GuidAge study suggests that memory complaints reported by elderly individuals can predict a decline in cognitive performance. Five specific items on the McNair and Kahn Scale were found to be statistically significant, including difficulty remembering phone numbers, appointments, and instructions.
A selective PDE4D inhibitor, BPN14770, has shown promise in treating Fragile X syndrome by reducing hyperarousal and improving social interactions. The treatment also exhibited long-term benefits, with no tolerance observed.
A neuroprotective compound has been shown to protect against nerve cell death, depression, and memory problems in a rat model of Alzheimer's disease. The treatment also prevented the development of depression-like behavior and delayed cognitive decline.
Researchers discovered that a neurotransmitter called GABA plays a crucial role in inhibiting unwanted thoughts, particularly in individuals with disorders such as schizophrenia and anxiety. The study found that higher GABA concentrations in the hippocampus are associated with better thought suppression abilities.
Researchers at NUS found that the brain changes the activity of neurons when distracted, but retains information by reorganizing the 'code' used to store it. This discovery could inspire novel artificial neural network architectures and improve our understanding of brain function.
Researchers found that variability in the medial temporal lobe's subfields is associated with differences in associative memory performance among older adults. The study's findings could help unravel age-related memory impairment by highlighting individual differences in brain structure and function.
Research reveals that wounds heal more than twice as fast in skin with prior inflammatory experience, thanks to sensitized stem cells. These cells remain active long after the initial inflammation has subsided and are better equipped to migrate into the wound.
The Canadian Foundation for Innovation provides a $1.8 million grant to Baycrest's Rotman Research Institute (RRI) to upgrade its MRI and MEG machines, enabling researchers to pursue unique ways to protect brain health during aging and prevent dementia.
Researchers discover how seizures trigger cognitive deficits in Alzheimer's disease through increased levels of the protein deltaFosB, leading to suppressed production of calbindin and disrupted brain activity. Further studies support the findings, showing potential new strategies for reducing cognitive deficits.
A new CAMH study found that people unaware of their memory loss are more likely to progress to Alzheimer's disease. Those aware of memory problems are unlikely to develop dementia. The study used PET brain scans to identify specific brain regions affected in impaired illness awareness.
Researchers discovered that activity in dendrites increases during sleep, linked to specific brain waves associated with memory formation. This study could lead to new treatments for learning and memory disorders, such as dementia.
Researchers will combine personalized music choices with Transcranial Direct Current Stimulation (tDCS) to improve memory among patients with MCI. The study aims to strengthen the brain pathway used by music to activate memories and slow down memory decline.
A new study by USC researchers suggests that the TOMM40 gene, neighboring ApoE4 on chromosome 19, has a significant influence on late-life development of dementia and Alzheimer's. The research found that a TOMM40 variant was more influential than ApoE4 in decline of immediate memory.
A ketogenic diet improved memory in aging mice and increased their chances of surviving to old age. The study suggests that the health benefits of BHB may go beyond memory and could affect tissues and organ systems.
A new study in mice has found that disruptions to the brain's center for spatial navigation, known as internal GPS, result in severe memory deficits seen in schizophrenia. This discovery offers promising avenues for drug intervention and treatment, targeting a near-universal symptom of the disorder.
A decline in navigational skills could be an early sign of Alzheimer's disease, according to researchers. Researchers are exploring the possibility of using navigational impairments as a diagnostic tool for neurodegenerative diseases.
A study led by Columbia University Medical Center researchers found that boosting blood levels of osteocalcin reverses age-related memory loss in mice. Osteocalcin binds to a receptor called Gpr158 in the brain's memory center, and restoring youthful levels of the hormone improves cognitive function.
Researchers found that individuals with difficulty identifying odors had elevated AD-related proteins in their cerebrospinal fluid. The study suggests a potential cheaper alternative for tracking the progression of Alzheimer's disease through simple smell tests.
Researchers at the University of Queensland have discovered that adult brains can produce new cells in the amygdala, a region important for processing emotional memories. This finding has significant implications for understanding the brain's ability to adapt and regenerate.
A Johns Hopkins study found that individuals with mild cognitive decline have lower levels of serotonin transporters, suggesting a possible driver of the disease. The research suggests increasing serotonin function may prevent memory loss and slow disease progression.
Researchers at MIT have found a way to precisely target the enzyme HDAC2, which blocks genes required for memory formation in Alzheimer's patients. By blocking its interaction with Sp3, they were able to reverse memory loss in mice, offering a potential new treatment approach.
Researchers at the University Medical Center Goettingen identified a molecular link between PTSD and Alzheimer's disease, specifically Formin 2. Formin 2 mutant mice show PTSD phenotypes at an early age and develop age-related memory decline.
