Research finds that young children aged 3-5 can recognize happiness, sadness, calmness, and fear in music. However, children with higher callous-unemotional traits show poorer emotion recognition in music compared to facial expressions.
Researchers from Shibaura Institute of Technology used machine learning algorithms to predict bearing layer depth and assess liquefaction risk. The study found that random forest models outperformed others, especially with increasing spatial data density.
A recent study published in Nature Climate Change confirms that tropical cyclone clusters are becoming more frequent in the North Atlantic due to climate warming. The research found that a La-Nina-like global warming pattern is shifting the hotspot for tropical cyclone clusters from the Northwestern Pacific to the North Atlantic basin.
Initiation of semaglutide in adults leads to reductions in weight and cardiovascular risk factors, while increasing health care expenditures. These findings suggest potential clinical benefits, highlighting the need for long-term evaluation of semaglutide's economic impact.
A new platform enables real-time super-resolution imaging visual guidance during manipulation, allowing for precise control of feature-sized targets. The microlens-AFM probe improves imaging resolution by over 10-fold and enhances manipulation accuracy by 50%.
A study from the University of Oregon found that debris flows and rockfall have been occurring in steep, rocky watersheds for thousands of years, regardless of fire. The researchers suggest that fire plays a relatively small role in triggering these events, highlighting the importance of considering geological history.
The book explores innovative computing technologies transforming healthcare delivery, diagnostics, and monitoring. It covers topics like artificial intelligence, machine learning, IoT, wearable devices, and real-time communication systems.
The nuclear phosphoinositide-p53 signalosome modulates AKT activation in the nucleus, integrating two oncogenic pathways into a unified mechanism driving cancer cell motility. This complex is highlighted as a central regulator of cancer cell migration and a promising target for metastasis therapy.
The Lancet commission emphasizes the need for concrete goals to reduce hepatocellular carcinoma's growing disease burden. The authors propose a 2% annual reduction in age-standardized incidence rates and recommend evidence-based strategies to tackle viral hepatitis, alcohol consumption, environmental risk factors, and disparities in he...
New research finds that wildfire smoke substantially increases ozone concentrations, even in remote areas with few human emission sources. The study suggests that removing anthropogenic NOx emissions would not eliminate ozone problems, as fires can still produce ozone.
Seoul National University researchers developed a wearable electronic device that continuously measures blood pressure with a compact, flexible patch. The device surpasses traditional cuff-based monitors in accuracy and convenience, paving the way for early diagnosis of chronic conditions like hypertension.
Researchers have created a novel method to culture living brain cells in Alzheimer's and Parkinson's disease, using affordable 'ring-inserts' that support high-quality tissue cultures and enable real-time imaging. This cost-effective approach reduces experimental costs by up to €3,500 while maintaining experimental quality.
A study published in Perception found that people consistently overestimate the steepness of a hill when viewed at an angle, regardless of their eye height. The researchers tested participants' ability to estimate the slope of a wooden ramp while seated, standing on a step ladder, or lying down.
Researchers at Dana-Farber Cancer Institute have developed a non-invasive blood test, SWIFT-seq, to profile circulating tumor cells in the blood. The test offers a detailed genetic profile, identifying key genetic changes crucial for understanding multiple myeloma.
The study identified significant alterations in chromatin accessibility of cis-regulatory elements associated with AML differentiation, linked to mutations in the WT1 transcription factor gene. These changes led to reduced chromatin accessibility and downregulation of target genes, promoting AML proliferation.
Researchers developed an organic molecule that simultaneously emits light suitable for displays and absorbs photons for deep-tissue bioimaging, overcoming a long-standing design challenge. The compound achieved high efficiency in both applications, paving the way for next-generation multifunctional materials.
TDCPP's binding to the membrane thyroid hormone receptor impairs motor neuron development and causes locomotor dysfunction in zebrafish. The study establishes a novel adverse outcome pathway framework for predicting TDCPP's neurotoxicity.
A cross-sectional study found that white populations use more prescription drugs than Asian or Pacific Islander and Hispanic populations. After adjusting for age and disease prevalence, Black populations have lower prescription fill rates compared to the overall population average.
Newly developed DNA nanostructures form flexible, fluid, and stimuli-responsive condensates without chemical cross-linking. These findings pave the way for adaptive soft materials with potential applications in drug delivery, artificial organelles, and bioengineering platforms.
The study resolved cryo-EM structures of the Nipah virus polymerase complex, unveiling binding modes between RdRp/PRNTase domains and the P tetramer. Two conserved zinc-binding sites were identified essential for polymerase activity.