A new study published in The FASEB Journal suggests that green tea's EGCG may alleviate high-fat diet-induced insulin resistance and cognitive impairment. Researchers found that mice fed with a high-fructose diet and given EGCG showed improved cognitive function and reduced weight gain.
Scientists suspect sleep apnea diminishes healthspan due to its link with age-related diseases, including non-alcoholic liver disease and Alzheimer's, prompting researchers to explore treatment options.
Researchers found a small-molecule drug improves synaptic plasticity in the hippocampus and object location memory in Rett syndrome mice. The treatment also restored general locomotor activity to normal levels, offering hope for patients with neurodevelopmental disorders.
Researchers found that thyroxine and metformin can repair memory and learning deficits caused by fetal alcohol exposure when given after birth. The study provides potential treatment for fetal alcohol spectrum disorder.
Researchers at King's College London have discovered a molecular mechanism that enables neurons to adapt to their environment, shaping learning and memory formation. The study reveals that Brevican protein plays a critical role in regulating experience-dependent plasticity, influencing the intrinsic properties of PV+ interneurons and s...
A new clinical trial will assess the effectiveness of improvisational dance in improving gait and balance problems associated with cognitive impairment and memory loss, as well as reducing apathy and depression. The 12-week program will be divided into four groups, including dance with social engagement and dance only.
Research found that reduced mastication in mice led to suppressed maxillofacial bone and muscle growth, as well as reduced neural activity in the hippocampus, a key component of memory. This study suggests maintaining or strengthening masticatory function may help prevent dementia and memory/learning dysfunction.
A new study published in Neuron provides direct experimental evidence for the 'Memory-Synapse Specificity' Hypothesis, linking a specific type of synapse to a particular behavior and memory. The research reveals that synaptic long-term potentiation (LTP) at a specific type of synapse encodes socially acquired olfactory memory.
A new study suggests that the small molecule LM22A-4 can improve spatial memory and motor skill defects in Rett syndrome mice by enhancing synaptic plasticity in the hippocampus. The treatment also shows promise for improving breathing problems associated with the disease.
A 'brain training' game developed by researchers at the University of Cambridge improved memory in patients with mild cognitive impairment by 40% through episodic memory tests. The app's engaging gameplay and individualization also boosted motivation and confidence.
New research finds that taking photos of experiences enhances visual memory, but hinders auditory memory. Participants who took photos recalled more visual details than those who didn't have a camera, while their auditory recall suffered compared to their non-photographing peers.
Researchers at Columbia University Medical Center found that selective memories can be erased from snail neurons, potentially developing drugs to delete memories triggering anxiety and PTSD. The study's results could lead to the development of treatments for these conditions by eliminating non-associative memories without affecting ass...
Researchers have developed a new technique to isolate neuronal activity during memory consolidation, revealing that individual hippocampal neurons respond selectively to specific memories. This study provides insight into the neural mechanisms of memory formation and its potential link to brain diseases like epilepsy.
Gulf War veterans experience long-term side effects of their service due to exposure to chemicals like pyridostigmine bromide, DEET, and permethrin. Animal models demonstrate how these chemicals cause brain dysfunction, inflammation, and oxidative stress, leading to symptoms such as cognitive decline, memory problems, and chronic fatigue.
Japanese scientists have developed a method to isolate and identify active compounds in plant medicines, which accurately accounts for drug behavior in the body. They identified several active compounds from Drynaria Rhizome that improve memory and reduce disease characteristics in a mouse model of Alzheimer's disease.
Recent studies suggest that excessive neural activity in specific brain regions can impair memory and attention. Inhibitory neurotransmission, mediated by GABA, plays a crucial role in regulating neural activity. The review highlights the importance of balancing aberrant neural activity to restore cognitive function.
Researchers found strong association between cognitive decline and small blood vessel disease in the brain, with 61% of older adults having at least one component of the condition. The study, part of the Atahualpa Project, suggests that vascular neurology may be an important factor in stroke and neurological disorders in Latin America.
A Penn study found that acetyl-CoA synthetase 2 (ACSS2) regulates gene expression in neurons to form and store spatial memories. Blocking ACSS2 impairs long-term memory, suggesting a potential target for neurological disorders like anxiety and depression.
Exposure to common anesthesia drug sevoflurane in infancy results in visual recognition memory impairment, which emerges after the first year of life and may persist long-term. Researchers used a rhesus monkey model to investigate the effects of repeated anesthesia exposure on neurocognitive function.
A study found that repeated exposure to anesthesia during infancy results in impaired visual recognition memory, which emerges after the first year of life. The research used a rhesus monkey model and confirmed that multiple anesthesia exposures alone lead to memory impairment, with deficits not apparent until later developmental stages.