A new project funded by the Weston Family Foundation's Homegrown Innovation Challenge will continue advancing indoor blueberry trials while expanding to include raspberries and blackberries. The goal is to develop compact, high-yield berry varieties and modular growing systems that support Canadian farmers year-round.
A recent study analyzed hourly data from nearly 750 low-cost and regulatory air pollution sensors throughout LA to understand the impact of wildfires on air quality. The findings suggest that combining different data sources, including ground-based sensors and satellite data, can provide more accurate and comprehensive information.
A mobile phone app designed to deliver suicide-specific therapy reduced suicidal behavior among psychiatric inpatients by 58.3%. Users experienced sustained reductions in suicidal thoughts for up to 24 weeks after hospitalization.
The report warns that immigration enforcement is a public health emergency for millions of children, causing constant anxiety and harm to their emotional development and academic performance. Clinical case studies reveal how trauma is transmitted across generations, shaping the mental health of immigrant children.
A team of researchers identified a complex network of regulatory proteins responsible for triggering the most appropriate immune response in macrophages. This study offers new insights into macrophage biology and sheds light on how these cells coordinate their responses to various pathogens.
Researchers investigate regional-specific gut microbial distribution, revealing its critical role in metabolic and immune regulation. Key findings include duodenal mucosal resection reducing small intestinal bacterial overgrowth and machine learning integrating multi-omics data to predict microbial dynamics.
Insects rely on carbon dioxide emissions from host plants to identify ideal egg-laying sites. Rising atmospheric CO₂ levels interfere with this natural signal, leading to maladaptive choices that threaten insect survival. The study highlights the urgent need for both emissions reductions and innovative agricultural adaptation.
Researchers aim to widen ADCs' therapeutic window and application scope by integrating AI, single-cell sequencing, and combination therapies. Precise antigen selection is crucial to minimize toxicity and improve efficacy in targeted cancer therapy.
Anish Sapkota is researching abiotic stressors like drought, heat, and soil nutrients in crops such as wheat and alfalfa to improve precision agriculture. Variable rate application of water and fertilizer can help farmers save money and products by targeting specific areas of the field.
A study by the University of Jyväskylä reveals an intergenerational link between parents' and their children's school commuting habits. Parents' own experiences and attitudes towards walking or cycling to school influence how they support and enable their children's physically active commuting.
A recent review paper on meditation apps, led by Carnegie Mellon University's J. David Creswell, found that these digital platforms can lead to benefits in reduced depression, anxiety, and stress. The study also highlights the potential for meditation apps to incorporate biometrics and AI-driven personalization.
Researchers found that children unexposed to HIV had higher taxonomic turnover in their oral microbiomes, indicating less adaptability to environmental changes. Children living with HIV had more stable oral microbiomes and higher frequencies of cavity-causing bacteria.
A new resource, EuPRI, maps RNA sequences for nearly 35,000 RBPs across nearly 700 species, offering insights into evolutionary history and potential therapeutic targets. Researchers also uncover how oxygen sensors regulate ferroptosis and how a specific transcription factor influences natural killer cell responses.
Neuroblastoma is often difficult to treat due to its ability to enter a dormant state when the MYCN gene is located outside chromosomes. A new study proposes targeting these dormant tumor cells with a combination of chemotherapy and a second drug, showing promising results in mouse models.
Scientists have decoded the complex genome of sweetpotato, revealing an intricate origin story and providing a powerful tool for improvement. The research showed that sweetpotato is a 'segmental allopolyploid,' with six sets of chromosomes that contribute to its remarkable adaptability and disease resistance.
Researchers have identified Laccase2 as essential for darkening and hardening overwintering eggs in pea aphids. Disrupting this gene eliminates egg protection, making them susceptible to infection and hindering hatching.
Dynamin 1 regulates EMT progression, cell polarity and migration through N-cadherin endocytosis and recycling, promoting ovarian cancer metastasis. The study identifies DNM1 as a critical regulator of EMT-associated metastasis.
A team of researchers found that a rare South African cycad's leaves owe their bluish color to a wax-based optical effect produced by lipid compounds. The coating of epicuticular wax on the leaves forms tubular crystals that reflect light, giving the plant its unique sheen.
Combining federal monitors, low-cost sensors, and satellite data can provide a more complete picture of local air quality, enabling people to make safer choices in real-time. The study highlights the importance of timely and accurate air quality information during wildfire events.
Researchers identify key symptom categories and biomarkers for anti-NMDAR encephalitis, a rare autoimmune brain condition. Clinical manifestations suggest the presence of anti-NMDAR encephalitis through NMDA antibody checks, uric acid levels, C-reactive protein, and thyroid-related hormones.
Researchers propose a quality management system for quantum technologies to ensure security, interoperability, transparency and accountability. International standards can facilitate cooperation among countries like China, the US, and Europe, creating trust in new technologies.
Scientists have discovered that MYOD protein can act as a gene silencer, clearing out old 'furniture' to reset the cell's identity. This finding challenges dogma and opens up new avenues for understanding cellular reprogramming and regenerative medicine therapies.
Researchers at Penn State have simulated a new class of protein misfolding using atomic-scale models, revealing a type of entanglement that disrupts protein function and persists in cells. The findings support the existence of this long-lasting type of misfolding, which is thought to contribute to aging and disease.
HTGAnalyzer is an automated tool simplifying complex transcriptomic workflows, enabling clinicians without bioinformatics expertise to perform essential analyses in precision medicine. The tool has been validated using multiple datasets and identified differentially expressed genes linked to cancer diagnosis, treatment, and prognosis.
A research team led by Professor Teruyuki Niimi has developed a new gene function analysis method for the Japanese rhinoceros beetle using electroporation. This advancement will significantly deepen our understanding of how the rhinoceros beetle's horn forms and evolves.
Researchers at ETH Zurich create a novel three-dimensional heart patch for intraventricular implantation, integrating into existing heart tissue. The RCPatch combines a fine mesh, 3D-printed scaffold, and hydrogel with living cells to promote complete repair and regeneration of damaged heart tissue.
A new American Heart Association Science Advisory highlights the negative impact of excessive ultraprocessed food consumption on cardiometabolic health. Research found a strong dose-response relationship between UPF intake and increased risk of cardiovascular events, Type 2 diabetes, obesity, and mortality.
The UCI-OC Poll finds a strong preference for flexibility in work arrangements, with many workers willing to relocate for remote job opportunities. However, there is also concern about the impact of artificial intelligence on jobs, highlighting the need for thoughtful integration and policy considerations.
Researchers at Osaka Metropolitan University have directly observed the quantum Kelvin-Helmholtz instability, producing eccentric fractional skyrmions. These exotic vortex patterns are governed by quantum mechanics and topology, challenging traditional classifications.
Scientists at Kyushu University have created a solid oxide fuel cell that operates at a low temperature of 300°C, overcoming a major hurdle in their development. The breakthrough uses scandium to create a 'ScO6 highway' for protons to travel efficiently, enabling the production of affordable hydrogen power.
A study found that social robots like Luka can become deeply embedded in families over time, taking on emotional and symbolic roles. Children often reinterpret their relationship with the robot as they grow older, repurposing it as a companion or keepsake.
A new study finds that up to 18% of women are advised to stop breastfeeding due to medication, while chronic illness increases this number to 58%. The research highlights the need for accurate and balanced information about medication safety during breastfeeding.
A recent study found that Arizona Bald Eagles migrate north instead of south, unlike most migratory birds in temperate zones. This adaptability allows them to take advantage of ephemeral food sources, such as spawning salmon or ungulate carcasses.
A new statistical model using GPS tracking data accurately predicted nest success for the California Condor, demonstrating its potential to inform conservation decisions. The model's results were corroborated by field observations and camera footage, allowing researchers to assess nest fate with high accuracy.
The study assesses autonomous vehicle adaptability on small-radius circular curves, showing ride comfort degrades to
Scientists create a spatiotemporal light system that emulates the behavior of potential-free Schrödinger equations, generating localized wavepackets without potential energy constraints. This breakthrough could provide new insights into quantum physics and applications in studying light-matter interactions.
Scientists have created a new process to break down per- and polyfluoroalkyl substances (PFAS) in water, producing harmless fluoride components. The breakthrough offers a low-energy solution for PFAS remediation with potential applications in water treatment and environmental cleanup.
A new bioactive wound dressing combining miR-221-3p and GelMA hydrogel promotes blood vessel formation, accelerating diabetic wound healing. The study shows a 90% wound closure rate within 12 days in animal trials.
A novel hydrogel has been developed to accelerate wound healing in infected wounds by regulating the skin microbiota. The hydrogel, PSG15, inhibited bacterial growth and promoted tissue regeneration, enhancing angiogenesis and collagen deposition.
SUTD researchers create lightweight, aerodynamic monocopter with passive stability, achieving 26 minutes of sustained flight. The design reverses traditional quadcopter inefficiencies by leveraging autorotation and minimising thrust.